LOCUS       NM_004947               9069 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens dedicator of cytokinesis 3 (DOCK3), mRNA.
ACCESSION   NM_004947
VERSION     NM_004947.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9069)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   2  (bases 1 to 9069)
  AUTHORS   Reid,A.L., Wang,Y., Samani,A., Hightower,R.M., Lopez,M.A.,
            Gilbert,S.R., Ianov,L., Crossman,D.K., Dell'Italia,L.J.,
            Millay,D.P., van Groen,T., Halade,G.V. and Alexander,M.S.
  TITLE     DOCK3 is a dosage-sensitive regulator of skeletal muscle and
            Duchenne muscular dystrophy-associated pathologies
  JOURNAL   Hum Mol Genet 29 (17), 2855-2871 (2020)
   PUBMED   32766788
  REMARK    GeneRIF: DOCK3 is a dosage-sensitive regulator of skeletal muscle
            and Duchenne muscular dystrophy-associated pathologies.
REFERENCE   3  (bases 1 to 9069)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 9069)
  AUTHORS   Muller,P.M., Rademacher,J., Bagshaw,R.D., Wortmann,C., Barth,C.,
            van Unen,J., Alp,K.M., Giudice,G., Eccles,R.L., Heinrich,L.E.,
            Pascual-Vargas,P., Sanchez-Castro,M., Brandenburg,L., Mbamalu,G.,
            Tucholska,M., Spatt,L., Czajkowski,M.T., Welke,R.W., Zhang,S.,
            Nguyen,V., Rrustemi,T., Trnka,P., Freitag,K., Larsen,B., Popp,O.,
            Mertins,P., Gingras,A.C., Roth,F.P., Colwill,K., Bakal,C.,
            Pertz,O., Pawson,T., Petsalaki,E. and Rocks,O.
  TITLE     Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals
            spatially organized RAC1 signalling from integrin adhesions
  JOURNAL   Nat Cell Biol 22 (4), 498-511 (2020)
   PUBMED   32203420
REFERENCE   5  (bases 1 to 9069)
  AUTHORS   Wiltrout,K., Ferrer,A., van de Laar,I., Namekata,K., Harada,T.,
            Klee,E.W., Zimmerman,M.T., Cousin,M.A., Kempainen,J.L.,
            Babovic-Vuksanovic,D., van Slegtenhorst,M.A., Aarts-Tesselaar,C.D.,
            Schnur,R.E., Andrews,M. and Shinawi,M.
  TITLE     Variants in DOCK3 cause developmental delay and hypotonia
  JOURNAL   Eur J Hum Genet 27 (8), 1225-1234 (2019)
   PUBMED   30976111
  REMARK    GeneRIF: hree patients with genetic variants in the dedicator of
            cytokinesis 3 (DOCK3) who presented with global developmental delay
            (GDD), hypotonia, and wide-based or uncoordinated gait.
REFERENCE   6  (bases 1 to 9069)
  AUTHORS   de Silva,M.G., Elliott,K., Dahl,H.H., Fitzpatrick,E., Wilcox,S.,
            Delatycki,M., Williamson,R., Efron,D., Lynch,M. and Forrest,S.
  TITLE     Disruption of a novel member of a sodium/hydrogen exchanger family
            and DOCK3 is associated with an attention deficit hyperactivity
            disorder-like phenotype
  JOURNAL   J Med Genet 40 (10), 733-740 (2003)
   PUBMED   14569117
REFERENCE   7  (bases 1 to 9069)
  AUTHORS   Cote,J.F. and Vuori,K.
  TITLE     Identification of an evolutionarily conserved superfamily of
            DOCK180-related proteins with guanine nucleotide exchange activity
  JOURNAL   J Cell Sci 115 (Pt 24), 4901-4913 (2002)
   PUBMED   12432077
REFERENCE   8  (bases 1 to 9069)
  AUTHORS   Chen,Q., Kimura,H. and Schubert,D.
  TITLE     A novel mechanism for the regulation of amyloid precursor protein
            metabolism
  JOURNAL   J Cell Biol 158 (1), 79-89 (2002)
   PUBMED   12093789
REFERENCE   9  (bases 1 to 9069)
  AUTHORS   Chen,Q., Yoshida,H., Schubert,D., Maher,P., Mallory,M. and
            Masliah,E.
  TITLE     Presenilin binding protein is associated with neurofibrillary
            alterations in Alzheimer's disease and stimulates tau
            phosphorylation
  JOURNAL   Am J Pathol 159 (5), 1597-1602 (2001)
   PUBMED   11696419
REFERENCE   10 (bases 1 to 9069)
  AUTHORS   Kashiwa,A., Yoshida,H., Lee,S., Paladino,T., Liu,Y., Chen,Q.,
            Dargusch,R., Schubert,D. and Kimura,H.
  TITLE     Isolation and characterization of novel presenilin binding protein
  JOURNAL   J Neurochem 75 (1), 109-116 (2000)
   PUBMED   10854253
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC096920.2, AY254099.1 and
            BC045793.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_004947.4.
            
            Summary: This gene is specifically expressed in the central nervous
            system (CNS). It encodes a member of the DOCK (dedicator of
            cytokinesis) family of guanine nucleotide exchange factors (GEFs).
            This protein, dedicator of cytokinesis 3 (DOCK3), is also known as
            modifier of cell adhesion (MOCA) and presenilin-binding protein
            (PBP). The DOCK3 and DOCK1, -2 and -4 share several conserved amino
            acids in their DHR-2 (DOCK homology region 2) domains that are
            required for GEF activity, and bind directly to WAVE proteins
            [Wiskott-Aldrich syndrome protein (WASP) family
            Verprolin-homologous proteins] via their DHR-1 domains. The DOCK3
            induces axonal outgrowth in CNS by stimulating membrane recruitment
            of the WAVE complex and activating the small G protein Rac1. This
            gene is associated with an attention deficit hyperactivity
            disorder-like phenotype by a complex chromosomal rearrangement.
            [provided by RefSeq, Aug 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY254099.1, AY145303.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2145743
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000266037.10/ ENSP00000266037.8
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-314               AC096920.2         38306-38619         c
            315-8769            AY254099.1         1-8455
            8770-9069           BC045793.1         1351-1650
FEATURES             Location/Qualifiers
     source          1..9069
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.2"
     gene            1..9069
                     /gene="DOCK3"
                     /gene_synonym="MOCA; NEDIDHA; PBP"
                     /note="dedicator of cytokinesis 3"
                     /db_xref="GeneID:1795"
                     /db_xref="HGNC:HGNC:2989"
                     /db_xref="MIM:603123"
     exon            1..374
                     /gene="DOCK3"
                     /gene_synonym="MOCA; NEDIDHA; PBP"
                     /inference="alignment:Splign:2.1.0"
     CDS             338..6430
                     /gene="DOCK3"
                     /gene_synonym="MOCA; NEDIDHA; PBP"
                     /note="modifier of cell adhesion; presenilin-binding
                     protein"
                     /codon_start=1
                     /product="dedicator of cytokinesis protein 3"
                     /protein_id="NP_004938.1"
                     /db_xref="CCDS:CCDS46835.1"
                     /db_xref="GeneID:1795"
                     /db_xref="HGNC:HGNC:2989"
                     /db_xref="MIM:603123"
                     /translation="MWTPTEEEKYGVVICSFRGSVPQGLVLEIGETVQILEKCEGWYR
                     GVSTKKPNVKGIFPANYIHLKKAIVSNRGQYETVVPLEDSIVTEVTATLQEWASLWKQ
                     LYVKHKVDLFYKLRHVMNELIDLRRQLLSGHLTQDQVREVKRHITVRLDWGNEHLGLD
                     LVPRKDFEVVDSDQISVSDLYKMHLSSRQSVQQSTSQVDTMRPRHGETCRMPVPHHFF
                     LSLKSFTYNTIGEDTDVFFSLYDMREGKQISERFLVRLNKNGGPRNPEKIERMCALFT
                     DLSSKDMKRDLYIVAHVIRIGRMLLNDSKKGPPHLHYRRPYGCAVLSILDVLQSLTEV
                     KEEKDFVLKVYTCNNESEWSQIHENIIRKSSAKYSAPSASHGLIISLQLLRGDMEQIR
                     RENPMIFNRGLAITRKLGFPDVIMPGDIRNDLYLTLEKGDFERGGKSVQKNIEVTMYV
                     LYADGEILKDCISLGSGEPNRSSYHSFVLYHSNSPRWGEIIKLPIPIDRFRGSHLRFE
                     FRHCSTKDKGEKKLFGFAFSTLMRDDGTTLSDDIHELYVYKCDENSTFNNHALYLGLP
                     CCKEDYNGCPNIPSSLIFQRSTKESFFISTQLSSTKLTQNVDLLALLKWKAFPDRIMD
                     VLGRLRHVSGEEIVKFLQDILDTLFVILDDNTEKYGLLVFQSLVFIINLLRDIKYFHF
                     RPVMDTYIQKHFAGALAYKELIRCLKWYMDCSAELIRQDHIQEAMRALEYLFKFIVQS
                     RILYSRATCGMEEEQFRSSIQELFQSIRFVLSLDSRNSETLLFTQAALLNSFPTIFDE
                     LLQMFTVQEVAEFVRGTLGSMPSTVHIGQSMDVVKLQSIARTVDSRLFSFSESRRILL
                     PVVLHHIHLHLRQQKELLICSGILGSIFSIVKTSSLEADVMEEVEMMVESLLDVLLQT
                     LLTIMSKSHAQEAVRGQRCPQCTAEITGEYVSCLLSLLRQMCDTHFQHLLDNFQSKDE
                     LKEFLLKIFCVFRNLMKMSVFPRDWMVMRLLTSNIIVTTVQYLSSALHKNFTETDFDF
                     KVWNSYFSLAVLFINQPSLQLEIITSAKRKKILDKYGDMRVMMAYELFSMWQNLGEHK
                     IHFIPGMIGPFLGVTLVPQPEVRNIMIPIFHDMMDWEQRKNGNFKQVEAELIDKLDSM
                     VSEGKGDESYRELFSLLTQLFGPYPSLLEKVEQETWRETGISFVTSVTRLMERLLDYR
                     DCMKGEETENKKIGCTVNLMNFYKSEINKEEMYIRYIHKLCDMHLQAENYTEAAFTLL
                     LYCELLQWEDRPLREFLHYPSQTEWQRKEGLCRKIIHYFNKGKSWEFGIPLCRELACQ
                     YESLYDYQSLSWIRKMEASYYDNIMEQQRLEPEFFRVGFYGRKFPFFLRNKEYVCRGH
                     DYERLEAFQQRMLSEFPQAVAMQHPNHPDDAILQCDAQYLQIYAVTPIPDYVDVLQMD
                     RVPDRVKSFYRVNNVRKFRYDRPFHKGPKDKENEFKSLWIERTTLTLTHSLPGISRWF
                     EVERRELVEVSPLENAIQVVENKNQELRSLISQYQHKQVHGNINLLSMCLNGVIDAAV
                     NGGIARYQEAFFDKDYINKHPGDAEKITQLKELMQEQVHVLGVGLAVHEKFVHPEMRP
                     LHKKLIDQFQMMRASLYHEFPGLDKLSPACSGTSTPRGNVLASHSPMSPESIKMTHRH
                     SPMNLMGTGRHSSSSLSSHASSEAGNMVMLGDGSMGDAPEDLYHHMQLAYPNPRYQGS
                     VTNVSVLSSSQASPSSSSLSSTHSAPSQMITSAPSSARGSPSLPDKYRHAREMMLLLP
                     TYRDRPSSAMYPAAILENGQPPNFQRALFQQVVGACKPCSDPNLSVAEKGHYSLHFDA
                     FHHPLGDTPPALPARTLRKSPLHPIPASPTSPQSGLDGSNSTLSGSASSGVSSLSESN
                     FGHSSEAPPRTDTMDSMPSQAWNADEDLEPPYLPVHYSLSESAVLDSIKAQPCRSHSA
                     PGCVIPQDPMDPPALPPKPYHPRLPALEHDEGVLLREETERPRGLHRKAPLPPGSAKE
                     EQARMAWEHGRGEQ"
     exon            375..458
                     /gene="DOCK3"
                     /gene_synonym="MOCA; NEDIDHA; PBP"
                     /inference="alignment:Splign:2.1.0"
     exon            459..499
                     /gene="DOCK3"
                     /gene_synonym="MOCA; NEDIDHA; PBP"
                     /inference="alignment:Splign:2.1.0"
     exon            500..555
                     /gene="DOCK3"
                     /gene_synonym="MOCA; NEDIDHA; PBP"
                     /inference="alignment:Splign:2.1.0"
     exon            556..652
                     /gene="DOCK3"
                     /gene_synonym="MOCA; NEDIDHA; PBP"
                     /inference="alignment:Splign:2.1.0"
     exon            653..801
                     /gene="DOCK3"
                     /gene_synonym="MOCA; NEDIDHA; PBP"
                     /inference="alignment:Splign:2.1.0"
     exon            802..886
                     /gene="DOCK3"
                     /gene_synonym="MOCA; NEDIDHA; PBP"
                     /inference="alignment:Splign:2.1.0"
     exon            887..928
                     /gene="DOCK3"
                     /gene_synonym="MOCA; NEDIDHA; PBP"
                     /inference="alignment:Splign:2.1.0"
     exon            929..1083
                     /gene="DOCK3"
                     /gene_synonym="MOCA; NEDIDHA; PBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1165
                     /gene="DOCK3"
                     /gene_synonym="MOCA; NEDIDHA; PBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1226
                     /gene="DOCK3"
                     /gene_synonym="MOCA; NEDIDHA; PBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1374
                     /gene="DOCK3"
                     /gene_synonym="MOCA; NEDIDHA; PBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..1463
                     /gene="DOCK3"
                     /gene_synonym="MOCA; NEDIDHA; PBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1464..1589
                     /gene="DOCK3"
                     /gene_synonym="MOCA; NEDIDHA; PBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1590..1714
                     /gene="DOCK3"
                     /gene_synonym="MOCA; NEDIDHA; PBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1715..1877
                     /gene="DOCK3"
                     /gene_synonym="MOCA; NEDIDHA; PBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1878..1984
                     /gene="DOCK3"
                     /gene_synonym="MOCA; NEDIDHA; PBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1985..2156
                     /gene="DOCK3"
                     /gene_synonym="MOCA; NEDIDHA; PBP"
                     /inference="alignment:Splign:2.1.0"
     exon            2157..2254
                     /gene="DOCK3"
                     /gene_synonym="MOCA; NEDIDHA; PBP"
                     /inference="alignment:Splign:2.1.0"
     exon            2255..2338
                     /gene="DOCK3"
                     /gene_synonym="MOCA; NEDIDHA; PBP"
                     /inference="alignment:Splign:2.1.0"
     exon            2339..2439
                     /gene="DOCK3"
                     /gene_synonym="MOCA; NEDIDHA; PBP"
                     /inference="alignment:Splign:2.1.0"
     exon            2440..2521
                     /gene="DOCK3"
                     /gene_synonym="MOCA; NEDIDHA; PBP"
                     /inference="alignment:Splign:2.1.0"
     exon            2522..2692
                     /gene="DOCK3"
                     /gene_synonym="MOCA; NEDIDHA; PBP"
                     /inference="alignment:Splign:2.1.0"
     exon            2693..2885
                     /gene="DOCK3"
                     /gene_synonym="MOCA; NEDIDHA; PBP"
                     /inference="alignment:Splign:2.1.0"
     exon            2886..3013
                     /gene="DOCK3"
                     /gene_synonym="MOCA; NEDIDHA; PBP"
                     /inference="alignment:Splign:2.1.0"
     exon            3014..3160
                     /gene="DOCK3"
                     /gene_synonym="MOCA; NEDIDHA; PBP"
                     /inference="alignment:Splign:2.1.0"
     exon            3161..3259
                     /gene="DOCK3"
                     /gene_synonym="MOCA; NEDIDHA; PBP"
                     /inference="alignment:Splign:2.1.0"
     exon            3260..3354
                     /gene="DOCK3"
                     /gene_synonym="MOCA; NEDIDHA; PBP"
                     /inference="alignment:Splign:2.1.0"
     exon            3355..3430
                     /gene="DOCK3"
                     /gene_synonym="MOCA; NEDIDHA; PBP"
                     /inference="alignment:Splign:2.1.0"
     exon            3431..3531
                     /gene="DOCK3"
                     /gene_synonym="MOCA; NEDIDHA; PBP"
                     /inference="alignment:Splign:2.1.0"
     exon            3532..3590
                     /gene="DOCK3"
                     /gene_synonym="MOCA; NEDIDHA; PBP"
                     /inference="alignment:Splign:2.1.0"
     exon            3591..3739
                     /gene="DOCK3"
                     /gene_synonym="MOCA; NEDIDHA; PBP"
                     /inference="alignment:Splign:2.1.0"
     exon            3740..3825
                     /gene="DOCK3"
                     /gene_synonym="MOCA; NEDIDHA; PBP"
                     /inference="alignment:Splign:2.1.0"
     exon            3826..3852
                     /gene="DOCK3"
                     /gene_synonym="MOCA; NEDIDHA; PBP"
                     /inference="alignment:Splign:2.1.0"
     exon            3853..3948
                     /gene="DOCK3"
                     /gene_synonym="MOCA; NEDIDHA; PBP"
                     /inference="alignment:Splign:2.1.0"
     exon            3949..4009
                     /gene="DOCK3"
                     /gene_synonym="MOCA; NEDIDHA; PBP"
                     /inference="alignment:Splign:2.1.0"
     exon            4010..4103
                     /gene="DOCK3"
                     /gene_synonym="MOCA; NEDIDHA; PBP"
                     /inference="alignment:Splign:2.1.0"
     exon            4104..4252
                     /gene="DOCK3"
                     /gene_synonym="MOCA; NEDIDHA; PBP"
                     /inference="alignment:Splign:2.1.0"
     exon            4253..4339
                     /gene="DOCK3"
                     /gene_synonym="MOCA; NEDIDHA; PBP"
                     /inference="alignment:Splign:2.1.0"
     exon            4340..4444
                     /gene="DOCK3"
                     /gene_synonym="MOCA; NEDIDHA; PBP"
                     /inference="alignment:Splign:2.1.0"
     exon            4445..4586
                     /gene="DOCK3"
                     /gene_synonym="MOCA; NEDIDHA; PBP"
                     /inference="alignment:Splign:2.1.0"
     exon            4587..4753
                     /gene="DOCK3"
                     /gene_synonym="MOCA; NEDIDHA; PBP"
                     /inference="alignment:Splign:2.1.0"
     exon            4754..4840
                     /gene="DOCK3"
                     /gene_synonym="MOCA; NEDIDHA; PBP"
                     /inference="alignment:Splign:2.1.0"
     exon            4841..5020
                     /gene="DOCK3"
                     /gene_synonym="MOCA; NEDIDHA; PBP"
                     /inference="alignment:Splign:2.1.0"
     exon            5021..5104
                     /gene="DOCK3"
                     /gene_synonym="MOCA; NEDIDHA; PBP"
                     /inference="alignment:Splign:2.1.0"
     exon            5105..5221
                     /gene="DOCK3"
                     /gene_synonym="MOCA; NEDIDHA; PBP"
                     /inference="alignment:Splign:2.1.0"
     exon            5222..5343
                     /gene="DOCK3"
                     /gene_synonym="MOCA; NEDIDHA; PBP"
                     /inference="alignment:Splign:2.1.0"
     exon            5344..5482
                     /gene="DOCK3"
                     /gene_synonym="MOCA; NEDIDHA; PBP"
                     /inference="alignment:Splign:2.1.0"
     exon            5483..5630
                     /gene="DOCK3"
                     /gene_synonym="MOCA; NEDIDHA; PBP"
                     /inference="alignment:Splign:2.1.0"
     exon            5631..5749
                     /gene="DOCK3"
                     /gene_synonym="MOCA; NEDIDHA; PBP"
                     /inference="alignment:Splign:2.1.0"
     exon            5750..5837
                     /gene="DOCK3"
                     /gene_synonym="MOCA; NEDIDHA; PBP"
                     /inference="alignment:Splign:2.1.0"
     exon            5838..5920
                     /gene="DOCK3"
                     /gene_synonym="MOCA; NEDIDHA; PBP"
                     /inference="alignment:Splign:2.1.0"
     exon            5921..9069
                     /gene="DOCK3"
                     /gene_synonym="MOCA; NEDIDHA; PBP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8748..8753
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DOCK3"
                     /gene_synonym="MOCA; NEDIDHA; PBP"
                     /note="hexamer: TATAAA"
     polyA_site      8769
                     /gene="DOCK3"
                     /gene_synonym="MOCA; NEDIDHA; PBP"
                     /note="major polyA site"
     regulatory      9045..9050
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DOCK3"
                     /gene_synonym="MOCA; NEDIDHA; PBP"
                     /note="hexamer: ATTAAA"
     polyA_site      9069
                     /gene="DOCK3"
                     /gene_synonym="MOCA; NEDIDHA; PBP"
                     /note="major polyA site"
ORIGIN      
        1 gagcccgctg gggcgagccg agccgcggcg gcgccgggag ccgggcggcg gagctgtgaa
       61 gaagcaagcg gcggcacggg agcagcggcg acggacaggt ggcgagcctt cgcccgcgcc
      121 gccaggggct gctgggccac ccgcggagcc tcgcggtcca gacgtggcgg gggtggcggc
      181 ggcatcccgg acggcctgtg agggatgcgc cgcccactgc cccgcgccgc ctgaccgtcc
      241 ccgcctcgac tcgcggtgcg ccacagccgg gcccgcggcc gtccccgccg cgttgtcgcc
      301 cggtcgccgc gcccgcgggg ccgcgcccgg cacggccatg tggaccccca cggaggagga
      361 gaaatacggc gtagtgatat gcagctttcg aggatctgtc cctcaagggt tggtcttaga
      421 aataggagaa acagtccaga ttcttgaaaa atgtgaaggt tggtacagag gagtttcaac
      481 aaagaagcca aatgtgaagg ggatctttcc tgcaaattac attcacttga aaaaggcaat
      541 tgtcagtaat agggggcagt atgaaactgt ggttccactt gaagattcta ttgtgactga
      601 ggttacagca actctacaag aatgggcaag tttgtggaaa cagttgtatg tgaaacacaa
      661 agtagatctt ttctacaaac tacgccatgt gatgaatgaa cttattgacc tgcgaaggca
      721 gctactgtct ggtcacctga ctcaggatca ggtgcgggag gttaagcggc acatcaccgt
      781 gcgcctggac tggggtaatg aacatttggg cctggacctg gtgcctcgga aggactttga
      841 agtagtggac tcggaccaga ttagtgtctc agatctctat aagatgcatt tatctagccg
      901 gcagagtgta cagcaaagca catcccaggt agatacaatg cgcccacgtc atggggaaac
      961 atgtcggatg ccagtgccac atcacttctt cctcagcctg aagagtttca cttacaatac
     1021 tattggggaa gataccgatg tcttcttttc cttatatgac atgagggaag gcaagcagat
     1081 cagtgagcgg tttctggtaa gactgaacaa gaatggtggg ccgaggaacc cagagaagat
     1141 agaacgaatg tgtgcccttt ttacagatct gagcagcaaa gatatgaaga gagatttgta
     1201 tatcgttgcc catgtgatcc gaataggccg gatgctcctg aacgactcaa agaaaggtcc
     1261 tcctcacctg cactacaggc gaccatatgg ctgtgcggtc ctaagcatct tggatgtcct
     1321 acagtcactc acagaagtaa aggaagaaaa ggattttgtt cttaaggttt acacgtgcaa
     1381 caacgagagt gagtggtccc agatccacga gaacatcatc cgaaagtcca gtgccaagta
     1441 ctctgccccc agcgccagcc atggtcttat catttctctg cagcttcttc gtggagacat
     1501 ggaacagatt cggagagaaa atcccatgat atttaatagg ggattggcaa ttacaagaaa
     1561 attgggattt cctgatgtca ttatgccagg tgatatccgc aatgacctgt acctaaccct
     1621 ggagaagggg gatttcgaga gaggaggaaa gagtgtacaa aagaatattg aagtgaccat
     1681 gtatgtgctt tatgcagatg gagaaatctt gaaggattgc atcagcttgg gttcaggaga
     1741 gccaaatagg agttcctacc actcctttgt cctctaccac agtaatagtc ctcgctgggg
     1801 agaaattatc aaattgccta tccccattga ccggttccgg ggctcccacc tgcgctttga
     1861 gttcagacat tgttccacaa aggacaaagg ggaaaagaaa ctctttggct ttgcattctc
     1921 aaccctgatg cgtgatgatg gcaccaccct ctcagatgat attcacgagc tttatgtgta
     1981 caagtgtgat gagaatagca cgtttaataa ccatgctctg tacctgggcc tgccctgctg
     2041 caaagaggac tacaatggct gccctaatat tccttctagc ctcatcttcc agcgcagcac
     2101 caaagagtct ttcttcatct ccactcagct ctcctctacc aaactcaccc agaatgtgga
     2161 cctcctagct ctgctgaagt ggaaagcctt ccccgaccgg atcatggatg tactagggcg
     2221 gctgcggcat gtcagtgggg aggaaattgt taagtttctg caggacatct tagatacact
     2281 ctttgtgatt ttggatgata atacagagaa gtacggcctg ttggtttttc agtctctggt
     2341 gttcatcatc aacctgctcc gagacatcaa gtattttcac tttcgacctg tgatggacac
     2401 gtatatccag aagcactttg ctggagctct ggcatacaag gagctcatcc gctgtttgaa
     2461 gtggtatatg gactgctcag cagaactgat tcgacaggac cacattcaag aagctatgcg
     2521 ggccttggag taccttttca agttcattgt acagtcacgg atcctgtact cacgagccac
     2581 ttgtggaatg gaagaggaac aattcagatc cagtatccaa gaacttttcc agtccatccg
     2641 gtttgtgctc agtctggaca gccgaaactc agaaacactc ctttttactc aggctgcact
     2701 cctcaattct ttcccaacca tctttgatga gcttctgcaa atgttcaccg tgcaagaggt
     2761 ggcagagttt gtgagaggga cactggggag catgcccagc actgtgcaca ttgggcagtc
     2821 aatggacgtg gtcaagctgc agtccattgc caggacagtg gatagccgcc tgttttcttt
     2881 ctcagaatcc cgccgcatcc tgcttcctgt ggttctccat cacattcacc ttcacctgag
     2941 gcagcagaaa gagctgctaa tttgctcagg gattcttggc agcatcttct ccatcgtcaa
     3001 gaccagctct ctggaggcag atgtcatgga ggaagtagag atgatggtgg agagcctcct
     3061 ggacgtgctc ttgcagactc tgctcaccat catgagcaaa tcgcacgctc aggaggcggt
     3121 aagagggcag cggtgcccgc agtgcacagc cgagatcact ggcgagtatg tgtcctgcct
     3181 tctctcactg ctccgccaga tgtgtgacac ccatttccag cacctcctgg acaacttcca
     3241 gagcaaagat gaactcaagg aatttctgct gaagattttt tgcgtgttcc ggaacctgat
     3301 gaagatgagt gtcttccctc gggactggat ggtaatgaga ctgctcacaa gcaatattat
     3361 agtcactact gtccagtacc tgtcctctgc actgcacaag aatttcacag agactgactt
     3421 tgactttaag gtgtggaatt cttactttag cctggcagtt ctattcataa atcagccaag
     3481 ccttcagcta gaaattatca cctcagccaa aaggaagaag attctagata agtatgggga
     3541 catgcgtgta atgatggcct atgaactgtt cagcatgtgg cagaatttgg gtgaacataa
     3601 gatccacttt attccgggaa tgattggtcc ttttctgggt gtgacactgg tcccacagcc
     3661 agaagtacgg aatatcatga ttcccatctt tcatgacatg atggactggg agcagagaaa
     3721 aaatggcaac ttcaaacagg tggaggccga gttgattgac aagctggaca gcatggtgtc
     3781 agaagggaaa ggtgacgaga gctacaggga gctcttcagc ctactaaccc agctgtttgg
     3841 gccctacccc agcctgctgg agaaggttga acaagaaaca tggcgcgaga ccggcatttc
     3901 ctttgtgacc tcagtcaccc gcctcatgga acgtcttctt gactacaggg actgcatgaa
     3961 aggagaggaa acagagaata agaagatagg ctgcactgtt aacctgatga atttttacaa
     4021 atctgagatt aacaaggaag aaatgtatat ccgctacatc cataagcttt gtgacatgca
     4081 cttgcaggcc gaaaactaca cagaggccgc atttaccctg ctcctttact gtgagctgct
     4141 gcagtgggag gaccggccac tacgggaatt cctccactac ccatcgcaga cagagtggca
     4201 gcggaaggag ggactgtgcc ggaagatcat tcactacttc aacaaaggca agagctggga
     4261 gtttgggatc ccactgtgca gggagctggc gtgtcagtac gagagcctct atgattacca
     4321 gagcctcagc tggattcgga aaatggaggc cagctactat gacaacatta tggagcagca
     4381 acgcctggag cctgagttct ttcgggtcgg cttctatggc aggaagtttc ctttctttct
     4441 tcggaacaaa gaatacgtgt gccgtggcca tgactacgag aggctggagg ccttccagca
     4501 gaggatgctc agtgagtttc cgcaggctgt cgccatgcag caccccaacc atcctgatga
     4561 cgccatccta cagtgcgatg cccagtactt gcagatctat gcagtgacgc ccattccaga
     4621 ttatgtggat gttctgcaga tggatagggt accagatcga gtcaagagct tctatcgcgt
     4681 caacaatgtg aggaagttcc ggtatgacag gccttttcac aaaggcccca aggacaagga
     4741 gaatgaattc aagagcctgt ggattgaacg taccacactg accctgaccc acagcttgcc
     4801 tggcatctct cggtggtttg aagtggagag gagggaactg gtggaggtga gccctctgga
     4861 gaatgccatc caagtggttg agaataagaa ccaggagcta cgctccctga tcagccagta
     4921 tcaacacaag caggtgcatg gcaacattaa cctgctaagc atgtgcctga atggtgtcat
     4981 tgatgcagct gtcaatggag gcattgcacg ctatcaggag gccttctttg ataaagatta
     5041 catcaacaag cacccaggag atgctgagaa gatcacccag ctcaaggagc ttatgcagga
     5101 gcaggttcat gtccttggag ttgggctagc agttcatgag aagtttgtgc acccagaaat
     5161 gcggcctctg cataagaagc taattgatca gttccagatg atgcgggcca gtctctacca
     5221 tgagtttcca ggtttggata agctaagtcc tgcatgttca ggcaccagca ccccacgggg
     5281 aaatgttctg gcatcccata gccccatgag tccggagagc atcaagatga cccaccggca
     5341 cagccccatg aacttgatgg gcacaggccg ccattcatca tcctctctct cctcacatgc
     5401 gtctagtgaa gcaggaaaca tggtgatgct gggtgacggc tccatgggtg atgctcctga
     5461 ggacctgtac caccacatgc agctcgcgta tcccaacccc aggtaccaag gctcagtcac
     5521 caacgtctct gttctgtcct cgtcccaggc aagcccttct tcctccagcc tgagttccac
     5581 tcactcagca ccatcccaga tgattacctc tgccccttcc agtgcccgag gctctccctc
     5641 tctgccagat aagtaccgcc atgcccgtga aatgatgttg ttgctgccca cataccggga
     5701 ccgcccaagc agtgccatgt atccagcagc catcctggag aacggacagc cgccgaattt
     5761 ccagcgagcc ctgttccagc aagtggtcgg agcctgcaaa ccctgcagtg atcccaatct
     5821 gtctgtggct gaaaaaggtc attactccct acactttgac gccttccacc accctctggg
     5881 tgataccccc ccagccctcc ctgcccggac cctgcgcaag tctcctctcc accctatccc
     5941 agcctccccc acaagccccc agtcaggtct ggacggcagc aactctacgc tgtccggcag
     6001 tgccagcagc ggcgtgtcct ccttgagtga gagtaacttt gggcactcct cggaggcccc
     6061 acctcgcact gacaccatgg actccatgcc aagtcaggcc tggaatgctg acgaagatct
     6121 tgagccaccc tacctccctg tccactacag cctctctgag tctgccgtcc tggactccat
     6181 caaggcccag ccatgccgaa gccactcagc cccagggtgc gtcatccctc aggaccccat
     6241 ggacccgcct gcgctgccgc ccaagcccta ccacccccgc ctgccggccc tggagcacga
     6301 tgagggggtg ctgctgcgtg aagagactga gaggcctcga ggcctgcacc gcaaggctcc
     6361 attgcctcct gggagcgcta aggaggagca ggcccgcatg gcctgggagc acggccgagg
     6421 ggagcagtga ggggcaacga ggcggctggg atgccgccct cagtaagcag cttgccaatc
     6481 actccaggtc tgaaaagcaa gtcccccagc cccaccccag ggagccagag aggcttgcac
     6541 tcaggagaga accaccccca agtctccgtt ctactgccgt gaactcatgt gttgccatgt
     6601 acagaggcca cagcagcatg aagggttgtg gcttcccttt ttattttttt acatttccat
     6661 ttctatgggt tttcctttct ttcctttatg cagtagatgc tttcttcctc ctgcagttct
     6721 ggaccatgtg gagctacatg gagaaattgc acagacagaa tcactttgcc acactgcagg
     6781 gcccaggagt gggagcccag gccctccctc cagggtagag atgcaccgaa tggaaattgc
     6841 actaaggacc tcttcctttg ctgtatggac agaagagttc atggttgcat tcagggattg
     6901 caaggaccat atagacatgt cacaggtgga aaaagggcca caagccgttt tgcacaaatg
     6961 cctgcccacc tgcccctctt ccatccagga gtgtgctact gaggggctgg ctggaccaac
     7021 ctgctggctc aggcatgtga ctggcctaac tgcatgccca gggcactgcc agggttcaat
     7081 gggccagccg tctcctactc caccttggat ttttctctcc atcacatcat ttctgaccat
     7141 ttgctccctt ccattcttga aacacctcat gccccacagg agccccagtg gtgactggat
     7201 ctgcaagggt tatctcccgc cctctggggt ttgagtggag gtatggagcc agagaggcta
     7261 tcctagctac cttcctccta gggggagctg gtccccttcc tatgtggtag agagactggt
     7321 gtaagagtgt ggggtgtggc aggcgccgga aatcctcaaa gctttcagaa gcatccagaa
     7381 tgcctaccat cagctcctga atcagggatt ttcagcacta cctctgagcc atggggttgg
     7441 ctgcccagcc aggcttccag gccctgagga catgtggtca ggttcagcag gctcctgggt
     7501 aaagagggtg ggagggggct tctccttttg gaagcagata gccatgcagg tagaattgtc
     7561 atctcccaag tggccacata cagcaaccca ctccaggcca tggggaccac cactcagggt
     7621 tcggggctgg caggagggta gtttctccag tctccccagt ctgttggtgt ctttatagga
     7681 aactataaag cagagcagtg gtgtctttag aggaaactca ttcaagtcag ggcactgatt
     7741 ttcctctcag tttattattt ggggggatag ggtcaggtgg gtatagtagt actttaccag
     7801 ggtgctttta agttacttta aaaaaagcct acaaaatatt ttttttcttt tatttgctcg
     7861 agttcacatt aatgatggtc acaaggctgc cttgttgggc aggcgtattg cccccagttc
     7921 ctcttctgct ggcctgtatg acctccacag ccaggccctg ggcccaagcc ccttgtccct
     7981 tctccactgc ccctctttcc agacagtaaa ggccatggtc agtgtgtttt tctcttgtaa
     8041 acaaacccca gcttgtttaa cagaaatgct aataacctac tgggaaagat ggaggtctaa
     8101 attacctcca gggtttttct gggggtttat caccagtgtg ggtcccttct gataccacca
     8161 ggttcactcc aggcagagtg gggcggaagg ctgctgagga tatgggtcag ttacagcagc
     8221 cctcacctca aagggctggc ctgcttctca gcctacattc atttgcaagc ttcaatctct
     8281 ggaccatctg gtgttcacag gtgttagagg gttaggggtt aggggctagt tttggatttg
     8341 attcataggt aggagggctt agattttaag gcacttctga aagtcaatcc ctggacaagg
     8401 cagtcatcac ataagaacag ctaccttctc cacttggtgg cacaagaggt agggagggga
     8461 gtatgggttc atttggcttc gcattatgca aggtgaaacc gtttgttttc cctctccatt
     8521 ttccctaact aaatgaaaag gacacattct gaaatccctt ttgttggaga ataagtcagt
     8581 ctgaggggaa atgggaggcc agagatgaga accctttgaa aagattgtaa aatactgatt
     8641 ttcattcttt caagcttatt tgtaaatacc tatttgaatg ctgtgtattt gtacaggaat
     8701 ttgagcaaaa aatgtataga gtgtgatgtc caattggtat tcagcactat aaatgtgttt
     8761 ttaacctccc gcattctgtg cttatttaaa acaaggaaac ttctaaccat ttcttttgtg
     8821 tattcatgtt taaagaaaaa aagtgattta aaaatgatct tacctgtacc agaaaagcaa
     8881 agttaaagga aacaaaattt gtaccattgt cccaagaggt attttactgt atatattgtg
     8941 gtagcatgtt caaaatccaa caagtaatgt gaattttaga tgtaaatatc tgccacttga
     9001 ttttttttcc ccctttcccc acttccttga ctgctgtgat gtgaattaaa gataaatacg
     9061 tgatactga
//
