LOCUS       NM_052951               1264 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens deoxynucleotidyltransferase terminal interacting
            protein 1 (DNTTIP1), mRNA.
ACCESSION   NM_052951
VERSION     NM_052951.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1264)
  AUTHORS   Ding,S., Gao,Y., Lv,D., Tao,Y., Liu,S., Chen,C., Huang,Z.,
            Zheng,S., Hu,Y., Chow,L.K., Wei,Y., Feng,P., Dai,W., Wang,X. and
            Xia,Y.
  TITLE     DNTTIP1 promotes nasopharyngeal carcinoma metastasis via recruiting
            HDAC1 to DUSP2 promoter and activating ERK signaling pathway
  JOURNAL   EBioMedicine 81, 104100 (2022)
   PUBMED   35689852
  REMARK    GeneRIF: DNTTIP1 promotes nasopharyngeal carcinoma metastasis via
            recruiting HDAC1 to DUSP2 promoter and activating ERK signaling
            pathway.
REFERENCE   2  (bases 1 to 1264)
  AUTHORS   Liu,Q., Xiong,J., Xu,D., Hao,N., Zhang,Y., Sang,Y., Wang,Z.,
            Zheng,X., Min,J., Diao,H., Raphael,J., Maleki Vareki,S.,
            Koropatnick,J. and Min,W.
  TITLE     TdIF1-LSD1 Axis Regulates Epithelial-Mesenchymal Transition and
            Metastasis via Histone Demethylation of E-Cadherin Promoter in Lung
            Cancer
  JOURNAL   Int J Mol Sci 23 (1), 250 (2021)
   PUBMED   35008676
  REMARK    GeneRIF: TdIF1-LSD1 Axis Regulates Epithelial-Mesenchymal
            Transition and Metastasis via Histone Demethylation of E-Cadherin
            Promoter in Lung Cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1264)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 1264)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1264)
  AUTHORS   Sawai,Y., Kasamatsu,A., Nakashima,D., Fushimi,K., Kasama,H.,
            Iyoda,M., Kouzu,Y., Shiiba,M., Tanzawa,H. and Uzawa,K.
  TITLE     Critical role of deoxynucleotidyl transferase terminal interacting
            protein 1 in oral cancer
  JOURNAL   Lab Invest 98 (8), 980-988 (2018)
   PUBMED   29855544
  REMARK    GeneRIF: Overexpressed deoxynucleotidyltransferase terminal
            interacting protein 1 (DNTTIP1) was observed in oral squamous cell
            carcinomas (OSCCs) in vitro and in vivo and was correlated
            positively with tumoral growth.
REFERENCE   6  (bases 1 to 1264)
  AUTHORS   Kubota,T., Maezawa,S., Koiwai,K., Hayano,T. and Koiwai,O.
  TITLE     Identification of functional domains in TdIF1 and its inhibitory
            mechanism for TdT activity
  JOURNAL   Genes Cells 12 (8), 941-959 (2007)
   PUBMED   17663723
  REMARK    GeneRIF: The TdT binding, DNA binding and dimerization regions, and
            nuclear localization signal (NLS) in TdIF1, were identified.
REFERENCE   7  (bases 1 to 1264)
  AUTHORS   Fujisaki,S., Sato,A., Toyomoto,T., Hayano,T., Sugai,M., Kubota,T.
            and Koiwai,O.
  TITLE     Direct binding of TReP-132 with TdT results in reduction of TdT
            activity
  JOURNAL   Genes Cells 11 (1), 47-57 (2006)
   PUBMED   16371131
REFERENCE   8  (bases 1 to 1264)
  AUTHORS   Tomarev,S.I., Wistow,G., Raymond,V., Dubois,S. and Malyukova,I.
  TITLE     Gene expression profile of the human trabecular meshwork: NEIBank
            sequence tag analysis
  JOURNAL   Invest Ophthalmol Vis Sci 44 (6), 2588-2596 (2003)
   PUBMED   12766061
REFERENCE   9  (bases 1 to 1264)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
REFERENCE   10 (bases 1 to 1264)
  AUTHORS   Yamashita,N., Shimazaki,N., Ibe,S., Kaneko,R., Tanabe,A.,
            Toyomoto,T., Fujita,K., Hasegawa,T., Toji,S., Tamai,K., Yamamoto,H.
            and Koiwai,O.
  TITLE     Terminal deoxynucleotidyltransferase directly interacts with a
            novel nuclear protein that is homologous to p65
  JOURNAL   Genes Cells 6 (7), 641-652 (2001)
   PUBMED   11473582
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BG720866.1 and AB035676.1.
            
            On Nov 22, 2018 this sequence version replaced NM_052951.2.
            
            Summary: DNTTIP1 binds DNA and enhances the activity of terminal
            deoxynucleotidyltransferase (TDT, or DNTT; MIM 187410), a DNA
            polymerase that catalyzes the polymerization of DNA in the absence
            of a DNA template (Yamashita et al., 2001 [PubMed
            11473582]).[supplied by OMIM, Mar 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.1064637.1, AB035676.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372622.8/ ENSP00000361705.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-557               BG720866.1         23-579
            558-1264            AB035676.1         570-1276
FEATURES             Location/Qualifiers
     source          1..1264
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.12"
     gene            1..1264
                     /gene="DNTTIP1"
                     /gene_synonym="C20orf167; dJ447F3.4; Tdif1"
                     /note="deoxynucleotidyltransferase terminal interacting
                     protein 1"
                     /db_xref="GeneID:116092"
                     /db_xref="HGNC:HGNC:16160"
                     /db_xref="MIM:611388"
     exon            1..156
                     /gene="DNTTIP1"
                     /gene_synonym="C20orf167; dJ447F3.4; Tdif1"
                     /inference="alignment:Splign:2.1.0"
     CDS             52..1041
                     /gene="DNTTIP1"
                     /gene_synonym="C20orf167; dJ447F3.4; Tdif1"
                     /note="TdT binding protein; tdT-interacting factor 1;
                     terminal deoxynucleotidyltransferase-interacting factor 1"
                     /codon_start=1
                     /product="deoxynucleotidyltransferase terminal-interacting
                     protein 1"
                     /protein_id="NP_443183.1"
                     /db_xref="CCDS:CCDS13369.1"
                     /db_xref="GeneID:116092"
                     /db_xref="HGNC:HGNC:16160"
                     /db_xref="MIM:611388"
                     /translation="MGATGDAEQPRGPSGAERGGLELGDAGAAGQLVLTNPWNIMIKH
                     RQVQRRGRRSQMTTSFTDPAISMDLLRAVLQPSINEEIQTVFNKYMKFFQKAALNVRD
                     NVGEEVDAEQLIQEACRSCLEQAKLLFSDGEKVIPRLTHELPGIKRGRQAEEECAHRG
                     SPLPKKRKGRPPGHILSSDRAAAGMVWKPKSCEPIRREGPKWDPARLNESTTFVLGSR
                     ANKALGMGGTRGRIYIKHPHLFKYAADPQDKHWLAEQHHMRATGGKMAYLLIEEDIRD
                     LAASDDYRGCLDLKLEELKSFVLPSWMVEKMRKYMETLRTENEHRAVEAPPQT"
     exon            157..227
                     /gene="DNTTIP1"
                     /gene_synonym="C20orf167; dJ447F3.4; Tdif1"
                     /inference="alignment:Splign:2.1.0"
     exon            228..324
                     /gene="DNTTIP1"
                     /gene_synonym="C20orf167; dJ447F3.4; Tdif1"
                     /inference="alignment:Splign:2.1.0"
     exon            325..423
                     /gene="DNTTIP1"
                     /gene_synonym="C20orf167; dJ447F3.4; Tdif1"
                     /inference="alignment:Splign:2.1.0"
     exon            424..492
                     /gene="DNTTIP1"
                     /gene_synonym="C20orf167; dJ447F3.4; Tdif1"
                     /inference="alignment:Splign:2.1.0"
     exon            493..549
                     /gene="DNTTIP1"
                     /gene_synonym="C20orf167; dJ447F3.4; Tdif1"
                     /inference="alignment:Splign:2.1.0"
     exon            550..608
                     /gene="DNTTIP1"
                     /gene_synonym="C20orf167; dJ447F3.4; Tdif1"
                     /inference="alignment:Splign:2.1.0"
     exon            609..654
                     /gene="DNTTIP1"
                     /gene_synonym="C20orf167; dJ447F3.4; Tdif1"
                     /inference="alignment:Splign:2.1.0"
     exon            655..713
                     /gene="DNTTIP1"
                     /gene_synonym="C20orf167; dJ447F3.4; Tdif1"
                     /inference="alignment:Splign:2.1.0"
     exon            714..774
                     /gene="DNTTIP1"
                     /gene_synonym="C20orf167; dJ447F3.4; Tdif1"
                     /inference="alignment:Splign:2.1.0"
     exon            775..846
                     /gene="DNTTIP1"
                     /gene_synonym="C20orf167; dJ447F3.4; Tdif1"
                     /inference="alignment:Splign:2.1.0"
     exon            847..902
                     /gene="DNTTIP1"
                     /gene_synonym="C20orf167; dJ447F3.4; Tdif1"
                     /inference="alignment:Splign:2.1.0"
     exon            903..1264
                     /gene="DNTTIP1"
                     /gene_synonym="C20orf167; dJ447F3.4; Tdif1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1241..1246
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DNTTIP1"
                     /gene_synonym="C20orf167; dJ447F3.4; Tdif1"
                     /note="hexamer: ATTAAA"
     polyA_site      1264
                     /gene="DNTTIP1"
                     /gene_synonym="C20orf167; dJ447F3.4; Tdif1"
                     /note="major polyA site"
ORIGIN      
        1 actttccggc cggtgacaga gtccagcgga gttgtggggg ccgggggcgc catgggagcc
       61 actggcgacg ccgagcagcc gcggggacct agcggggccg agaggggcgg cttggagctg
      121 ggggatgcgg gcgcagcggg gcagctggtt cttacgaacc cttggaacat aatgataaag
      181 caccggcagg tgcagcggag gggccgccgc tcacagatga caacaagttt cacagatcct
      241 gccatctcca tggatctcct ccgagctgtc ctgcagccca gcatcaacga ggagatccag
      301 actgtcttca acaagtacat gaagttcttc cagaaggcag cactgaacgt gcgagacaat
      361 gttggggagg aggtggacgc agagcagctg atccaggaag cctgtcggag ctgcctggag
      421 caggctaaac tgctcttttc agatggagaa aaagtaatac ccagattgac ccatgagctt
      481 ccaggaataa agcgtggccg tcaggcagaa gaagaatgtg cccatcgagg aagccccctt
      541 cctaaaaaga ggaaaggacg gcctcctgga cacatcctgt caagcgaccg ggcagccgcc
      601 ggcatggtat ggaaaccaaa atcctgtgaa ccaattcgcc gggaaggccc caagtgggac
      661 ccagctcgcc tgaatgaatc taccaccttt gtgttgggat ctcgagccaa caaagccctg
      721 gggatggggg gcaccagagg aagaatctac atcaagcacc cacacctctt taagtatgca
      781 gctgaccccc aggataagca ctggctggct gagcagcatc acatgcgggc aacagggggc
      841 aagatggcct acctcctcat cgaggaggac atccgggacc ttgcggccag tgatgattac
      901 agaggatgcc tggatctgaa gctagaggaa ttgaaatcct ttgtcctacc ctcctggatg
      961 gtggagaaga tgagaaagta tatggagaca ctacggacag agaatgagca tcgtgctgtt
     1021 gaagcacctc cacagacctg aggccgggtc ccctggccac acttggcagc cctcctccaa
     1081 agccctcttc ctcacgtggc tgaggccacc gctgggactg ctcctagatg gatctcagcg
     1141 gcattaagct gtgcctgagc gagtttgtag tgactcactg cacagcaccc ccagactagc
     1201 atgtggttct atatttgtaa agttattggg ataagaaaca attaaacagt ttgtagtaaa
     1261 caca
//
