LOCUS       NM_014597               5896 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens deoxynucleotidyltransferase terminal interacting
            protein 2 (DNTTIP2), mRNA.
ACCESSION   NM_014597
VERSION     NM_014597.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5896)
  AUTHORS   Yoshizawa,M., Shiozaki,A. and Ashihara,E.
  TITLE     Depletion of DNTTIP2 Induces Cell Cycle Arrest in Pancreatic Cancer
            Cells
  JOURNAL   Cancer Genomics Proteomics 21 (1), 18-29 (2024)
   PUBMED   38151292
  REMARK    GeneRIF: Depletion of DNTTIP2 Induces Cell Cycle Arrest in
            Pancreatic Cancer Cells.
REFERENCE   2  (bases 1 to 5896)
  AUTHORS   Singh,S., Vanden Broeck,A., Miller,L., Chaker-Margot,M. and
            Klinge,S.
  TITLE     Nucleolar maturation of the human small subunit processome
  JOURNAL   Science 373 (6560), eabj5338 (2021)
   PUBMED   34516797
REFERENCE   3  (bases 1 to 5896)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 5896)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   5  (bases 1 to 5896)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   6  (bases 1 to 5896)
  AUTHORS   Koiwai,K., Noma,S., Takahashi,Y., Hayano,T., Maezawa,S., Kouda,K.,
            Matsumoto,T., Suzuki,M., Furuichi,M. and Koiwai,O.
  TITLE     TdIF2 is a nucleolar protein that promotes rRNA gene promoter
            activity
  JOURNAL   Genes Cells 16 (7), 748-764 (2011)
   PUBMED   21668587
  REMARK    GeneRIF: The TdIF2 might promote hrDNAP activity by suppressing
            Tip60's HAT activity and promoting UBF acetylation.
REFERENCE   7  (bases 1 to 5896)
  AUTHORS   Edmiston,J.S., Archer,K.J., Scian,M.J., Joyce,A.R., Zedler,B.K. and
            Murrelle,E.L.
  TITLE     Gene expression profiling of peripheral blood leukocytes identifies
            potential novel biomarkers of chronic obstructive pulmonary disease
            in current and former smokers
  JOURNAL   Biomarkers 15 (8), 715-730 (2010)
   PUBMED   20887155
REFERENCE   8  (bases 1 to 5896)
  AUTHORS   Bu,H., Kashireddy,P., Chang,J., Zhu,Y.T., Zhang,Z., Zheng,W.,
            Rao,S.M. and Zhu,Y.J.
  TITLE     ERBP, a novel estrogen receptor binding protein enhancing the
            activity of estrogen receptor
  JOURNAL   Biochem Biophys Res Commun 317 (1), 54-59 (2004)
   PUBMED   15047147
REFERENCE   9  (bases 1 to 5896)
  AUTHORS   Fujita,K., Shimazaki,N., Ohta,Y., Kubota,T., Ibe,S., Toji,S.,
            Tamai,K., Fujisaki,S., Hayano,T. and Koiwai,O.
  TITLE     Terminal deoxynucleotidyltransferase forms a ternary complex with a
            novel chromatin remodeling protein with 82 kDa and core histone
  JOURNAL   Genes Cells 8 (6), 559-571 (2003)
   PUBMED   12786946
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AU134239.1, AL049796.28,
            AA832262.1 and AI436814.1.
            
            On Nov 23, 2018 this sequence version replaced NM_014597.4.
            
            Summary: This gene is thought to be involved in chromatin
            remodeling and gene transcription. The encoded nuclear protein
            binds to and enhances the transcriptional activity of the estrogen
            receptor alpha, and also interacts with terminal
            deoxynucleotidyltransferase. The expression profile of this gene is
            a potential biomarker for chronic obstructive pulmonary disease.
            [provided by RefSeq, Dec 2010].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.116056.1,
                                           SRR1660809.206858.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1966682,
                                           SAMEA1968540 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000436063.7/ ENSP00000411010.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                AU134239.1         1-25
            26-130              AL049796.28        10585-10689
            131-1725            AL049796.28        11904-13498
            1726-1864           AL049796.28        13983-14121
            1865-1960           AL049796.28        16552-16647
            1961-2125           AL049796.28        17530-17694
            2126-2235           AL049796.28        18974-19083
            2236-2365           AL049796.28        19822-19951
            2366-2704           AA832262.1         26-364              c
            2705-2722           AI436814.1         4-21                c
            2723-5896           AL049796.28        20309-23482
FEATURES             Location/Qualifiers
     source          1..5896
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p22.1"
     gene            1..5896
                     /gene="DNTTIP2"
                     /gene_synonym="ERBP; FCF2; HSU15552; LPTS-RP2; TdIF2"
                     /note="deoxynucleotidyltransferase terminal interacting
                     protein 2"
                     /db_xref="GeneID:30836"
                     /db_xref="HGNC:HGNC:24013"
                     /db_xref="MIM:611199"
     exon            1..130
                     /gene="DNTTIP2"
                     /gene_synonym="ERBP; FCF2; HSU15552; LPTS-RP2; TdIF2"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..2329
                     /gene="DNTTIP2"
                     /gene_synonym="ERBP; FCF2; HSU15552; LPTS-RP2; TdIF2"
                     /note="estrogen receptor binding protein; acidic 82 kDa
                     protein mRNA; tdT-interacting factor 2; LPTS-interacting
                     protein 2"
                     /codon_start=1
                     /product="deoxynucleotidyltransferase terminal-interacting
                     protein 2"
                     /protein_id="NP_055412.2"
                     /db_xref="CCDS:CCDS44174.1"
                     /db_xref="GeneID:30836"
                     /db_xref="HGNC:HGNC:24013"
                     /db_xref="MIM:611199"
                     /translation="MVVTRSARAKASIQAASAESSGQKSFAANGIQAHPESSTGSDAR
                     TTAESQTTGKQSLIPRTPKARKRKSRTTGSLPKGTEPSTDGETSEAESNYSVSEHHDT
                     ILRVTRRRQILIACSPVSSVRKKPKVTPTKESYTEEIVSEAESHVSGISRIVLPTEKT
                     TGARRSKAKSLTDPSQESHTEAISDAETSSSDISFSGIATRRTRSMQRKLKAQTEKKD
                     SKIVPGNEKQIVGTPVNSEDSDTRQTSHLQARSLSEINKPNFYNNDFDDDFSHRSSEN
                     ILTVHEQANVESLKETKQNCKDLDEDANGITDEGKEINEKSSQLKNLSELQDTSLQQL
                     VSQRHSTPQNKNAVSVHSNLNSEAVMKSLTQTFATVEVGRWNNNKKSPIKASDLTKFG
                     DCGGSDDEEESTVISVSEDMNSEGNVDFECDTKLYTSAPNTSQGKDNSVLLVLSSDES
                     QQSENSENEEDTLCFVENSGQRESLSGDTGSLSCDNALFVIDTTPGMSADKNFYLEEE
                     DKASEVAIEEEKEEEEDEKSEEDSSDHDENEDEFSDEEDFLNSTKAKLLKLTSSSIDP
                     GLSIKQLGGLYINFNADKLQSNKRTLTQIKEKKKNELLQKAVITPDFEKNHCVPPYSE
                     SKYQLQKKRRKERQKTAGDGWFGMKAPEMTNELKNDLKALKMRASMDPKRFYKKNDRD
                     GFPKYFQIGTIVDNPADFYHSRIPKKQRKRTIVEELLADSEFRRYNRRKYSEIMAEKA
                     ANAAGKKFRKKKKFRN"
     exon            131..1725
                     /gene="DNTTIP2"
                     /gene_synonym="ERBP; FCF2; HSU15552; LPTS-RP2; TdIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1726..1864
                     /gene="DNTTIP2"
                     /gene_synonym="ERBP; FCF2; HSU15552; LPTS-RP2; TdIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1865..1960
                     /gene="DNTTIP2"
                     /gene_synonym="ERBP; FCF2; HSU15552; LPTS-RP2; TdIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1961..2125
                     /gene="DNTTIP2"
                     /gene_synonym="ERBP; FCF2; HSU15552; LPTS-RP2; TdIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2126..2235
                     /gene="DNTTIP2"
                     /gene_synonym="ERBP; FCF2; HSU15552; LPTS-RP2; TdIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2236..5896
                     /gene="DNTTIP2"
                     /gene_synonym="ERBP; FCF2; HSU15552; LPTS-RP2; TdIF2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2378..2383
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DNTTIP2"
                     /gene_synonym="ERBP; FCF2; HSU15552; LPTS-RP2; TdIF2"
                     /note="hexamer: ATTAAA"
     polyA_site      2400
                     /gene="DNTTIP2"
                     /gene_synonym="ERBP; FCF2; HSU15552; LPTS-RP2; TdIF2"
                     /note="major polyA site"
     regulatory      2696..2701
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DNTTIP2"
                     /gene_synonym="ERBP; FCF2; HSU15552; LPTS-RP2; TdIF2"
                     /note="hexamer: TATAAA"
     polyA_site      2716
                     /gene="DNTTIP2"
                     /gene_synonym="ERBP; FCF2; HSU15552; LPTS-RP2; TdIF2"
     regulatory      3622..3627
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DNTTIP2"
                     /gene_synonym="ERBP; FCF2; HSU15552; LPTS-RP2; TdIF2"
                     /note="hexamer: AGTAAA"
     polyA_site      3654
                     /gene="DNTTIP2"
                     /gene_synonym="ERBP; FCF2; HSU15552; LPTS-RP2; TdIF2"
     regulatory      3956..3961
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DNTTIP2"
                     /gene_synonym="ERBP; FCF2; HSU15552; LPTS-RP2; TdIF2"
                     /note="hexamer: CATAAA"
     polyA_site      3974
                     /gene="DNTTIP2"
                     /gene_synonym="ERBP; FCF2; HSU15552; LPTS-RP2; TdIF2"
     regulatory      4404..4409
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DNTTIP2"
                     /gene_synonym="ERBP; FCF2; HSU15552; LPTS-RP2; TdIF2"
                     /note="hexamer: GATAAA"
     polyA_site      4428
                     /gene="DNTTIP2"
                     /gene_synonym="ERBP; FCF2; HSU15552; LPTS-RP2; TdIF2"
     regulatory      4509..4514
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DNTTIP2"
                     /gene_synonym="ERBP; FCF2; HSU15552; LPTS-RP2; TdIF2"
                     /note="hexamer: AATAAG"
     polyA_site      4534
                     /gene="DNTTIP2"
                     /gene_synonym="ERBP; FCF2; HSU15552; LPTS-RP2; TdIF2"
     regulatory      4558..4563
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DNTTIP2"
                     /gene_synonym="ERBP; FCF2; HSU15552; LPTS-RP2; TdIF2"
                     /note="hexamer: ACTAAA"
     polyA_site      4582
                     /gene="DNTTIP2"
                     /gene_synonym="ERBP; FCF2; HSU15552; LPTS-RP2; TdIF2"
     regulatory      5875..5880
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DNTTIP2"
                     /gene_synonym="ERBP; FCF2; HSU15552; LPTS-RP2; TdIF2"
                     /note="hexamer: ATTAAA"
     polyA_site      5896
                     /gene="DNTTIP2"
                     /gene_synonym="ERBP; FCF2; HSU15552; LPTS-RP2; TdIF2"
ORIGIN      
        1 gcatttccgg agcgccaggg aagagggaag tcgtggtggt cgcgagggag ccggaaagat
       61 ggtggttacc agatctgcac gggctaaggc cagcatccaa gccgcgtcgg ctgaaagttc
      121 cgggcaaaag agttttgctg ctaatgggat tcaagcgcat ccagaaagta gtactggatc
      181 tgatgcccga actactgctg aatcacagac cactgggaag caaagtttaa tccctagaac
      241 tcctaaagct agaaagagga agagcagaac tacaggctca ctaccaaagg ggactgaacc
      301 atctacggat ggagaaacct ctgaggcaga gtcaaattat tctgtgtctg agcaccatga
      361 taccatttta agggtaacta ggagaaggca gatcttaatt gcatgctccc cagtgtccag
      421 tgttaggaaa aagccgaaag taactccaac aaaggagtct tacactgaag aaatagtgtc
      481 tgaagcagaa tctcatgttt caggtatttc tagaattgtg cttcctacag aaaaaactac
      541 aggagccaga agaagtaagg ctaaatctct gacagatcca agccaagaat ctcatacaga
      601 agctatatct gatgctgaga catcaagctc agacatttca ttctctggaa ttgcaactag
      661 aagaaccagg agtatgcaga ggaaattaaa ggcacaaact gaaaagaaag atagtaagat
      721 tgtaccagga aatgagaaac agatcgtggg tacacctgtg aattcagagg attcagatac
      781 cagacaaact tcccatttac aagcaagatc tctttctgag ataaataagc caaatttcta
      841 taataatgac tttgatgatg atttctccca cagaagttca gaaaatatat taacagtgca
      901 cgaacaggcc aatgttgaat ctcttaaaga aacaaaacag aattgtaagg atttggatga
      961 agatgccaat ggaataacag atgaggggaa agaaattaat gagaaaagtt ctcagctgaa
     1021 gaatctttct gaacttcagg acactagcct tcaacagtta gtttctcaga gacattcaac
     1081 cccccaaaat aaaaatgctg tatcagtgca ctctaatctg aactctgagg ctgtaatgaa
     1141 atcattaact caaacatttg caactgtgga agtaggcaga tggaataaca acaaaaagag
     1201 ccccataaaa gcaagtgact tgacaaagtt tggtgattgt ggtggtagtg atgatgaaga
     1261 agagtccaca gttataagtg tcagtgaaga catgaacagt gaagggaatg tagattttga
     1321 atgtgatacc aaactataca cgtctgcgcc caacacatct cagggtaaag ataattctgt
     1381 cttactagtt ctcagcagtg atgaaagcca acagtctgaa aacagtgaga atgaagagga
     1441 tactttatgt tttgttgaaa atagtggcca aagggagtca ttaagtggag acacaggaag
     1501 tctgtcatgt gacaatgcat tgtttgtaat tgacacaact cctggaatga gtgctgataa
     1561 aaatttttac ttggaagagg aagacaaggc aagtgaggtt gccattgagg aagaaaaaga
     1621 agaggaagag gatgaaaaaa gtgaagaaga ttcatcagac catgacgaaa atgaagatga
     1681 gtttagtgat gaagaagact tcctaaatag cacaaaggct aaacttctga agttgacaag
     1741 cagcagcata gaccctggtc tgagtatcaa gcagttgggt ggtttgtata ttaattttaa
     1801 tgcagataaa ctacagtcta acaagagaac cctaacacag atcaaggaga aaaagaaaaa
     1861 tgagcttctg cagaaagccg tcattacacc tgattttgaa aaaaaccact gtgttccacc
     1921 atatagtgaa tcaaagtatc aacttcagaa aaaacgcaga aaagaacgac aaaaaacagc
     1981 aggggatggc tggtttggta tgaaagctcc agaaatgaca aatgaactga aaaatgatct
     2041 caaagcactg aagatgagag ccagcatgga cccgaaaaga ttttacaaga aaaatgatag
     2101 agatggcttc cccaagtact tccagattgg aaccattgtt gacaatccag ctgatttcta
     2161 ccattcacga attcccaaga agcaaaggaa aagaactatt gtggaagaac tgctggctga
     2221 ttctgaattc agaagataca accgaaggaa gtactcagag atcatggctg aaaaagcagc
     2281 aaatgcagca ggaaaaaagt tccgaaagaa gaagaaattt cgcaattaag atttaccaag
     2341 caaactgcaa cattttacat tgctccttta tttacttatt aaagacgttt ggaaaactaa
     2401 caccatcatc taaattaatt taccatagac tggccctgtt catacaggaa tttgtatttg
     2461 gaaaaagttg atttgagaat cgattacatg cccttagaaa ataggggtgt ctaaaagacc
     2521 caccctggtg tagactcttt atgggaaaaa aggaaaaaaa atctcaacca ttttaagata
     2581 actgatggtt tgtaaagttt tcaatgctta gttatttaaa gaaaatttaa ttaaaagata
     2641 ggaagtataa agtttgctaa catgttcaaa gaactttaaa aaatgatcaa agatatataa
     2701 acattattgt aattaatagg tagttttatg tgtgtatgtg tgtgtgtgtc tgtgtagggg
     2761 acgggagatg gtagagaggc aatgccctat agttagctat aaaattcaga tccagaaagt
     2821 tgggatacaa agatatgaag aatatgacct agaaagcttg ggcagaggag ctgttttcct
     2881 tgcttggcaa ctgaaacagg gaggaataat tggtttttat ctagatttaa gtgttgtggt
     2941 ccaagtaaaa caggattaaa ctataattta agttggccag ggtttcttcg aagttaaccc
     3001 agcttacctc ttctccagtg gtacagtatg caccctggct aagctggttt ctggcaccca
     3061 aggagtgttg gtcatttctg ttgatacttg gtgagttgta gcttccttta tgttactatt
     3121 cactttacct ctatttttcc agcatactgc ttccttgaga tatcagcaaa tatgaaatct
     3181 tttttttttt taataatagt tttggggtac atgtgtagaa catgcaggtt acataggtat
     3241 acacgtgcca tggtggtttg ctgcacccat caacctatct acattaggta tttctcctag
     3301 tgctatccct cccctagtcc cccacccaca acaggcccca gtgtgtgatg ttcccctccc
     3361 tgtgtccatg tgttctcatt gtttacctcc cacttacgag taagaacatg cagtgtttgg
     3421 ttttctgttc ttgtgttagt tttctgttct tgctgagatg atttccagct tcagccatgt
     3481 ccctgcaaag gacatgaact catgcttttt tatggccaca tagtattcca tggtgtatat
     3541 gtgccacatt ttctttatcc agtctatcat tcatgggcat ttgggttggt tccaagtctt
     3601 ttctattgtg aacagtgcca cagtaaacat acttgtgtat gtgtctttat agtagaatga
     3661 tttataatcc tttgggtata tacccagtaa tgggattgct gggtcaaatg gtatttctgg
     3721 tcctagatcc ttgcggaatc accacactgt cttccacaat ggttgaacta gtttacactc
     3781 ccaccaacag tgtaaaagtg ttcctagttc tccatatcct ctccagcatc tgttgtttcc
     3841 tgacttttta atgattgcca ttctaactgg caatgagatg gtatctcatt gtggttttga
     3901 tttgcatttc tctaatgagc agtgataatg agcgtttttt catgtttgtt ggctgcataa
     3961 atgtcttctt ttgagaagtg tctgttcata tccttcaccc actttttgat ggggtttttt
     4021 cttgtaaatt tgtttaagtt ctttgtagat tctggatatt agccctttgt cagatggata
     4081 gattacagaa attttctccc attctgtaga ttgcctgtgc actctgataa tagtttcttt
     4141 tgctgtgcag aaactcttta gtttaattag atcccacttg tcaattttgc cttttgttgc
     4201 cattgctttt ggtgttttag tcatgcagtc tgcccatacc tatgtccaaa atctcatatt
     4261 tactgcttgg agtcaaaagc tagtaatagc agaactgaca ataacattca tagttggagt
     4321 tagggaagca tctatgtctg ttctctttta ttttaaaaaa aaactacttt tgtttctgga
     4381 atactatgtt ttgccttcta ctggataaaa taaggaccca gtatgagaga attgtatcct
     4441 ttagtgcttc tggccttcta caaatacctg gatatttaaa taatggatga agttatgttt
     4501 tgctttttaa taagcaagtc ttttgagaaa caggttttac tgactttggc ctgtgtcact
     4561 aaactcagtt cacctactgg aacttttttt tttttttttg agacgtctca ctccatcacc
     4621 caggttggag tgcagtggtg ccatctcagc tcactgcaac ctccgcctcc caagttcaag
     4681 cgattatcat acctcagcct gccaagtagc tgggactact gggcatgcca ttatgcccag
     4741 ctaacttttg tatttttagt agagatgggg ttttgccatc cttacctcaa gtgatccacc
     4801 cgcctcggcc tcccaaagtg ctgggattac aggtgtgagc caccatgccc agccaactgg
     4861 aactatttga aggctttata ccagaaaagt ataaagaatc caaagggctg ccacagtcag
     4921 gtgtgctggt gaaagagacc ttcaagatac ccctgagaag atcttgaaag atttcgaaaa
     4981 gaatgctgta tttatacacc atctggctcc aagatgcttt tttttttttt ttttttgaga
     5041 gacggactct cgctctgtcg cccaggctgg agtgtagtgg catgatcttg gttcactgca
     5101 acctccgcct cccgggttca agcaattctg cctcagcctc ccaagtacct gggattaaca
     5161 ggcacccacc accacacccg gctaattttt gtatttttag tagagacggg gtttcaccat
     5221 gttggccagg ctggtcttga acttctgacc tcaggtgatc caccggcctc agcctcccaa
     5281 agtgctggga ttacaggcag gagccaccac gtctggccca aaatgttctt aaaacaaagt
     5341 agatgctgta agactacagt tgataaagtt gggctctggg ctaggttctt agcatccaac
     5401 acaatcagtt ctgtgttcag tgttctgctg tatgataaac caactgctct agagaaacac
     5461 caatattcct cttctgaaac ctgggaaaat gtcttttttg ggtcccataa ctagatgtca
     5521 caaaaggagt ggggagtggg gaggctatat aaaaaagttc aacaaaacct tagtaactgg
     5581 tatacattaa taggatccca ttcttagaaa cagcaagtta aagaaaatac cataatggga
     5641 aaaaaaagtt aacatttctg agagatgtac caggtattca gtctctcagg cagtgacaac
     5701 ttgttcagaa taattaccta caatagatcc caaaccattg aaaaatgcct aattgtttac
     5761 ttaatggaat ttgtacttac tatttaatta gatgaatatc tttattgaaa gttttcagta
     5821 agggttgcaa caaaaagggc tttctaatta accaattccc caagcatctg tctaattaaa
     5881 atgtaaagtg caatta
//
