LOCUS       NM_014689               7286 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens dedicator of cytokinesis 10 (DOCK10), transcript
            variant 1, mRNA.
ACCESSION   NM_014689 XM_371595
VERSION     NM_014689.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7286)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 7286)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 7286)
  AUTHORS   Parrado,A.
  TITLE     Expression of DOCK10.1 protein revealed with a specific antiserum:
            insights into regulation of first exon isoforms of DOCK10
  JOURNAL   Mol Biol Rep 47 (4), 3003-3010 (2020)
   PUBMED   32112301
  REMARK    GeneRIF: Expression of DOCK10.1 protein revealed with a specific
            antiserum: insights into regulation of first exon isoforms of
            DOCK10.
REFERENCE   4  (bases 1 to 7286)
  AUTHORS   Shin,S., Buel,G.R., Nagiec,M.J., Han,M.J., Roux,P.P., Blenis,J. and
            Yoon,S.O.
  TITLE     ERK2 regulates epithelial-to-mesenchymal plasticity through
            DOCK10-dependent Rac1/FoxO1 activation
  JOURNAL   Proc Natl Acad Sci U S A 116 (8), 2967-2976 (2019)
   PUBMED   30728292
  REMARK    GeneRIF: we identified the transcription factor FoxO1 as a
            potential mediator of ERK2-induced EMT, and thus we investigated
            the mechanism by which ERK2 regulates FoxO1. Additionally, our
            analysis revealed that ERK2 induced the expression of Dock10, a
            Rac1/Cdc42 GEF, during EMT
REFERENCE   5  (bases 1 to 7286)
  AUTHORS   Kim,J.H., Cheong,H.S., Park,J.S., Jang,A.S., Uh,S.T., Kim,Y.H.,
            Kim,M.K., Choi,I.S., Cho,S.H., Choi,B.W., Bae,J.S., Park,C.S. and
            Shin,H.D.
  TITLE     A genome-wide association study of total serum and mite-specific
            IgEs in asthma patients
  JOURNAL   PLoS One 8 (8), e71958 (2013)
   PUBMED   23967269
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7286)
  AUTHORS   Alcaraz-Garcia,M.J., Ruiz-Lafuente,N., Sebastian-Ruiz,S.,
            Majado,M.J., Gonzalez-Garcia,C., Bernardo,M.V., Alvarez-Lopez,M.R.
            and Parrado,A.
  TITLE     Human and mouse DOCK10 splicing isoforms with alternative first
            coding exon usage are differentially expressed in T and B
            lymphocytes
  JOURNAL   Hum Immunol 72 (7), 531-537 (2011)
   PUBMED   21514340
  REMARK    GeneRIF: T cells and B cells exhibited inverse expression patterns
            of the DOCK10 isoforms
REFERENCE   7  (bases 1 to 7286)
  AUTHORS   Gadea,G., Sanz-Moreno,V., Self,A., Godi,A. and Marshall,C.J.
  TITLE     DOCK10-mediated Cdc42 activation is necessary for amoeboid invasion
            of melanoma cells
  JOURNAL   Curr Biol 18 (19), 1456-1465 (2008)
   PUBMED   18835169
  REMARK    GeneRIF: Silencing DOCK10 expression in melanoma promotes
            conversion to mesenchymal migration and is associated with
            decreased MLC2 phosphorylation and increased Rac1 activation.
REFERENCE   8  (bases 1 to 7286)
  AUTHORS   Yelo,E., Bernardo,M.V., Gimeno,L., Alcaraz-Garcia,M.J., Majado,M.J.
            and Parrado,A.
  TITLE     Dock10, a novel CZH protein selectively induced by interleukin-4 in
            human B lymphocytes
  JOURNAL   Mol Immunol 45 (12), 3411-3418 (2008)
   PUBMED   18499258
  REMARK    GeneRIF: Dock10 could represent a point of convergence for
            interleukin 4 signalling and small Rho GTPase function in B cells.
REFERENCE   9  (bases 1 to 7286)
  AUTHORS   Nishikimi,A., Meller,N., Uekawa,N., Isobe,K., Schwartz,M.A. and
            Maruyama,M.
  TITLE     Zizimin2: a novel, DOCK180-related Cdc42 guanine nucleotide
            exchange factor expressed predominantly in lymphocytes
  JOURNAL   FEBS Lett 579 (5), 1039-1046 (2005)
   PUBMED   15710388
REFERENCE   10 (bases 1 to 7286)
  AUTHORS   Cote,J.F. and Vuori,K.
  TITLE     Identification of an evolutionarily conserved superfamily of
            DOCK180-related proteins with guanine nucleotide exchange activity
  JOURNAL   J Cell Sci 115 (Pt 24), 4901-4913 (2002)
   PUBMED   12432077
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AB014594.2, AC017095.7,
            EG328495.1, AC011739.7, EG328193.1, DN991477.1, EG328223.1,
            EG328562.1, EG328531.1, EG328518.1 and CR749492.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_014689.2.
            
            Summary: This gene encodes a member of the dedicator of cytokinesis
            protein family. Members of this family are guanosine nucleotide
            exchange factors for Rho GTPases and defined by the presence of
            conserved DOCK-homology regions. The encoded protein belongs to the
            D (or Zizimin) subfamily of DOCK proteins, which also contain an
            N-terminal pleckstrin homology domain. Alternatively spliced
            transcript variants that encode different isoforms have been
            described. [provided by RefSeq, Mar 2014].
            
            Transcript Variant: This variant (1; also known as DOCK10.1)
            encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000258390.12/ ENSP00000258390.7
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                AB014594.2         146-180
            36-36               AC017095.7         59240-59240         c
            37-1779             AB014594.2         182-1924
            1780-1924           EG328495.1         255-399
            1925-1939           AC011739.7         127466-127480       c
            1940-2004           EG328193.1         225-289             c
            2005-2639           DN991477.1         9-643
            2640-2886           EG328223.1         175-421
            2887-2942           EG328562.1         217-272
            2943-2949           EG328531.1         229-235
            2950-3022           EG328518.1         188-260             c
            3023-6278           CR749492.1         13-3268
            6279-6279           AC011739.7         45636-45636         c
            6280-6371           CR749492.1         3270-3361
            6372-6372           AC011739.7         43032-43032         c
            6373-6706           CR749492.1         3363-3696
            6707-7286           AC011739.7         37550-38129         c
FEATURES             Location/Qualifiers
     source          1..7286
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q36.2"
     gene            1..7286
                     /gene="DOCK10"
                     /gene_synonym="DRIP2; Nbla10300; ZIZ3"
                     /note="dedicator of cytokinesis 10"
                     /db_xref="GeneID:55619"
                     /db_xref="HGNC:HGNC:23479"
                     /db_xref="MIM:611518"
     exon            1..217
                     /gene="DOCK10"
                     /gene_synonym="DRIP2; Nbla10300; ZIZ3"
                     /inference="alignment:Splign:2.1.0"
     CDS             95..6655
                     /gene="DOCK10"
                     /gene_synonym="DRIP2; Nbla10300; ZIZ3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     zizimin3; dopamine receptor interacting protein 2"
                     /codon_start=1
                     /product="dedicator of cytokinesis protein 10 isoform 1"
                     /protein_id="NP_055504.2"
                     /db_xref="CCDS:CCDS46528.1"
                     /db_xref="GeneID:55619"
                     /db_xref="HGNC:HGNC:23479"
                     /db_xref="MIM:611518"
                     /translation="MAGERTRRFTRSLLRPGQAAELRHSAASAAAVAVSSRQQQRQEK
                     PRLLEPLDYETVIEELEKTYRNDPLQDLLFFPSDDFSAATVSWDIRTLYSTVPEDAEH
                     KAENLLVKEACKFYSSQWHVVNYKYEQYSGDIRQLPRAEYKPEKLPSHSFEIDHEDAD
                     KDEDTTSHSSSKGGGGAGGTGVFKSGWLYKGNFNSTVNNTVTVRSFKKRYFQLTQLPD
                     NSYIMNFYKDEKISKEPKGCIFLDSCTGVVQNNRLRKYAFELKMNDLTYFVLAAETES
                     DMDEWIHTLNRILQISPEGPLQGRRSTELTDLGLDSLDNSVTCECTPEETDSSENNLH
                     ADFAKYLTETEDTVKTTRNMERLNLFSLDPDIDTLKLQKKDLLEPESVIKPFEEKAAK
                     RIMIICKALNSNLQGCVTENENDPITNIEPFFVSVALYDLRDSRKISADFHVDLNHAA
                     VRQMLLGASVALENGNIDTITPRQSEEPHIKGLPEEWLKFPKQAVFSVSNPHSEIVLV
                     AKIEKVLMGNIASGAEPYIKNPDSNKYAQKILKSNRQFCSKLGKYRMPFAWAVRSVFK
                     DNQGNVDRDSRFSPLFRQESSKISTEDLVKLVSDYRRADRISKMQTIPGSLDIAVDNV
                     PLEHPNCVTSSFIPVKPFNMMAQTEPTVEVEEFVYDSTKYCRPYRVYKNQIYIYPKHL
                     KYDSQKCFNKARNITVCIEFKNSDEESAKPLKCIYGKPGGPLFTSAAYTAVLHHSQNP
                     DFSDEVKIELPTQLHEKHHILFSFYHVTCDINAKANAKKKEALETSVGYAWLPLMKHD
                     QIASQEYNIPIATSLPPNYLSFQDSASGKHGGSDIKWVDGGKPLFKVSTFVVSTVNTQ
                     DPHVNAFFQECQKREKDMSQSPTSNFIRSCKNLLNVEKIHAIMSFLPIILNQLFKVLV
                     QNEEDEITTTVTRVLTDIVAKCHEEQLDHSVQSYIKFVFKTRACKERTVHEELAKNVT
                     GLLKSNDSTTVKHVLKHSWFFFAIILKSMAQHLIDTNKIQLPRPQRFPESYQNELDNL
                     VMVLSDHVIWKYKDALEETRRANHSVARFLKRCFTFMDRGYVFKMVNNYISMFSSGDL
                     KTLCQYKFDFLQEVCQHEHFIPLCLPIRSANIPDPLTPSESTQELHASDMPEYSVTNE
                     FCRKHFLIGILLREVGFALQEDQDVRHLALAVLKNLMAKHSFDDRYREPRKQAQIASL
                     YMPLYGMLLDNMPRIYLKDLYPFTVNTSNQGSRDDLSTNGGFQSQTAIKHANSVDTSF
                     SKDVLNSIAAFSSIAISTVNHADSRASLASLDSNPSTNEKSSEKTDNCEKIPRPLSLI
                     GSTLRFDKLDQAETRSLLMCFLHIMKTISYETLIAYWQRAPSPEVSDFFSILDVCLQN
                     FRYLGKRNIIRKIAAAFKFVQSTQNNGTLKGSNPSCQTSGLLSQWMHSTSSHEGHKQH
                     RSQTLPIIRGKNALSNPKLLQMLDNTMTSNSNEIDIVHHVDTEANIATEVCLTILDLL
                     SLFTQTHQRQLQQCDCQNSLMKRVFDTYMLFFQVNQSATALKHVFASLRLFVCKFPSA
                     FFQGPADLCGSFCYEVLKCCNHRSRSTQTEASALLYFFMRKNFEFNKQKSIVRSHLQL
                     IKAVSQLIADAGIGGSRFQHSLAITNNFANGDKQMKNSNFPAEVKDLTKRIRTVLMAT
                     AQMKEHEKDPEMLVDLQYSLANSYASTPELRRTWLESMAKIHARNGDLSEAAMCYIHI
                     AALIAEYLKRKGYWKVEKICTASLLSEDTHPCDSNSLLTTPSGGSMFSMGWPAFLSIT
                     PNIKEEGAMKEDSGMQDTPYNENILVEQLYMCVEFLWKSERYELIADVNKPIIAVFEK
                     QRDFKKLSDLYYDIHRSYLKVAEVVNSEKRLFGRYYRVAFYGQGFFEEEEGKEYIYKE
                     PKLTGLSEISQRLLKLYADKFGADNVKIIQDSNKVNPKDLDPKYAYIQVTYVTPFFEE
                     KEIEDRKTDFEMHHNINRFVFETPFTLSGKKHGGVAEQCKRRTILTTSHLFPYVKKRI
                     QVISQSSTELNPIEVAIDEMSKKVSELNQLCTMEEVDMIRLQLKLQGSVSVKVNAGPM
                     AYARAFLEETNAKKYPDNQVKLLKEIFRQFADACGQALDVNERLIKEDQLEYQEELRS
                     HYKDMLSELSTVMNEQITGRDDLSKRGVDQTCTRVISKATPALPTVSISSSAEV"
     exon            218..337
                     /gene="DOCK10"
                     /gene_synonym="DRIP2; Nbla10300; ZIZ3"
                     /inference="alignment:Splign:2.1.0"
     exon            338..427
                     /gene="DOCK10"
                     /gene_synonym="DRIP2; Nbla10300; ZIZ3"
                     /inference="alignment:Splign:2.1.0"
     exon            428..510
                     /gene="DOCK10"
                     /gene_synonym="DRIP2; Nbla10300; ZIZ3"
                     /inference="alignment:Splign:2.1.0"
     exon            511..583
                     /gene="DOCK10"
                     /gene_synonym="DRIP2; Nbla10300; ZIZ3"
                     /inference="alignment:Splign:2.1.0"
     exon            584..706
                     /gene="DOCK10"
                     /gene_synonym="DRIP2; Nbla10300; ZIZ3"
                     /inference="alignment:Splign:2.1.0"
     exon            707..841
                     /gene="DOCK10"
                     /gene_synonym="DRIP2; Nbla10300; ZIZ3"
                     /inference="alignment:Splign:2.1.0"
     exon            842..1025
                     /gene="DOCK10"
                     /gene_synonym="DRIP2; Nbla10300; ZIZ3"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1111
                     /gene="DOCK10"
                     /gene_synonym="DRIP2; Nbla10300; ZIZ3"
                     /inference="alignment:Splign:2.1.0"
     exon            1112..1195
                     /gene="DOCK10"
                     /gene_synonym="DRIP2; Nbla10300; ZIZ3"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..1351
                     /gene="DOCK10"
                     /gene_synonym="DRIP2; Nbla10300; ZIZ3"
                     /inference="alignment:Splign:2.1.0"
     exon            1352..1573
                     /gene="DOCK10"
                     /gene_synonym="DRIP2; Nbla10300; ZIZ3"
                     /inference="alignment:Splign:2.1.0"
     exon            1574..1696
                     /gene="DOCK10"
                     /gene_synonym="DRIP2; Nbla10300; ZIZ3"
                     /inference="alignment:Splign:2.1.0"
     exon            1697..1779
                     /gene="DOCK10"
                     /gene_synonym="DRIP2; Nbla10300; ZIZ3"
                     /inference="alignment:Splign:2.1.0"
     exon            1780..1902
                     /gene="DOCK10"
                     /gene_synonym="DRIP2; Nbla10300; ZIZ3"
                     /inference="alignment:Splign:2.1.0"
     exon            1903..1982
                     /gene="DOCK10"
                     /gene_synonym="DRIP2; Nbla10300; ZIZ3"
                     /inference="alignment:Splign:2.1.0"
     exon            1983..2170
                     /gene="DOCK10"
                     /gene_synonym="DRIP2; Nbla10300; ZIZ3"
                     /inference="alignment:Splign:2.1.0"
     exon            2171..2236
                     /gene="DOCK10"
                     /gene_synonym="DRIP2; Nbla10300; ZIZ3"
                     /inference="alignment:Splign:2.1.0"
     exon            2237..2329
                     /gene="DOCK10"
                     /gene_synonym="DRIP2; Nbla10300; ZIZ3"
                     /inference="alignment:Splign:2.1.0"
     exon            2330..2453
                     /gene="DOCK10"
                     /gene_synonym="DRIP2; Nbla10300; ZIZ3"
                     /inference="alignment:Splign:2.1.0"
     exon            2454..2575
                     /gene="DOCK10"
                     /gene_synonym="DRIP2; Nbla10300; ZIZ3"
                     /inference="alignment:Splign:2.1.0"
     exon            2576..2662
                     /gene="DOCK10"
                     /gene_synonym="DRIP2; Nbla10300; ZIZ3"
                     /inference="alignment:Splign:2.1.0"
     exon            2663..2755
                     /gene="DOCK10"
                     /gene_synonym="DRIP2; Nbla10300; ZIZ3"
                     /inference="alignment:Splign:2.1.0"
     exon            2756..2874
                     /gene="DOCK10"
                     /gene_synonym="DRIP2; Nbla10300; ZIZ3"
                     /inference="alignment:Splign:2.1.0"
     exon            2875..2944
                     /gene="DOCK10"
                     /gene_synonym="DRIP2; Nbla10300; ZIZ3"
                     /inference="alignment:Splign:2.1.0"
     exon            2945..3058
                     /gene="DOCK10"
                     /gene_synonym="DRIP2; Nbla10300; ZIZ3"
                     /inference="alignment:Splign:2.1.0"
     exon            3059..3130
                     /gene="DOCK10"
                     /gene_synonym="DRIP2; Nbla10300; ZIZ3"
                     /inference="alignment:Splign:2.1.0"
     exon            3131..3277
                     /gene="DOCK10"
                     /gene_synonym="DRIP2; Nbla10300; ZIZ3"
                     /inference="alignment:Splign:2.1.0"
     exon            3278..3361
                     /gene="DOCK10"
                     /gene_synonym="DRIP2; Nbla10300; ZIZ3"
                     /inference="alignment:Splign:2.1.0"
     exon            3362..3458
                     /gene="DOCK10"
                     /gene_synonym="DRIP2; Nbla10300; ZIZ3"
                     /inference="alignment:Splign:2.1.0"
     exon            3459..3503
                     /gene="DOCK10"
                     /gene_synonym="DRIP2; Nbla10300; ZIZ3"
                     /inference="alignment:Splign:2.1.0"
     exon            3504..3679
                     /gene="DOCK10"
                     /gene_synonym="DRIP2; Nbla10300; ZIZ3"
                     /inference="alignment:Splign:2.1.0"
     exon            3680..3796
                     /gene="DOCK10"
                     /gene_synonym="DRIP2; Nbla10300; ZIZ3"
                     /inference="alignment:Splign:2.1.0"
     exon            3797..3908
                     /gene="DOCK10"
                     /gene_synonym="DRIP2; Nbla10300; ZIZ3"
                     /inference="alignment:Splign:2.1.0"
     exon            3909..4030
                     /gene="DOCK10"
                     /gene_synonym="DRIP2; Nbla10300; ZIZ3"
                     /inference="alignment:Splign:2.1.0"
     exon            4031..4145
                     /gene="DOCK10"
                     /gene_synonym="DRIP2; Nbla10300; ZIZ3"
                     /inference="alignment:Splign:2.1.0"
     exon            4146..4212
                     /gene="DOCK10"
                     /gene_synonym="DRIP2; Nbla10300; ZIZ3"
                     /inference="alignment:Splign:2.1.0"
     exon            4213..4260
                     /gene="DOCK10"
                     /gene_synonym="DRIP2; Nbla10300; ZIZ3"
                     /inference="alignment:Splign:2.1.0"
     exon            4261..4362
                     /gene="DOCK10"
                     /gene_synonym="DRIP2; Nbla10300; ZIZ3"
                     /inference="alignment:Splign:2.1.0"
     exon            4363..4487
                     /gene="DOCK10"
                     /gene_synonym="DRIP2; Nbla10300; ZIZ3"
                     /inference="alignment:Splign:2.1.0"
     exon            4488..4600
                     /gene="DOCK10"
                     /gene_synonym="DRIP2; Nbla10300; ZIZ3"
                     /inference="alignment:Splign:2.1.0"
     exon            4601..4738
                     /gene="DOCK10"
                     /gene_synonym="DRIP2; Nbla10300; ZIZ3"
                     /inference="alignment:Splign:2.1.0"
     exon            4739..4921
                     /gene="DOCK10"
                     /gene_synonym="DRIP2; Nbla10300; ZIZ3"
                     /inference="alignment:Splign:2.1.0"
     exon            4922..5032
                     /gene="DOCK10"
                     /gene_synonym="DRIP2; Nbla10300; ZIZ3"
                     /inference="alignment:Splign:2.1.0"
     exon            5033..5248
                     /gene="DOCK10"
                     /gene_synonym="DRIP2; Nbla10300; ZIZ3"
                     /inference="alignment:Splign:2.1.0"
     exon            5249..5306
                     /gene="DOCK10"
                     /gene_synonym="DRIP2; Nbla10300; ZIZ3"
                     /inference="alignment:Splign:2.1.0"
     exon            5307..5405
                     /gene="DOCK10"
                     /gene_synonym="DRIP2; Nbla10300; ZIZ3"
                     /inference="alignment:Splign:2.1.0"
     exon            5406..5512
                     /gene="DOCK10"
                     /gene_synonym="DRIP2; Nbla10300; ZIZ3"
                     /inference="alignment:Splign:2.1.0"
     exon            5513..5635
                     /gene="DOCK10"
                     /gene_synonym="DRIP2; Nbla10300; ZIZ3"
                     /inference="alignment:Splign:2.1.0"
     exon            5636..5749
                     /gene="DOCK10"
                     /gene_synonym="DRIP2; Nbla10300; ZIZ3"
                     /inference="alignment:Splign:2.1.0"
     exon            5750..5896
                     /gene="DOCK10"
                     /gene_synonym="DRIP2; Nbla10300; ZIZ3"
                     /inference="alignment:Splign:2.1.0"
     exon            5897..6107
                     /gene="DOCK10"
                     /gene_synonym="DRIP2; Nbla10300; ZIZ3"
                     /inference="alignment:Splign:2.1.0"
     exon            6108..6298
                     /gene="DOCK10"
                     /gene_synonym="DRIP2; Nbla10300; ZIZ3"
                     /inference="alignment:Splign:2.1.0"
     exon            6299..6399
                     /gene="DOCK10"
                     /gene_synonym="DRIP2; Nbla10300; ZIZ3"
                     /inference="alignment:Splign:2.1.0"
     exon            6400..6538
                     /gene="DOCK10"
                     /gene_synonym="DRIP2; Nbla10300; ZIZ3"
                     /inference="alignment:Splign:2.1.0"
     exon            6539..7286
                     /gene="DOCK10"
                     /gene_synonym="DRIP2; Nbla10300; ZIZ3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7263..7268
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DOCK10"
                     /gene_synonym="DRIP2; Nbla10300; ZIZ3"
                     /note="hexamer: AATAAA"
     polyA_site      7286
                     /gene="DOCK10"
                     /gene_synonym="DRIP2; Nbla10300; ZIZ3"
                     /note="major polyA site"
ORIGIN      
        1 gcttcctgaa cggcgggtgg atagagaagg ttggcgcggg gaagaccggc gggaggcgcg
       61 ccccgggccc gcggcgcgat tggcgtgacc ggcgatggcc ggtgagcgga cccgcaggtt
      121 cacccggagc ctgttgagac ctgggcaggc ggccgagctc cggcacagcg ccgcgtccgc
      181 cgccgcggtg gcagtcagca gccggcagca gcagcggcaa gaaaagccta ggcttctcga
      241 gcctttggat tatgagactg tcattgaaga acttgaaaag acctaccgga atgatcctct
      301 tcaagatctc ttgttcttcc ccagtgatga cttttcagca gccacagttt cctgggatat
      361 ccgcacgttg tactcaacag tacctgaaga tgcagagcac aaggcagaaa atttactggt
      421 taaggaggct tgtaaatttt atagttccca gtggcatgtg gtaaactaca aatatgaaca
      481 atattctgga gacattcgac agctaccccg agcagaatac aaaccagaga agcttccttc
      541 acattccttt gagattgacc atgaagatgc tgataaggat gaagatacca cttcccactc
      601 gtcttccaag gggggtggag gagcgggagg aactggtgtt ttcaagtccg gctggctcta
      661 caaggggaat tttaacagca ccgtgaacaa caccgttact gttcggtcat tcaaaaagcg
      721 ctacttccag ctgactcagt taccagataa ctcctacatt atgaactttt acaaagatga
      781 gaaaatatcc aaagaaccca aaggatgcat ctttttggat tcctgtacag gagtggtgca
      841 gaataacaga ctaagaaaat atgcctttga attgaaaatg aatgatctga cctattttgt
      901 gctggcagct gaaacagagt cagatatgga tgaatggatc cacaccctca accgcattct
      961 gcaaatcagt cctgaggggc ccctccaagg gaggaggagc acagagctca ctgatctggg
     1021 tctggattcg ctggataatt ctgtaacttg tgaatgcacg ccagaggaaa cagattcttc
     1081 agagaacaac ctacacgcag actttgcaaa gtacctcaca gaaacagaag atactgtaaa
     1141 aacaactcga aacatggaga ggctaaatct gttctctcta gatccagaca tagatacctt
     1201 gaaacttcaa aaaaaagatc tcttggaacc tgagtctgtg atcaaaccat ttgaagaaaa
     1261 agctgccaag agaatcatga tcatctgtaa agccctcaac tcaaatcttc agggatgtgt
     1321 tacggagaat gaaaatgatc cgataacgaa tattgagcct ttttttgtga gtgtggcact
     1381 ttatgacctc agagacagca ggaagatttc tgctgatttt catgtggatc taaaccatgc
     1441 tgctgtcaga cagatgctct tgggggcttc tgtggctttg gaaaatggca acatcgacac
     1501 catcactcca agacaatcag aagaacctca catcaaggga cttccagagg aatggctaaa
     1561 atttccaaag caggctgtat tttctgtaag caatccacat tctgaaattg ttttggtggc
     1621 caaaatcgaa aaagtcttga tgggaaacat tgcaagtggt gccgaacctt atattaagaa
     1681 cccagactcc aacaagtatg cacaaaagat actaaaatcc aacagacaat tctgcagcaa
     1741 attgggaaaa taccgtatgc cttttgcttg ggcagtaaga tcagtattta aggacaacca
     1801 gggaaatgtg gacagagact caagattttc accattgttt agacaagaaa gtagcaagat
     1861 ttcaactgag gacctagtta aactagtatc agattataga agggccgaca gaataagcaa
     1921 aatgcagacc attcctggaa gcctggatat tgctgttgac aacgttccct tggagcatcc
     1981 aaattgtgta acatcgtcct ttatccctgt caagcctttc aacatgatgg ctcaaacaga
     2041 acccacagtg gaggtggaag aatttgttta cgattcaaca aagtattgtc ggccttacag
     2101 agtatataaa aatcaaattt atatttaccc caaacacctc aagtatgata gccagaaatg
     2161 cttcaacaag gcacggaata taactgtgtg cattgaattc aaaaattcag atgaagaaag
     2221 tgccaagccc ctgaagtgta tttatggaaa acctggaggg cccctcttca cctcagccgc
     2281 ctacacagca gttctgcacc actctcagaa tccggatttc tcagatgagg tgaaaattga
     2341 gctaccaaca caactccatg agaaacacca tattttgttt tctttttatc acgtcacctg
     2401 tgacatcaat gcaaaagcta atgccaaaaa gaaggaggct ctggaaacgt cagttggata
     2461 tgcttggctt cctctgatga aacacgatca gatagcttct caagagtaca acatcccaat
     2521 agcaacaagt ctgcctccta attatttaag ctttcaagat tctgcaagtg gaaagcatgg
     2581 tgggagtgac attaaatggg ttgatggtgg caaaccactt ttcaaagtgt cgacatttgt
     2641 tgtatcaaca gtaaatactc aggatccaca tgtgaatgca tttttccaag agtgccaaaa
     2701 aagagagaaa gatatgtctc agtcacctac ctcaaatttc atccgctctt gtaagaactt
     2761 attgaatgtg gaaaagattc atgcaatcat gagttttctg cctataattt tgaatcagct
     2821 cttcaaagtt ctggtacaga atgaggaaga tgaaataact acaactgtca ccagggttct
     2881 gaccgacatt gtggccaagt gccatgagga gcagctggat cattctgtcc agtcatatat
     2941 taagttcgtg ttcaagacca gggcatgcaa ggagaggact gtacatgagg aactggctaa
     3001 aaatgtgact ggtcttttga aatcaaatga ctcaacaaca gtaaagcatg tcctaaagca
     3061 ttcctggttc ttctttgcaa ttatcctaaa atcgatggca cagcacttga ttgacacaaa
     3121 taaaatccag cttccccggc ctcagagatt tcctgaatct taccaaaatg aattggacaa
     3181 tcttgtcatg gtcctatccg accatgtgat ttggaaatac aaggatgcac ttgaagaaac
     3241 aagaagggca aaccacagcg ttgccagatt tctcaagcgc tgctttacat ttatggaccg
     3301 agggtatgtg tttaagatgg tcaacaatta catcagcatg ttctcctccg gtgaccttaa
     3361 gaccttgtgc cagtataaat ttgattttct tcaagaagta tgtcaacatg aacactttat
     3421 ccctttgtgt ctgcccataa gatcagcaaa cattccagat cctttgacac cttcagaatc
     3481 gactcaagag ttacatgcat cagatatgcc tgaatattca gtcacaaatg aattttgtcg
     3541 caaacacttc ttaatcggaa ttctgctccg agaagttggc tttgccctgc aggaagacca
     3601 agatgtcaga cacttagctt tagctgtcct aaaaaatcta atggctaagc attcatttga
     3661 tgatcgatac agagagccaa gaaagcaggc ccagatagca agtttataca tgcccctgta
     3721 cggcatgctc ctggacaata tgccaaggat ttatctgaag gacctgtatc cttttactgt
     3781 caatacatct aatcaggggt ctagagatga tctaagcacc aatggaggat ttcaaagcca
     3841 gacagctatc aaacatgcaa actctgtgga tacatcattt tctaaagatg ttttaaattc
     3901 catagcagca ttttcatcaa tagctatttc tacagtaaac catgctgact ccagagcatc
     3961 tttagcaagt cttgactcca atccaagtac caatgagaag agcagtgaga agacggacaa
     4021 ctgtgaaaag atcccaagac ccttgtcttt gattggctca actcttcgat ttgacaagtt
     4081 agatcaagca gaaaccagga gtctcctgat gtgttttctt cacattatga aaacgatttc
     4141 gtacgagact ctgattgcct actggcagag agctcccagc ccagaggtgt ccgacttctt
     4201 cagcatcttg gacgtttgtc ttcaaaattt cagataccta ggaaaacgca acataataag
     4261 aaaaattgct gctgcattta aatttgtgca gtccacccag aacaatggaa ctctcaaagg
     4321 atccaatcct tcctgccaga catcaggtct cttgtcacaa tggatgcact ccacttccag
     4381 tcatgaaggc cataagcagc acagatcaca aactttacct ataattcgag gcaaaaatgc
     4441 actttctaac cccaaactct tacagatgtt agacaatacc atgaccagca actccaatga
     4501 aatagacatc gtgcatcatg tagacactga ggccaatata gctacggagg tttgcctcac
     4561 tattctggac ctgttatccc tcttcacaca gactcatcag agacaactcc aacaatgtga
     4621 ctgtcaaaat tcattgatga aaagggtctt tgatacctac atgctctttt tccaagtcaa
     4681 tcagtcagcc acagcgctga agcatgtgtt tgcctccttg agactgtttg tatgcaagtt
     4741 tccttcagcg ttctttcaag ggcctgctga cctctgtgga tcattctgtt acgaagtcct
     4801 aaaatgctgt aaccacaggt cacggtcaac tcagacagaa gcctcagccc ttctgtactt
     4861 tttcatgagg aagaattttg aatttaacaa gcagaagtca attgtccggt cccacttaca
     4921 actcatcaaa gctgtgagcc agttaatagc cgatgctggg attggaggct ctcggtttca
     4981 acattcgctt gcaattacca ataatttcgc caatggagat aagcaaatga aaaacagcaa
     5041 tttcccagca gaggtgaagg acctgactaa gcgtataagg actgttttga tggccacagc
     5101 tcagatgaag gagcacgaga aggaccccga gatgctggtg gatctccagt acagcctggc
     5161 aaactcctac gcaagcactc ctgaactacg caggacctgg ctggaaagta tggccaagat
     5221 tcatgccaga aacggagatt tatctgaggc tgccatgtgt tacatccata ttgctgctct
     5281 cattgcagag tatctgaaaa gaaagggtta ctggaaagtg gaaaagattt gcacagcatc
     5341 cctgctctcg gaggataccc acccctgtga tagcaactca ttactaacaa ctcccagtgg
     5401 aggaagcatg ttctctatgg gatggccagc ttttttgagc attacaccaa acattaagga
     5461 agaaggagcg atgaaagagg attctggaat gcaagataca ccatacaatg agaatatcct
     5521 ggtggagcag ctatacatgt gtgtggagtt tctctggaag tctgagcgat atgaactcat
     5581 tgctgatgtc aacaagccca tcattgctgt ctttgagaaa caacgagact tcaaaaaatt
     5641 gtcagatctc tactacgaca ttcatcggtc atatctgaaa gtggcagagg tggtgaattc
     5701 ggagaagcgg ctgtttggtc gctactatcg tgtggcattt tatgggcagg gcttttttga
     5761 agaagaagaa ggtaaagagt atatttataa agagcctaag ctgacaggtc tgtccgagat
     5821 ttcccaaaga ttactcaagc tctatgcaga taaatttgga gcagacaatg tgaagataat
     5881 ccaggattcc aacaaggtaa accccaagga tttggacccc aaatatgcct acatccaggt
     5941 gacctatgtg acgccgttct ttgaggaaaa ggaaatcgaa gaccggaaga cagatttcga
     6001 aatgcaccac aacatcaacc gctttgtctt cgagacaccc ttcacgctgt cgggcaagaa
     6061 gcacggtggg gtggcggagc agtgcaagcg gcggacgatc ctgacaacga gtcacctgtt
     6121 cccctacgtg aagaagagaa tacaagtaat tagccaatcg agcacagaac tgaatccaat
     6181 tgaagtggca attgacgaga tgtccaagaa ggtttctgag cttaatcagc tttgcacaat
     6241 ggaagaagtg gacatgatca gactgcagct caaactgcaa ggaagtgtca gcgtgaaggt
     6301 taatgctggg ccaatggcct atgcacgagc ttttcttgaa gaaaccaatg caaagaagta
     6361 ccctgacaac caagtaaagc ttttgaagga gatcttcagg caatttgcag atgcatgtgg
     6421 gcaggccctt gacgtgaatg agcgcctcat caaagaggac cagctggagt accaggaaga
     6481 actgaggtcc cactacaagg acatgctcag cgaactctcc acagtcatga atgagcagat
     6541 tacgggcagg gacgacctgt caaagcgcgg agtggaccaa acctgcactc gagtaattag
     6601 caaagcaact ccggccctac ccacggtctc catctcatct agtgctgaag tctgagggct
     6661 ctgcagcatc agacccacct ctaagagaac tttctgaatt tgcagctaat ctcggggaag
     6721 agaaagatag gtttaattta tttgaagttt tcatggtgtt aatatttttg tttacctcgc
     6781 tagcttcaga attttgccaa cctctgaatt tgcacatttt gtataatttt tttttctttg
     6841 agcagtgttg atcaagccag gttgaatatt tgccatgaaa ttccagtgaa tgtgtagctc
     6901 aaatgcaaac cctaagtttg ctgtcagtta ttgtatggtc agtaccccag tcctagtaca
     6961 catattttaa aggttaaagt gaatgttttt gtaacattta agcatatttc agatgtaaat
     7021 aaaagattgt aaaatatacg gtttttacca aatttaaaag atccttttta gttaatacta
     7081 tgacagtact aaaaatatat gaataacatt tcagatacca ttatattaaa atatttgtgt
     7141 atgtgtacaa aagcgttgat aaatactaat ctttaaagtt tgtggagttc ctttatttgt
     7201 aatatatgtg ctcttaaaag caatgggatg tgaaattatg aaagtatttt attgttcata
     7261 gaaataaaaa acacagttac tttgca
//
