LOCUS       NM_001130823            5274 bp    mRNA    linear   PRI 15-OCT-2024
DEFINITION  Homo sapiens DNA methyltransferase 1 (DNMT1), transcript variant 1,
            mRNA.
ACCESSION   NM_001130823
VERSION     NM_001130823.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5274)
  AUTHORS   De,I., Weidenhausen,J., Concha,N. and Muller,C.W.
  TITLE     Structural insight into the DNMT1 reaction cycle by cryo-electron
            microscopy
  JOURNAL   PLoS One 19 (9), e0307850 (2024)
   PUBMED   39226277
  REMARK    GeneRIF: Structural insight into the DNMT1 reaction cycle by
            cryo-electron microscopy.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5274)
  AUTHORS   Wang,R., Yu,X., Ye,H., Ao,M., Xi,M. and Hou,M.
  TITLE     LncRNA FAM83H-AS1 inhibits ferroptosis of endometrial cancer by
            promoting DNMT1-mediated CDO1 promoter hypermethylation
  JOURNAL   J Biol Chem 300 (9), 107680 (2024)
   PUBMED   39159808
  REMARK    GeneRIF: LncRNA FAM83H-AS1 inhibits ferroptosis of endometrial
            cancer by promoting DNMT1-mediated CDO1 promoter hypermethylation.
REFERENCE   3  (bases 1 to 5274)
  AUTHORS   Bonfils,C., Beaulieu,N., Chan,E., Cotton-Montpetit,J. and
            MacLeod,A.R.
  TITLE     Characterization of the human DNA methyltransferase splice variant
            Dnmt1b
  JOURNAL   J Biol Chem 275 (15), 10754-10760 (2000)
   PUBMED   10753866
REFERENCE   4  (bases 1 to 5274)
  AUTHORS   Bigey,P., Ramchandani,S., Theberge,J., Araujo,F.D. and Szyf,M.
  TITLE     Transcriptional regulation of the human DNA Methyltransferase
            (dnmt1) gene
  JOURNAL   Gene 242 (1-2), 407-418 (2000)
   PUBMED   10721735
REFERENCE   5  (bases 1 to 5274)
  AUTHORS   Hsu,D.W., Lin,M.J., Lee,T.L., Wen,S.C., Chen,X. and Shen,C.K.
  TITLE     Two major forms of DNA (cytosine-5) methyltransferase in human
            somatic tissues
  JOURNAL   Proc Natl Acad Sci U S A 96 (17), 9751-9756 (1999)
   PUBMED   10449766
REFERENCE   6  (bases 1 to 5274)
  AUTHORS   Yoder,J.A., Yen,R.W., Vertino,P.M., Bestor,T.H. and Baylin,S.B.
  TITLE     New 5' regions of the murine and human genes for DNA
            (cytosine-5)-methyltransferase
  JOURNAL   J Biol Chem 271 (49), 31092-31097 (1996)
   PUBMED   8940105
REFERENCE   7  (bases 1 to 5274)
  AUTHORS   Klein,C.J.
  TITLE     DNMT1-Related Disorder
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   22338191
REFERENCE   8  (bases 1 to 5274)
  AUTHORS   Yen,R.W., Vertino,P.M., Nelkin,B.D., Yu,J.J., el-Deiry,W.,
            Cumaraswamy,A., Lennon,G.G., Trask,B.J., Celano,P. and Baylin,S.B.
  TITLE     Isolation and characterization of the cDNA encoding human DNA
            methyltransferase
  JOURNAL   Nucleic Acids Res 20 (9), 2287-2291 (1992)
   PUBMED   1594447
REFERENCE   9  (bases 1 to 5274)
  AUTHORS   el-Deiry,W.S., Nelkin,B.D., Celano,P., Yen,R.W., Falco,J.P.,
            Hamilton,S.R. and Baylin,S.B.
  TITLE     High expression of the DNA methyltransferase gene characterizes
            human neoplastic cells and progression stages of colon cancer
  JOURNAL   Proc Natl Acad Sci U S A 88 (8), 3470-3474 (1991)
   PUBMED   2014266
REFERENCE   10 (bases 1 to 5274)
  AUTHORS   Bestor,T.H.
  TITLE     DNA methylation: evolution of a bacterial immune function into a
            regulator of gene expression and genome structure in higher
            eukaryotes
  JOURNAL   Philos Trans R Soc Lond B Biol Sci 326 (1235), 179-187 (1990)
   PUBMED   1968655
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC126227.1, BC092517.1,
            DA653750.1 and X63692.1.
            
            On Nov 24, 2018 this sequence version replaced NM_001130823.2.
            
            Summary: This gene encodes an enzyme that transfers methyl groups
            to cytosine nucleotides of genomic DNA. This protein is the major
            enzyme responsible for maintaining methylation patterns following
            DNA replication and shows a preference for hemi-methylated DNA.
            Methylation of DNA is an important component of mammalian
            epigenetic gene regulation. Aberrant methylation patterns are found
            in human tumors and associated with developmental abnormalities.
            Variation in this gene has been associated with cerebellar ataxia,
            deafness, and narcolepsy, and neuropathy, hereditary sensory, type
            IE. Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Jan 2016].
            
            Transcript Variant: This variant (1, also known as Dnmt1b in PMIDs
            10449766 and 10753866) represents the longest transcript and
            encodes the longest isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC144093.1, SRR11853567.15044.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000359526.9/ ENSP00000352516.3
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1442              BC126227.1         127-1568
            1443-1835           BC092517.1         1384-1776
            1836-1870           DA653750.1         65-99
            1871-5274           X63692.1           2006-5409
FEATURES             Location/Qualifiers
     source          1..5274
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.2"
     gene            1..5274
                     /gene="DNMT1"
                     /gene_synonym="ADCADN; AIM; CXXC9; DNMT; HSN1E; m.HsaI;
                     MCMT"
                     /note="DNA methyltransferase 1"
                     /db_xref="GeneID:1786"
                     /db_xref="HGNC:HGNC:2976"
                     /db_xref="MIM:126375"
     exon            1..134
                     /gene="DNMT1"
                     /gene_synonym="ADCADN; AIM; CXXC9; DNMT; HSN1E; m.HsaI;
                     MCMT"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..4953
                     /gene="DNMT1"
                     /gene_synonym="ADCADN; AIM; CXXC9; DNMT; HSN1E; m.HsaI;
                     MCMT"
                     /EC_number="2.1.1.37"
                     /note="isoform a is encoded by transcript variant 1; DNA
                     MTase HsaI; DNA methyltransferase HsaI; CXXC-type zinc
                     finger protein 9; DNA (cytosine-5-)-methyltransferase 1"
                     /codon_start=1
                     /product="DNA (cytosine-5)-methyltransferase 1 isoform a"
                     /protein_id="NP_001124295.1"
                     /db_xref="CCDS:CCDS45958.1"
                     /db_xref="GeneID:1786"
                     /db_xref="HGNC:HGNC:2976"
                     /db_xref="MIM:126375"
                     /translation="MPARTAPARVPTLAVPAISLPDDVRRRLKDLERDSLTEKECVKE
                     KLNLLHEFLQTEIKNQLCDLETKLRKEELSEEGYLAKVKSLLNKDLSLENGAHAYNRE
                     VNGRLENGNQARSEARRVGMADANSPPKPLSKPRTPRRSKSDGEAKRSRDPPASASQV
                     TGIRAEPSPSPRITRKSTRQTTITSHFAKGPAKRKPQEESERAKSDESIKEEDKDQDE
                     KRRRVTSRERVARPLPAEEPERAKSGTRTEKEEERDEKEEKRLRSQTKEPTPKQKLKE
                     EPDREARAGVQADEDEDGDEKDEKKHRSQPKDLAAKRRPEEKEPEKVNPQISDEKDED
                     EKEEKRRKTTPKEPTEKKMARAKTVMNSKTHPPKCIQCGQYLDDPDLKYGQHPPDAVD
                     EPQMLTNEKLSIFDANESGFESYEALPQHKLTCFSVYCKHGHLCPIDTGLIEKNIELF
                     FSGSAKPIYDDDPSLEGGVNGKNLGPINEWWITGFDGGEKALIGFSTSFAEYILMDPS
                     PEYAPIFGLMQEKIYISKIVVEFLQSNSDSTYEDLINKIETTVPPSGLNLNRFTEDSL
                     LRHAQFVVEQVESYDEAGDSDEQPIFLTPCMRDLIKLAGVTLGQRRAQARRQTIRHST
                     REKDRGPTKATTTKLVYQIFDTFFAEQIEKDDREDKENAFKRRRCGVCEVCQQPECGK
                     CKACKDMVKFGGSGRSKQACQERRCPNMAMKEADDDEEVDDNIPEMPSPKKMHQGKKK
                     KQNKNRISWVGEAVKTDGKKSYYKKVCIDAETLEVGDCVSVIPDDSSKPLYLARVTAL
                     WEDSSNGQMFHAHWFCAGTDTVLGATSDPLELFLVDECEDMQLSYIHSKVKVIYKAPS
                     ENWAMEGGMDPESLLEGDDGKTYFYQLWYDQDYARFESPPKTQPTEDNKFKFCVSCAR
                     LAEMRQKEIPRVLEQLEDLDSRVLYYSATKNGILYRVGDGVYLPPEAFTFNIKLSSPV
                     KRPRKEPVDEDLYPEHYRKYSDYIKGSNLDAPEPYRIGRIKEIFCPKKSNGRPNETDI
                     KIRVNKFYRPENTHKSTPASYHADINLLYWSDEEAVVDFKAVQGRCTVEYGEDLPECV
                     QVYSMGGPNRFYFLEAYNAKSKSFEDPPNHARSPGNKGKGKGKGKGKPKSQACEPSEP
                     EIEIKLPKLRTLDVFSGCGGLSEGFHQAGISDTLWAIEMWDPAAQAFRLNNPGSTVFT
                     EDCNILLKLVMAGETTNSRGQRLPQKGDVEMLCGGPPCQGFSGMNRFNSRTYSKFKNS
                     LVVSFLSYCDYYRPRFFLLENVRNFVSFKRSMVLKLTLRCLVRMGYQCTFGVLQAGQY
                     GVAQTRRRAIILAAAPGEKLPLFPEPLHVFAPRACQLSVVVDDKKFVSNITRLSSGPF
                     RTITVRDTMSDLPEVRNGASALEISYNGEPQSWFQRQLRGAQYQPILRDHICKDMSAL
                     VAARMRHIPLAPGSDWRDLPNIEVRLSDGTMARKLRYTHHDRKNGRSSSGALRGVCSC
                     VEAGKACDPAARQFNTLIPWCLPHTGNRHNHWAGLYGRLEWDGFFSTTVTNPEPMGKQ
                     GRVLHPEQHRVVSVRECARSQGFPDTYRLFGNILDKHRQVGNAVPPPLAKAIGLEIKL
                     CMLAKARESASAKIKEEEAAKD"
     exon            135..171
                     /gene="DNMT1"
                     /gene_synonym="ADCADN; AIM; CXXC9; DNMT; HSN1E; m.HsaI;
                     MCMT"
                     /inference="alignment:Splign:2.1.0"
     exon            172..279
                     /gene="DNMT1"
                     /gene_synonym="ADCADN; AIM; CXXC9; DNMT; HSN1E; m.HsaI;
                     MCMT"
                     /inference="alignment:Splign:2.1.0"
     exon            280..499
                     /gene="DNMT1"
                     /gene_synonym="ADCADN; AIM; CXXC9; DNMT; HSN1E; m.HsaI;
                     MCMT"
                     /inference="alignment:Splign:2.1.0"
     exon            500..547
                     /gene="DNMT1"
                     /gene_synonym="ADCADN; AIM; CXXC9; DNMT; HSN1E; m.HsaI;
                     MCMT"
                     /inference="alignment:Splign:2.1.0"
     exon            548..623
                     /gene="DNMT1"
                     /gene_synonym="ADCADN; AIM; CXXC9; DNMT; HSN1E; m.HsaI;
                     MCMT"
                     /inference="alignment:Splign:2.1.0"
     exon            624..702
                     /gene="DNMT1"
                     /gene_synonym="ADCADN; AIM; CXXC9; DNMT; HSN1E; m.HsaI;
                     MCMT"
                     /inference="alignment:Splign:2.1.0"
     exon            703..737
                     /gene="DNMT1"
                     /gene_synonym="ADCADN; AIM; CXXC9; DNMT; HSN1E; m.HsaI;
                     MCMT"
                     /inference="alignment:Splign:2.1.0"
     exon            738..822
                     /gene="DNMT1"
                     /gene_synonym="ADCADN; AIM; CXXC9; DNMT; HSN1E; m.HsaI;
                     MCMT"
                     /inference="alignment:Splign:2.1.0"
     exon            823..857
                     /gene="DNMT1"
                     /gene_synonym="ADCADN; AIM; CXXC9; DNMT; HSN1E; m.HsaI;
                     MCMT"
                     /inference="alignment:Splign:2.1.0"
     exon            858..945
                     /gene="DNMT1"
                     /gene_synonym="ADCADN; AIM; CXXC9; DNMT; HSN1E; m.HsaI;
                     MCMT"
                     /inference="alignment:Splign:2.1.0"
     exon            946..980
                     /gene="DNMT1"
                     /gene_synonym="ADCADN; AIM; CXXC9; DNMT; HSN1E; m.HsaI;
                     MCMT"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1062
                     /gene="DNMT1"
                     /gene_synonym="ADCADN; AIM; CXXC9; DNMT; HSN1E; m.HsaI;
                     MCMT"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..1097
                     /gene="DNMT1"
                     /gene_synonym="ADCADN; AIM; CXXC9; DNMT; HSN1E; m.HsaI;
                     MCMT"
                     /inference="alignment:Splign:2.1.0"
     exon            1098..1143
                     /gene="DNMT1"
                     /gene_synonym="ADCADN; AIM; CXXC9; DNMT; HSN1E; m.HsaI;
                     MCMT"
                     /inference="alignment:Splign:2.1.0"
     exon            1144..1224
                     /gene="DNMT1"
                     /gene_synonym="ADCADN; AIM; CXXC9; DNMT; HSN1E; m.HsaI;
                     MCMT"
                     /inference="alignment:Splign:2.1.0"
     exon            1225..1334
                     /gene="DNMT1"
                     /gene_synonym="ADCADN; AIM; CXXC9; DNMT; HSN1E; m.HsaI;
                     MCMT"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1453
                     /gene="DNMT1"
                     /gene_synonym="ADCADN; AIM; CXXC9; DNMT; HSN1E; m.HsaI;
                     MCMT"
                     /inference="alignment:Splign:2.1.0"
     exon            1454..1546
                     /gene="DNMT1"
                     /gene_synonym="ADCADN; AIM; CXXC9; DNMT; HSN1E; m.HsaI;
                     MCMT"
                     /inference="alignment:Splign:2.1.0"
     exon            1547..1698
                     /gene="DNMT1"
                     /gene_synonym="ADCADN; AIM; CXXC9; DNMT; HSN1E; m.HsaI;
                     MCMT"
                     /inference="alignment:Splign:2.1.0"
     exon            1699..1886
                     /gene="DNMT1"
                     /gene_synonym="ADCADN; AIM; CXXC9; DNMT; HSN1E; m.HsaI;
                     MCMT"
                     /inference="alignment:Splign:2.1.0"
     exon            1887..2073
                     /gene="DNMT1"
                     /gene_synonym="ADCADN; AIM; CXXC9; DNMT; HSN1E; m.HsaI;
                     MCMT"
                     /inference="alignment:Splign:2.1.0"
     exon            2074..2171
                     /gene="DNMT1"
                     /gene_synonym="ADCADN; AIM; CXXC9; DNMT; HSN1E; m.HsaI;
                     MCMT"
                     /inference="alignment:Splign:2.1.0"
     exon            2172..2319
                     /gene="DNMT1"
                     /gene_synonym="ADCADN; AIM; CXXC9; DNMT; HSN1E; m.HsaI;
                     MCMT"
                     /inference="alignment:Splign:2.1.0"
     exon            2320..2435
                     /gene="DNMT1"
                     /gene_synonym="ADCADN; AIM; CXXC9; DNMT; HSN1E; m.HsaI;
                     MCMT"
                     /inference="alignment:Splign:2.1.0"
     exon            2436..2640
                     /gene="DNMT1"
                     /gene_synonym="ADCADN; AIM; CXXC9; DNMT; HSN1E; m.HsaI;
                     MCMT"
                     /inference="alignment:Splign:2.1.0"
     exon            2641..2774
                     /gene="DNMT1"
                     /gene_synonym="ADCADN; AIM; CXXC9; DNMT; HSN1E; m.HsaI;
                     MCMT"
                     /inference="alignment:Splign:2.1.0"
     exon            2775..2948
                     /gene="DNMT1"
                     /gene_synonym="ADCADN; AIM; CXXC9; DNMT; HSN1E; m.HsaI;
                     MCMT"
                     /inference="alignment:Splign:2.1.0"
     exon            2949..3170
                     /gene="DNMT1"
                     /gene_synonym="ADCADN; AIM; CXXC9; DNMT; HSN1E; m.HsaI;
                     MCMT"
                     /inference="alignment:Splign:2.1.0"
     exon            3171..3363
                     /gene="DNMT1"
                     /gene_synonym="ADCADN; AIM; CXXC9; DNMT; HSN1E; m.HsaI;
                     MCMT"
                     /inference="alignment:Splign:2.1.0"
     exon            3364..3448
                     /gene="DNMT1"
                     /gene_synonym="ADCADN; AIM; CXXC9; DNMT; HSN1E; m.HsaI;
                     MCMT"
                     /inference="alignment:Splign:2.1.0"
     exon            3449..3577
                     /gene="DNMT1"
                     /gene_synonym="ADCADN; AIM; CXXC9; DNMT; HSN1E; m.HsaI;
                     MCMT"
                     /inference="alignment:Splign:2.1.0"
     exon            3578..3860
                     /gene="DNMT1"
                     /gene_synonym="ADCADN; AIM; CXXC9; DNMT; HSN1E; m.HsaI;
                     MCMT"
                     /inference="alignment:Splign:2.1.0"
     exon            3861..4002
                     /gene="DNMT1"
                     /gene_synonym="ADCADN; AIM; CXXC9; DNMT; HSN1E; m.HsaI;
                     MCMT"
                     /inference="alignment:Splign:2.1.0"
     exon            4003..4169
                     /gene="DNMT1"
                     /gene_synonym="ADCADN; AIM; CXXC9; DNMT; HSN1E; m.HsaI;
                     MCMT"
                     /inference="alignment:Splign:2.1.0"
     exon            4170..4347
                     /gene="DNMT1"
                     /gene_synonym="ADCADN; AIM; CXXC9; DNMT; HSN1E; m.HsaI;
                     MCMT"
                     /inference="alignment:Splign:2.1.0"
     exon            4348..4543
                     /gene="DNMT1"
                     /gene_synonym="ADCADN; AIM; CXXC9; DNMT; HSN1E; m.HsaI;
                     MCMT"
                     /inference="alignment:Splign:2.1.0"
     exon            4544..4710
                     /gene="DNMT1"
                     /gene_synonym="ADCADN; AIM; CXXC9; DNMT; HSN1E; m.HsaI;
                     MCMT"
                     /inference="alignment:Splign:2.1.0"
     exon            4711..4827
                     /gene="DNMT1"
                     /gene_synonym="ADCADN; AIM; CXXC9; DNMT; HSN1E; m.HsaI;
                     MCMT"
                     /inference="alignment:Splign:2.1.0"
     exon            4828..4918
                     /gene="DNMT1"
                     /gene_synonym="ADCADN; AIM; CXXC9; DNMT; HSN1E; m.HsaI;
                     MCMT"
                     /inference="alignment:Splign:2.1.0"
     exon            4919..5274
                     /gene="DNMT1"
                     /gene_synonym="ADCADN; AIM; CXXC9; DNMT; HSN1E; m.HsaI;
                     MCMT"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5253..5258
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DNMT1"
                     /gene_synonym="ADCADN; AIM; CXXC9; DNMT; HSN1E; m.HsaI;
                     MCMT"
                     /note="hexamer: AATAAA"
     polyA_site      5274
                     /gene="DNMT1"
                     /gene_synonym="ADCADN; AIM; CXXC9; DNMT; HSN1E; m.HsaI;
                     MCMT"
                     /note="major polyA site"
ORIGIN      
        1 gcgaaaagcc ggggcgcctg cgctgccgcc gccgcgtctg ctgaagcctc cgagatgccg
       61 gcgcgtaccg ccccagcccg ggtgcccaca ctggccgtcc cggccatctc gctgcccgac
      121 gatgtccgca ggcggctcaa agatttggaa agagacagct taacagaaaa ggaatgtgtg
      181 aaggagaaat tgaatctctt gcacgaattt ctgcaaacag aaataaagaa tcagttatgt
      241 gacttggaaa ccaaattacg taaagaagaa ttatccgagg agggctacct ggctaaagtc
      301 aaatcccttt taaataaaga tttgtccttg gagaacggtg ctcatgctta caaccgggaa
      361 gtgaatggac gtctagaaaa cgggaaccaa gcaagaagtg aagcccgtag agtgggaatg
      421 gcagatgcca acagcccccc caaacccctt tccaaacctc gcacgcccag gaggagcaag
      481 tccgatggag aggctaagcg ttcaagagac cctcctgcct cagcctccca agtaactggg
      541 attagagctg aaccttcacc tagccccagg attacaagga aaagcaccag gcaaaccacc
      601 atcacatctc attttgcaaa gggccctgcc aaacggaaac ctcaggaaga gtctgaaaga
      661 gccaaatcgg atgagtccat caaggaagaa gacaaagacc aggatgagaa gagacgtaga
      721 gttacatcca gagaacgagt tgctagaccg cttcctgcag aagaacctga aagagcaaaa
      781 tcaggaacgc gcactgaaaa ggaagaagaa agagatgaaa aagaagaaaa gagactccga
      841 agtcaaacca aagaaccaac acccaaacag aaactgaagg aggagccgga cagagaagcc
      901 agggcaggcg tgcaggctga cgaggacgaa gatggagacg agaaagatga gaagaagcac
      961 agaagtcaac ccaaagatct agctgccaaa cggaggcccg aagaaaaaga acctgaaaaa
     1021 gtaaatccac agatttctga tgaaaaagac gaggatgaaa aggaggagaa gagacgcaaa
     1081 acgaccccca aagaaccaac ggagaaaaaa atggctcgcg ccaaaacagt catgaactcc
     1141 aagacccacc ctcccaagtg cattcagtgc gggcagtacc tggacgaccc tgacctcaaa
     1201 tatgggcagc acccaccaga cgcggtggat gagccacaga tgctgacaaa tgagaagctg
     1261 tccatctttg atgccaacga gtctggcttt gagagttatg aggcgcttcc ccagcacaaa
     1321 ctgacctgct tcagtgtgta ctgtaagcac ggtcacctgt gtcccatcga caccggcctc
     1381 atcgagaaga atatcgaact cttcttttct ggttcagcaa aaccaatcta tgatgatgac
     1441 ccatctcttg aaggtggtgt taatggcaaa aatcttggcc ccataaatga atggtggatc
     1501 actggctttg atggaggtga aaaggccctc atcggcttca gcacctcatt tgccgaatac
     1561 attctgatgg atcccagtcc cgagtatgcg cccatatttg ggctgatgca ggagaagatc
     1621 tacatcagca agattgtggt ggagttcctg cagagcaatt ccgactcgac ctatgaggac
     1681 ctgatcaaca agatcgagac cacggttcct ccttctggcc tcaacttgaa ccgcttcaca
     1741 gaggactccc tcctgcgaca cgcgcagttt gtggtggagc aggtggagag ttatgacgag
     1801 gccggggaca gtgatgagca gcccatcttc ctgacaccct gcatgcggga cctgatcaag
     1861 ctggctgggg tcacgctggg acagaggcga gcccaggcga ggcggcagac catcaggcat
     1921 tctaccaggg agaaggacag gggacccacg aaagccacca ccaccaagct ggtctaccag
     1981 atcttcgata ctttcttcgc agagcaaatt gaaaaggatg acagagaaga caaggagaac
     2041 gcctttaagc gccggcgatg tggcgtctgt gaggtgtgtc agcagcctga gtgtgggaaa
     2101 tgtaaagcct gcaaggacat ggttaaattt ggtggcagtg gacggagcaa gcaggcttgc
     2161 caagagcgga ggtgtcccaa tatggccatg aaggaggcag atgacgatga ggaagtcgat
     2221 gataacatcc cagagatgcc gtcacccaaa aaaatgcacc aggggaagaa gaagaaacag
     2281 aacaagaatc gcatctcttg ggtcggagaa gccgtcaaga ctgatgggaa gaagagttac
     2341 tataagaagg tgtgcattga tgcggaaacc ctggaagtgg gggactgtgt ctctgttatt
     2401 ccagatgatt cctcaaaacc gctgtatcta gcaagggtca cggcgctgtg ggaggacagc
     2461 agcaacgggc agatgtttca cgcccactgg ttctgcgctg ggacagacac agtcctcggg
     2521 gccacgtcgg accctctgga gctgttcttg gtggatgaat gtgaggacat gcagctttca
     2581 tatatccaca gcaaagtgaa agtcatctac aaagccccct ccgaaaactg ggccatggag
     2641 ggaggcatgg atcccgagtc cctgctggag ggggacgacg ggaagaccta cttctaccag
     2701 ctgtggtatg atcaagacta cgcgagattc gagtcccctc caaaaaccca gccaacagag
     2761 gacaacaagt tcaaattctg tgtgagctgt gcccgtctgg ctgagatgag gcaaaaagaa
     2821 atccccaggg tcctggagca gctcgaggac ctggatagcc gggtcctcta ctactcagcc
     2881 accaagaacg gcatcctgta ccgagttggt gatggtgtgt acctgccccc tgaggccttc
     2941 acgttcaaca tcaagctgtc cagtcccgtg aaacgcccac ggaaggagcc cgtggatgag
     3001 gacctgtacc cagagcacta ccggaaatac tccgactaca tcaaaggcag caacctggat
     3061 gcccctgagc cctaccgaat tggccggatc aaagagatct tctgtcccaa gaagagcaac
     3121 ggcaggccca atgagactga catcaaaatc cgggtcaaca agttctacag gcctgagaac
     3181 acccacaagt ccactccagc gagctaccac gcagacatca acctgctcta ctggagcgac
     3241 gaggaggccg tggtggactt caaggctgtg cagggccgct gcaccgtgga gtatggggag
     3301 gacctgcccg agtgcgtcca ggtgtactcc atgggcggcc ccaaccgctt ctacttcctc
     3361 gaggcctata atgcaaagag caaaagcttt gaagatcctc ccaaccatgc ccgtagccct
     3421 ggaaacaaag ggaagggcaa gggaaaaggg aagggcaagc ccaagtccca agcctgtgag
     3481 ccgagcgagc cagagataga gatcaagctg cccaagctgc ggaccctgga tgtgttttct
     3541 ggctgcgggg ggttgtcgga gggattccac caagcaggca tctctgacac gctgtgggcc
     3601 atcgagatgt gggaccctgc ggcccaggcg ttccggctga acaaccccgg ctccacagtg
     3661 ttcacagagg actgcaacat cctgctgaag ctggtcatgg ctggggagac caccaactcc
     3721 cgcggccagc ggctgcccca gaagggagac gtggagatgc tgtgcggcgg gccgccctgc
     3781 cagggcttca gcggcatgaa ccgcttcaat tcgcgcacct actccaagtt caaaaactct
     3841 ctggtggttt ccttcctcag ctactgcgac tactaccggc cccggttctt cctcctggag
     3901 aatgtcagga actttgtctc cttcaagcgc tccatggtcc tgaagctcac cctccgctgc
     3961 ctggtccgca tgggctatca gtgcaccttc ggcgtgctgc aggccggtca gtacggcgtg
     4021 gcccagacta ggaggcgggc catcatcctg gccgcggccc ctggagagaa gctccctctg
     4081 ttcccggagc cactgcacgt gtttgctccc cgggcctgcc agctgagcgt ggtggtggat
     4141 gacaagaagt ttgtgagcaa cataaccagg ttgagctcgg gtcctttccg gaccatcacg
     4201 gtgcgagaca cgatgtccga cctgccggag gtgcggaatg gagcctcggc actggagatc
     4261 tcctacaacg gggagcctca gtcctggttc cagaggcagc tccggggcgc acagtaccag
     4321 cccatcctca gggaccacat ctgtaaggac atgagtgcat tggtggctgc ccgcatgcgg
     4381 cacatcccct tggccccagg gtcagactgg cgcgatctgc ccaacatcga ggtgcggctc
     4441 tcagacggca ccatggccag gaagctgcgg tatacccacc atgacaggaa gaacggccgc
     4501 agcagctctg gggccctccg tggggtctgc tcctgcgtgg aagccggcaa agcctgcgac
     4561 cccgcagcca ggcagttcaa caccctcatc ccctggtgcc tgccccacac cgggaaccgg
     4621 cacaaccact gggctggcct ctatggaagg ctcgagtggg acggcttctt cagcacaacc
     4681 gtcaccaacc ccgagcccat gggcaagcag ggccgcgtgc tccacccaga gcagcaccgt
     4741 gtggtgagcg tgcgggagtg tgcccgctcc cagggcttcc ctgacaccta ccggctcttc
     4801 ggcaacatcc tggacaagca ccggcaggtg ggcaatgccg tgccaccgcc cctggccaaa
     4861 gccattggct tggagatcaa gctttgtatg ttggccaaag cccgagagag tgcctcagct
     4921 aaaataaagg aggaggaagc tgctaaggac tagttctgcc ctcccgtcac ccctgtttct
     4981 ggcaccagga atccccaaca tgcactgatg ttgtgttttt aacatgtcaa tctgtccgtt
     5041 cacatgtgtg gtacatggtg tttgtggcct tggctgacat gaagctgttg tgtgaggttc
     5101 gcttatcaac taatgattta gtgatcaaat tgtgcagtac tttgtgcatt ctggatttta
     5161 aaagtttttt attatgcatt atatcaaatc taccactgta tgagtggaaa ttaagacttt
     5221 atgtagtttt tatatgttgt aatatttctt caaataaatc tctcctataa acca
//
