LOCUS       NM_144658               6719 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens dedicator of cytokinesis 11 (DOCK11), mRNA.
ACCESSION   NM_144658
VERSION     NM_144658.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6719)
  AUTHORS   Tangye,S.G. and Meyts,I.
  TITLE     DOCK11 and Immune Disease
  JOURNAL   N Engl J Med 389 (6), 563-567 (2023)
   PUBMED   37590454
  REMARK    GeneRIF: DOCK11 and Immune Disease.
REFERENCE   2  (bases 1 to 6719)
  AUTHORS   Block,J., Rashkova,C., Castanon,I., Zoghi,S., Platon,J., Ardy,R.C.,
            Fujiwara,M., Chaves,B., Schoppmeyer,R., van der Made,C.I., Jimenez
            Heredia,R., Harms,F.L., Alavi,S., Alsina,L., Sanchez Moreno,P.,
            Avila Polo,R., Cabrera-Perez,R., Kostel Bal,S., Pfajfer,L.,
            Ransmayr,B., Mautner,A.K., Kondo,R., Tinnacher,A., Caldera,M.,
            Schuster,M., Dominguez Conde,C., Platzer,R., Salzer,E., Boyer,T.,
            Brunner,H.G., Nooitgedagt-Frons,J.E., Iglesias,E.,
            Deya-Martinez,A., Camacho-Lovillo,M., Menche,J., Bock,C.,
            Huppa,J.B., Pickl,W.F., Distel,M., Yoder,J.A., Traver,D.,
            Engelhardt,K.R., Linden,T., Kager,L., Hannich,J.T., Hoischen,A.,
            Hambleton,S., Illsinger,S., Da Costa,L., Kutsche,K.,
            Chavoshzadeh,Z., van Buul,J.D., Anton,J., Calzada-Hernandez,J.,
            Neth,O., Viaud,J., Nishikimi,A., Dupre,L. and Boztug,K.
  TITLE     Systemic Inflammation and Normocytic Anemia in DOCK11 Deficiency
  JOURNAL   N Engl J Med 389 (6), 527-539 (2023)
   PUBMED   37342957
  REMARK    GeneRIF: Systemic Inflammation and Normocytic Anemia in DOCK11
            Deficiency.
REFERENCE   3  (bases 1 to 6719)
  AUTHORS   Boussard,C., Delage,L., Gajardo,T., Kauskot,A., Batignes,M.,
            Goudin,N., Stolzenberg,M.C., Brunaud,C., Panikulam,P., Riller,Q.,
            Moya-Nilges,M., Solarz,J., Reperant,C., Durel,B., Bordet,J.C.,
            Pelle,O., Lebreton,C., Magerus,A., Pirabakaran,V., Vargas,P.,
            Dupichaud,S., Jeanpierre,M., Vinit,A., Zarhrate,M., Masson,C.,
            Aladjidi,N., Arkwright,P.D., Bader-Meunier,B., Baron Joly,S.,
            Benadiba,J., Bernard,E., Berrebi,D., Bodemer,C., Castelle,M.,
            Charbit-Henrion,F., Chbihi,M., Debray,A., Drabent,P., Fraitag,S.,
            Hie,M., Landman-Parker,J., Lhermitte,L., Moshous,D., Rohrlich,P.,
            Ruemmele,F., Welfringer-Morin,A., Tusseau,M., Belot,A.,
            Cerf-Bensussan,N., Roelens,M., Picard,C., Neven,B., Fischer,A.,
            Callebaut,I., Menager,M., Sepulveda,F.E., Adam,F. and
            Rieux-Laucat,F.
  TITLE     DOCK11 deficiency in patients with X-linked actinopathy and
            autoimmunity
  JOURNAL   Blood 141 (22), 2713-2726 (2023)
   PUBMED   36952639
  REMARK    GeneRIF: DOCK11 deficiency in patients with X-linked actinopathy
            and autoimmunity.
REFERENCE   4  (bases 1 to 6719)
  AUTHORS   Hashimoto,S., Shirasaki,T., Yamashita,T., Iwabuchi,S., Suzuki,Y.,
            Takamura,Y., Ukita,Y., Deshimaru,S., Okayama,T., Ikeo,K.,
            Kuroki,K., Kawaguchi,K., Mizukoshi,E., Matsushima,K., Honda,M. and
            Kaneko,S.
  TITLE     DOCK11 and DENND2A play pivotal roles in the maintenance of
            hepatitis B virus in host cells
  JOURNAL   PLoS One 16 (2), e0246313 (2021)
   PUBMED   33539396
  REMARK    GeneRIF: DOCK11 and DENND2A play pivotal roles in the maintenance
            of hepatitis B virus in host cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6719)
  AUTHORS   Williamson,R.C., Cowell,C.A., Hammond,C.L., Bergen,D.J.,
            Roper,J.A., Feng,Y., Rendall,T.C., Race,P.R. and Bass,M.D.
  TITLE     Coronin-1C and RCC2 guide mesenchymal migration by trafficking Rac1
            and controlling GEF exposure
  JOURNAL   J Cell Sci 127 (Pt 19), 4292-4307 (2014)
   PUBMED   25074804
REFERENCE   6  (bases 1 to 6719)
  AUTHORS   Lin,Q., Yang,W., Baird,D., Feng,Q. and Cerione,R.A.
  TITLE     Identification of a DOCK180-related guanine nucleotide exchange
            factor that is capable of mediating a positive feedback activation
            of Cdc42
  JOURNAL   J Biol Chem 281 (46), 35253-35262 (2006)
   PUBMED   16968698
REFERENCE   7  (bases 1 to 6719)
  AUTHORS   Cote,J.F. and Vuori,K.
  TITLE     Identification of an evolutionarily conserved superfamily of
            DOCK180-related proteins with guanine nucleotide exchange activity
  JOURNAL   J Cell Sci 115 (Pt 24), 4901-4913 (2002)
   PUBMED   12432077
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC007021.3, AY692226.1 and AK124735.1.
            
            On Aug 11, 2020 this sequence version replaced NM_144658.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY692226.1, SRR18074967.2355937.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000276202.9/ ENSP00000276202.7
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-94                AC007021.3         91145-91238         c
            95-1282             AY692226.1         1-1188
            1283-1706           AK124735.1         574-997
            1707-1827           AY692226.1         1613-1733
            1828-2336           AK124735.1         1119-1627
            2337-2376           AY692226.1         2243-2282
            2377-3449           AK124735.1         1668-2740
            3450-6106           AY692226.1         3356-6012
            6107-6558           AK124735.1         5436-5887
            6559-6719           AY692226.1         6465-6625
FEATURES             Location/Qualifiers
     source          1..6719
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq24"
     gene            1..6719
                     /gene="DOCK11"
                     /gene_synonym="ACG; ADMIDX; bB128O4.1; ZIZ2"
                     /note="dedicator of cytokinesis 11"
                     /db_xref="GeneID:139818"
                     /db_xref="HGNC:HGNC:23483"
                     /db_xref="MIM:300681"
     exon            1..259
                     /gene="DOCK11"
                     /gene_synonym="ACG; ADMIDX; bB128O4.1; ZIZ2"
                     /inference="alignment:Splign:2.1.0"
     CDS             158..6379
                     /gene="DOCK11"
                     /gene_synonym="ACG; ADMIDX; bB128O4.1; ZIZ2"
                     /note="Activated Cdc42-associated guanine nucleotide
                     exchange factor, ACG; zizimin2; zizimin-2"
                     /codon_start=1
                     /product="dedicator of cytokinesis protein 11"
                     /protein_id="NP_653259.3"
                     /db_xref="CCDS:CCDS35373.1"
                     /db_xref="GeneID:139818"
                     /db_xref="HGNC:HGNC:23483"
                     /db_xref="MIM:300681"
                     /translation="MAEVRKFTKRLSKPGTAAELRQSVSEAVRGSVVLEKAKVVEPLD
                     YENVIAQRKTQIYSDPLRDLLMFPMEDISISVIGRQRRTVQSTVPEDAEKRAQSLFVK
                     ECIKTYSTDWHVVNYKYEDFSGDFRMLPCKSLRPEKIPNHVFEIDEDCEKDEDSSSLC
                     SQKGGVIKQGWLHKANVNSTITVTMKVFKRRYFYLTQLPDGSYILNSYKDEKNSKESK
                     GCIYLDACIDVVQCPKMRRHAFELKMLDKYSHYLAAETEQEMEEWLITLKKIIQINTD
                     SLVQEKKETVETAQDDETSSQGKAENIMASLERSMHPELMKYGRETEQLNKLSRGDGR
                     QNLFSFDSEVQRLDFSGIEPDIKPFEEKCNKRFLVNCHDLTFNILGQIGDNAKGPPTN
                     VEPFFINLALFDVKNNCKISADFHVDLNPPSVREMLWGSSTQLASDGSPKGSSPESYI
                     HGIAESQLRYIQQGIFSVTNPHPEIFLVARIEKVLQGNITHCAEPYIKNSDPVKTAQK
                     VHRTAKQVCSRLGQYRMPFAWAARPIFKDTQGSLDLDGRFSPLYKQDSSKLSSEDILK
                     LLSEYKKPEKTKLQIIPGQLNITVECVPVDLSNCITSSYVPLKPFEKNCQNITVEVEE
                     FVPEMTKYCYPFTIYKNHLYVYPLQLKYDSQKTFAKARNIAVCVEFRDSDESDASALK
                     CIYGKPAGSVFTTNAYAVVSHHNQNPEFYDEIKIELPIHLHQKHHLLFTFYHVSCEIN
                     TKGTTKKQDTVETPVGFAWVPLLKDGRIITFEQQLPVSANLPPGYLNLNDAESRRQCN
                     VDIKWVDGAKPLLKIKSHLESTIYTQDLHVHKFFHHCQLIQSGSKEVPGELIKYLKCL
                     HAMEIQVMIQFLPVILMQLFRVLTNMTHEDDVPINCTMVLLHIVSKCHEEGLDSYLRS
                     FIKYSFRPEKPSAPQAQLIHETLATTMIAILKQSADFLSINKLLKYSWFFFEIIAKSM
                     ATYLLEENKIKLPRGQRFPETYHHVLHSLLLAIIPHVTIRYAEIPDESRNVNYSLASF
                     LKRCLTLMDRGFIFNLINDYISGFSPKDPKVLAEYKFEFLQTICNHEHYIPLNLPMAF
                     AKPKLQRVQDSNLEYSLSDEYCKHHFLVGLLLRETSIALQDNYEIRYTAISVIKNLLI
                     KHAFDTRYQHKNQQAKIAQLYLPFVGLLLENIQRLAGRDTLYSCAAMPNSASRDEFPC
                     GFTSPANRGSLSTDKDTAYGSFQNGHGIKREDSRGSLIPEGATGFPDQGNTGENTRQS
                     STRSSVSQYNRLDQYEIRSLLMCYLYIVKMISEDTLLTYWNKVSPQELINILILLEVC
                     LFHFRYMGKRNIARVHDAWLSKHFGIDRKSQTMPALRNRSGVMQARLQHLSSLESSFT
                     LNHSSTTTEADIFHQALLEGNTATEVSLTVLDTISFFTQCFKTQLLNNDGHNPLMKKV
                     FDIHLAFLKNGQSEVSLKHVFASLRAFISKFPSAFFKGRVNMCAAFCYEVLKCCTSKI
                     SSTRNEASALLYLLMRNNFEYTKRKTFLRTHLQIIIAVSQLIADVALSGGSRFQESLF
                     IINNFANSDRPMKATAFPAEVKDLTKRIRTVLMATAQMKEHEKDPEMLIDLQYSLAKS
                     YASTPELRKTWLDSMAKIHVKNGDFSEAAMCYVHVAALVAEFLHRKKLFPNGCSAFKK
                     ITPNIDEEGAMKEDAGMMDVHYSEEVLLELLEQCVDGLWKAERYEIISEISKLIVPIY
                     EKRREFEKLTQVYRTLHGAYTKILEVMHTKKRLLGTFFRVAFYGQSFFEEEDGKEYIY
                     KEPKLTGLSEISLRLVKLYGEKFGTENVKIIQDSDKVNAKELDPKYAHIQVTYVKPYF
                     DDKELTERKTEFERNHNISRFVFEAPYTLSGKKQGCIEEQCKRRTILTTSNSFPYVKK
                     RIPINCEQQINLKPIDVATDEIKDKTAELQKLCSSTDVDMIQLQLKLQGCVSVQVNAG
                     PLAYARAFLNDSQASKYPPKKVSELKDMFRKFIQACSIALELNERLIKEDQVEYHEGL
                     KSNFRDMVKELSDIIHEQILQEDTMHSPWMSNTLHVFCAISGTSSDRGYGSPRYAEV"
     exon            260..376
                     /gene="DOCK11"
                     /gene_synonym="ACG; ADMIDX; bB128O4.1; ZIZ2"
                     /inference="alignment:Splign:2.1.0"
     exon            377..466
                     /gene="DOCK11"
                     /gene_synonym="ACG; ADMIDX; bB128O4.1; ZIZ2"
                     /inference="alignment:Splign:2.1.0"
     exon            467..549
                     /gene="DOCK11"
                     /gene_synonym="ACG; ADMIDX; bB128O4.1; ZIZ2"
                     /inference="alignment:Splign:2.1.0"
     exon            550..619
                     /gene="DOCK11"
                     /gene_synonym="ACG; ADMIDX; bB128O4.1; ZIZ2"
                     /inference="alignment:Splign:2.1.0"
     exon            620..715
                     /gene="DOCK11"
                     /gene_synonym="ACG; ADMIDX; bB128O4.1; ZIZ2"
                     /inference="alignment:Splign:2.1.0"
     exon            716..850
                     /gene="DOCK11"
                     /gene_synonym="ACG; ADMIDX; bB128O4.1; ZIZ2"
                     /inference="alignment:Splign:2.1.0"
     exon            851..1028
                     /gene="DOCK11"
                     /gene_synonym="ACG; ADMIDX; bB128O4.1; ZIZ2"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1108
                     /gene="DOCK11"
                     /gene_synonym="ACG; ADMIDX; bB128O4.1; ZIZ2"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1192
                     /gene="DOCK11"
                     /gene_synonym="ACG; ADMIDX; bB128O4.1; ZIZ2"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1333
                     /gene="DOCK11"
                     /gene_synonym="ACG; ADMIDX; bB128O4.1; ZIZ2"
                     /inference="alignment:Splign:2.1.0"
     exon            1334..1546
                     /gene="DOCK11"
                     /gene_synonym="ACG; ADMIDX; bB128O4.1; ZIZ2"
                     /inference="alignment:Splign:2.1.0"
     exon            1547..1669
                     /gene="DOCK11"
                     /gene_synonym="ACG; ADMIDX; bB128O4.1; ZIZ2"
                     /inference="alignment:Splign:2.1.0"
     exon            1670..1752
                     /gene="DOCK11"
                     /gene_synonym="ACG; ADMIDX; bB128O4.1; ZIZ2"
                     /inference="alignment:Splign:2.1.0"
     exon            1753..1875
                     /gene="DOCK11"
                     /gene_synonym="ACG; ADMIDX; bB128O4.1; ZIZ2"
                     /inference="alignment:Splign:2.1.0"
     exon            1876..1952
                     /gene="DOCK11"
                     /gene_synonym="ACG; ADMIDX; bB128O4.1; ZIZ2"
                     /inference="alignment:Splign:2.1.0"
     exon            1953..2137
                     /gene="DOCK11"
                     /gene_synonym="ACG; ADMIDX; bB128O4.1; ZIZ2"
                     /inference="alignment:Splign:2.1.0"
     exon            2138..2203
                     /gene="DOCK11"
                     /gene_synonym="ACG; ADMIDX; bB128O4.1; ZIZ2"
                     /inference="alignment:Splign:2.1.0"
     exon            2204..2296
                     /gene="DOCK11"
                     /gene_synonym="ACG; ADMIDX; bB128O4.1; ZIZ2"
                     /inference="alignment:Splign:2.1.0"
     exon            2297..2420
                     /gene="DOCK11"
                     /gene_synonym="ACG; ADMIDX; bB128O4.1; ZIZ2"
                     /inference="alignment:Splign:2.1.0"
     exon            2421..2542
                     /gene="DOCK11"
                     /gene_synonym="ACG; ADMIDX; bB128O4.1; ZIZ2"
                     /inference="alignment:Splign:2.1.0"
     exon            2543..2629
                     /gene="DOCK11"
                     /gene_synonym="ACG; ADMIDX; bB128O4.1; ZIZ2"
                     /inference="alignment:Splign:2.1.0"
     exon            2630..2719
                     /gene="DOCK11"
                     /gene_synonym="ACG; ADMIDX; bB128O4.1; ZIZ2"
                     /inference="alignment:Splign:2.1.0"
     exon            2720..2838
                     /gene="DOCK11"
                     /gene_synonym="ACG; ADMIDX; bB128O4.1; ZIZ2"
                     /inference="alignment:Splign:2.1.0"
     exon            2839..2908
                     /gene="DOCK11"
                     /gene_synonym="ACG; ADMIDX; bB128O4.1; ZIZ2"
                     /inference="alignment:Splign:2.1.0"
     exon            2909..3034
                     /gene="DOCK11"
                     /gene_synonym="ACG; ADMIDX; bB128O4.1; ZIZ2"
                     /inference="alignment:Splign:2.1.0"
     exon            3035..3106
                     /gene="DOCK11"
                     /gene_synonym="ACG; ADMIDX; bB128O4.1; ZIZ2"
                     /inference="alignment:Splign:2.1.0"
     exon            3107..3253
                     /gene="DOCK11"
                     /gene_synonym="ACG; ADMIDX; bB128O4.1; ZIZ2"
                     /inference="alignment:Splign:2.1.0"
     exon            3254..3337
                     /gene="DOCK11"
                     /gene_synonym="ACG; ADMIDX; bB128O4.1; ZIZ2"
                     /inference="alignment:Splign:2.1.0"
     exon            3338..3449
                     /gene="DOCK11"
                     /gene_synonym="ACG; ADMIDX; bB128O4.1; ZIZ2"
                     /inference="alignment:Splign:2.1.0"
     exon            3450..3628
                     /gene="DOCK11"
                     /gene_synonym="ACG; ADMIDX; bB128O4.1; ZIZ2"
                     /inference="alignment:Splign:2.1.0"
     exon            3629..3745
                     /gene="DOCK11"
                     /gene_synonym="ACG; ADMIDX; bB128O4.1; ZIZ2"
                     /inference="alignment:Splign:2.1.0"
     exon            3746..3821
                     /gene="DOCK11"
                     /gene_synonym="ACG; ADMIDX; bB128O4.1; ZIZ2"
                     /inference="alignment:Splign:2.1.0"
     exon            3822..3931
                     /gene="DOCK11"
                     /gene_synonym="ACG; ADMIDX; bB128O4.1; ZIZ2"
                     /inference="alignment:Splign:2.1.0"
     exon            3932..4043
                     /gene="DOCK11"
                     /gene_synonym="ACG; ADMIDX; bB128O4.1; ZIZ2"
                     /inference="alignment:Splign:2.1.0"
     exon            4044..4110
                     /gene="DOCK11"
                     /gene_synonym="ACG; ADMIDX; bB128O4.1; ZIZ2"
                     /inference="alignment:Splign:2.1.0"
     exon            4111..4158
                     /gene="DOCK11"
                     /gene_synonym="ACG; ADMIDX; bB128O4.1; ZIZ2"
                     /inference="alignment:Splign:2.1.0"
     exon            4159..4301
                     /gene="DOCK11"
                     /gene_synonym="ACG; ADMIDX; bB128O4.1; ZIZ2"
                     /inference="alignment:Splign:2.1.0"
     exon            4302..4417
                     /gene="DOCK11"
                     /gene_synonym="ACG; ADMIDX; bB128O4.1; ZIZ2"
                     /inference="alignment:Splign:2.1.0"
     exon            4418..4555
                     /gene="DOCK11"
                     /gene_synonym="ACG; ADMIDX; bB128O4.1; ZIZ2"
                     /inference="alignment:Splign:2.1.0"
     exon            4556..4738
                     /gene="DOCK11"
                     /gene_synonym="ACG; ADMIDX; bB128O4.1; ZIZ2"
                     /inference="alignment:Splign:2.1.0"
     exon            4739..4852
                     /gene="DOCK11"
                     /gene_synonym="ACG; ADMIDX; bB128O4.1; ZIZ2"
                     /inference="alignment:Splign:2.1.0"
     exon            4853..5068
                     /gene="DOCK11"
                     /gene_synonym="ACG; ADMIDX; bB128O4.1; ZIZ2"
                     /inference="alignment:Splign:2.1.0"
     exon            5069..5126
                     /gene="DOCK11"
                     /gene_synonym="ACG; ADMIDX; bB128O4.1; ZIZ2"
                     /inference="alignment:Splign:2.1.0"
     exon            5127..5233
                     /gene="DOCK11"
                     /gene_synonym="ACG; ADMIDX; bB128O4.1; ZIZ2"
                     /inference="alignment:Splign:2.1.0"
     exon            5234..5356
                     /gene="DOCK11"
                     /gene_synonym="ACG; ADMIDX; bB128O4.1; ZIZ2"
                     /inference="alignment:Splign:2.1.0"
     exon            5357..5470
                     /gene="DOCK11"
                     /gene_synonym="ACG; ADMIDX; bB128O4.1; ZIZ2"
                     /inference="alignment:Splign:2.1.0"
     exon            5471..5617
                     /gene="DOCK11"
                     /gene_synonym="ACG; ADMIDX; bB128O4.1; ZIZ2"
                     /inference="alignment:Splign:2.1.0"
     exon            5618..5828
                     /gene="DOCK11"
                     /gene_synonym="ACG; ADMIDX; bB128O4.1; ZIZ2"
                     /inference="alignment:Splign:2.1.0"
     exon            5829..6019
                     /gene="DOCK11"
                     /gene_synonym="ACG; ADMIDX; bB128O4.1; ZIZ2"
                     /inference="alignment:Splign:2.1.0"
     exon            6020..6120
                     /gene="DOCK11"
                     /gene_synonym="ACG; ADMIDX; bB128O4.1; ZIZ2"
                     /inference="alignment:Splign:2.1.0"
     exon            6121..6259
                     /gene="DOCK11"
                     /gene_synonym="ACG; ADMIDX; bB128O4.1; ZIZ2"
                     /inference="alignment:Splign:2.1.0"
     exon            6260..6719
                     /gene="DOCK11"
                     /gene_synonym="ACG; ADMIDX; bB128O4.1; ZIZ2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6695..6700
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DOCK11"
                     /gene_synonym="ACG; ADMIDX; bB128O4.1; ZIZ2"
                     /note="hexamer: AATAAA"
     polyA_site      6719
                     /gene="DOCK11"
                     /gene_synonym="ACG; ADMIDX; bB128O4.1; ZIZ2"
                     /note="major polyA site"
ORIGIN      
        1 agcgtgagcc gcgccgccgc cgagctgcga tgtggccggc cggccggcga gtaaacagag
       61 ggagcagcag cggccgcggc cgccgcgggc cggggcagtg agtccacccg cccgccgagg
      121 tccgcccgcc cgccgagacc cgcccgccgc cgctgccatg gccgaagtgc gcaaattcac
      181 caaacggctc agcaagcctg gcacggcggc tgagctccgg cagagcgtgt ctgaggccgt
      241 gcggggctcc gtggtgctgg aaaaggccaa agttgttgag cccctggact atgagaatgt
      301 tattgcccaa agaaaaaccc agatttacag cgaccccctc cgagatctgc ttatgttccc
      361 aatggaagat atatctatct cggtgatagg tcgtcaacgc agaacggtgc agtctactgt
      421 accagaagat gctgaaaaga gggcccagag tttatttgtt aaagagtgta ttaaaaccta
      481 tagcacagat tggcacgtgg taaactacaa gtatgaggac ttctctgggg actttcgaat
      541 gttgccatgt aaatctttga gaccagaaaa gattcctaat catgtatttg agatagatga
      601 agactgtgag aaagatgagg actcatcttc tttatgttct cagaagggtg gtgtgataaa
      661 acaaggctgg ttgcataaag caaatgtaaa tagtaccatc acagtaacca tgaaggtatt
      721 caagagacga tatttttact tgacccaact tcctgacggt tcatatattc tcaattccta
      781 taaagatgag aaaaattcaa aagaatcgaa aggttgcatc tacttggacg cctgcattga
      841 tgttgttcag tgccccaaaa tgcgccgtca tgcttttgaa ctcaagatgt tagataaata
      901 tagccattat ctggctgctg aaactgagca ggaaatggag gaatggttga taactttgaa
      961 aaagattatt cagatcaaca ccgacagttt agttcaagaa aaaaaggaga cggtagaaac
     1021 agcacaagat gatgaaacta gcagccaagg aaaagccgag aacatcatgg caagtttgga
     1081 aaggagcatg catccggaac tgatgaagta tggaagagaa actgaacaac taaacaaact
     1141 cagtagagga gatggaagac agaatctctt ttcttttgat tcagaagttc agaggttgga
     1201 cttttcagga attgaacctg atataaagcc atttgaagaa aaatgcaata aacgtttcct
     1261 ggtgaattgc catgatttaa ctttcaatat cttgggccaa attggagaca atgcaaaagg
     1321 accacccaca aatgttgagc ccttttttat caatcttgcc ttatttgatg taaagaacaa
     1381 ttgtaagatt tcagcagact ttcatgtaga cctgaatccc ccatctgtcc gtgaaatgct
     1441 gtggggctct tcaacccaac tggccagtga cggtagccca aagggctctt cacccgaatc
     1501 ttacattcat ggaattgccg aatctcagtt acgctacata caacagggaa ttttctcagt
     1561 gacgaatcca catcctgaaa tttttctagt tgccagaatt gaaaaggtac tacagggaaa
     1621 cattacacac tgtgcagaac cctatatcaa aaattctgat ccagtaaaga cggcccagaa
     1681 ggtgcacagg acagctaaac aagtgtgtag ccgccttgga caatacagaa tgcccttcgc
     1741 ttgggctgcc agacccattt tcaaagatac tcaaggctct cttgatctgg atgggagatt
     1801 ttctcctctg tataaacaag acagtagcaa gctttcaagt gaagacattc tcaagttgct
     1861 ctcagaatat aagaagccag aaaagaccaa actgcagatt attcctgggc agctaaacat
     1921 cacagtagaa tgtgttcctg tggatttatc aaattgtatt acttcttcat atgtgccctt
     1981 gaagcctttt gaaaagaatt gccaaaatat tactgtggag gttgaagagt ttgttccaga
     2041 aatgacaaaa tattgttatc catttactat ttacaaaaac catctgtatg tatatcccct
     2101 gcaattaaaa tacgatagcc agaaaacatt tgccaaggca aggaacattg cagtctgtgt
     2161 ggaattccgg gattcagatg aaagtgacgc tagtgcccta aagtgtattt atggaaaacc
     2221 tgcagggtct gtttttacca caaatgctta tgctgttgtc tcgcatcaca accaaaatcc
     2281 agagttctat gatgagatta aaattgagct tcccattcac ctacatcaaa aacatcattt
     2341 gcttttcact ttttatcatg taagttgtga aattaacaca aagggaacaa ccaaaaagca
     2401 agacacagtt gaaactccag ttgggtttgc ctgggtacct ttgctgaaag atggtagaat
     2461 catcacattt gagcagcagc tgccagtttc cgccaatctt cccccaggct acttgaatct
     2521 gaatgatgca gaatcaagaa ggcaatgtaa cgtggatatt aaatgggtag atggtgcaaa
     2581 gcctttgttg aagattaaaa gccacttaga atctaccatt tacactcaag atctgcatgt
     2641 gcacaaattc ttccatcatt gccagctgat tcagtcaggc tcgaaagaag ttccagggga
     2701 gctcattaaa tatttaaagt gtttgcatgc catggagatc caagtcatga tacagtttct
     2761 acctgtaatt cttatgcaac tcttccgagt tctcacaaat atgacccatg aagatgacgt
     2821 tcctatcaac tgcaccatgg ttctcttaca tattgtatca aagtgccatg aagaaggctt
     2881 ggatagttat ctaagatcat tcataaagta tagcttccga cctgaaaaac cgagtgctcc
     2941 tcaggcccag ctgatacatg aaaccctggc tactacgatg atagcaatat tgaaacagtc
     3001 tgcagatttt ttatcaataa acaaattgct aaagtactca tggtttttct ttgaaataat
     3061 tgcaaagtca atggccacat acttgttgga agagaataag attaagcttc cccgaggcca
     3121 gagatttccc gagacatatc atcatgtctt acattcactg cttcttgcaa taattcccca
     3181 tgtgactatt cggtatgcgg agattcccga tgagtccaga aatgtgaact atagtttggc
     3241 tagcttcctg aagcgctgtt tgacactaat ggatagagga tttattttca atttaataaa
     3301 tgactatata tctggattca gccccaaaga tcctaaggtt ctggctgaat acaagtttga
     3361 atttctgcaa acaatttgca atcacgaaca ttacattcct ctgaacttgc caatggcatt
     3421 tgcaaaacct aaactgcagc gggttcaaga ttcaaatctt gaatacagtt tatcagatga
     3481 gtattgcaag catcacttct tggttggtct acttctgagg gaaacttcca ttgctcttca
     3541 ggacaattat gagatcagat atacagctat ctctgttata aagaatcttt tgataaaaca
     3601 tgcatttgac acaagatacc agcacaagaa ccaacaagcc aaaatagcac aattgtacct
     3661 cccctttgtt ggactacttt tggaaaatat acagcgatta gcaggtcgag ataccttgta
     3721 ttcttgtgca gccatgccta attctgcatc cagagatgag tttccatgtg gctttacttc
     3781 acctgccaat agagggagtc tgagcactga caaagacacc gcttatgggt cttttcaaaa
     3841 tggacatgga attaagagag aagattcaag aggttccctc atcccagaag gagcaacagg
     3901 atttccagat cagggcaaca ctggtgaaaa tacccgacag agttctacaa ggagtagtgt
     3961 atcccagtat aaccgcctgg atcagtatga aatcagaagc ctcctgatgt gctacctgta
     4021 tatagtaaaa atgatttcag aagatactct cttaacttac tggaataaag tatcacctca
     4081 ggagctcata aacattctta tacttttaga agtatgcttg tttcacttta gatatatggg
     4141 gaaaagaaac atagcaaggg tgcatgatgc ctggctgtca aaacacttcg gaatagaccg
     4201 aaaatcgcaa accatgcctg ctcttcgaaa cagatcagga gtaatgcagg cccggcttca
     4261 gcatcttagt agcctagaaa gttcatttac acttaatcac agttctacaa caactgaagc
     4321 agacattttc caccaggcac ttcttgaagg caatacagct actgaagttt ccctaacagt
     4381 actagacacc atatcatttt tcactcagtg cttcaagacc caacttttaa ataatgatgg
     4441 ccataaccca ttaatgaaaa aagtgtttga tatacatctt gcttttctta aaaatggaca
     4501 atctgaagtg tcgctgaaac atgtatttgc ctcactgaga gctttcatca gtaagtttcc
     4561 ttcagcattt ttcaaaggaa gagtaaacat gtgtgctgca ttttgctatg aggttttaaa
     4621 gtgctgcaca tcgaagatta gctcaaccag gaatgaagca tctgcacttt tgtatctttt
     4681 gatgagaaac aactttgagt ataccaaaag gaaaaccttt ttgaggacac atctacagat
     4741 aataattgct gtaagccaac tgatagctga tgtagcacta agcggaggat caagatttca
     4801 ggagtcttta ttcattatca ataattttgc aaatagtgac agacctatga aggcaactgc
     4861 ctttcccgca gaagtcaaag acttgaccaa gagaatccgc actgttctta tggccactgc
     4921 ccaaatgaag gagcatgaga aagaccctga aatgctaatt gatctccagt atagcttagc
     4981 caagtcctat gcaagcaccc cagagctcag gaaaacctgg cttgatagca tggccaagat
     5041 tcatgtaaaa aatggagatt tttcagaggc tgcgatgtgt tatgtccatg tagcagctct
     5101 agttgcagag tttcttcatc gaaaaaaatt atttcctaac ggatgttcag cgttcaagaa
     5161 aattactccc aatatagatg aagaaggagc aatgaaagaa gatgctggga tgatggatgt
     5221 ccattatagt gaagaggtct tgctggagtt gctagaacaa tgtgtggatg gcttatggaa
     5281 ggcagaacgt tatgaaataa tttctgagat ttccaagttg atcgttccaa tttatgagaa
     5341 acgtcgtgag tttgagaaac ttactcaagt ttatagaact cttcatggag cttacacaaa
     5401 aattctggaa gttatgcata caaaaaagag acttttaggc actttcttca gagttgcctt
     5461 ttatggccaa tctttttttg aagaagaaga tggaaaggag tacatctata aagaaccaaa
     5521 gctcactggc ctctcagaaa tttccttgag acttgttaaa ctttatggtg aaaagtttgg
     5581 tacggagaat gtcaaaataa ttcaggattc agacaaggta aatgccaaag agcttgatcc
     5641 aaaatatgct catatacaag ttacttatgt gaagccttac tttgatgaca aagaactcac
     5701 agaaaggaag accgagtttg aaagaaatca taatatcagc agatttgttt ttgaggcccc
     5761 ttacacttta tcaggcaaaa aacagggctg tatagaagaa cagtgcaaac gccgtacaat
     5821 cttgacaact tcaaactcgt ttccttacgt gaagaagagg attcctatta actgtgaaca
     5881 gcagattaat ttaaaaccaa ttgatgttgc cactgatgaa ataaaagata aaactgcaga
     5941 gctgcaaaag ctttgctcct ctactgacgt ggacatgatt cagctccaac ttaaattgca
     6001 gggctgtgtt tctgtgcagg tcaatgctgg tccattagca tatgcaagag ctttcttaaa
     6061 tgacagccaa gctagcaagt atccacctaa gaaagtgagt gagttgaaag acatgtttag
     6121 gaaatttata caagcatgca gcattgcact tgaactaaat gagcggctaa ttaaagaaga
     6181 tcaagttgag taccatgaag ggctaaagtc aaatttcaga gacatggtaa aagaattatc
     6241 tgacattatc catgagcaga tattacaaga agacacaatg cattctccct ggatgagcaa
     6301 cacattacat gtattttgtg caattagtgg tacatcaagt gaccgaggtt atggttcccc
     6361 aagatacgct gaagtgtgag gaaatgcaga tgtacgtgac aatgagactg acctttctca
     6421 ggaatatttg gagctgtgca aatgttaaaa tttaaagatt tgatatacat ggagtgtttc
     6481 ttctcgacac caaaattttc atgtgttcca acagggtgct tacatatttg taaataagca
     6541 acttgaaagt gcctggaaaa ttgcaccact gtgcttggtt tgtacttttt taggtaaatc
     6601 tatatgctga aaagtagagc tcaaaaacag tagttcaatt tgcttaatta ttgcttaaaa
     6661 taatggtact atgtaaaatt gtataatgga atacaataaa aggtaaaact tatttgtaa
//
