LOCUS       NM_015221               6428 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens dynamin binding protein (DNMBP), transcript variant 1,
            mRNA.
ACCESSION   NM_015221 XM_050742
VERSION     NM_015221.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6428)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 6428)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 6428)
  AUTHORS   Ouyang,C., Mu,J., Lu,Q., Li,J., Zhu,H., Wang,Q., Zou,M.H. and
            Xie,Z.
  TITLE     Autophagic degradation of KAT2A/GCN5 promotes directional migration
            of vascular smooth muscle cells by reducing TUBA/alpha-tubulin
            acetylation
  JOURNAL   Autophagy 16 (10), 1753-1770 (2020)
   PUBMED   31878840
  REMARK    GeneRIF: Autophagic degradation of KAT2A/GCN5 promotes directional
            migration of vascular smooth muscle cells by reducing
            TUBA/alpha-tubulin acetylation.
REFERENCE   4  (bases 1 to 6428)
  AUTHORS   Ansar,M., Chung,H.L., Taylor,R.L., Nazir,A., Imtiaz,S.,
            Sarwar,M.T., Manousopoulou,A., Makrythanasis,P., Saeed,S.,
            Falconnet,E., Guipponi,M., Pournaras,C.J., Ansari,M.A., Ranza,E.,
            Santoni,F.A., Ahmed,J., Shah,I., Gul,K., Black,G.C., Bellen,H.J.
            and Antonarakis,S.E.
  TITLE     Bi-allelic Loss-of-Function Variants in DNMBP Cause Infantile
            Cataracts
  JOURNAL   Am J Hum Genet 103 (4), 568-578 (2018)
   PUBMED   30290152
  REMARK    GeneRIF: DNMBP loss-of-function variants cause infantile-onset
            cataracts in humans.
REFERENCE   5  (bases 1 to 6428)
  AUTHORS   Tatjewski,M., Gruca,A., Plewczynski,D. and Grynberg,M.
  TITLE     The proline-rich region of glyceraldehyde-3-phosphate dehydrogenase
            from human sperm may bind SH3 domains, as revealed by a
            bioinformatic study of low-complexity protein segments
  JOURNAL   Mol Reprod Dev 83 (2), 144-148 (2016)
   PUBMED   26660717
REFERENCE   6  (bases 1 to 6428)
  AUTHORS   Minster,R.L., DeKosky,S.T. and Kamboh,M.I.
  TITLE     No association of dynamin binding protein (DNMBP) gene SNPs and
            Alzheimer's disease
  JOURNAL   Neurobiol Aging 29 (10), 1602-1604 (2008)
   PUBMED   17442457
  REMARK    GeneRIF: We observed no association of statistical significance in
            either the total sample or the APOE*4 non-carriers for any of the
            SNPs of Dynamin Binding Protein.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 6428)
  AUTHORS   Otani,T., Ichii,T., Aono,S. and Takeichi,M.
  TITLE     Cdc42 GEF Tuba regulates the junctional configuration of simple
            epithelial cells
  JOURNAL   J Cell Biol 175 (1), 135-146 (2006)
   PUBMED   17015620
  REMARK    GeneRIF: Tuba controls the shaping of cell junctions through the
            local activation of Cdc42 and its effectors.
REFERENCE   8  (bases 1 to 6428)
  AUTHORS   Kuwano,R., Miyashita,A., Arai,H., Asada,T., Imagawa,M., Shoji,M.,
            Higuchi,S., Urakami,K., Kakita,A., Takahashi,H., Tsukie,T.,
            Toyabe,S., Akazawa,K., Kanazawa,I. and Ihara,Y.
  CONSRTM   Japanese Genetic Study Consortium for Alzeheimer's Disease
  TITLE     Dynamin-binding protein gene on chromosome 10q is associated with
            late-onset Alzheimer's disease
  JOURNAL   Hum Mol Genet 15 (13), 2170-2182 (2006)
   PUBMED   16740596
  REMARK    GeneRIF: Results confirmed DNMBP may be one of the susceptibility
            genes for Alzheimer's disease.
            GeneRIF: Observational study of gene-disease association and
            gene-gene interaction. (HuGE Navigator)
REFERENCE   9  (bases 1 to 6428)
  AUTHORS   Cestra,G., Kwiatkowski,A., Salazar,M., Gertler,F. and De Camilli,P.
  TITLE     Tuba, a GEF for CDC42, links dynamin to actin regulatory proteins
  JOURNAL   Methods Enzymol 404, 537-545 (2005)
   PUBMED   16413298
REFERENCE   10 (bases 1 to 6428)
  AUTHORS   Salazar,M.A., Kwiatkowski,A.V., Pellegrini,L., Cestra,G.,
            Butler,M.H., Rossman,K.L., Serna,D.M., Sondek,J., Gertler,F.B. and
            De Camilli,P.
  TITLE     Tuba, a novel protein containing bin/amphiphysin/Rvs and Dbl
            homology domains, links dynamin to regulation of the actin
            cytoskeleton
  JOURNAL   J Biol Chem 278 (49), 49031-49043 (2003)
   PUBMED   14506234
  REMARK    GeneRIF: functions to bring together dynamin with actin regulatory
            proteins
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB481528.1, AL833283.1,
            AB023227.1 and AI023943.1.
            
            On Nov 22, 2018 this sequence version replaced NM_015221.3.
            
            Summary: This gene encodes a protein belonging to the guanine
            nucleotide exchange factor family, and which regulates the
            configuration of cell junctions. It contains multiple binding sites
            for dynamin and thus links dynamin to actin regulatory proteins.
            Polymorphisms in this gene have been linked to Alzheimer's disease
            in some populations, though there are conflicting reports of such
            linkages in other populations. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Dec 2015].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.29545.1, AL833283.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000324109.9/ ENSP00000315659.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                DB481528.1         7-34
            29-1153             AL833283.1         1-1125
            1154-6300           AB023227.1         250-5396
            6301-6428           AI023943.1         8-135               c
FEATURES             Location/Qualifiers
     source          1..6428
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q24.2"
     gene            1..6428
                     /gene="DNMBP"
                     /gene_synonym="ARHGEF36; CTRCT48; TUBA"
                     /note="dynamin binding protein"
                     /db_xref="GeneID:23268"
                     /db_xref="HGNC:HGNC:30373"
                     /db_xref="MIM:611282"
     exon            1..110
                     /gene="DNMBP"
                     /gene_synonym="ARHGEF36; CTRCT48; TUBA"
                     /inference="alignment:Splign:2.1.0"
     exon            111..265
                     /gene="DNMBP"
                     /gene_synonym="ARHGEF36; CTRCT48; TUBA"
                     /inference="alignment:Splign:2.1.0"
     CDS             121..4854
                     /gene="DNMBP"
                     /gene_synonym="ARHGEF36; CTRCT48; TUBA"
                     /note="isoform a is encoded by transcript variant 1;
                     scaffold protein TUBA"
                     /codon_start=1
                     /product="dynamin-binding protein isoform a"
                     /protein_id="NP_056036.1"
                     /db_xref="CCDS:CCDS7485.1"
                     /db_xref="GeneID:23268"
                     /db_xref="HGNC:HGNC:30373"
                     /db_xref="MIM:611282"
                     /translation="MEAGSVVRAIFDFCPSVSEELPLFVGDIIEVLAVVDEFWLLGKK
                     EDVTGQFPSSFVEIVTIPSLKEGERLFVCICEFTSQELDNLPLHRGDLVILDGIPTAG
                     WLQGRSCWGARGFFPSSCVRELCLSSQSRQWHSQSALFQIPEYSMGQARALMGLSAQL
                     DEELDFREGDVITIIGVPEPGWFEGELEGRRGIFPEGFVELLGPLRTVDESVSSGNQD
                     DCIVNGEVDTPVGEEEIGPDEDEEEPGTYGVALYRFQALEPNELDFEVGDKIRILATL
                     EDGWLEGSLKGRTGIFPYRFVKLCPDTRVEETMALPQEGSLARIPETSLDCLENTLGV
                     EEQRHETSDHEAEEPDCIISEAPTSPLGHLTSEYDTDRNSYQDEDTAGGPPRSPGVEW
                     EMPLATDSPTSDPTEVVNGISSQPQVPFHPNLQKSQYYSTVGGSHPHSEQYPDLLPLE
                     ARTRDYASLPPKRMYSQLKTLQKPVLPLYRGSSVSASRVVKPRQSSPQLHNLASYTKK
                     HHTSSVYSISERLEMKPGPQAQGLVMEAATHSQGDGSTDLDSKLTQQLIEFEKSLAGP
                     GTEPDKILRHFSIMDFNSEKDIVRGSSKLITEQELPERRKALRPPPPRPCTPVSTSPH
                     LLVDQNLKPAPPLVVRPSRPAPLPPSAQQRTNAVSPKLLSRHRPTCETLEKEGPGHMG
                     RSLDQTSPCPLVLVRIEEMERDLDMYSRAQEELNLMLEEKQDESSRAETLEDLKFCES
                     NIESLNMELQQLREMTLLSSQSSSLVAPSGSVSAENPEQRMLEKRAKVIEELLQTERD
                     YIRDLEMCIERIMVPMQQAQVPNIDFEGLFGNMQMVIKVSKQLLAALEISDAVGPVFL
                     GHRDELEGTYKIYCQNHDEAIALLEIYEKDEKIQKHLQDSLADLKSLYNEWGCTNYIN
                     LGSFLIKPVQRVMRYPLLLMELLNSTPESHPDKVPLTNAVLAVKEINVNINEYKRRKD
                     LVLKYRKGDEDSLMEKISKLNIHSIIKKSNRVSSHLKHLTGFAPQIKDEVFEETEKNF
                     RMQERLIKSFIRDLSLYLQHIRESACVKVVAAVSMWDVCMERGHRDLEQFERVHRYIS
                     DQLFTNFKERTERLVISPLNQLLSMFTGPHKLVQKRFDKLLDFYNCTERAEKLKDKKT
                     LEELQSARNNYEALNAQLLDELPKFHQYAQGLFTNCVHGYAEAHCDFVHQALEQLKPL
                     LSLLKVAGREGNLIAIFHEEHSRVLQQLQVFTFFPESLPATKKPFERKTIDRQSARKP
                     LLGLPSYMLQSEELRASLLARYPPEKLFQAERNFNAAQDLDVSLLEGDLVGVIKKKDP
                     MGSQNRWLIDNGVTKGFVYSSFLKPYNPRRSHSDASVGSHSSTESEHGSSSPRFPRQN
                     SGSTLTFNPSSMAVSFTSGSCQKQPQDASPPPKECDQGTLSASLNPSNSESSPSRCPS
                     DPDSTSQPRSGDSADVARDVKQPTATPRSYRNFRHPEIVGYSVPGRNGQSQDLVKGCA
                     RTAQAPEDRSTEPDGSEAEGNQVYFAVYTFKARNPNELSVSANQKLKILEFKDVTGNT
                     EWWLAEVNGKKGYVPSNYIRKTEYT"
     exon            266..388
                     /gene="DNMBP"
                     /gene_synonym="ARHGEF36; CTRCT48; TUBA"
                     /inference="alignment:Splign:2.1.0"
     exon            389..2380
                     /gene="DNMBP"
                     /gene_synonym="ARHGEF36; CTRCT48; TUBA"
                     /inference="alignment:Splign:2.1.0"
     exon            2381..2574
                     /gene="DNMBP"
                     /gene_synonym="ARHGEF36; CTRCT48; TUBA"
                     /inference="alignment:Splign:2.1.0"
     exon            2575..2674
                     /gene="DNMBP"
                     /gene_synonym="ARHGEF36; CTRCT48; TUBA"
                     /inference="alignment:Splign:2.1.0"
     exon            2675..2822
                     /gene="DNMBP"
                     /gene_synonym="ARHGEF36; CTRCT48; TUBA"
                     /inference="alignment:Splign:2.1.0"
     exon            2823..2840
                     /gene="DNMBP"
                     /gene_synonym="ARHGEF36; CTRCT48; TUBA"
                     /inference="alignment:Splign:2.1.0"
     exon            2841..3040
                     /gene="DNMBP"
                     /gene_synonym="ARHGEF36; CTRCT48; TUBA"
                     /inference="alignment:Splign:2.1.0"
     exon            3041..3171
                     /gene="DNMBP"
                     /gene_synonym="ARHGEF36; CTRCT48; TUBA"
                     /inference="alignment:Splign:2.1.0"
     exon            3172..3276
                     /gene="DNMBP"
                     /gene_synonym="ARHGEF36; CTRCT48; TUBA"
                     /inference="alignment:Splign:2.1.0"
     exon            3277..3405
                     /gene="DNMBP"
                     /gene_synonym="ARHGEF36; CTRCT48; TUBA"
                     /inference="alignment:Splign:2.1.0"
     exon            3406..3738
                     /gene="DNMBP"
                     /gene_synonym="ARHGEF36; CTRCT48; TUBA"
                     /inference="alignment:Splign:2.1.0"
     exon            3739..3918
                     /gene="DNMBP"
                     /gene_synonym="ARHGEF36; CTRCT48; TUBA"
                     /inference="alignment:Splign:2.1.0"
     exon            3919..4117
                     /gene="DNMBP"
                     /gene_synonym="ARHGEF36; CTRCT48; TUBA"
                     /inference="alignment:Splign:2.1.0"
     exon            4118..4668
                     /gene="DNMBP"
                     /gene_synonym="ARHGEF36; CTRCT48; TUBA"
                     /inference="alignment:Splign:2.1.0"
     exon            4669..6428
                     /gene="DNMBP"
                     /gene_synonym="ARHGEF36; CTRCT48; TUBA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6408..6413
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DNMBP"
                     /gene_synonym="ARHGEF36; CTRCT48; TUBA"
                     /note="hexamer: AATAAA"
     polyA_site      6428
                     /gene="DNMBP"
                     /gene_synonym="ARHGEF36; CTRCT48; TUBA"
                     /note="major polyA site"
ORIGIN      
        1 acacgggatc gacccgcccg ccgcttccag gggcggaggt gacagcgggc tggggactgg
       61 cggctgcaac tgcctgccgc gccgagggac cgccgggcgg cggaaagcag gttataaaac
      121 atggaggctg gctcagtggt tcgagccatt tttgacttct gccctagcgt atcagaagaa
      181 ctgccgctct ttgtgggaga tattattgag gtgctggcag tggtggatga attttggctt
      241 ctaggaaaga aggaggatgt tacaggacaa ttccccagca gttttgtgga aattgtgacc
      301 attcccagtc taaaagaggg agagaggctg tttgtgtgca tttgtgaatt cacatcccaa
      361 gagttggata atcttcccct ccatcgaggt gacctggtga ttctcgatgg cattcccact
      421 gcaggctggc tgcagggccg aagctgctgg ggcgcacggg gcttcttccc atcttcatgt
      481 gtccgcgagc tctgcctctc ctcacagagc cggcagtggc actcccagag cgccctgttt
      541 cagattccgg aatattccat gggacaagcc cgggccctaa tggggctttc tgctcagctg
      601 gatgaagagc tggacttcag ggaaggggat gtgatcacca ttattggagt tcctgaacca
      661 ggctggtttg aaggggagtt agagggccga agaggcattt ttccagaagg ttttgtagag
      721 ctgttggggc ccctgaggac tgtggatgag tcagtaagtt ctggaaatca agatgactgc
      781 attgttaatg gtgaagtaga tacccctgta ggagaagaag agatagggcc ggatgaggat
      841 gaggaggagc cagggaccta tggggtcgcc ctgtacagat tccaagccct ggagccaaat
      901 gagctggatt tcgaggtcgg ggataaaatc cgaattctgg cgaccttgga agatggctgg
      961 ctggaaggat ccctgaaggg caggacaggc atctttcctt accggtttgt gaaattatgt
     1021 cctgacacac gggtggagga aaccatggct ctgccccagg aaggcagcct tgccaggatc
     1081 ccggaaactt ctttggattg tttggagaac accttaggag tagaggaaca aagacatgaa
     1141 accagtgacc atgaggccga ggagcctgac tgcattattt ctgaagcacc cacttctccc
     1201 ctcggtcatc tgacttcaga gtatgacaca gacagaaact cttatcagga cgaggacacc
     1261 gcaggagggc ccccgagaag cccaggcgtg gagtgggaaa tgcctcttgc cacagactct
     1321 cccacatctg accctacaga agtagtcaat ggtatttcct cccaacctca ggtccctttt
     1381 catcccaact tgcagaaaag ccagtattat tctacagtgg gagggagcca cccgcactca
     1441 gaacagtacc ccgaccttct tcccctagaa gcaaggacta gagactatgc cagcctacct
     1501 cccaaaagaa tgtattccca gctaaaaact cttcagaagc cagtgctccc tctttacagg
     1561 ggctcttctg tttcagcttc aagggtagtc aaacccagac aatcaagtcc tcagctccac
     1621 aacctagcaa gttatactaa aaagcaccac acgtccagtg tttactccat ctcagagaga
     1681 ttggagatga agcctggtcc gcaagcccaa gggcttgtta tggaagcagc aacacattca
     1741 cagggagacg gcagcactga cctggactcg aagctgacac aacagctgat cgagtttgag
     1801 aagagcttgg cagggcccgg cacagagcca gataaaattt tacgccactt ttcaatcatg
     1861 gactttaact ctgagaagga tattgtccga ggttcctcaa agttaatcac cgagcaggag
     1921 ctgccggaaa ggagaaaggc cctaaggcca ccgccacctc gtccctgtac tccggtatcc
     1981 acttctcccc atttgctggt tgaccagaac ctaaaacctg caccaccctt ggtggtgcga
     2041 ccctctcgcc cagctcccct gcctccctca gcacagcaga gaacgaatgc ggtatccccc
     2101 aagctcctat ctcgacaccg tcctacctgt gagaccttag aaaaggaggg ccctggtcat
     2161 atgggaagga gtctggacca gacctcccca tgccccttag tgctggtgag gattgaggaa
     2221 atggagcggg acttggatat gtacagtaga gctcaagaag agctaaacct catgctggag
     2281 gagaagcagg atgaatcatc aagagcagag accctcgagg atctcaagtt ctgtgaaagt
     2341 aacattgaaa gtttgaatat ggaactccag caactaagag aaatgacgct cctctcctcc
     2401 cagtcttcat cactggtggc cccttctggg tctgtgtctg ccgaaaatcc agagcagagg
     2461 atgctggaga agagagccaa ggtcatagaa gaacttcttc agacagaaag agactacatt
     2521 cgggatctgg aaatgtgtat tgagcggatc atggtaccca tgcagcaggc acaggtacca
     2581 aacattgatt ttgagggact ttttggaaat atgcagatgg tgattaaggt ctcgaagcaa
     2641 ttattggctg ctctggaaat cagcgatgct gtaggacctg tgtttcttgg tcaccgggat
     2701 gagcttgagg gaacatacaa gatttactgc cagaatcatg atgaggccat tgcgctgctt
     2761 gaaatctacg agaaggatga gaagatccag aagcatcttc aggactcctt ggcagatctg
     2821 aagagcctat acaacgaatg gggatgcaca aattatatta acctgggctc cttcctcatc
     2881 aaaccagtac agagagtaat gcgttacccg ctgttgctaa tggagttgct gaattccacc
     2941 ccagaatccc acccagataa agtgccttta accaatgcag tccttgcggt caaggaaatc
     3001 aacgttaaca ttaatgaata taaacggcga aaggacctgg tcctcaagta ccgtaagggt
     3061 gatgaagata gccttatgga gaaaatttcc aaactgaaca tccactccat catcaagaaa
     3121 tccaaccgag ttagcagtca cctgaagcat ctcactggct ttgctcctca gataaaagat
     3181 gaagtatttg aagaaacaga aaaaaacttc cgaatgcaag aaagattgat taagtctttt
     3241 atccgagacc tgtctctcta cctccagcac atccgggagt ccgcatgtgt gaaagtggtg
     3301 gctgctgtga gcatgtggga tgtgtgcatg gagagaggac accgggacct ggagcagttt
     3361 gagagggtgc atcgctacat cagtgaccag ctcttcacaa actttaagga gaggacagag
     3421 cggcttgtca tctccccctt aaatcagtta ctgagcatgt ttacagggcc ccataagctg
     3481 gtacagaaac gctttgacaa gctcctggac ttctataact gtacagaacg ggcagaaaag
     3541 ctaaaggaca agaagaccct ggaggagctg cagtcggccc ggaacaacta tgaggccctg
     3601 aatgcacagc tgctggatga gctgcccaag ttccaccagt acgcccaggg cctcttcacc
     3661 aactgtgtcc acggctatgc tgaagcccac tgtgactttg tgcaccaggc tctggagcaa
     3721 ttaaagccac tgctttcgtt actcaaagtg gctggcagag agggaaacct tattgccatc
     3781 ttccacgaag agcacagcag agttctgcag caactccagg tttttacctt cttcccggag
     3841 tctcttccag ctaccaagaa gccatttgag aggaaaacca ttgaccgcca gtctgctcga
     3901 aagccactcc tgggcctgcc aagttacatg ctacagtcag aagaactccg ggcctccctc
     3961 ctggccaggt atccccctga aaaactcttc caggcagaac ggaacttcaa tgctgctcaa
     4021 gacttggatg tctcactttt ggaaggtgac ctggtgggtg tgattaagaa aaaagacccc
     4081 atgggcagcc agaaccgctg gctgattgac aatggagtca ccaaaggctt cgtgtacagc
     4141 tctttcctaa agccctacaa tcctcgccgc agccactccg atgcctccgt gggtagccac
     4201 tcctccacag agtctgagca cggcagctcc tcccccaggt tcccacgcca gaacagcggc
     4261 agcaccctga ccttcaaccc cagcagcatg gctgtatcct ttacctcggg gtcttgccag
     4321 aagcagcctc aagatgcatc tcctccgcca aaagaatgtg accaaggaac tctcagtgca
     4381 tccctaaatc cgagtaattc agagagtagt ccttccagat gcccttcaga cccagactcc
     4441 acctcccagc caaggtcagg ggactctgca gatgtagcta gagatgtaaa gcaacccact
     4501 gccacgccga ggagctaccg gaacttcagg catccagaaa tagttggcta ctccgtacca
     4561 ggacgaaatg ggcaaagtca agacctcgtc aaaggatgtg caagaacagc ccaggctccg
     4621 gaagacagaa gtacagagcc agatggcagt gaggcagaag gcaaccaggt ctattttgct
     4681 gtctacacct tcaaggcacg aaacccaaat gagctgagcg tgtcagccaa tcagaaactc
     4741 aagatcctcg agtttaaaga tgttacagga aatacagagt ggtggttagc tgaggttaac
     4801 gggaagaagg gctacgttcc ctccaattat atccgcaaaa ccgagtacac ctgagcccac
     4861 gttgcctgcc acccagcctt gctgcctttg ctttcagtcc gccgagggtt ctggcggccc
     4921 accgagaggg cgcctgctcc tgagacacag gccctgtctg cgttgcttaa ccatggcatg
     4981 gtggagcaca ccacagatct tgttctcctc gattgggttg taaaccttga tgctcactag
     5041 aatctctaga atttgaaatg gaccctgggg ctttgcaaat gacttagtga ctatgagaag
     5101 agagacaagt cttagagctg gcttttggaa aggagaaact tgcagtcaga agcccagtgt
     5161 cctatgtatg caggaagctg tgctctagca atagacagtg ttggtaatgg ttgtgctgta
     5221 cggcgtttgg ggtggcccca tgttccatgc tcagctgacc ggatgccaac tcagatgaaa
     5281 agaattcatg gctctgggca ccccgtgagg cagtgcttgc acatggctgg gagtttgtcg
     5341 ggattgaacc aaacctagtg cttcaaagct cctgggacac ctccagtgtc cagcacacat
     5401 tctcatacat actgccccta atttctaaag tccctaaagc actacattct gtaaccttgt
     5461 ttcttttact ccattcccag attagttatg caaaattcaa ctgcgttcta cttttagaag
     5521 tgtttagggt ctttattttc tgttgaccct tcatctgaaa gattctcttc ccttgttagg
     5581 tacaatcact gcccccccgc tttttttttt gagatggggt cttgctatgt tgcccaggct
     5641 ggtcttaaac gcctgggctc aagcaaccct cccgcctccc tgctgagatt acaggtgtaa
     5701 gccaccatac cgcaacctca atgacacctt tctgatggtc tttacacagt ctgtgatgtc
     5761 tggtggcccc cctgccctgg actcaataat tgatagattt tcctagagta acagtatgag
     5821 agctccagcc attccattaa aagtattagt tctgctttga gctgaaacca gttgagccta
     5881 atggaagact ggatgtcttt cttcttcatc caagcaccct aatgactgtt tagttacatc
     5941 catagatgca gacaacataa cacctgtgac ttacttgaat tgggataagc cattccagaa
     6001 gtagcttatc ctagacttgg aaataagatt tttttcacca ctaacttcca tgcttcagag
     6061 atgacattca aagccagatt cccaagtgcc tgatcatacc tcccagtctc aggaagatat
     6121 ttgcttaccc cttagaccaa gaatcttaag atcttcccca gctatgaagc ctatcttgga
     6181 atgggaaacc atgaaatttg tcttttaaaa gaaagggaag aaatagcctt acagcccctg
     6241 ttcctccaag tgcacattta gccttaaaat cctgggagtc gggagacacc gtggagtcct
     6301 aacatccaca gtgtctgctg gtcgtggtca gaaggcagta atgcaagagt ccttttgtga
     6361 agagtgtttc tatgtagaga tgtttatatt taagtagttc ttttataaat aaaagcattt
     6421 ctaatggc
//
