LOCUS       XM_047424702            6866 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens dedicator of cytokinesis 1 (DOCK1),
            transcript variant X9, mRNA.
ACCESSION   XM_047424702
VERSION     XM_047424702.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000010.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6866
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
     gene            1..6866
                     /gene="DOCK1"
                     /gene_synonym="ced5; DOCK180"
                     /note="dedicator of cytokinesis 1; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 25
                     ESTs, 267 long SRA reads, 2 Proteins, and 96% coverage of
                     the annotated genomic feature by RNAseq alignments,
                     including 5 samples with support for all annotated
                     introns"
                     /db_xref="GeneID:1793"
                     /db_xref="HGNC:HGNC:2987"
                     /db_xref="MIM:601403"
     CDS             16..2871
                     /gene="DOCK1"
                     /gene_synonym="ced5; DOCK180"
                     /codon_start=1
                     /product="dedicator of cytokinesis protein 1 isoform X8"
                     /protein_id="XP_047280658.1"
                     /db_xref="GeneID:1793"
                     /db_xref="HGNC:HGNC:2987"
                     /db_xref="MIM:601403"
                     /translation="MLLDKCNPGRISAPTCPFSPEPLAVNTPTNYTWQSKVAFYNYDA
                     RGADELSLQIGDTVHILETYEGWYRGYTLRKKSKKGIFPASYIHLKEAIVEGKGQHET
                     VIPGDLPLIQEVTTTLREWSTIWRQLYVQDNREMFRSVRHMIYDLIEWRSQILSGTLP
                     QDELKELKKKVTAKIDYGNRILDLDLVVRDEDGNILDPELTSTISLFRAHEIASKQVE
                     ERLQEEKSQKQNIDINRQAKFAATPSLALFVNLKNVVCKIGEDAEVLMSLYDPVESKF
                     ISENYLVRWSSSGLPKDIDRLHNLRAVFTDLGSKDLKREKISFVCQIVRVGRMELRDN
                     NTRKLTSGLRRPFGVAVMDVTDIINGKVDDEDKQHFIPFQPVAGENDFLQTVINKVIA
                     AKEVNHKGQGLWVTLKLLPGDIHQIRKEFPHLVDRTTAVARKTGFPEIIMPGDVRNDI
                     YVTLVQGDFDKGSKTTAKNVEVTVSVYDEDGKRLEHVIFPGAGDEAISEYKSVIYYQV
                     KQPRWFETVKVAIPIEDVNRSHLRFTFRHRSSQDSKDKSEKIFALAFVKLMRYDGTTL
                     RDGEHDLIVYKAEAKKLEDAATYLSLPSTKAELEEKGHSATGKSMQSLGSCTISKDSF
                     QISTLVCSTKLTQNVDLLGLLKWRSNTSLLQQNLRQLMKVDGGEVVKFLQDTLDALFN
                     IMMENSESETFDTLVFDALVFIIGLIADRKFQHFNPVLETYIKKHFSATLAYTKLTKV
                     LKNYVDGAEKPGVNEQLYKAMKALESIFKFIVRSRILFNQLYENKGEADFVESLLQLF
                     RSINDMMSSMSDQTVRVKGAALKYLPTIVNDVKLVFDPKELSKMFTEFILNVPMGLLT
                     IQKLYCLIEIVHSDLFTQHDCREILLPMMTDQLKYHLERQEDLEACCQLLSHILEVLY
                     RKDVGPTQRHVQIIMEKLLRTVNRTVISMGRDSELIS"
     polyA_site      6866
                     /gene="DOCK1"
                     /gene_synonym="ced5; DOCK180"
                     /experiment="COORDINATES: polyA evidence [ECO:0006239]"
ORIGIN      
        1 acttcttggt tggacatgtt gcttgacaag tgcaacccag gcaggatttc ggctcccacg
       61 tgtcccttca gccctgagcc tttggcagtg aacacaccta ccaactatac atggcagtcc
      121 aaagtggctt tttataacta tgatgccaga ggagcggatg aactttcttt acagatcgga
      181 gacactgtgc acatcttaga aacatatgaa gggtggtacc gaggttacac gttacgaaaa
      241 aagtctaaga agggtatatt tcctgcttca tatattcatc ttaaagaagc gatagttgaa
      301 ggaaaagggc aacatgaaac agtcatcccg ggtgacctcc ccctcatcca ggaagtcacc
      361 acgacactcc gagagtggtc caccatctgg aggcagctct acgtgcaaga taacagggag
      421 atgtttcgaa gtgtgcggca catgatctat gaccttattg aatggcgatc acaaattctt
      481 tctggaactc tgcctcagga tgaactcaaa gaactgaaga agaaggtcac agccaaaatt
      541 gattatggaa acagaattct agatttggac ctggtggtta gagatgaaga tgggaatatt
      601 ttggatccag aattaactag cacgattagt ctcttcagag ctcatgaaat agcttctaaa
      661 caagtggagg aaaggttaca agaggaaaaa tctcaaaagc agaacataga tattaacaga
      721 caagccaagt ttgctgcaac cccttctctg gccttgtttg tgaacctcaa aaatgtggtt
      781 tgtaaaatag gagaagatgc tgaagtcctc atgtctctat atgaccctgt ggagtccaaa
      841 ttcatcagtg agaactacct ggttcgctgg tccagttcag gattacctaa agacatagac
      901 agattacata atttgcgagc cgtgtttact gacctcggaa gcaaagacct gaaaagggag
      961 aaaatcagtt ttgtctgtca gattgttcgc gtgggtcgca tggagctgag ggacaacaac
     1021 accaggaaac tgacctcggg gttgcggcga ccttttggag tggctgtgat ggatgtaaca
     1081 gatataataa atggaaaagt agatgatgaa gataagcagc atttcattcc ctttcagccg
     1141 gtggcagggg agaatgactt ccttcagact gttataaaca aagtcatcgc tgccaaagaa
     1201 gtcaaccaca aggggcaggg tttgtgggta acattgaaat tacttcctgg agatatccat
     1261 cagatccgaa aagagtttcc gcatttagtg gacaggacca cagctgtggc tcgaaaaaca
     1321 gggtttccgg agataatcat gcctggtgat gttcgaaatg atatctatgt aacattagtt
     1381 caaggagatt ttgataaagg aagcaaaaca acagcgaaga acgtggaggt cacggtgtct
     1441 gtgtacgatg aggatgggaa acgattagag catgtgattt tcccgggtgc tggtgatgaa
     1501 gcgatttcag agtacaaatc tgtgatttac taccaagtaa agcagccacg ctggtttgag
     1561 actgttaagg tggccattcc catcgaggac gttaaccgca gtcaccttcg gtttaccttc
     1621 cgccacaggt catcacagga ctctaaggat aaatctgaga aaatatttgc actagcattt
     1681 gtcaagctga tgagatacga tggtaccacc ctgcgagacg gagagcacga tcttatcgtc
     1741 tataaggccg aagcaaagaa gctggaagat gctgccacgt acttgagtct gccctccacg
     1801 aaggcagagt tggaagaaaa gggccactcg gccaccggca agagcatgca gagccttggg
     1861 agctgcacca ttagcaagga ctccttccag atctccacgc tcgtgtgctc caccaaactg
     1921 actcagaacg tggaccttct ggggctcttg aaatggcgct ccaacaccag cctgctgcag
     1981 cagaacttga ggcagctgat gaaagtcgat ggtggtgaag tagtgaagtt tcttcaggac
     2041 acgttggatg ccctcttcaa catcatgatg gagaactcag agagtgagac ttttgacacg
     2101 ttagtctttg atgctctggt atttatcatt ggactgattg ctgatagaaa atttcagcat
     2161 tttaatcctg ttttggaaac ttacattaag aaacacttta gtgcaacgtt agcctacacg
     2221 aagttgacaa aagtgttgaa gaactacgtg gacggtgctg agaagccggg agtaaatgag
     2281 cagctgtaca aagccatgaa agcgctagaa tccatcttca agttcatcgt gcgctccagg
     2341 atcctgttca atcaactgta tgaaaacaag ggagaggctg acttcgtgga atctttgctg
     2401 cagctcttca ggtccatcaa tgacatgatg agcagcatgt cagaccagac cgtccgggtg
     2461 aagggggcag cactgaaata cttaccaacg atcgtcaacg atgtgaaatt ggtgtttgat
     2521 cccaaagagc tcagcaaaat gtttactgaa ttcatcctca atgttcccat gggcttgctg
     2581 accatccaga aactctactg cttgatcgaa atcgtccaca gtgacctctt cacacagcat
     2641 gactgcagag agatcctgct tcccatgatg accgatcagc tcaagtacca tctggagaga
     2701 caggaggacc tggaggcctg ctgtcagctg ctcagccaca tcctggaggt gctgtacagg
     2761 aaggacgtgg ggccaaccca gaggcacgtc cagattatca tggagaaact tctccggacc
     2821 gtgaaccgaa ccgtcatttc catgggacga gattctgaac tcatttcttg aaacacattt
     2881 ggaacacatt aatatggaat gggcactgag cccatggaga aggatttgca gtgactccac
     2941 gagccacctg ttgacccctg aggtctggcg ttgacccctg atgtccagcg ttgacccctg
     3001 acgtctgacg ttcctgtctt cttggagtcg tgccgcaggt gcactctgca cagtctcagg
     3061 agtggaactg gaaagggcct tatgtagagc aaagagcatg tggcttgaac ttgaaccaag
     3121 tgtggttctg ccaagaccct cttgggatgg gcggacttag agaggctggg gatgacatga
     3181 tggcatgcag gggtggtggc agatgaggga gagggtagaa gtggaggcag gtggtctcat
     3241 gagactgttt tgtctctgtt taggggagca tggttctgcc tgtgcttagg gaaacatggt
     3301 tctgtctctg gttagtgggt cttggtcctc tctctccgat taggaggtcc tgtctctggt
     3361 caggggggca cagtccagtc tctggttagg gggtgtggtc ctgtctctag ttggggcaca
     3421 atcctgcctc cagttagggt cttctttttt tttttttttt tttttttttt tttttcccct
     3481 gagatagagt cttgctctgt cgcccaggct ggagtgcagt ggtgcaatct tgactcactg
     3541 caacctctgt ctcctgggtt caagtgattc ttgtgcctcg gactcccgag aagctgggat
     3601 tacaggtgca catcaccaca ctcaagataa tttttgtatt ttttagtaca gttggggttt
     3661 caccatgttg gctaggctgg tctcaaattc ctgacctcag gtgatccatc cgcttcggcc
     3721 tcccaaagtg ctgggattac aggcatgagc caccatgccc agccttattt agggtcttta
     3781 tgctaggtgt gtgttcactt gacttgtagc ccactggtca acagttaaac tggagggaag
     3841 agggcacaga aaaagctcat aaagtttgga tgggaagctg ggaatgtgga gagattataa
     3901 gatgtgctca cagcttcatc aaagggtaga atagaccctg cagggaatga tatctcctct
     3961 cagaccatgt ggtccaggat gtctttgaga aatttctcct atctcaggca tgataataag
     4021 tgtggtagta ataatggcac ctcttcactg agcatgcatt tacgtgctat gcactctata
     4081 atgaacagga agattctcat ttaattctca cagtgccctg cagacagaca agaaacagtt
     4141 caagatccca cagctagcat ggcagcactt gtttccagcc tggatttggt tcccatgtat
     4201 gctgtcagtc ccttctataa gacacaggca cacgatgctg atggccgtgg tccacttcag
     4261 aagtcatcga aaggactgag ctgctcctag atccctgtcc tgcttaggga gacagctgtt
     4321 cagggaaata agcacctttc tattttctat catgtcgtat ccatggtcca actctaggat
     4381 ctccttgcta gaagggccag accacaagct aggtgcccat ttcctgaagg gcttgggatg
     4441 ctccagcttg gaagaacccc tgtgttctaa ggaaccctga ggagttcctc aggaagaagc
     4501 cttgcatgtt ctaagaaggg ggtgtgacag cgaggaccca tgcttggtct tatccagagc
     4561 cacattgata tcaagcattt ggcatagggg tctaagcact gtccgggaat ggaagaggta
     4621 gaacaaactt cccacctcca gaaccatcct ccacagccct gatcttccca aacagaagcc
     4681 tcaaagtggg aagaggagag aggtcttaaa cggactcctc ccaattccac catctctaag
     4741 atctgtaaag aagtaaaaaa aatccttgga gtttctttta taaaatgcag ctgtcttgaa
     4801 aggactctca aaaaaattct gaataagcta taatcattta atgagtgatg acaacatcaa
     4861 gatgttttca agaagggtgt ttgccactga aaattcgagt tgtttagtgg gaccttgtaa
     4921 tccccaacca gccacgagcc ccctctctgg agtcaacaga gcagtgtgag tgaaatgcta
     4981 ccctgtttag gatgcctgcc cttgctcttc caatttgcat caaatgtaga tttgtgcatt
     5041 aactttttaa agtcgttgct ctgtgaattt agattagagg aagatcaagg caaaaagtat
     5101 ccctgacaag gtggacaaaa accttaatca gtagaccttc tagagtggaa aaagagtaga
     5161 aaatagttca taggtctgtt ttgggtaggc tgttccattc cattatatct tagagatttc
     5221 agcctttatg tgttactcat ttttgctaaa tatagtggaa attatgtaac tatgaatcag
     5281 cttaaaaatt ctaagtaatc actgaaaatg agtttttaaa aattaaagtg attaaaaaga
     5341 actctgaaat taatatactt tacttaatga tttattccat gatgttgtca acaacagtac
     5401 tagaaatgtg gcctctttcc atcggaataa ggcattaact gggaatgtga ttatgccctg
     5461 acagcttccc cctattaatg taaggaatag aaaactgggg aacttcacac ttaattagat
     5521 aaattgggat atgcaatata aggcttttct ttatctgtgg gattttacaa aaactcgact
     5581 ttgcagtcag ttgtatattg tttgctttag ttgattatat ttgaaatggg tgattggaat
     5641 gcgtctcgtg cctaggataa taatgtgcta tgatccgaag tattacatcc ttaagaaaaa
     5701 accaaaacaa ctctatttgg cagttgcaga attgtagacc atgtgaatac ctagcacatg
     5761 cccagagaca gaagcgttgc aataaccttg ccacagaaca aaaaggtcat tttatcttta
     5821 ctctgatgta gtctgatgct gtagaagcat ggagtgaaat acttattttt atattaagtc
     5881 agacttcagg atttatttca gccttccttt ttgagaagct ttctaagccc tcagcattaa
     5941 gcagcatttt tcctcatcac acacggatct gagcaggtga ccgcggctgg gataggtgct
     6001 gttgtgttgt gtgcaggtgg gctggccagc cattgggtgt gtgtttttcc tagagtaaga
     6061 agcactccag gctgagatga gagctgttga aatgagtaac atttccgtct cctgtgatac
     6121 gcgctgctgt tgcttctttc aaatgatcag atttacattc ttttaatggg tcctttaaaa
     6181 atgtaatcga gtgagaagga cttctaaaca tttttctttg gcctggatac acacgagggg
     6241 attggaaatt actaattcat gaaaatgaaa atgtgggctt cttttaagga aaaattccct
     6301 ttgaacattg acagaagtgg gcatagggaa ggggaagatt ttgcctggat tctccactta
     6361 actcttgtca ccactggagc atcctgactc cctagacaca agtgatggaa gttattttgt
     6421 ttccactcta aacactgtct cagggggaca ttgatgggat ggtggagggt gtgtttcatt
     6481 gtgacaacag catctttggt ggggaatttg ctgttggtga aaacccagtg ctttctctga
     6541 gcatgggtga ttgataaggg cctgacatgc tccttcattt ggaaaatggt attaatagaa
     6601 ttggtttccc agtgaatagt gccttttacc caagactcat aaccaaatat tttcacaaag
     6661 atgttatatc cccatgcatg agcattcatt ttgagatgtt cattataata gagtttaagt
     6721 atgaatgtgt tttaaaaatg attttaaaat catctgcaaa aaaatgttgt gtttcaaatg
     6781 gacagtgtct gggttttgta tagtcatcat aaaaatgtct ataattgtac tgtttgctaa
     6841 taaacctgcc tgctttcaga aaatca
//
