LOCUS       NM_004946               6069 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens dedicator of cytokinesis 2 (DOCK2), transcript variant
            1, mRNA.
ACCESSION   NM_004946
VERSION     NM_004946.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6069)
  AUTHORS   Qian,G., Adeyanju,O., Cai,D., Tucker,T.A., Idell,S., Chen,S.Y. and
            Guo,X.
  TITLE     DOCK2 Promotes Atherosclerosis by Mediating the Endothelial Cell
            Inflammatory Response
  JOURNAL   Am J Pathol 194 (4), 599-611 (2024)
   PUBMED   37838011
  REMARK    GeneRIF: DOCK2 Promotes Atherosclerosis by Mediating the
            Endothelial Cell Inflammatory Response.
REFERENCE   2  (bases 1 to 6069)
  AUTHORS   Shi,N., Zhang,J. and Chen,S.Y.
  TITLE     DOCK2 Promotes Asthma Development by Eliciting Airway
            Epithelial-Mesenchymal Transition
  JOURNAL   Am J Respir Cell Mol Biol 69 (3), 310-320 (2023)
   PUBMED   36883952
  REMARK    GeneRIF: DOCK2 Promotes Asthma Development by Eliciting Airway
            Epithelial-Mesenchymal Transition.
REFERENCE   3  (bases 1 to 6069)
  AUTHORS   Li,W., Sun,Y., Yu,L., Chen,R., Gan,R., Qiu,L., Sun,G., Chen,J.,
            Zhou,L., Ding,Y., Du,H., Shu,Z., Zhang,Z., Tang,X., Chen,Y.,
            Zhao,X., Zhao,Q. and An,Y.
  TITLE     Multiple Immune Defects in Two Patients with Novel DOCK2 Mutations
            Result in Recurrent Multiple Infection Including Live Attenuated
            Virus Vaccine
  JOURNAL   J Clin Immunol 43 (6), 1193-1207 (2023)
   PUBMED   36947335
  REMARK    GeneRIF: Multiple Immune Defects in Two Patients with Novel DOCK2
            Mutations Result in Recurrent Multiple Infection Including Live
            Attenuated Virus Vaccine.
REFERENCE   4  (bases 1 to 6069)
  AUTHORS   Guo,X., Cai,D., Dong,K., Li,C., Xu,Z. and Chen,S.Y.
  TITLE     DOCK2 Deficiency Attenuates Abdominal Aortic Aneurysm
            Formation-Brief Report
  JOURNAL   Arterioscler Thromb Vasc Biol 43 (6), e210-e217 (2023)
   PUBMED   37021575
  REMARK    GeneRIF: DOCK2 Deficiency Attenuates Abdominal Aortic Aneurysm
            Formation-Brief Report.
REFERENCE   5  (bases 1 to 6069)
  AUTHORS   Scharler,C., Poupardin,R., Ebner-Peking,P., Wolf,M., Schreck,C.,
            Brachtl,G., Cronemberger Andrade,A., Krisch,L., Daheron,L.,
            Schallmoser,K., Jurchott,K., Kuchler,J., Stachelscheid,H.,
            Volk,H.D., Oostendorp,R.A.J. and Strunk,D.
  TITLE     Extra-hematopoietic immunomodulatory role of the guanine-exchange
            factor DOCK2
  JOURNAL   Commun Biol 5 (1), 1246 (2022)
   PUBMED   36380073
  REMARK    GeneRIF: Extra-hematopoietic immunomodulatory role of the
            guanine-exchange factor DOCK2.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6069)
  AUTHORS   Nishihara,H., Maeda,M., Tsuda,M., Makino,Y., Sawa,H., Nagashima,K.
            and Tanaka,S.
  TITLE     DOCK2 mediates T cell receptor-induced activation of Rac2 and IL-2
            transcription
  JOURNAL   Biochem Biophys Res Commun 296 (3), 716-720 (2002)
   PUBMED   12176041
  REMARK    GeneRIF: DOCK2 mediates T cell receptor-induced activation of Rac2
            and IL-2 transcription in jurkat cells
REFERENCE   7  (bases 1 to 6069)
  AUTHORS   Reif,K. and Cyster,J.
  TITLE     The CDM protein DOCK2 in lymphocyte migration
  JOURNAL   Trends Cell Biol 12 (8), 368-373 (2002)
   PUBMED   12191913
  REMARK    Review article
REFERENCE   8  (bases 1 to 6069)
  AUTHORS   Brugnera,E., Haney,L., Grimsley,C., Lu,M., Walk,S.F.,
            Tosello-Trampont,A.C., Macara,I.G., Madhani,H., Fink,G.R. and
            Ravichandran,K.S.
  TITLE     Unconventional Rac-GEF activity is mediated through the
            Dock180-ELMO complex
  JOURNAL   Nat Cell Biol 4 (8), 574-582 (2002)
   PUBMED   12134158
REFERENCE   9  (bases 1 to 6069)
  AUTHORS   Fukui,Y., Hashimoto,O., Sanui,T., Oono,T., Koga,H., Abe,M.,
            Inayoshi,A., Noda,M., Oike,M., Shirai,T. and Sasazuki,T.
  TITLE     Haematopoietic cell-specific CDM family protein DOCK2 is essential
            for lymphocyte migration
  JOURNAL   Nature 412 (6849), 826-831 (2001)
   PUBMED   11518968
REFERENCE   10 (bases 1 to 6069)
  AUTHORS   Nishihara,H., Kobayashi,S., Hashimoto,Y., Ohba,F., Mochizuki,N.,
            Kurata,T., Nagashima,K. and Matsuda,M.
  TITLE     Non-adherent cell-specific expression of DOCK2, a member of the
            human CDM-family proteins
  JOURNAL   Biochim Biophys Acta 1452 (2), 179-187 (1999)
   PUBMED   10559471
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB145764.1, BC104900.1,
            BC113457.1, BC084556.1 and AK128449.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 30, 2018 this sequence version replaced NM_004946.2.
            
            Summary: The protein encoded by this gene belongs to the CDM
            protein family. It is specifically expressed in hematopoietic cells
            and is predominantly expressed in peripheral blood leukocytes. The
            protein is involved in remodeling of the actin cytoskeleton
            required for lymphocyte migration in response to chemokine
            signaling. It activates members of the Rho family of GTPases, for
            example RAC1 and RAC2, by acting as a guanine nucleotide exchange
            factor (GEF) to exchange bound GDP for free GTP. Mutations in this
            gene result in immunodeficiency 40 (IMD40), a combined form of
            immunodeficiency that affects T cell number and function, also with
            variable defects in B cell and NK cell function. [provided by
            RefSeq, May 2018].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D86964.1, BC104900.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000520908.7/ ENSP00000429283.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                DB145764.1         29-44
            17-3246             BC104900.1         1-3230
            3247-3507           BC113457.1         3231-3491
            3508-5621           BC104900.1         3492-5605
            5622-5705           BC084556.1         1931-2014
            5706-6064           AK128449.1         2416-2774
            6065-6069           BC084556.1         2374-2378
FEATURES             Location/Qualifiers
     source          1..6069
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q35.1"
     gene            1..6069
                     /gene="DOCK2"
                     /gene_synonym="IMD40"
                     /note="dedicator of cytokinesis 2"
                     /db_xref="GeneID:1794"
                     /db_xref="HGNC:HGNC:2988"
                     /db_xref="MIM:603122"
     exon            1..95
                     /gene="DOCK2"
                     /gene_synonym="IMD40"
                     /inference="alignment:Splign:2.1.0"
     CDS             53..5545
                     /gene="DOCK2"
                     /gene_synonym="IMD40"
                     /note="dedicator of cyto-kinesis 2"
                     /codon_start=1
                     /product="dedicator of cytokinesis protein 2"
                     /protein_id="NP_004937.1"
                     /db_xref="CCDS:CCDS4371.1"
                     /db_xref="GeneID:1794"
                     /db_xref="HGNC:HGNC:2988"
                     /db_xref="MIM:603122"
                     /translation="MAPWRKADKERHGVAIYNFQGSGAPQLSLQIGDVVRIQETCGDW
                     YRGYLIKHKMLQGIFPKSFIHIKEVTVEKRRNTENIIPAEIPLAQEVTTTLWEWGSIW
                     KQLYVASKKERFLQVQSMMYDLMEWRSQLLSGTLPKDELKELKQKVTSKIDYGNKILE
                     LDLIVRDEDGNILDPDNTSVISLFHAHEEATDKITERIKEEMSKDQPDYAMYSRISSS
                     PTHSLYVFVRNFVCRIGEDAELFMSLYDPNKQTVISENYLVRWGSRGFPKEIEMLNNL
                     KVVFTDLGNKDLNRDKIYLICQIVRVGKMDLKDTGAKKCTQGLRRPFGVAVMDITDII
                     KGKAESDEEKQHFIPFHPVTAENDFLHSLLGKVIASKGDSGGQGLWVTMKMLVGDIIQ
                     IRKDYPHLVDRTTVVARKLGFPEIIMPGDVRNDIYITLLQGDFDKYNKTTQRNVEVIM
                     CVCAEDGKTLPNAICVGAGDKPMNEYRSVVYYQVKQPRWMETVKVAVPIEDMQRIHLR
                     FMFRHRSSLESKDKGEKNFAMSYVKLMKEDGTTLHDGFHDLVVLKGDSKKMEDASAYL
                     TLPSYRHHVENKGATLSRSSSSVGGLSVSSRDVFSISTLVCSTKLTQNVGLLGLLKWR
                     MKPQLLQENLEKLKIVDGEEVVKFLQDTLDALFNIMMEHSQSDEYDILVFDALIYIIG
                     LIADRKFQHFNTVLEAYIQQHFSATLAYKKLMTVLKTYLDTSSRGEQCEPILRTLKAL
                     EYVFKFIVRSRTLFSQLYEGKEQMEFEESMRRLFESINNLMKSQYKTTILLQVAALKY
                     IPSVLHDVEMVFDAKLLSQLLYEFYTCIPPVKLQKQKVQSMNEIVQSNLFKKQECRDI
                     LLPVITKELKELLEQKDDMQHQVLERKYCVELLNSILEVLSYQDAAFTYHHIQEIMVQ
                     LLRTVNRTVITMGRDHILISHFVACMTAILNQMGDQHYSFYIETFQTSSELVDFLMET
                     FIMFKDLIGKNVYPGDWMAMSMVQNRVFLRAINKFAETMNQKFLEHTNFEFQLWNNYF
                     HLAVAFITQDSLQLEQFSHAKYNKILNKYGDMRRLIGFSIRDMWYKLGQNKICFIPGM
                     VGPILEMTLIPEAELRKATIPIFFDMMLCEYQRSGDFKKFENEIILKLDHEVEGGRGD
                     EQYMQLLESILMECAAEHPTIAKSVENFVNLVKGLLEKLLDYRGVMTDESKDNRMSCT
                     VNLLNFYKDNNREEMYIRYLYKLRDLHLDCDNYTEAAYTLLLHTWLLKWSDEQCASQV
                     MQTGQQHPQTHRQLKETLYETIIGYFDKGKMWEEAISLCKELAEQYEMEIFDYELLSQ
                     NLIQQAKFYESIMKILRPKPDYFAVGYYGQGFPSFLRNKVFIYRGKEYERREDFQMQL
                     MTQFPNAEKMNTTSAPGDDVKNAPGQYIQCFTVQPVLDEHPRFKNKPVPDQIINFYKS
                     NYVQRFHYSRPVRRGTVDPENEFASMWIERTSFVTAYKLPGILRWFEVVHMSQTTISP
                     LENAIETMSTANEKILMMINQYQSDETLPINPLSMLLNGIVDPAVMGGFAKYEKAFFT
                     EEYVRDHPEDQDKLTHLKDLIAWQIPFLGAGIKIHEKRVSDNLRPFHDRMEECFKNLK
                     MKVEKEYGVREMPDFDDRRVGRPRSMLRSYRQMSIISLASMNSDCSTPSKPTSESFDL
                     ELASPKTPRVEQEEPISPGSTLPEVKLRRSKKRTKRSSVVFADEKAAAESDLKRLSRK
                     HEFMSDTNLSEHAAIPLKASVLSQMSFASQSMPTIPALALSVAGIPGLDEANTSPRLS
                     QTFLQLSDGDKKTLTRKKVNQFFKTMLASKSAEEGKQIPDSLSTDL"
     exon            96..179
                     /gene="DOCK2"
                     /gene_synonym="IMD40"
                     /inference="alignment:Splign:2.1.0"
     exon            180..220
                     /gene="DOCK2"
                     /gene_synonym="IMD40"
                     /inference="alignment:Splign:2.1.0"
     exon            221..276
                     /gene="DOCK2"
                     /gene_synonym="IMD40"
                     /inference="alignment:Splign:2.1.0"
     exon            277..373
                     /gene="DOCK2"
                     /gene_synonym="IMD40"
                     /inference="alignment:Splign:2.1.0"
     exon            374..522
                     /gene="DOCK2"
                     /gene_synonym="IMD40"
                     /inference="alignment:Splign:2.1.0"
     exon            523..658
                     /gene="DOCK2"
                     /gene_synonym="IMD40"
                     /inference="alignment:Splign:2.1.0"
     exon            659..813
                     /gene="DOCK2"
                     /gene_synonym="IMD40"
                     /inference="alignment:Splign:2.1.0"
     exon            814..895
                     /gene="DOCK2"
                     /gene_synonym="IMD40"
                     /inference="alignment:Splign:2.1.0"
     exon            896..1031
                     /gene="DOCK2"
                     /gene_synonym="IMD40"
                     /inference="alignment:Splign:2.1.0"
     exon            1032..1107
                     /gene="DOCK2"
                     /gene_synonym="IMD40"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1184
                     /gene="DOCK2"
                     /gene_synonym="IMD40"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1310
                     /gene="DOCK2"
                     /gene_synonym="IMD40"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..1435
                     /gene="DOCK2"
                     /gene_synonym="IMD40"
                     /inference="alignment:Splign:2.1.0"
     exon            1436..1534
                     /gene="DOCK2"
                     /gene_synonym="IMD40"
                     /inference="alignment:Splign:2.1.0"
     exon            1535..1607
                     /gene="DOCK2"
                     /gene_synonym="IMD40"
                     /inference="alignment:Splign:2.1.0"
     exon            1608..1711
                     /gene="DOCK2"
                     /gene_synonym="IMD40"
                     /inference="alignment:Splign:2.1.0"
     exon            1712..1895
                     /gene="DOCK2"
                     /gene_synonym="IMD40"
                     /inference="alignment:Splign:2.1.0"
     exon            1896..1993
                     /gene="DOCK2"
                     /gene_synonym="IMD40"
                     /inference="alignment:Splign:2.1.0"
     exon            1994..2083
                     /gene="DOCK2"
                     /gene_synonym="IMD40"
                     /inference="alignment:Splign:2.1.0"
     exon            2084..2184
                     /gene="DOCK2"
                     /gene_synonym="IMD40"
                     /inference="alignment:Splign:2.1.0"
     exon            2185..2319
                     /gene="DOCK2"
                     /gene_synonym="IMD40"
                     /inference="alignment:Splign:2.1.0"
     exon            2320..2428
                     /gene="DOCK2"
                     /gene_synonym="IMD40"
                     /inference="alignment:Splign:2.1.0"
     exon            2429..2499
                     /gene="DOCK2"
                     /gene_synonym="IMD40"
                     /inference="alignment:Splign:2.1.0"
     exon            2500..2606
                     /gene="DOCK2"
                     /gene_synonym="IMD40"
                     /inference="alignment:Splign:2.1.0"
     exon            2607..2755
                     /gene="DOCK2"
                     /gene_synonym="IMD40"
                     /inference="alignment:Splign:2.1.0"
     exon            2756..2851
                     /gene="DOCK2"
                     /gene_synonym="IMD40"
                     /inference="alignment:Splign:2.1.0"
     exon            2852..2950
                     /gene="DOCK2"
                     /gene_synonym="IMD40"
                     /inference="alignment:Splign:2.1.0"
     exon            2951..3045
                     /gene="DOCK2"
                     /gene_synonym="IMD40"
                     /inference="alignment:Splign:2.1.0"
     exon            3046..3124
                     /gene="DOCK2"
                     /gene_synonym="IMD40"
                     /inference="alignment:Splign:2.1.0"
     exon            3125..3225
                     /gene="DOCK2"
                     /gene_synonym="IMD40"
                     /inference="alignment:Splign:2.1.0"
     exon            3226..3284
                     /gene="DOCK2"
                     /gene_synonym="IMD40"
                     /inference="alignment:Splign:2.1.0"
     exon            3285..3433
                     /gene="DOCK2"
                     /gene_synonym="IMD40"
                     /inference="alignment:Splign:2.1.0"
     exon            3434..3519
                     /gene="DOCK2"
                     /gene_synonym="IMD40"
                     /inference="alignment:Splign:2.1.0"
     exon            3520..3676
                     /gene="DOCK2"
                     /gene_synonym="IMD40"
                     /inference="alignment:Splign:2.1.0"
     exon            3677..3717
                     /gene="DOCK2"
                     /gene_synonym="IMD40"
                     /inference="alignment:Splign:2.1.0"
     exon            3718..3808
                     /gene="DOCK2"
                     /gene_synonym="IMD40"
                     /inference="alignment:Splign:2.1.0"
     exon            3809..3928
                     /gene="DOCK2"
                     /gene_synonym="IMD40"
                     /inference="alignment:Splign:2.1.0"
     exon            3929..4018
                     /gene="DOCK2"
                     /gene_synonym="IMD40"
                     /inference="alignment:Splign:2.1.0"
     exon            4019..4123
                     /gene="DOCK2"
                     /gene_synonym="IMD40"
                     /inference="alignment:Splign:2.1.0"
     exon            4124..4265
                     /gene="DOCK2"
                     /gene_synonym="IMD40"
                     /inference="alignment:Splign:2.1.0"
     exon            4266..4347
                     /gene="DOCK2"
                     /gene_synonym="IMD40"
                     /inference="alignment:Splign:2.1.0"
     exon            4348..4432
                     /gene="DOCK2"
                     /gene_synonym="IMD40"
                     /inference="alignment:Splign:2.1.0"
     exon            4433..4519
                     /gene="DOCK2"
                     /gene_synonym="IMD40"
                     /inference="alignment:Splign:2.1.0"
     exon            4520..4696
                     /gene="DOCK2"
                     /gene_synonym="IMD40"
                     /inference="alignment:Splign:2.1.0"
     exon            4697..4780
                     /gene="DOCK2"
                     /gene_synonym="IMD40"
                     /inference="alignment:Splign:2.1.0"
     exon            4781..4918
                     /gene="DOCK2"
                     /gene_synonym="IMD40"
                     /inference="alignment:Splign:2.1.0"
     exon            4919..5046
                     /gene="DOCK2"
                     /gene_synonym="IMD40"
                     /inference="alignment:Splign:2.1.0"
     exon            5047..5218
                     /gene="DOCK2"
                     /gene_synonym="IMD40"
                     /inference="alignment:Splign:2.1.0"
     exon            5219..5339
                     /gene="DOCK2"
                     /gene_synonym="IMD40"
                     /inference="alignment:Splign:2.1.0"
     exon            5340..5482
                     /gene="DOCK2"
                     /gene_synonym="IMD40"
                     /inference="alignment:Splign:2.1.0"
     exon            5483..6069
                     /gene="DOCK2"
                     /gene_synonym="IMD40"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6041..6046
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DOCK2"
                     /gene_synonym="IMD40"
                     /note="hexamer: AATAAA"
     polyA_site      6066
                     /gene="DOCK2"
                     /gene_synonym="IMD40"
                     /note="major polyA site"
ORIGIN      
        1 agccaccccc tgacggcttc cccacgggag gacgcgaggc cccggcccag ccatggcccc
       61 ctggcgcaaa gctgacaagg agcggcacgg cgtggccata tacaacttcc aaggcagcgg
      121 agccccccag ctctccctgc agatcggcga tgtggtgcga atacaggaga cgtgtggaga
      181 ctggtatagg ggatacctca taaagcacaa aatgttacag ggcatttttc ctaagtcatt
      241 tatccacatc aaggaagtga cagttgagaa aagaagaaat actgagaaca tcattcctgc
      301 agaaattcct ctggcacaag aagtgacaac gacactttgg gaatggggaa gcatctggaa
      361 acaactctat gtggccagca aaaaggagcg ttttctccag gtgcagtcca tgatgtacga
      421 tctgatggag tggaggtccc agcttctctc aggaacctta cccaaggatg agctgaagga
      481 actgaagcag aaagtcacgt ccaaaattga ctatggcaac aaaatccttg agcttgattt
      541 gattgtcaga gatgaagacg gaaatatctt ggaccctgat aataccagtg tcatcagctt
      601 gttccatgca catgaggaag caactgataa aatcacagag cgtatcaaag aagaaatgtc
      661 aaaagaccag ccagattatg caatgtattc ccggatctcc tcatccccca cccatagcct
      721 ctatgtgttt gtgagaaact ttgtgtgcag aattggggaa gatgctgagc tcttcatgtc
      781 tctctacgac cccaacaagc aaacggtcat aagtgagaac tacctagtgc gatggggcag
      841 ccggggcttc cctaaggaga ttgagatgct caacaatctg aaggtggtct tcacggatct
      901 tggaaacaaa gacctcaaca gggataaaat ttacttgatt tgtcaaatag tccgggtcgg
      961 caagatggat cttaaggata ctggtgcaaa gaagtgcacg cagggactga ggaggccctt
     1021 tggggtggca gttatggata taacagacat catcaagggg aaagcagaga gtgatgaaga
     1081 aaagcagcac ttcattcctt ttcacccggt tacagctgag aatgacttcc tacacagcct
     1141 gctgggcaaa gtcatagcct ccaaggggga cagtggaggg caaggcctct gggtgaccat
     1201 gaagatgctg gtgggtgaca tcattcagat tcgcaaggac tatccacacc tggtggacag
     1261 gaccaccgtg gtggccagga agctgggatt cccagagatc atcatgccag gggatgtcag
     1321 gaacgacatc tacattactc tcttacaagg tgactttgac aagtacaaca agaccacaca
     1381 gaggaatgtg gaagtcatca tgtgtgtgtg cgcggaggat ggcaaaacgc tgcctaatgc
     1441 aatttgcgtg ggagcagggg acaagcccat gaatgagtat cgctccgttg tgtactatca
     1501 agtcaaacag ccacgctgga tggaaacagt caaggtggct gtccctattg aagacatgca
     1561 gaggatccat ctgcgattca tgtttcgaca tcggtcatct ctggaatcta aagataaagg
     1621 agaaaagaac tttgccatgt cctatgtgaa gctgatgaaa gaagatggga ctactctaca
     1681 cgatggattc catgacttag ttgtcctcaa gggggacagc aagaagatgg aggatgccag
     1741 cgcatacctg acccttcctt cttatcgaca ccatgtggaa aacaaggggg ccacgctgag
     1801 caggagctcc agcagtgttg gggggctttc tgtcagctcc cgggatgtgt tctccatttc
     1861 caccctggtg tgctccacaa agctcactca gaatgtgggc ttgctgggtt tgctgaagtg
     1921 gcgtatgaag cctcaactgc tacaggagaa tttagaaaag ttgaagattg tggatggaga
     1981 ggaagtggtg aagtttctcc aggatactct ggatgccctc ttcaacatca tgatggagca
     2041 ttctcaaagt gatgaatatg acatcctcgt ctttgatgcc ttgatttaca taataggact
     2101 cattgcagac cggaaatttc agcatttcaa caccgttctg gaggcttaca tccaacagca
     2161 tttcagtgcg accttggctt acaagaaatt gatgacagtg ctgaagactt acttggatac
     2221 ctccagcaga ggggagcaat gtgagccaat cctaagaacg ctgaaggctt tggaatatgt
     2281 gttcaagttc attgttcggt cgaggacatt attttcacag ctttatgaag gcaaagaaca
     2341 gatggagttt gaagaatcca tgagacggct ctttgaatcc atcaacaatc tgatgaaaag
     2401 tcaatacaaa actaccatcc ttttgcaggt ggcggctttg aaatacatcc catctgtcct
     2461 gcatgatgta gaaatggtct ttgatgcgaa gttactcagc caactcctgt atgagttcta
     2521 cacctgcatc cctcctgtga aactccagaa gcagaaagta cagtctatga atgagatagt
     2581 ccagagcaac ctctttaaaa agcaagaatg ccgggacatt ctgcttcctg tcatcaccaa
     2641 agagctgaag gagctgctgg agcagaagga tgacatgcaa caccaggtcc tggagaggaa
     2701 gtactgcgtt gaattgctca acagcatctt ggaagtcctt agctaccagg atgcggcctt
     2761 cacctaccac catatccagg agatcatggt ccagctgctg cggacagtga accggacagt
     2821 catcaccatg ggccgggatc acattctgat tagtcacttt gtggcatgta tgacagccat
     2881 cttaaaccag atgggtgacc agcactactc cttctacatt gagaccttcc agaccagctc
     2941 tgaacttgtg gacttcttga tggagacctt catcatgttc aaggacctca ttggaaagaa
     3001 cgtgtaccct ggagactgga tggccatgag catggttcaa aacagggtct tcctgagagc
     3061 tatcaacaag tttgcagaaa ccatgaacca gaagttccta gaacacacga actttgagtt
     3121 ccagctgtgg aacaactatt ttcatctggc agtggctttt atcacccagg attctctgca
     3181 gctggagcag ttctcacacg ccaaatacaa caaaatcctg aataagtatg gggacatgag
     3241 acggctaatt ggcttctcca tccgtgatat gtggtacaag cttggtcaga acaaaatctg
     3301 cttcatccca ggcatggtag gacctatatt agagatgaca cttatccctg aggctgagct
     3361 ccggaaagcc accataccaa tcttcttcga catgatgctg tgtgaatatc aaagaagtgg
     3421 ggatttcaaa aagtttgaaa acgaaatcat cctgaagctg gaccacgagg tagaaggggg
     3481 ccgaggcgac gagcagtaca tgcagctcct ggagtcaatc ctgatggaat gtgctgcaga
     3541 gcacccaacc attgccaagt cggtggagaa cttcgtgaac ctggtcaaag gcctcctgga
     3601 gaagctgctg gattaccggg gtgtgatgac agatgagagc aaagacaacc gcatgagctg
     3661 caccgtgaac ctgctgaatt tctacaaaga taacaacagg gaggagatgt acataaggta
     3721 cctgtacaaa ctccgcgatc ttcacctgga ctgtgacaat tacacagagg ctgcctacac
     3781 gctccttctc cacacctggc ttctcaagtg gtcggatgag cagtgtgcat cacaggtcat
     3841 gcagacaggc cagcagcacc cccagacaca ccggcagctg aaggagacgc tctacgagac
     3901 catcataggc tactttgaca aaggaaagat gtgggaagag gccataagtc tgtgcaagga
     3961 gctggcggaa cagtacgaga tggagatctt tgactatgag ctgctcagcc agaacctgat
     4021 ccagcaggca aaattctatg aaagcatcat gaaaatcctc aggcccaaac cagactactt
     4081 tgctgttgga tactacggcc agggattccc ctccttcctg cggaacaaag tgttcatcta
     4141 ccgcgggaag gaatatgagc gaagagaaga tttccagatg cagctgatga cccagttccc
     4201 caatgcagag aagatgaaca ccacctctgc cccgggagat gatgtgaaga atgccccagg
     4261 ccagtatatc cagtgcttca ctgtccagcc tgtcttggat gaacatccca ggttcaagaa
     4321 taagccagtg cctgaccaga ttataaactt ctacaaatcc aactacgtgc aaaggttcca
     4381 ctactcccgg cccgtgcgca gggggaccgt agacccagag aatgagtttg cttccatgtg
     4441 gattgagaga acctccttcg tgactgcata caagctgccg gggatcctgc gctggtttga
     4501 ggtggtgcac atgtcgcaga ccacaattag tcctctggag aatgccatag aaaccatgtc
     4561 cacggccaat gagaagatcc tgatgatgat aaaccagtac cagagtgatg agaccctccc
     4621 catcaaccca ctctccatgc tcctgaacgg gattgtggac cctgctgtca tgggaggctt
     4681 cgccaagtat gagaaggcct tcttcactga agagtatgtc agggaccacc ctgaggacca
     4741 ggacaagctg acccacctca aggacctgat tgcatggcag atccccttct tgggagctgg
     4801 gattaagatc catgagaaaa gggtgtcaga taacttgcga cccttccatg accggatgga
     4861 ggaatgtttc aagaacctga aaatgaaggt ggagaaggag tacggtgtcc gagagatgcc
     4921 tgactttgac gacaggagag tgggccgtcc caggtctatg ctgcgctcat acagacagat
     4981 gtccatcatc tctctggctt ccatgaattc tgactgcagc acccccagca agcctacctc
     5041 agagagcttt gacctggaat tagcatcacc caagacgccg agagtggagc aggaggaacc
     5101 gatctccccg gggagcaccc tgcctgaggt caagctgcgg aggtccaaga agaggacaaa
     5161 gagaagcagc gtagtttttg cggatgagaa agcagctgca gagtcggacc tgaagcggct
     5221 ttccaggaag catgagttca tgagtgacac caacctctcg gagcatgcgg ccatccccct
     5281 caaggcgtct gtcctctctc aaatgagctt tgccagccag tccatgccta ccatcccagc
     5341 cctggcgctc tcagtggcag gcatccctgg gttggatgag gccaacacat ctccccgcct
     5401 cagccagacc ttcctccaac tctcagatgg tgacaagaag acactcacac ggaagaaggt
     5461 caatcagttc ttcaagacaa tgctggccag caaatcggct gaagaaggca aacagatccc
     5521 agactcgctg tccacggacc tgtgagctgc tgctgactag ggctgcatgg gagagccagg
     5581 gaggggagtt tctggaagag gaaagccatg cgtggaacat cgaagcctca gagagtggga
     5641 gactgtcccc atcagttgtc cttacttaga ggagacagag aggccaatca ggtcccagag
     5701 cttgaatgct aacaagccca gcatcccctg gggctgtgat catggtggat gaggaagcct
     5761 caacgtagat tcctgaactc aaggtaccag caagaatgcc ttctcccagt gtgctctccc
     5821 caacatccta ggcacagctt tcataaccca gtttcttagg tgtaagaaac tgtttttatc
     5881 tcatttatta agtctcagaa cttaacagaa aaggaagcct tttaaatatt ctttttaatt
     5941 ttattttaga ttaacagttt tgtactttac atttttttat acaaccaacc agtttctttt
     6001 ctagccaatc atctctgaag agttgctgtt tcttactgac aataaaaaat gttctcttgg
     6061 ttcgaataa
//
