LOCUS       NM_001290223            6840 bp    mRNA    linear   PRI 19-AUG-2024
DEFINITION  Homo sapiens dedicator of cytokinesis 1 (DOCK1), transcript variant
            1, mRNA.
ACCESSION   NM_001290223 XM_006717681
VERSION     NM_001290223.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6840)
  AUTHORS   Najafi,S., Hashemi-Gorji,F., Roudgari,H., Goudarzi,M.,
            Jafarzadegan,A.M. and Sheykhbahaei,N.
  TITLE     Genetic change investigation in DOCK1 gene in an Iranian family
            with sign and symptoms of temporomandibular joint disorder (TMD)
  JOURNAL   Clin Oral Investig 28 (8), 432 (2024)
   PUBMED   39020145
  REMARK    GeneRIF: Genetic change investigation in DOCK1 gene in an Iranian
            family with sign and symptoms of temporomandibular joint disorder
            (TMD).
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6840)
  AUTHORS   Liu,D., Dredge,B.K., Bert,A.G., Pillman,K.A., Toubia,J., Guo,W.,
            Dyakov,B.J.A., Migault,M.M., Conn,V.M., Conn,S.J., Gregory,P.A.,
            Gingras,A.C., Patel,D., Wu,B. and Goodall,G.J.
  TITLE     ESRP1 controls biogenesis and function of a large abundant
            multiexon circRNA
  JOURNAL   Nucleic Acids Res 52 (3), 1387-1403 (2024)
   PUBMED   38015468
  REMARK    GeneRIF: ESRP1 controls biogenesis and function of a large abundant
            multiexon circRNA.
REFERENCE   3  (bases 1 to 6840)
  AUTHORS   Xu,Y., Liu,X., Zeng,W., Zhu,Y., Dong,J., Wu,F., Chen,C., Sharma,S.
            and Lin,Y.
  TITLE     DOCK1 insufficiency disrupts trophoblast function and pregnancy
            outcomes via DUSP4-ERK pathway
  JOURNAL   Life Sci Alliance 7 (2), e202302247 (2023)
   PUBMED   37967942
  REMARK    GeneRIF: DOCK1 insufficiency disrupts trophoblast function and
            pregnancy outcomes via DUSP4-ERK pathway.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6840)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   5  (bases 1 to 6840)
  AUTHORS   Li,S., Liu,F., Zheng,K., Wang,W., Qiu,E., Pei,Y., Wang,S., Zhang,J.
            and Zhang,X.
  TITLE     CircDOCK1 promotes the tumorigenesis and cisplatin resistance of
            osteogenic sarcoma via the miR-339-3p/IGF1R axis
  JOURNAL   Mol Cancer 20 (1), 161 (2021)
   PUBMED   34876132
  REMARK    GeneRIF: CircDOCK1 promotes the tumorigenesis and cisplatin
            resistance of osteogenic sarcoma via the miR-339-3p/IGF1R axis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6840)
  AUTHORS   Wu,Y.C. and Horvitz,H.R.
  TITLE     C. elegans phagocytosis and cell-migration protein CED-5 is similar
            to human DOCK180
  JOURNAL   Nature 392 (6675), 501-504 (1998)
   PUBMED   9548255
REFERENCE   7  (bases 1 to 6840)
  AUTHORS   Savill,J.
  TITLE     Apoptosis. Phagocytic docking without shocking
  JOURNAL   Nature 392 (6675), 442-443 (1998)
   PUBMED   9548247
REFERENCE   8  (bases 1 to 6840)
  AUTHORS   Takai,S., Hasegawa,H., Kiyokawa,E., Yamada,K., Kurata,T. and
            Matsuda,M.
  TITLE     Chromosomal mapping of the gene encoding DOCK180, a major
            Crk-binding protein, to 10q26.13-q26.3 by fluorescence in situ
            hybridization
  JOURNAL   Genomics 35 (2), 403-404 (1996)
   PUBMED   8661160
REFERENCE   9  (bases 1 to 6840)
  AUTHORS   Matsuda,M., Ota,S., Tanimura,R., Nakamura,H., Matuoka,K.,
            Takenawa,T., Nagashima,K. and Kurata,T.
  TITLE     Interaction between the amino-terminal SH3 domain of CRK and its
            natural target proteins
  JOURNAL   J Biol Chem 271 (24), 14468-14472 (1996)
   PUBMED   8662907
REFERENCE   10 (bases 1 to 6840)
  AUTHORS   Hasegawa,H., Kiyokawa,E., Tanaka,S., Nagashima,K., Gotoh,N.,
            Shibuya,M., Kurata,T. and Matsuda,M.
  TITLE     DOCK180, a major CRK-binding protein, alters cell morphology upon
            translocation to the cell membrane
  JOURNAL   Mol Cell Biol 16 (4), 1770-1776 (1996)
   PUBMED   8657152
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL607029.17, BX470155.5,
            BX470201.4, AL359094.14, AL390920.22, AL157711.12 and AL355316.12.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jan 21, 2020 this sequence version replaced NM_001290223.1.
            
            Summary: This gene encodes a member of the dedicator of cytokinesis
            protein family. Dedicator of cytokinesis proteins act as guanine
            nucleotide exchange factors for small Rho family G proteins. The
            encoded protein regulates the small GTPase Rac, thereby influencing
            several biological processes, including phagocytosis and cell
            migration. Overexpression of this gene has also been associated
            with certain cancers. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Mar 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC144632.1, SRR11853567.4596.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000623213.2/ ENSP00000485033.1
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-136               AL607029.17        46663-46798
            137-220             BX470155.5         2897-2980
            221-261             BX470201.4         8918-8958
            262-317             AL359094.14        2687-2742
            318-414             AL359094.14        8290-8386
            415-563             AL359094.14        11224-11372
            564-699             AL359094.14        17517-17652
            700-857             AL359094.14        18861-19018
            858-939             AL359094.14        20123-20204
            940-1075            AL359094.14        20941-21076
            1076-1148           AL359094.14        29501-29573
            1149-1291           AL359094.14        33001-33143
            1292-1417           AL359094.14        39479-39604
            1418-1542           AL359094.14        43969-44093
            1543-1641           AL359094.14        45454-45552
            1642-1714           AL359094.14        47121-47193
            1715-1818           AL359094.14        52419-52522
            1819-2002           AL359094.14        52906-53089
            2003-2100           AL359094.14        58488-58585
            2101-2190           AL359094.14        63394-63483
            2191-2291           AL359094.14        63833-63933
            2292-2426           AL359094.14        73450-73584
            2427-2535           AL359094.14        82437-82545
            2536-2606           AL359094.14        127000-127070
            2607-2713           AL359094.14        131017-131123
            2714-2841           AL390920.22        15214-15341
            2842-2937           AL390920.22        17409-17504
            2938-3039           AL390920.22        137748-137849
            3040-3134           AL390920.22        147075-147169
            3135-3213           AL157711.12        55029-55107
            3214-3314           AL157711.12        59669-59769
            3315-3373           AL157711.12        70692-70750
            3374-3522           AL157711.12        78087-78235
            3523-3608           AL157711.12        89804-89889
            3609-3765           AL157711.12        90081-90237
            3766-3806           AL157711.12        96105-96145
            3807-3897           AL157711.12        97301-97391
            3898-4017           AL157711.12        100813-100932
            4018-4107           AL157711.12        119078-119167
            4108-4212           AL157711.12        120348-120452
            4213-4354           AL157711.12        125060-125201
            4355-4433           AL157711.12        125336-125414
            4434-4518           AL157711.12        126863-126947
            4519-4605           AL157711.12        131175-131261
            4606-4782           AL157711.12        134388-134564
            4783-4866           AL157711.12        135689-135772
            4867-5004           AL157711.12        141897-142034
            5005-5150           AL157711.12        149306-149451
            5151-5349           AL355316.12        2222-2420
            5350-5503           AL355316.12        7321-7474
            5504-5655           AL355316.12        10589-10740
            5656-6840           AL355316.12        14527-15711
FEATURES             Location/Qualifiers
     source          1..6840
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q26.2"
     gene            1..6840
                     /gene="DOCK1"
                     /gene_synonym="ced5; DOCK180"
                     /note="dedicator of cytokinesis 1"
                     /db_xref="GeneID:1793"
                     /db_xref="HGNC:HGNC:2987"
                     /db_xref="MIM:601403"
     exon            1..136
                     /gene="DOCK1"
                     /gene_synonym="ced5; DOCK180"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..5751
                     /gene="DOCK1"
                     /gene_synonym="ced5; DOCK180"
                     /note="isoform 1 is encoded by transcript variant 1;
                     DOwnstream of CrK; 180 kDa protein downstream of CRK"
                     /codon_start=1
                     /product="dedicator of cytokinesis protein 1 isoform 1"
                     /protein_id="NP_001277152.2"
                     /db_xref="CCDS:CCDS76359.1"
                     /db_xref="GeneID:1793"
                     /db_xref="HGNC:HGNC:2987"
                     /db_xref="MIM:601403"
                     /translation="MTRWVPTKREEKYGVAFYNYDARGADELSLQIGDTVHILETYEG
                     WYRGYTLRKKSKKGIFPASYIHLKEAIVEGKGQHETVIPGDLPLIQEVTTTLREWSTI
                     WRQLYVQDNREMFRSVRHMIYDLIEWRSQILSGTLPQDELKELKKKVTAKIDYGNRIL
                     DLDLVVRDEDGNILDPELTSTISLFRAHEIASKQVEERLQEEKSQKQNIDINRQAKFA
                     ATPSLALFVNLKNVVCKIGEDAEVLMSLYDPVESKFISENYLVRWSSSGLPKDIDRLH
                     NLRAVFTDLGSKDLKREKISFVCQIVRVGRMELRDNNTRKLTSGLRRPFGVAVMDVTD
                     IINGKVDDEDKQHFIPFQPLALDDAIRHKPLNMSSRFSPRVAGENDFLQTVINKVIAA
                     KEVNHKGQGLWVTLKLLPGDIHQIRKEFPHLVDRTTAVARKTGFPEIIMPGDVRNDIY
                     VTLVQGDFDKGSKTTAKNVEVTVSVYDEDGKRLEHVIFPGAGDEAISEYKSVIYYQVK
                     QPRWFETVKVAIPIEDVNRSHLRFTFRHRSSQDSKDKSEKIFALAFVKLMRYDGTTLR
                     DGEHDLIVYKAEAKKLEDAATYLSLPSTKAELEEKGHSATGKSMQSLGSCTISKDSFQ
                     ISTLVCSTKLTQNVDLLGLLKWRSNTSLLQQNLRQLMKVDGGEVVKFLQDTLDALFNI
                     MMENSESETFDTLVFDALVFIIGLIADRKFQHFNPVLETYIKKHFSATLAYTKLTKVL
                     KNYVDGAEKPGVNEQLYKAMKALESIFKFIVRSRILFNQLYENKGEADFVESLLQLFR
                     SINDMMSSMSDQTVRVKGAALKYLPTIVNDVKLVFDPKELSKMFTEFILNVPMGLLTI
                     QKLYCLIEIVHSDLFTQHDCREILLPMMTDQLKYHLERQEDLEACCQLLSHILEVLYR
                     KDVGPTQRHVQIIMEKLLRTVNRTVISMGRDSELIGNFVACMTAILRQMEDYHYAHLI
                     KTFGKMRTDVVDFLMETFIMFKNLIGKNVYPFDWVIMNMVQNKVFLRAINQYADMLNK
                     KFLDQANFELQLWNNYFHLAVAFLTQESLQLENFSSAKRAKILNKYGDMRRQIGFEIR
                     DMWYNLGQHKIKFIPEMVGPILEMTLIPETELRKATIPIFFDMMQCEFHSTRSFQMFE
                     NEIITKLDHEVEGGRGDEQYKVLFDKILLEHCRKHKYLAKTGETFVKLVVRLMERLLD
                     YRTIMHDENKENRMSCTVNVLNFYKEIEREEMYIRYLYKLCDLHKECDNYTEAAYTLL
                     LHAKLLKWSEDVCVAHLTQRDGYQATTQGQLKEQLYQEIIHYFDKGKMWEEAIALGKE
                     LAEQYENEMFDYEQLSELLKKQAQFYENIVKVIRPKPDYFAVGYYGQGFPTFLRGKVF
                     IYRGKEYERREDFEARLLTQFPNAEKMKTTSPPGDDIKNSPGQYIQCFTVKPKLDLPP
                     KFHRPVSEQIVSFYRVNEVQRFEYSRPIRKGEKNPDNEFANMWIERTIYTTAYKLPGI
                     LRWFEVKSVFMVEISPLENAIETMQLTNDKINSMVQQHLDDPSLPINPLSMLLNGIVD
                     PAVMGGFANYEKAFFTDRYLQEHPEAHEKIEKLKDLIAWQIPFLAEGIRIHGDKVTEA
                     LRPFHERMEACFKQLKEKVEKEYGVRIMPSSLDDRRGSRPRSMVRSFTMPSSSRPLSV
                     ASVSSLSSDSTPSRPGSDGFALEPLLPKKMHSRSQDKLDKDDLEKEKKDKKKEKRNSK
                     HQEIFEKEFKPTDISLQQSEAVILSETISPLRPQRPKSQVMNVIGSERRFSVSPSSPS
                     SQQTPPPVTPRAKLSFSMQSSLELNGMTGADVADVPPPLPLKGSVADYGNLMENQDLL
                     GSPTPPPPPPHQRHLPPPLPSKTPPPPPPKTTRKQASVDSGIVQ"
     exon            137..220
                     /gene="DOCK1"
                     /gene_synonym="ced5; DOCK180"
                     /inference="alignment:Splign:2.1.0"
     exon            221..261
                     /gene="DOCK1"
                     /gene_synonym="ced5; DOCK180"
                     /inference="alignment:Splign:2.1.0"
     exon            262..317
                     /gene="DOCK1"
                     /gene_synonym="ced5; DOCK180"
                     /inference="alignment:Splign:2.1.0"
     exon            318..414
                     /gene="DOCK1"
                     /gene_synonym="ced5; DOCK180"
                     /inference="alignment:Splign:2.1.0"
     exon            415..563
                     /gene="DOCK1"
                     /gene_synonym="ced5; DOCK180"
                     /inference="alignment:Splign:2.1.0"
     exon            564..699
                     /gene="DOCK1"
                     /gene_synonym="ced5; DOCK180"
                     /inference="alignment:Splign:2.1.0"
     exon            700..857
                     /gene="DOCK1"
                     /gene_synonym="ced5; DOCK180"
                     /inference="alignment:Splign:2.1.0"
     exon            858..939
                     /gene="DOCK1"
                     /gene_synonym="ced5; DOCK180"
                     /inference="alignment:Splign:2.1.0"
     exon            940..1075
                     /gene="DOCK1"
                     /gene_synonym="ced5; DOCK180"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1148
                     /gene="DOCK1"
                     /gene_synonym="ced5; DOCK180"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1291
                     /gene="DOCK1"
                     /gene_synonym="ced5; DOCK180"
                     /inference="alignment:Splign:2.1.0"
     exon            1292..1417
                     /gene="DOCK1"
                     /gene_synonym="ced5; DOCK180"
                     /inference="alignment:Splign:2.1.0"
     exon            1418..1542
                     /gene="DOCK1"
                     /gene_synonym="ced5; DOCK180"
                     /inference="alignment:Splign:2.1.0"
     exon            1543..1641
                     /gene="DOCK1"
                     /gene_synonym="ced5; DOCK180"
                     /inference="alignment:Splign:2.1.0"
     exon            1642..1714
                     /gene="DOCK1"
                     /gene_synonym="ced5; DOCK180"
                     /inference="alignment:Splign:2.1.0"
     exon            1715..1818
                     /gene="DOCK1"
                     /gene_synonym="ced5; DOCK180"
                     /inference="alignment:Splign:2.1.0"
     exon            1819..2002
                     /gene="DOCK1"
                     /gene_synonym="ced5; DOCK180"
                     /inference="alignment:Splign:2.1.0"
     exon            2003..2100
                     /gene="DOCK1"
                     /gene_synonym="ced5; DOCK180"
                     /inference="alignment:Splign:2.1.0"
     exon            2101..2190
                     /gene="DOCK1"
                     /gene_synonym="ced5; DOCK180"
                     /inference="alignment:Splign:2.1.0"
     exon            2191..2291
                     /gene="DOCK1"
                     /gene_synonym="ced5; DOCK180"
                     /inference="alignment:Splign:2.1.0"
     exon            2292..2426
                     /gene="DOCK1"
                     /gene_synonym="ced5; DOCK180"
                     /inference="alignment:Splign:2.1.0"
     exon            2427..2535
                     /gene="DOCK1"
                     /gene_synonym="ced5; DOCK180"
                     /inference="alignment:Splign:2.1.0"
     exon            2536..2606
                     /gene="DOCK1"
                     /gene_synonym="ced5; DOCK180"
                     /inference="alignment:Splign:2.1.0"
     exon            2607..2713
                     /gene="DOCK1"
                     /gene_synonym="ced5; DOCK180"
                     /inference="alignment:Splign:2.1.0"
     exon            2714..2841
                     /gene="DOCK1"
                     /gene_synonym="ced5; DOCK180"
                     /inference="alignment:Splign:2.1.0"
     exon            2842..2937
                     /gene="DOCK1"
                     /gene_synonym="ced5; DOCK180"
                     /inference="alignment:Splign:2.1.0"
     exon            2938..3039
                     /gene="DOCK1"
                     /gene_synonym="ced5; DOCK180"
                     /inference="alignment:Splign:2.1.0"
     exon            3040..3134
                     /gene="DOCK1"
                     /gene_synonym="ced5; DOCK180"
                     /inference="alignment:Splign:2.1.0"
     exon            3135..3213
                     /gene="DOCK1"
                     /gene_synonym="ced5; DOCK180"
                     /inference="alignment:Splign:2.1.0"
     exon            3214..3314
                     /gene="DOCK1"
                     /gene_synonym="ced5; DOCK180"
                     /inference="alignment:Splign:2.1.0"
     exon            3315..3373
                     /gene="DOCK1"
                     /gene_synonym="ced5; DOCK180"
                     /inference="alignment:Splign:2.1.0"
     exon            3374..3522
                     /gene="DOCK1"
                     /gene_synonym="ced5; DOCK180"
                     /inference="alignment:Splign:2.1.0"
     exon            3523..3608
                     /gene="DOCK1"
                     /gene_synonym="ced5; DOCK180"
                     /inference="alignment:Splign:2.1.0"
     exon            3609..3765
                     /gene="DOCK1"
                     /gene_synonym="ced5; DOCK180"
                     /inference="alignment:Splign:2.1.0"
     exon            3766..3806
                     /gene="DOCK1"
                     /gene_synonym="ced5; DOCK180"
                     /inference="alignment:Splign:2.1.0"
     exon            3807..3897
                     /gene="DOCK1"
                     /gene_synonym="ced5; DOCK180"
                     /inference="alignment:Splign:2.1.0"
     exon            3898..4017
                     /gene="DOCK1"
                     /gene_synonym="ced5; DOCK180"
                     /inference="alignment:Splign:2.1.0"
     exon            4018..4107
                     /gene="DOCK1"
                     /gene_synonym="ced5; DOCK180"
                     /inference="alignment:Splign:2.1.0"
     exon            4108..4212
                     /gene="DOCK1"
                     /gene_synonym="ced5; DOCK180"
                     /inference="alignment:Splign:2.1.0"
     exon            4213..4354
                     /gene="DOCK1"
                     /gene_synonym="ced5; DOCK180"
                     /inference="alignment:Splign:2.1.0"
     exon            4355..4433
                     /gene="DOCK1"
                     /gene_synonym="ced5; DOCK180"
                     /inference="alignment:Splign:2.1.0"
     exon            4434..4518
                     /gene="DOCK1"
                     /gene_synonym="ced5; DOCK180"
                     /inference="alignment:Splign:2.1.0"
     exon            4519..4605
                     /gene="DOCK1"
                     /gene_synonym="ced5; DOCK180"
                     /inference="alignment:Splign:2.1.0"
     exon            4606..4782
                     /gene="DOCK1"
                     /gene_synonym="ced5; DOCK180"
                     /inference="alignment:Splign:2.1.0"
     exon            4783..4866
                     /gene="DOCK1"
                     /gene_synonym="ced5; DOCK180"
                     /inference="alignment:Splign:2.1.0"
     exon            4867..5004
                     /gene="DOCK1"
                     /gene_synonym="ced5; DOCK180"
                     /inference="alignment:Splign:2.1.0"
     exon            5005..5150
                     /gene="DOCK1"
                     /gene_synonym="ced5; DOCK180"
                     /inference="alignment:Splign:2.1.0"
     exon            5151..5349
                     /gene="DOCK1"
                     /gene_synonym="ced5; DOCK180"
                     /inference="alignment:Splign:2.1.0"
     exon            5350..5503
                     /gene="DOCK1"
                     /gene_synonym="ced5; DOCK180"
                     /inference="alignment:Splign:2.1.0"
     exon            5504..5655
                     /gene="DOCK1"
                     /gene_synonym="ced5; DOCK180"
                     /inference="alignment:Splign:2.1.0"
     exon            5656..6840
                     /gene="DOCK1"
                     /gene_synonym="ced5; DOCK180"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6819..6824
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DOCK1"
                     /gene_synonym="ced5; DOCK180"
                     /note="hexamer: AATAAA"
     polyA_site      6840
                     /gene="DOCK1"
                     /gene_synonym="ced5; DOCK180"
                     /note="major polyA site"
ORIGIN      
        1 ctccccatcc tgtcgcggct cgaaaggaat ggaaaatggc ggcctagacg cggagtttcc
       61 tgcccgaccc gcggcggctc cggcggcgcc atgacgcgct gggtgcccac caagcgcgag
      121 gagaagtacg gcgtggcttt ttataactat gatgccagag gagcggatga actttcttta
      181 cagatcggag acactgtgca catcttagaa acatatgaag ggtggtaccg aggttacacg
      241 ttacgaaaaa agtctaagaa gggtatattt cctgcttcat atattcatct taaagaagcg
      301 atagttgaag gaaaagggca acatgaaaca gtcatcccgg gtgacctccc cctcatccag
      361 gaagtcacca cgacactccg agagtggtcc accatctgga ggcagctcta cgtgcaagat
      421 aacagggaga tgtttcgaag tgtgcggcac atgatctatg accttattga atggcgatca
      481 caaattcttt ctggaactct gcctcaggat gaactcaaag aactgaagaa gaaggtcaca
      541 gccaaaattg attatggaaa cagaattcta gatttggacc tggtggttag agatgaagat
      601 gggaatattt tggatccaga attaactagc acgattagtc tcttcagagc tcatgaaata
      661 gcttctaaac aagtggagga aaggttacaa gaggaaaaat ctcaaaagca gaacatagat
      721 attaacagac aagccaagtt tgctgcaacc ccttctctgg ccttgtttgt gaacctcaaa
      781 aatgtggttt gtaaaatagg agaagatgct gaagtcctca tgtctctata tgaccctgtg
      841 gagtccaaat tcatcagtga gaactacctg gttcgctggt ccagttcagg attacctaaa
      901 gacatagaca gattacataa tttgcgagcc gtgtttactg acctcggaag caaagacctg
      961 aaaagggaga aaatcagttt tgtctgtcag attgttcgcg tgggtcgcat ggagctgagg
     1021 gacaacaaca ccaggaaact gacctcgggg ttgcggcgac cttttggagt ggctgtgatg
     1081 gatgtaacag atataataaa tggaaaagta gatgatgaag ataagcagca tttcattccc
     1141 tttcagccgc tcgcgttgga cgacgccatt cgacacaagc cgctgaacat gtcatcccgt
     1201 ttttcaccca gggtggcagg ggagaatgac ttccttcaga ctgttataaa caaagtcatc
     1261 gctgccaaag aagtcaacca caaggggcag ggtttgtggg taacattgaa attacttcct
     1321 ggagatatcc atcagatccg aaaagagttt ccgcatttag tggacaggac cacagctgtg
     1381 gctcgaaaaa cagggtttcc ggagataatc atgcctggtg atgttcgaaa tgatatctat
     1441 gtaacattag ttcaaggaga ttttgataaa ggaagcaaaa caacagcgaa gaacgtggag
     1501 gtcacggtgt ctgtgtacga tgaggatggg aaacgattag agcatgtgat tttcccgggt
     1561 gctggtgatg aagcgatttc agagtacaaa tctgtgattt actaccaagt aaagcagcca
     1621 cgctggtttg agactgttaa ggtggccatt cccatcgagg acgttaaccg cagtcacctt
     1681 cggtttacct tccgccacag gtcatcacag gactctaagg ataaatctga gaaaatattt
     1741 gcactagcat ttgtcaagct gatgagatac gatggtacca ccctgcgaga cggagagcac
     1801 gatcttatcg tctataaggc cgaagcaaag aagctggaag atgctgccac gtacttgagt
     1861 ctgccctcca cgaaggcaga gttggaagaa aagggccact cggccaccgg caagagcatg
     1921 cagagccttg ggagctgcac cattagcaag gactccttcc agatctccac gctcgtgtgc
     1981 tccaccaaac tgactcagaa cgtggacctt ctggggctct tgaaatggcg ctccaacacc
     2041 agcctgctgc agcagaactt gaggcagctg atgaaagtcg atggtggtga agtagtgaag
     2101 tttcttcagg acacgttgga tgccctcttc aacatcatga tggagaactc agagagtgag
     2161 acttttgaca cgttagtctt tgatgctctg gtatttatca ttggactgat tgctgataga
     2221 aaatttcagc attttaatcc tgttttggaa acttacatta agaaacactt tagtgcaacg
     2281 ttagcctaca cgaagttgac aaaagtgttg aagaactacg tggacggtgc tgagaagccg
     2341 ggagtaaatg agcagctgta caaagccatg aaagcgctag aatccatctt caagttcatc
     2401 gtgcgctcca ggatcctgtt caatcaactg tatgaaaaca agggagaggc tgacttcgtg
     2461 gaatctttgc tgcagctctt caggtccatc aatgacatga tgagcagcat gtcagaccag
     2521 accgtccggg tgaagggggc agcactgaaa tacttaccaa cgatcgtcaa cgatgtgaaa
     2581 ttggtgtttg atcccaaaga gctcagcaaa atgtttactg aattcatcct caatgttccc
     2641 atgggcttgc tgaccatcca gaaactctac tgcttgatcg aaatcgtcca cagtgacctc
     2701 ttcacacagc atgactgcag agagatcctg cttcccatga tgaccgatca gctcaagtac
     2761 catctggaga gacaggagga cctggaggcc tgctgtcagc tgctcagcca catcctggag
     2821 gtgctgtaca ggaaggacgt ggggccaacc cagaggcacg tccagattat catggagaaa
     2881 cttctccgga ccgtgaaccg aaccgtcatt tccatgggac gagattctga actcattgga
     2941 aacttcgtgg cttgcatgac agctatttta cgacaaatgg aagattacca ttatgcccac
     3001 ttgatcaaga cttttgggaa aatgaggact gatgtggtag atttcctaat ggaaacattc
     3061 atcatgttta agaacctcat tggaaagaac gtttacccct tcgactgggt gatcatgaac
     3121 atggtgcaaa ataaagtctt cctgcgagca attaatcagt atgcagatat gctgaacaaa
     3181 aaatttctgg atcaagccaa ctttgagcta cagctgtgga acaactactt tcacctggct
     3241 gttgctttcc ttactcaaga gtccctgcaa ctggagaatt tttcaagtgc caagagagcc
     3301 aaaatcctta acaagtacgg agatatgagg agacagattg gctttgaaat cagagacatg
     3361 tggtacaacc ttggtcaaca caagataaag ttcattccag aaatggtggg cccaatatta
     3421 gaaatgacat taattcccga gacggagctg cgcaaagcca ccatccccat cttctttgat
     3481 atgatgcagt gtgaattcca ttcgacccga agcttccaaa tgtttgaaaa tgagatcatc
     3541 accaagctgg atcatgaagt cgaaggaggc agaggagacg aacagtacaa agtgttattt
     3601 gataaaatcc ttctggaaca ctgcaggaag cacaaatacc tcgccaaaac aggagaaact
     3661 tttgtaaaac tcgttgtgcg cttaatggaa aggcttttgg attatagaac catcatgcac
     3721 gacgagaaca aagaaaaccg catgagctgc accgtcaatg tgctgaattt ctacaaagaa
     3781 attgaaagag aagaaatgta tataaggtat ttgtacaagc tctgtgacct gcacaaggag
     3841 tgtgataact acaccgaagc ggcttacacc ttgcttctcc atgcaaagct tcttaagtgg
     3901 tcggaggatg tgtgtgtggc ccacctcacc cagcgggacg ggtaccaggc caccacgcag
     3961 ggacagctga aggagcagct ctaccaggaa atcatccact acttcgacaa aggcaagatg
     4021 tgggaggagg ccattgcctt gggcaaggag ctagccgagc agtatgagaa cgaaatgttt
     4081 gattatgagc aactcagcga attgctgaaa aaacaggctc agttttatga aaacatcgtc
     4141 aaagtgatca ggcccaagcc tgactatttt gctgttggct actacggaca agggttcccc
     4201 acattcctgc ggggaaaagt tttcatttac cgagggaaag agtatgagcg ccgggaagat
     4261 tttgaggctc ggctcttaac tcagtttcca aacgccgaga aaatgaagac aacatctcca
     4321 ccaggcgacg atattaaaaa ctctcctggc cagtatattc agtgcttcac agtgaagccc
     4381 aaactcgatc tgcctcctaa gtttcacagg ccagtgtcag agcagattgt aagtttttac
     4441 agggtgaacg aggtccagcg atttgaatat tctcggccaa tccggaaggg agagaaaaac
     4501 ccagacaatg aatttgcgaa tatgtggatc gagagaacca tatatacaac tgcatataaa
     4561 ttacctggaa ttttaaggtg gtttgaggtc aagtctgttt tcatggtgga aatcagcccc
     4621 ctggagaatg ccattgagac catgcagctg acgaacgaca agatcaacag catggtgcag
     4681 cagcacctgg atgaccccag cctgcccatc aacccgctct ccatgctcct gaacggcatc
     4741 gtggacccag ctgtcatggg gggcttcgca aactacgaaa aggccttctt tacagaccgg
     4801 tacctgcagg agcaccctga ggcccatgaa aagatcgaga agctcaagga cctgattgct
     4861 tggcagattc cttttctggc cgaagggatc agaatccatg gagacaaagt cacggaggca
     4921 ctgaggccgt tccacgagag gatggaggcc tgtttcaaac agctgaagga aaaggtggag
     4981 aaagagtacg gcgtccgaat catgccctca agtctggatg atagaagagg cagccgcccc
     5041 cggtccatgg tgcggtcctt cacgatgcct tcctcatccc gccctctgtc tgtggcctct
     5101 gtctcttccc tctcatcgga cagcacccct tccagaccag gctccgacgg gtttgccctg
     5161 gagcctctcc tgccaaagaa aatgcactcc aggtcccagg acaagctgga caaggatgac
     5221 ctggagaagg agaagaagga caagaagaag gaaaaaagga acagcaaaca tcaagagata
     5281 tttgagaaag aatttaaacc caccgacatt tccctgcagc agtctgaggc tgtgatcctt
     5341 tcggaaacga taagtcccct gcggccccag agaccgaaga gccaggtgat gaacgtcatt
     5401 ggaagcgaaa ggcgcttctc ggtgtccccc tcgtcaccgt cctcccagca aacaccccct
     5461 ccagttacac caagggccaa gctcagcttc agcatgcagt cgagcttgga gctgaacggc
     5521 atgacggggg cggacgtggc cgatgtccca ccccctctgc ctctcaaagg cagcgtggca
     5581 gattacggga atttgatgga aaaccaggac ttgctgggct cgccaacacc tccacctccc
     5641 cctccacacc agaggcatct gccacctcca ctgcccagca aaactccgcc tcctccccct
     5701 ccaaagacaa ctcgcaagca ggcatcggtg gactccggga tcgtgcagtg acgtcgcaag
     5761 cctctctgga aagagtgtgc tgcccctccc catctccatg ccctctcctt ctgtgtcccc
     5821 tgagtctgct gtttacctca ttgggcctgt gatgttaaca tttcgtgcga ctgctttttc
     5881 ttcaaaggag ttcagttctc accatggagt gagtggcctt tagcgtcatg gagcaaggtg
     5941 ggtctgggag gtagatatgg gtccgggatg tgctatcgta gttatcagag ttgggggcct
     6001 ctgagtgtgt ctggctctga gagagtctga gtcttgccca aacattcttt ctttttgtgc
     6061 caaatgactt gcatttgcaa agagctcaat tgctctgagc tcagccaagt aggagaggct
     6121 aggccatcac tcttaggaag ctgtgtagtg atgatgtata agaatcctcc tcactgtcat
     6181 gggatgttgt atccagcccc tccttgttcc agccggtggt gtgacttcgt tggttgaggt
     6241 gtgtctccaa cctacatcag accatgaagt tcaacccctc cagggaagct cctgatttcc
     6301 cctgcataat tgaaaatagg atatttctca gctattgaac agttactaat ttatggggtg
     6361 gaaacagcat taagaatact gaatcaaatg gaaaaacaaa tgaatacagg aagataagtg
     6421 ttcgttcttt tctgaaaaag agtatgtgta ccacaagagc tggttttaat tgggtgaatt
     6481 gtttttgtcc tcattctgta cagaaatttg tatatatgat ggttcttaga acttgtttta
     6541 atttttgtgg tccttccgtt tattataata ggcgtccacc aatgattatc catatgtgtt
     6601 cttaattttt aactgctgga agtgttaaaa cacacacaca cacacacaca catttttttt
     6661 ttgagaactc caaagtcctg aaaattttgg tggacaatga tttttaaaaa actaactttg
     6721 tataacctaa tatttgtatt ctctcatcta tattttttta ttcactataa tcatgatact
     6781 cttctaatag acttaaaagt taatcattga caacgaaaaa taaaatgtta ttttaaaaga
//
