LOCUS       NM_024940              10246 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens dedicator of cytokinesis 5 (DOCK5), transcript variant
            1, mRNA.
ACCESSION   NM_024940 XM_209883
VERSION     NM_024940.8
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10246)
  AUTHORS   Qu,H., Liu,X., Zhu,J., Xiong,X., Li,L., He,Q., Wang,Y., Yang,G.,
            Zhang,L., Yang,Q., Luo,G., Zheng,Y. and Zheng,H.
  TITLE     Dock5 Deficiency Promotes Proteinuric Kidney Diseases via
            Modulating Podocyte Lipid Metabolism
  JOURNAL   Adv Sci (Weinh) 11 (11), e2306365 (2024)
   PUBMED   38161229
  REMARK    GeneRIF: Dock5 Deficiency Promotes Proteinuric Kidney Diseases via
            Modulating Podocyte Lipid Metabolism.
REFERENCE   2  (bases 1 to 10246)
  AUTHORS   Liu,C., Li,G., Zheng,S., She,L., Lu,S., Wang,Y., Huang,D.,
            Zhang,X., Sun,L., Liu,Y. and Qiu,Y.
  TITLE     PHF5A regulates the expression of the DOCK5 variant to promote
            HNSCC progression through p38 MAPK activation
  JOURNAL   Biol Direct 18 (1), 39 (2023)
   PUBMED   37434235
  REMARK    GeneRIF: PHF5A regulates the expression of the DOCK5 variant to
            promote HNSCC progression through p38 MAPK activation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 10246)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   4  (bases 1 to 10246)
  AUTHORS   Meng,L., Zheng,Y., Liu,S., Ju,Y., Ren,S., Sang,Y., Zhu,Y., Gu,L.,
            Liu,F., Zhao,Y., Zhang,X. and Sang,M.
  TITLE     ZEB1 represses biogenesis of circ-DOCK5 to facilitate metastasis in
            esophageal squamous cell carcinoma via a positive feedback loop
            with TGF-beta
  JOURNAL   Cancer Lett 519, 117-129 (2021)
   PUBMED   34216686
  REMARK    GeneRIF: ZEB1 represses biogenesis of circ-DOCK5 to facilitate
            metastasis in esophageal squamous cell carcinoma via a positive
            feedback loop with TGF-beta.
REFERENCE   5  (bases 1 to 10246)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 10246)
  AUTHORS   El-Sayed Moustafa,J.S., Eleftherohorinou,H., de Smith,A.J.,
            Andersson-Assarsson,J.C., Alves,A.C., Hadjigeorgiou,E.,
            Walters,R.G., Asher,J.E., Bottolo,L., Buxton,J.L., Sladek,R.,
            Meyre,D., Dina,C., Visvikis-Siest,S., Jacobson,P., Sjostrom,L.,
            Carlsson,L.M., Walley,A., Falchi,M., Froguel,P., Blakemore,A.I. and
            Coin,L.J.
  TITLE     Novel association approach for variable number tandem repeats
            (VNTRs) identifies DOCK5 as a susceptibility gene for severe
            obesity
  JOURNAL   Hum Mol Genet 21 (16), 3727-3738 (2012)
   PUBMED   22595969
  REMARK    GeneRIF: the potential role of DOCK5 in human obesity
REFERENCE   7  (bases 1 to 10246)
  AUTHORS   Kang,H., Davis-Dusenbery,B.N., Nguyen,P.H., Lal,A., Lieberman,J.,
            Van Aelst,L., Lagna,G. and Hata,A.
  TITLE     Bone morphogenetic protein 4 promotes vascular smooth muscle
            contractility by activating microRNA-21 (miR-21), which
            down-regulates expression of family of dedicator of cytokinesis
            (DOCK) proteins
  JOURNAL   J Biol Chem 287 (6), 3976-3986 (2012)
   PUBMED   22158624
REFERENCE   8  (bases 1 to 10246)
  AUTHORS   Sanders,M.A., Ampasala,D. and Basson,M.D.
  TITLE     DOCK5 and DOCK1 regulate Caco-2 intestinal epithelial cell
            spreading and migration on collagen IV
  JOURNAL   J Biol Chem 284 (1), 27-35 (2009)
   PUBMED   19004829
  REMARK    GeneRIF: along with DOCK1, DOCK5 is an important mediator of
            CrkII/CrkL regulation of Caco-2 spreading and migration on collagen
            IV.
REFERENCE   9  (bases 1 to 10246)
  AUTHORS   Nusbaum,C., Mikkelsen,T.S., Zody,M.C., Asakawa,S., Taudien,S.,
            Garber,M., Kodira,C.D., Schueler,M.G., Shimizu,A., Whittaker,C.A.,
            Chang,J.L., Cuomo,C.A., Dewar,K., FitzGerald,M.G., Yang,X.,
            Allen,N.R., Anderson,S., Asakawa,T., Blechschmidt,K., Bloom,T.,
            Borowsky,M.L., Butler,J., Cook,A., Corum,B., DeArellano,K.,
            DeCaprio,D., Dooley,K.T., Dorris,L. 3rd, Engels,R., Glockner,G.,
            Hafez,N., Hagopian,D.S., Hall,J.L., Ishikawa,S.K., Jaffe,D.B.,
            Kamat,A., Kudoh,J., Lehmann,R., Lokitsang,T., Macdonald,P.,
            Major,J.E., Matthews,C.D., Mauceli,E., Menzel,U., Mihalev,A.H.,
            Minoshima,S., Murayama,Y., Naylor,J.W., Nicol,R., Nguyen,C.,
            O'Leary,S.B., O'Neill,K., Parker,S.C., Polley,A., Raymond,C.K.,
            Reichwald,K., Rodriguez,J., Sasaki,T., Schilhabel,M., Siddiqui,R.,
            Smith,C.L., Sneddon,T.P., Talamas,J.A., Tenzin,P., Topham,K.,
            Venkataraman,V., Wen,G., Yamazaki,S., Young,S.K., Zeng,Q.,
            Zimmer,A.R., Rosenthal,A., Birren,B.W., Platzer,M., Shimizu,N. and
            Lander,E.S.
  TITLE     DNA sequence and analysis of human chromosome 8
  JOURNAL   Nature 439 (7074), 331-335 (2006)
   PUBMED   16421571
REFERENCE   10 (bases 1 to 10246)
  AUTHORS   Cote,J.F. and Vuori,K.
  TITLE     Identification of an evolutionarily conserved superfamily of
            DOCK180-related proteins with guanine nucleotide exchange activity
  JOURNAL   J Cell Sci 115 (Pt 24), 4901-4913 (2002)
   PUBMED   12432077
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC041005.20, BC015352.1,
            BC011877.2, BF884637.1, CR749353.1, AC091185.6, AK126249.1,
            BC041761.2, AK024687.1, BX648352.1, AK026663.1, CR627414.1,
            BE549612.1 and BF195734.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_024940.7.
            
            Summary: This gene encodes a member of the dedicator of cytokinesis
            protein family. Members of this family act as guanine nucleotide
            exchange factors for small Rho family G proteins. The protein
            encoded by this gene is thought to associate with adaptors CRK and
            CRKL, and function in regulation of intestinal epithelial cell
            spreading and migration on collagen IV. Similar proteins in mouse
            and zebrafish also function in myoblast fusion. [provided by
            RefSeq, Oct 2016].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC137175.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000276440.12/ ENSP00000276440.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                AC041005.20        25890-25923
            35-83               BC015352.1         1-49
            84-1110             BC011877.2         1-1027
            1111-1120           BF884637.1         155-164             c
            1121-1269           BC011877.2         1038-1186
            1270-2028           CR749353.1         377-1135
            2029-2029           AC091185.6         101214-101214       c
            2030-2868           CR749353.1         1137-1975
            2869-2869           AC091185.6         81161-81161         c
            2870-3287           CR749353.1         1977-2394
            3288-3701           AK126249.1         373-786
            3702-4073           BC041761.2         249-620
            4074-4074           AC091185.6         49325-49325         c
            4075-5214           BC041761.2         622-1761
            5215-5992           AK024687.1         305-1082
            5993-6295           BC041761.2         2540-2842
            6296-6296           AC091185.6         14906-14906         c
            6297-6624           BC041761.2         2844-3171
            6625-6636           BX648352.1         4683-4694
            6637-6791           BX648352.1         4696-4850
            6792-7134           BC041761.2         3327-3669
            7135-7526           AK026663.1         1483-1874
            7527-7638           CR627414.1         2730-2841
            7639-9458           AC091185.6         11744-13563         c
            9459-9810           BE549612.1         1-352
            9811-10246          BF195734.1         12-447              c
FEATURES             Location/Qualifiers
     source          1..10246
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p21.2"
     gene            1..10246
                     /gene="DOCK5"
                     /note="dedicator of cytokinesis 5"
                     /db_xref="GeneID:80005"
                     /db_xref="HGNC:HGNC:23476"
                     /db_xref="MIM:616904"
     exon            1..263
                     /gene="DOCK5"
                     /inference="alignment:Splign:2.1.0"
     CDS             221..5833
                     /gene="DOCK5"
                     /note="isoform 1 is encoded by transcript variant 1;
                     dedicator of cytokinesis protein 5"
                     /codon_start=1
                     /product="dedicator of cytokinesis protein 5 isoform 1"
                     /protein_id="NP_079216.4"
                     /db_xref="CCDS:CCDS6047.1"
                     /db_xref="GeneID:80005"
                     /db_xref="HGNC:HGNC:23476"
                     /db_xref="MIM:616904"
                     /translation="MARWIPTKRQKYGVAIYNYNASQDVELSLQIGDTVHILEMYEGW
                     YRGYTLQNKSKKGIFPETYIHLKEATVEDLGQHETVIPGELPLVQELTSTLREWAVIW
                     RKLYVNNKLTLFRQLQQMTYSLIEWRSQILSGTLPKDELAELKKKVTAKIDHGNRMLG
                     LDLVVRDDNGNILDPDETSTIALFKAHEVASKRIEEKIQEEKSILQNLDLRGQSIFST
                     IHTYGLYVNFKNFVCNIGEDAELFMALYDPDQSTFISENYLIRWGSNGMPKEIEKLNN
                     LQAVFTDLSSMDLIRPRVSLVCQIVRVGHMELKEGKKHTCGLRRPFGVAVMDITDIIH
                     GKVDDEEKQHFIPFQQIAMETYIRQRQLIMSPLITSHVIGENEPLTSVLNKVIAAKEV
                     NHKGQGLWVSLKLLPGDLTQVQKNFSHLVDRSTAIARKMGFPEIILPGDVRNDIYVTL
                     IHGEFDKGKKKTPKNVEVTMSVHDEEGKLLEKAIHPGAGYEGISEYKSVVYYQVKQPC
                     WYETVKVSIAIEEVTRCHIRFTFRHRSSQETRDKSERAFGVAFVKLMNPDGTTLQDGR
                     HDLVVYKGDNKKMEDAKFYLTLPGTKMEMEEKELQASKNLVTFTPSKDSTKDSFQIAT
                     LICSTKLTQNVDLLGLLNWRSNSQNIKHNLKKLMEVDGGEIVKFLQDTLDALFNIMME
                     MSDSETYDFLVFDALVFIISLIGDIKFQHFNPVLETYIYKHFSATLAYVKLSKVLNFY
                     VANADDSSKTELLFAALKALKYLFRFIIQSRVLYLRFYGQSKDGDEFNNSIRQLFLAF
                     NMLMDRPLEEAVKIKGAALKYLPSIINDVKLVFDPVELSVLFCKFIQSIPDNQLVRQK
                     LNCMTKIVESTLFRQSECREVLLPLLTDQLSGQLDDNSNKPDHEASSQLLSNILEVLD
                     RKDVGATAVHIQLIMERLLRRINRTVIGMNRQSPHIGSFVACMIALLQQMDDSHYSHY
                     ISTFKTRQDIIDFLMETFIMFKDLIGKNVYAKDWMVMNMTQNRVFLRAINQFAEVLTR
                     FFMDQASFELQLWNNYFHLAVAFLTHESLQLETFSQAKRNKIVKKYGDMRKEIGFRIR
                     DMWYNLGPHKIKFIPSMVGPILEVTLTPEVELRKATIPIFFDMMQCEFNFSGNGNFHM
                     FENELITKLDQEVEGGRGDEQYKVLLEKLLLEHCRKHKYLSSSGEVFALLVSSLLENL
                     LDYRTIIMQDESKENRMSCTVNVLNFYKEKKREDIYIRYLYKLRDLHRDCENYTEAAY
                     TLLLHAELLQWSDKPCVPHLLQKDSYYVYTQQELKEKLYQEIISYFDKGKMWEKAIKL
                     SKELAETYESKVFDYEGLGNLLKKRASFYENIIKAMRPQPEYFAVGYYGQGFPSFLRN
                     KIFIYRGKEYERREDFSLRLLTQFPNAEKMTSTTPPGEDIKSSPKQYMQCFTVKPVMS
                     LPPSYKDKPVPEQILNYYRANEVQQFRYSRPFRKGEKDPDNEFATMWIERTTYTTAYT
                     FPGILKWFEVKQISTEEISPLENAIETMELTNERISNCVQQHAWDRSLSVHPLSMLLS
                     GIVDPAVMGGFSNYEKAFFTEKYLQEHPEDQEKVELLKRLIALQMPLLTEGIRIHGEK
                     LTEQLKPLHERLSSCFRELKEKVEKHYGVITLPPNLTERKQSRTGSIVLPYIMSSTLR
                     RLSITSVTSSVVSTSSNSSDNAPSRPGSDGSILEPLLERRASSGARVEDLSLREENSE
                     NRISKFKRKDWSLSKSQVIAEKAPEPDLMSPTRKAQRPKSLQLMDNRLSPFHGSSPPQ
                     STPLSPPPLTPKATRTLSSPSLQTDGIAATPVPPPPPPKSKPYEGSQRNSTELAPPLP
                     VRREAKAPPPPPPKARKSGIPTSEPGSQ"
     exon            264..347
                     /gene="DOCK5"
                     /inference="alignment:Splign:2.1.0"
     exon            348..388
                     /gene="DOCK5"
                     /inference="alignment:Splign:2.1.0"
     exon            389..444
                     /gene="DOCK5"
                     /inference="alignment:Splign:2.1.0"
     exon            445..541
                     /gene="DOCK5"
                     /inference="alignment:Splign:2.1.0"
     exon            542..690
                     /gene="DOCK5"
                     /inference="alignment:Splign:2.1.0"
     exon            691..826
                     /gene="DOCK5"
                     /inference="alignment:Splign:2.1.0"
     exon            827..984
                     /gene="DOCK5"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1066
                     /gene="DOCK5"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1196
                     /gene="DOCK5"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..1269
                     /gene="DOCK5"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..1412
                     /gene="DOCK5"
                     /inference="alignment:Splign:2.1.0"
     exon            1413..1538
                     /gene="DOCK5"
                     /inference="alignment:Splign:2.1.0"
     exon            1539..1663
                     /gene="DOCK5"
                     /inference="alignment:Splign:2.1.0"
     exon            1664..1762
                     /gene="DOCK5"
                     /inference="alignment:Splign:2.1.0"
     exon            1763..1835
                     /gene="DOCK5"
                     /inference="alignment:Splign:2.1.0"
     exon            1836..1939
                     /gene="DOCK5"
                     /inference="alignment:Splign:2.1.0"
     exon            1940..2123
                     /gene="DOCK5"
                     /inference="alignment:Splign:2.1.0"
     exon            2124..2221
                     /gene="DOCK5"
                     /inference="alignment:Splign:2.1.0"
     exon            2222..2311
                     /gene="DOCK5"
                     /inference="alignment:Splign:2.1.0"
     exon            2312..2412
                     /gene="DOCK5"
                     /inference="alignment:Splign:2.1.0"
     exon            2413..2547
                     /gene="DOCK5"
                     /inference="alignment:Splign:2.1.0"
     exon            2548..2659
                     /gene="DOCK5"
                     /inference="alignment:Splign:2.1.0"
     exon            2660..2730
                     /gene="DOCK5"
                     /inference="alignment:Splign:2.1.0"
     exon            2731..2837
                     /gene="DOCK5"
                     /inference="alignment:Splign:2.1.0"
     exon            2838..2974
                     /gene="DOCK5"
                     /inference="alignment:Splign:2.1.0"
     exon            2975..3070
                     /gene="DOCK5"
                     /inference="alignment:Splign:2.1.0"
     exon            3071..3169
                     /gene="DOCK5"
                     /inference="alignment:Splign:2.1.0"
     exon            3170..3264
                     /gene="DOCK5"
                     /inference="alignment:Splign:2.1.0"
     exon            3265..3343
                     /gene="DOCK5"
                     /inference="alignment:Splign:2.1.0"
     exon            3344..3444
                     /gene="DOCK5"
                     /inference="alignment:Splign:2.1.0"
     exon            3445..3503
                     /gene="DOCK5"
                     /inference="alignment:Splign:2.1.0"
     exon            3504..3658
                     /gene="DOCK5"
                     /inference="alignment:Splign:2.1.0"
     exon            3659..3744
                     /gene="DOCK5"
                     /inference="alignment:Splign:2.1.0"
     exon            3745..3904
                     /gene="DOCK5"
                     /inference="alignment:Splign:2.1.0"
     exon            3905..3945
                     /gene="DOCK5"
                     /inference="alignment:Splign:2.1.0"
     exon            3946..4036
                     /gene="DOCK5"
                     /inference="alignment:Splign:2.1.0"
     exon            4037..4156
                     /gene="DOCK5"
                     /inference="alignment:Splign:2.1.0"
     exon            4157..4246
                     /gene="DOCK5"
                     /inference="alignment:Splign:2.1.0"
     exon            4247..4351
                     /gene="DOCK5"
                     /inference="alignment:Splign:2.1.0"
     exon            4352..4493
                     /gene="DOCK5"
                     /inference="alignment:Splign:2.1.0"
     exon            4494..4575
                     /gene="DOCK5"
                     /inference="alignment:Splign:2.1.0"
     exon            4576..4660
                     /gene="DOCK5"
                     /inference="alignment:Splign:2.1.0"
     exon            4661..4747
                     /gene="DOCK5"
                     /inference="alignment:Splign:2.1.0"
     exon            4748..4924
                     /gene="DOCK5"
                     /inference="alignment:Splign:2.1.0"
     exon            4925..5008
                     /gene="DOCK5"
                     /inference="alignment:Splign:2.1.0"
     exon            5009..5146
                     /gene="DOCK5"
                     /inference="alignment:Splign:2.1.0"
     exon            5147..5313
                     /gene="DOCK5"
                     /inference="alignment:Splign:2.1.0"
     exon            5314..5485
                     /gene="DOCK5"
                     /inference="alignment:Splign:2.1.0"
     exon            5486..5624
                     /gene="DOCK5"
                     /inference="alignment:Splign:2.1.0"
     exon            5625..5728
                     /gene="DOCK5"
                     /inference="alignment:Splign:2.1.0"
     exon            5729..10246
                     /gene="DOCK5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6767..6772
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DOCK5"
                     /note="hexamer: AATACA"
     polyA_site      6791
                     /gene="DOCK5"
     regulatory      10222..10227
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DOCK5"
                     /note="hexamer: ATTAAA"
     polyA_site      10246
                     /gene="DOCK5"
                     /note="major polyA site"
ORIGIN      
        1 actgctgcgc tgcagcccgg cccagcaggt gaccgcgggc ggcgcgggca cgggcacggg
       61 cgcgggcggc gcggcgagga ggcggcccgc ggagtccagc gaagtttggc ggaacatggc
      121 ggaagcgtct ggggcacgca ggagcgcggg gcggcggcgg ccggagcccg aggagctgta
      181 gcagccttag tcgccgccgc cgcggggcga ggtcgccgcc atggcccgct ggatcccgac
      241 caagaggcag aagtacgggg ttgcgatcta taactacaat gcttctcaag atgtggagct
      301 ctccttgcag atcggtgaca cagttcacat cctggagatg tacgagggtt ggtacagagg
      361 atataccctc caaaataaat ctaaaaaggg cattttccct gaaacatata tccatttgaa
      421 agaggcaact gtggaagacc tggggcagca tgaaaccgtg attcctggcg agctccccct
      481 ggtgcaggag ctcacgtcca ctctgcgaga atgggctgtc atctggcgaa agctctacgt
      541 gaacaacaag ctcaccctct tccgccagct gcagcagatg acgtacagcc tgatcgagtg
      601 gcggtcccag atcctgtctg ggacgctccc caaggatgaa ctggcagagc tcaagaagaa
      661 agtcacagcc aaaattgatc atgggaacag aatgctgggg ttagatctgg tggtgcgaga
      721 tgacaatggg aacatcctag accctgacga aaccagcacc attgccctct tcaaggccca
      781 tgaggtggcc tccaaaagga ttgaggaaaa gatccaagaa gagaagtcaa tcctgcagaa
      841 cctcgatttg cggggccagt ccatcttcag taccatccac acctatggcc tctatgtgaa
      901 cttcaagaac tttgtctgca acatcgggga agatgcagag ttgtttatgg ccctctacga
      961 cccagaccag tccactttta tcagtgagaa ctatctaatt cgttggggca gtaacgggat
     1021 gcccaaggaa atagagaagc tcaataacct ccaagcagtg tttacagacc ttagcagcat
     1081 ggacctcatc cggccccgcg tcagccttgt gtgccagatt gtccgcgtgg gccatatgga
     1141 gctgaaggaa ggcaagaagc acacctgtgg actccgaaga ccttttggag tggcagtgat
     1201 ggatattact gatatcatac atgggaaggt ggatgatgaa gaaaagcagc attttattcc
     1261 ctttcagcaa attgcgatgg aaacctacat ccgccagagg cagctcatca tgtcgccttt
     1321 gataacatca cacgtgattg gggagaatga gccactcact tcagtcttga ataaagtgat
     1381 tgcagcaaag gaagtgaatc acaaagggca aggcctttgg gtatccttga agctcttgcc
     1441 cggtgacctc acccaggttc agaagaattt ttcacacttg gttgatagat caacagcaat
     1501 agcccggaag atgggctttc ctgaaatcat actgccagga gatgttcgga atgacattta
     1561 tgtcaccctg atccacggtg agtttgacaa agggaagaag aagacgccaa agaatgtgga
     1621 ggtgacgatg tctgtgcacg atgaggaggg caagctcttg gagaaagcaa ttcaccctgg
     1681 tgctggatat gaaggcattt cagaatacaa atcagtagtc tattaccaag tcaagcagcc
     1741 ctgttggtat gagactgtca aggtatccat tgctatagaa gaagtcacac gctgtcatat
     1801 aagatttacc ttccgacaca ggtcatctca ggaaaccaga gataaatcgg agcgagcatt
     1861 tggggtggcc ttcgtgaagc tgatgaaccc ggatggcacc actctgcagg atgggaggca
     1921 cgatctggtg gtttataagg gtgacaacaa aaaaatggaa gatgctaaat tctacctgac
     1981 cctgcctgga accaagatgg agatggaaga aaaagagctt caagcatcca aaaacctggt
     2041 caccttcacc ccaagcaagg atagcactaa agacagcttt cagattgcca ccctcatctg
     2101 ctccacaaag ctcacccaga atgttgacct gttaggcttg ttaaattggc gttccaactc
     2161 ccagaacatt aaacacaacc taaagaagtt aatggaagtg gatggaggag agattgttaa
     2221 gtttttgcaa gatacactag atgcactctt taacataatg atggaaatgt cagacagtga
     2281 aacctatgac ttccttgtgt ttgacgcact ggtatttatt atttcactga taggagacat
     2341 caagttccag cattttaatc ctgtacttga aacctacatt tacaagcact tcagcgccac
     2401 tttggcatat gtgaaactct ccaaggtact gaacttctat gtggctaatg cagatgactc
     2461 cagcaagact gaactgcttt ttgctgcgtt gaaagccttg aagtacttgt ttagattcat
     2521 catccaatcc cgagtgctct acttgagatt ttatgggcag agcaaagatg gagatgagtt
     2581 taataattca attcgccagt tatttcttgc tttcaatatg ctgatggaca ggcctctgga
     2641 ggaagccgtc aagatcaagg gggcagcttt gaagtacctt cctagcataa ttaatgatgt
     2701 caaacttgta tttgatcctg ttgagctcag cgtgctcttc tgcaaattca ttcaaagcat
     2761 tcctgacaac cagctggttc ggcagaaact taactgcatg accaagatag tagagagcac
     2821 tctttttcga cagtcagagt gcagagaagt gctgctgcca ctgctgacag accagctcag
     2881 cggccagtta gatgacaact ccaacaagcc tgaccacgag gcaagctcgc agcttctgag
     2941 caacatcctg gaggtgctgg acaggaagga tgtgggtgcc actgcggtgc acattcagct
     3001 tataatggaa cggctgctga gaaggatcaa ccggacagtg attgggatga accggcagtc
     3061 tccccacatc gggagttttg tggcttgcat gattgccctg ctgcagcaaa tggacgacag
     3121 ccactatagc cactacatca gcactttcaa aaccagacaa gacatcatcg acttcctcat
     3181 ggaaactttt atcatgttca aggacctgat tggaaagaat gtctatgcca aagattggat
     3241 ggtgatgaat atgactcaaa acagggtttt tctccgtgct ataaatcagt ttgctgaagt
     3301 tctcacaaga ttcttcatgg atcaggcaag ctttgaactt cagctctgga acaattactt
     3361 ccatttggca gttgcatttc tcacccatga gtcccttcag cttgaaacct tctcacaagc
     3421 caagcgcaac aaaattgtta aaaaatatgg ggacatgaga aaggaaatcg gctttagaat
     3481 ccgggacatg tggtataacc tgggtcccca caaaatcaaa ttcatcccat ccatggtggg
     3541 tcccattctg gaggtcactc tgacccctga agtagagctc cggaaagcca caatccccat
     3601 tttctttgat atgatgcagt gtgagttcaa tttcagtgga aatggcaatt tccatatgtt
     3661 tgagaatgag ctgatcacaa agctggacca ggaggtagaa gggggcagag gagacgaaca
     3721 atacaaggtt cttctggaaa aactgctcct agaacattgc cggaaacaca aatacctctc
     3781 cagctctggg gaggtcttcg ccctcctggt cagcagcctc ttagagaacc tgctggacta
     3841 tagaaccatc atcatgcaag atgagagcaa ggagaaccgt atgagctgca ctgtgaacgt
     3901 gctgaacttt tataaagaaa agaagagaga ggacatatac ataagatatc tgtacaagct
     3961 tcgagatttg caccgagact gtgagaacta cacagaagct gcctacacgc ttctcttgca
     4021 cgctgagctt ctgcagtggt ctgacaagcc ctgtgtgcct catttgcttc agaaggacag
     4081 ttactatgtt tatacccagc aagagcttaa agagaagctg tatcaagaaa tcatatcata
     4141 tttcgacaaa ggcaaaatgt gggagaaggc catcaagctg agcaaagagt tggctgagac
     4201 ttacgaaagc aaagtatttg actacgaggg ccttggcaac ctcctgaaaa aaagggcctc
     4261 attttatgag aacatcatta aggcaatgag gcctcagcct gaatactttg ctgttggata
     4321 ctatggacag ggctttcctt ctttcctacg gaataaaatc ttcatctatc ggggaaagga
     4381 gtatgagagg cgagaggact tcagcctgag gttgttaacc cagttcccca atgcggagaa
     4441 gatgaccagt accacgcctc ctggggaaga catcaagtcg tcccccaagc agtacatgca
     4501 gtgcttcact gtaaagccag tgatgagctt gccgcccagc tacaaggata aacctgttcc
     4561 agagcagatc ttaaactact acagagccaa tgaagtgcag cagttcagat actcccggcc
     4621 gttccggaaa ggagaaaagg atccagacaa tgaatttgct acgatgtgga ttgaacggac
     4681 cacgtatacg actgcatata cctttcctgg gattctcaag tggtttgaag tcaaacagat
     4741 ttcaacagaa gagatcagtc ctctggagaa tgccatcgaa accatggagc tgaccaacga
     4801 gaggatcagc aactgtgttc agcagcatgc ctgggaccgg tccctctctg tgcaccctct
     4861 ctccatgctg ctcagtggca tcgtggaccc ggccgtcatg gggggcttct ccaactatga
     4921 aaaggctttt tttacagaaa agtacttgca ggagcatcct gaagaccagg agaaggttga
     4981 gctgctaaag cgactaatag cattacagat gcccctgcta acagaaggga tccgcatcca
     5041 tggggagaaa ctcacagagc agctgaagcc gctgcatgag cggttgtctt cttgcttccg
     5101 ggaactcaag gagaaagtag aaaagcacta tggggttata acactgccac ccaacttgac
     5161 ggagaggaag caaagccgca cggggtctat tgtgctcccc tacatcatgt cttccactct
     5221 gcggaggttg tccatcacct cagtcacttc ctctgtggtt tccacctctt caaactcgtc
     5281 tgacaatgct ccttccagac cgggatctga tggctcaatc ttggagccac ttttggagcg
     5341 cagggcctcg tcaggtgcca gagttgaaga tctgtccctt agagaggaga acagcgagaa
     5401 ccggatcagc aagtttaaga gaaaagactg gagtctgagc aagtcccagg tcattgcaga
     5461 gaaagcacca gaacccgatt tgatgagccc aaccagaaaa gcacaaaggc caaagagtct
     5521 ccagttgatg gataatcggc tatcaccatt tcacggttct tcacctcctc agtcaacacc
     5581 cttgagccca cctccactca ctcccaaagc caccaggacc ctaagctccc catcgttgca
     5641 gacagatgga atcgcggcca ctcctgtccc acctccacct ccccccaaaa gcaagcccta
     5701 tgaaggcagc cagaggaact ccactgagct cgctccccca ctgcctgtcc gaagagaagc
     5761 caaagcacca ccccctccac ctccaaaggc tcggaagtct ggcatcccta cttccgagcc
     5821 tggatcccag taaggatctt gccctccctg caacaccgag tgccttagac agctgctgcc
     5881 tgagaactgg cctccagccg gtgtcctcat tccatggggc tccctgctga ctgcatttcc
     5941 tgatctggga tgatgtttac cagcccaaaa ccagtcatgt tcttccaaaa gcttctcttt
     6001 gatagaattt tgaggccatg ccacctccct tccagtccac atggaattcc agaatcagtc
     6061 acagcctctg attttttcca agaagagatt gccttcacca ttgttaaatg tcagcctgta
     6121 cggcagagac atggtggtct gcacaagcct ggacaagttc ttccatattg atggtggagc
     6181 aacccctgta atctactcct tggaaggatt ttttgctttg cttatgaaaa gctgtgcttg
     6241 agacttaggt acttttctca cgtggacaca ctgatcccat cccatattgc atcttggaag
     6301 agatggatat caagtacact ttggtagctg aaataatcat atctttctga tgtctattgt
     6361 atctcctttg aggaaaagaa cacacatttt taatggagat tggctgcttt caggtatgtg
     6421 tgtctatcat tgaaagagca tggactcaaa catcagccct gagttcttga gtccacccaa
     6481 ctcccatctt cttgtggcac aggaaagctg ccctctccct ctcccaccac actcctgact
     6541 aatggccttc actgcgtcgc agtcactcct tccctacgga cttctttgaa gctcttcctt
     6601 ttgcacatac ggcttttttt tttttttttt ttttttgtcc tattacctcc tctgagcgca
     6661 aatcactggc tacaagggac ttaccagtct ggattcagca gtttcttttc taaaacccat
     6721 ttgggtgact cagcagccgc atctgctacc tgattttatc ctggagaata cagtgcaata
     6781 tttctctttg attatttatt cctcttgatt gtggaattaa tttgattgct tgctaatggt
     6841 actagtagta ctcctttcag aagaaaaaat ggagcgattt aggtgaccaa atattacata
     6901 cataaatagc cacatgaagt tttagacgtt tggacttgaa gcctcaaaga tcaaccaacc
     6961 agtcccctta tttagtaaat aaggaaattg aggctacaca cagaaaattg tgctacagat
     7021 tattactaat aacccagctt gctaaattag gctataccta ggtaatctct agaagacaac
     7081 tctgacagac tctttaatat ttacccctgg ttggaacaat atttgaaatg tcccagatat
     7141 ttctatgcta cttagatatt tgtggcaaag cagaaagctt tttgactgtg aaggcagagg
     7201 tcagcactgg gggaaacttg ctggtggtct ctcccacaac cttgcccaga gtcctttcca
     7261 ctaaggaggt gaagagaaca gagaaagaga tttccatttc tgctgccaga gctggtattt
     7321 gcctgcctga ttctctgtgt ttcctgtttc accgccaccc tttcaggaga gaactacacc
     7381 agttcatcat gagggtcagg gaagcaaaag ctctcagatg tgtccagggc gttacttaag
     7441 aaatgagtat gcagattctg gaaggggtgt ggaaaaggtg atcctttacc cccacccagg
     7501 aaaacctgca ttgtgctagc atggaagaat catgggcttt ggaattaaac ccatttggtg
     7561 gaattaaacc catttggttt caaatcccag ttatgacatc tgttaacttt gcaaactcac
     7621 aaaaattatt tgaaattatc tgagttttca ttttctcacc ttccagaatg gggataatgc
     7681 ctcctgcatc ggttgttgtg aggtttcaat gagatgaaat atgggaaaga agaggtactc
     7741 acctgatggt ccctgctttc ctctgctagg cctgagtagg aactggaact ctctaagagc
     7801 attactcata cttttttttt cttccaaggt agtttggaat gtgagtgcaa gttagttctg
     7861 cacatacagc ccttctccaa atggtggttt cctttgaggt cttttacatg attatttatg
     7921 actagagaca aacttaataa gaactcaaga ggattttaaa tggagagaac tcaagctgta
     7981 gagaaaggag gaggcaacag acaggatatg taggggctta cctagagcct ggcacgactt
     8041 ctgagaagtc acccagcaga ccggctagag gggatttgtg tgccacactc tacttgccgg
     8101 gctgccatta aaatagaaag atataaaact gggtcaccaa aaaaaccaaa cctcaaggct
     8161 atccttccag agcagtagaa atgagtccca cagcctggtc tttgagcaga ggctgggaag
     8221 ataggataca tcactgtctg gataccttct ctttttaata gaatatattc cgtatgattc
     8281 cctttccacc ttaatggaaa taatagctct ctcctgcctg aacaaaaggg attccaggta
     8341 gtattgtggc taagagatta cagcggacga tggaaggttc attttttagg gaaggtgttg
     8401 ggtaggaaga gtcacatttg acagaattca taaataatgt gtcctgaagt cagaggatga
     8461 ctgcaaagaa acacctcatg attccattaa atataaagag ataaggagca aggaggaaaa
     8521 aagagaaaga attggtcttt atttttcttg ctaagaactc tctggagtat tgaaagacat
     8581 tgaaattatc cctaaaattg tcacaacttt tgtgaatact ggtatacggt tggaggtgtt
     8641 tttaaatctt tatttcctct ctttctttgt tctagtgact tgtcttgctt taagattttt
     8701 tttaaaggat tgttttattc aacatatatc aagttcttat ggaatgccag tcatggtact
     8761 agccccttgg gatgtagtgg ttgagtgtgt tcaatggaaa cagccccagt atacaaagac
     8821 agttcactct ggtgtgctgt aggattggaa agggagtggt accagatgaa aatgaaaccc
     8881 taaagaagac tgctgggcca tgagttgctt cctcctcctc caccttaacc ctctgattcc
     8941 agaattgcag tcattttctt ctgccaagga aatccattaa aaactgcagc cacactgcaa
     9001 tttcctaatg tagaacaaga tataaagcag gctttgagac aacaacctac ctttgtttac
     9061 tctttccaag ctggaagagt ccttctcctc tagttgcccc taggtcactg gctaatttat
     9121 tttaaaattt agatggaact catgtatagt taagtgcaca aatcttagcc gtgcagatgg
     9181 gtaattttca catagctatt tgcccacatc cgtgcctcta agatagagac atacactgtt
     9241 ttcagcaccc cagaaagttc ccacatgccc atggtgccat tttgtgaaag gtatttataa
     9301 ggcccttcaa atttgtggct tcctttctca tacttctcag gtataatgaa agggggagaa
     9361 aaaccccacc atcaacacaa aacaaggcta taaagactgt gcacctttta acaagtcaat
     9421 ttgtagtcag tccctgggcc tgtctttttt tttttttaat tttgaagcta cctgaggttt
     9481 agaattcctt cagccctagc tgcttttatt ctgcttttta tttaaacaaa aagaggggga
     9541 ggatctgaag gaaactagtt ttctgtacaa aggctttgag gtccatggac tatacttgtc
     9601 ccatttatca tcccaggtgg tgctttgacc ctgccatacc ctggctatta agataaaaag
     9661 atttgtggac attaaaatta tgaatatgtc agtaataatc cagcacacat tgaaatattg
     9721 acacagatta ccataatttg tgcaacatct tataaacaat gtcatttcca tagtagtcta
     9781 aggcttcacc agcctggccc actgtatcta gactttaggt tcattttaat aattatgctt
     9841 tccttctctg tatcatttgg gaagttgata aatatcactt ccttagatac cttcattcag
     9901 tgatatatct ggcttttaca attaaattgg aaaaggtaag tttctctttg gtgggttgag
     9961 agttggacca tcaattctaa tctacaaaag gaaattcatg atttcactct gacgcctagg
    10021 atctagccaa ggctggtctg cagtatcaga tgtccaaact catctactat tagccatatt
    10081 ttgtgagtcg tttgtctaaa ctttgtcaaa aatgcctttg ccatgatttt gttgctatct
    10141 ggatttcaaa catggacagt taggaagatg tgcattgaag taggaaaatt ttgttcagat
    10201 ttgctgttat ttatttttta aattaaaaat ggaaatgtat tttaaa
//
