LOCUS       NM_015569               7627 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens dynamin 3 (DNM3), transcript variant 1, mRNA.
ACCESSION   NM_015569
VERSION     NM_015569.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7627)
  AUTHORS   Wong,K.K., Bateman,N.W., Ng,C.W., Tsang,Y.T.M., Sun,C.S.,
            Celestino,J., Nguyen,T.V., Malpica,A., Hillman,R.T., Zhang,J.,
            Futreal,P.A., Rojas,C., Conrads,K.A., Hood,B.L., Dalgard,C.L.,
            Wilkerson,M.D., Phippen,N.T., Conrads,T.P., Maxwell,G.L., Sood,A.K.
            and Gershenson,D.M.
  TITLE     Integrated multi-omic analysis of low-grade ovarian serous
            carcinoma collected from short and long-term survivors
  JOURNAL   J Transl Med 20 (1), 606 (2022)
   PUBMED   36528667
  REMARK    GeneRIF: Integrated multi-omic analysis of low-grade ovarian serous
            carcinoma collected from short and long-term survivors.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7627)
  AUTHORS   JuknytE,G., LaurinaitytE,I., VilkeviCiUtE,A., GedvilaitE,G.,
            GlebauskienE,B., KriauCiUnienE,L. and LiutkeviCienE,R.
  TITLE     TBX15 rs98422, DNM3 rs1011731, RAD51B rs8017304, and rs2588809 Gene
            Polymorphisms and Associations With Pituitary Adenoma
  JOURNAL   In Vivo 35 (2), 815-826 (2021)
   PUBMED   33622874
  REMARK    GeneRIF: TBX15 rs98422, DNM3 rs1011731, RAD51B rs8017304, and
            rs2588809 Gene Polymorphisms and Associations With Pituitary
            Adenoma.
REFERENCE   3  (bases 1 to 7627)
  AUTHORS   Brown,E.E., Blauwendraat,C., Trinh,J., Rizig,M., Nalls,M.A.,
            Leveille,E., Ruskey,J.A., Jonvik,H., Tan,M.M.X., Bandres-Ciga,S.,
            Hassin-Baer,S., Brockmann,K., Infante,J., Tolosa,E., Ezquerra,M.,
            Ben Romdhan,S., Benmahdjoub,M., Arezki,M., Mhiri,C., Hardy,J.,
            Singleton,A.B., Alcalay,R.N., Gasser,T., Grosset,D.G.,
            Williams,N.M., Pittman,A., Gan-Or,Z., Fernandez-Santiago,R.,
            Brice,A., Lesage,S., Farrer,M., Wood,N. and Morris,H.R.
  CONSRTM   International Parkinson Disease Genomics Consortium (IPDGC)
  TITLE     Analysis of DNM3 and VAMP4 as genetic modifiers of LRRK2
            Parkinson's disease
  JOURNAL   Neurobiol Aging 97, 148 (2021)
   PUBMED   32873436
  REMARK    GeneRIF: Analysis of DNM3 and VAMP4 as genetic modifiers of LRRK2
            Parkinson's disease.
REFERENCE   4  (bases 1 to 7627)
  AUTHORS   Tian,M., Yang,X., Li,Y. and Guo,S.
  TITLE     The Expression of Dynamin 1, 2, and 3 in Human Hepatocellular
            Carcinoma and Patient Prognosis
  JOURNAL   Med Sci Monit 26, e923359 (2020)
   PUBMED   32573516
  REMARK    GeneRIF: The Expression of Dynamin 1, 2, and 3 in Human
            Hepatocellular Carcinoma and Patient Prognosis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7627)
  AUTHORS   Berge-Seidl,V., Pihlstrom,L., Wszolek,Z.K., Ross,O.A. and Toft,M.
  TITLE     No evidence for DNM3 as genetic modifier of age at onset in
            idiopathic Parkinson's disease
  JOURNAL   Neurobiol Aging 74, 236 (2019)
   PUBMED   30340792
  REMARK    GeneRIF: There is no evidence of an association between DNM3
            variants and age at onset in idiopathic Parkinson's disease.
REFERENCE   6  (bases 1 to 7627)
  AUTHORS   Larsen,M.R., Graham,M.E., Robinson,P.J. and Roepstorff,P.
  TITLE     Improved detection of hydrophilic phosphopeptides using graphite
            powder microcolumns and mass spectrometry: evidence for in vivo
            doubly phosphorylated dynamin I and dynamin III
  JOURNAL   Mol Cell Proteomics 3 (5), 456-465 (2004)
   PUBMED   14762214
REFERENCE   7  (bases 1 to 7627)
  AUTHORS   Orth,J.D. and McNiven,M.A.
  TITLE     Dynamin at the actin-membrane interface
  JOURNAL   Curr Opin Cell Biol 15 (1), 31-39 (2003)
   PUBMED   12517701
  REMARK    Review article
REFERENCE   8  (bases 1 to 7627)
  AUTHORS   Sever,S.
  TITLE     Dynamin and endocytosis
  JOURNAL   Curr Opin Cell Biol 14 (4), 463-467 (2002)
   PUBMED   12383797
  REMARK    Review article
REFERENCE   9  (bases 1 to 7627)
  AUTHORS   Wiejak,J. and Wyroba,E.
  TITLE     Dynamin: characteristics, mechanism of action and function
  JOURNAL   Cell Mol Biol Lett 7 (4), 1073-1080 (2002)
   PUBMED   12511974
  REMARK    Review article
REFERENCE   10 (bases 1 to 7627)
  AUTHORS   Tu,J.C., Xiao,B., Yuan,J.P., Lanahan,A.A., Leoffert,K., Li,M.,
            Linden,D.J. and Worley,P.F.
  TITLE     Homer binds a novel proline-rich motif and links group 1
            metabotropic glutamate receptors with IP3 receptors
  JOURNAL   Neuron 21 (4), 717-726 (1998)
   PUBMED   9808459
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC334207.1, AB020627.2,
            AL136712.1, AL035110.1, Z97195.1 and BC037326.1.
            
            On Nov 23, 2018 this sequence version replaced NM_015569.4.
            
            Summary: This gene encodes a member of a family of guanosine
            triphosphate (GTP)-binding proteins that associate with
            microtubules and are involved in vesicular transport. The encoded
            protein functions in the development of megakaryocytes. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, May 2013].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.111926.1, AL136712.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000627582.3/ ENSP00000486701.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                DC334207.1         21-49
            30-2040             AB020627.2         1-2011
            2041-2052           AL136712.1         2039-2050
            2053-2381           AB020627.2         2012-2340
            2382-2681           AL035110.1         330-629
            2682-2815           AB020627.2         2641-2774
            2816-3031           AL136712.1         2814-3029
            3032-6235           AB020627.2         2991-6194
            6236-7054           Z97195.1           117699-118517       c
            7055-7627           BC037326.1         2736-3308
FEATURES             Location/Qualifiers
     source          1..7627
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q24.3"
     gene            1..7627
                     /gene="DNM3"
                     /gene_synonym="Dyna III"
                     /note="dynamin 3"
                     /db_xref="GeneID:26052"
                     /db_xref="HGNC:HGNC:29125"
                     /db_xref="MIM:611445"
     exon            1..320
                     /gene="DNM3"
                     /gene_synonym="Dyna III"
                     /inference="alignment:Splign:2.1.0"
     CDS             160..2751
                     /gene="DNM3"
                     /gene_synonym="Dyna III"
                     /EC_number="3.6.5.5"
                     /note="isoform a is encoded by transcript variant 1;
                     dynamin family member; T-dynamin; dynamin, testicular"
                     /codon_start=1
                     /product="dynamin-3 isoform a"
                     /protein_id="NP_056384.2"
                     /db_xref="CCDS:CCDS53431.1"
                     /db_xref="GeneID:26052"
                     /db_xref="HGNC:HGNC:29125"
                     /db_xref="MIM:611445"
                     /translation="MGNREMEELIPLVNRLQDAFSALGQSCLLELPQIAVVGGQSAGK
                     SSVLENFVGRDFLPRGSGIVTRRPLVLQLVTSKAEYAEFLHCKGKKFTDFDEVRLEIE
                     AETDRVTGMNKGISSIPINLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIREMI
                     MQFITRENCLILAVTPANTDLANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDARD
                     VLENKLLPLRRGYVGVVNRSQKDIDGKKDIKAAMLAERKFFLSHPAYRHIADRMGTPH
                     LQKVLNQQLTNHIRDTLPNFRNKLQGQLLSIEHEVEAYKNFKPEDPTRKTKALLQMVQ
                     QFAVDFEKRIEGSGDQVDTLELSGGAKINRIFHERFPFEIVKMEFNEKELRREISYAI
                     KNIHGIRTGLFTPDMAFEAIVKKQIVKLKGPSLKSVDLVIQELINTVKKCTKKLANFP
                     RLCEETERIVANHIREREGKTKDQVLLLIDIQVSYINTNHEDFIGFANAQQRSSQVHK
                     KTTVGNQVIRKGWLTISNIGIMKGGSKGYWFVLTAESLSWYKDDEEKEKKYMLPLDNL
                     KVRDVEKSFMSSKHIFALFNTEQRNVYKDYRFLELACDSQEDVDSWKASLLRAGVYPD
                     KSVGNNKAENDENGQAENFSMDPQLERQVETIRNLVDSYMSIINKCIRDLIPKTIMHL
                     MINNVKDFINSELLAQLYSSEDQNTLMEESAEQAQRRDEMLRMYQALKEALGIIGDIS
                     TATVSTPAPPPVDDSWIQHSRRSPPPSPTTQRRPTLSAPLARPTSGRGPAPAIPSPGP
                     HSGAPPVPFRPGPLPPFPSSSDSFGAPPQVPSRPTRAPPSVPSRRPPPSPTRPTIIRP
                     LESSLLD"
     exon            321..394
                     /gene="DNM3"
                     /gene_synonym="Dyna III"
                     /inference="alignment:Splign:2.1.0"
     exon            395..544
                     /gene="DNM3"
                     /gene_synonym="Dyna III"
                     /inference="alignment:Splign:2.1.0"
     exon            545..748
                     /gene="DNM3"
                     /gene_synonym="Dyna III"
                     /inference="alignment:Splign:2.1.0"
     exon            749..847
                     /gene="DNM3"
                     /gene_synonym="Dyna III"
                     /inference="alignment:Splign:2.1.0"
     exon            848..1008
                     /gene="DNM3"
                     /gene_synonym="Dyna III"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1151
                     /gene="DNM3"
                     /gene_synonym="Dyna III"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1287
                     /gene="DNM3"
                     /gene_synonym="Dyna III"
                     /inference="alignment:Splign:2.1.0"
     exon            1288..1355
                     /gene="DNM3"
                     /gene_synonym="Dyna III"
                     /inference="alignment:Splign:2.1.0"
     exon            1356..1494
                     /gene="DNM3"
                     /gene_synonym="Dyna III"
                     /inference="alignment:Splign:2.1.0"
     exon            1495..1581
                     /gene="DNM3"
                     /gene_synonym="Dyna III"
                     /inference="alignment:Splign:2.1.0"
     exon            1582..1652
                     /gene="DNM3"
                     /gene_synonym="Dyna III"
                     /inference="alignment:Splign:2.1.0"
     exon            1653..1704
                     /gene="DNM3"
                     /gene_synonym="Dyna III"
                     /inference="alignment:Splign:2.1.0"
     exon            1705..1818
                     /gene="DNM3"
                     /gene_synonym="Dyna III"
                     /inference="alignment:Splign:2.1.0"
     exon            1819..1928
                     /gene="DNM3"
                     /gene_synonym="Dyna III"
                     /inference="alignment:Splign:2.1.0"
     exon            1929..2040
                     /gene="DNM3"
                     /gene_synonym="Dyna III"
                     /inference="alignment:Splign:2.1.0"
     exon            2041..2052
                     /gene="DNM3"
                     /gene_synonym="Dyna III"
                     /inference="alignment:Splign:2.1.0"
     exon            2053..2217
                     /gene="DNM3"
                     /gene_synonym="Dyna III"
                     /inference="alignment:Splign:2.1.0"
     exon            2218..2444
                     /gene="DNM3"
                     /gene_synonym="Dyna III"
                     /inference="alignment:Splign:2.1.0"
     exon            2445..2681
                     /gene="DNM3"
                     /gene_synonym="Dyna III"
                     /inference="alignment:Splign:2.1.0"
     exon            2682..7627
                     /gene="DNM3"
                     /gene_synonym="Dyna III"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7605..7610
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DNM3"
                     /gene_synonym="Dyna III"
                     /note="hexamer: AATAAA"
     polyA_site      7627
                     /gene="DNM3"
                     /gene_synonym="Dyna III"
                     /note="major polyA site"
ORIGIN      
        1 agagccaagc ggcgggctgg cggcgggctc cgacgtctgc gccaggacct ggctggctga
       61 gcccggcgca gcagcagcag ccagggcagc gcggccccta ctccctgtca ggtcgtagag
      121 gcgagcaggg accagctggt cgccggcccc tcgggcaaga tggggaaccg ggagatggag
      181 gagctgatcc cgctggtgaa ccgtctgcag gacgcgtttt cggcgctggg acagagctgc
      241 ctgctggagc tgccgcagat cgccgtggtg ggcggccaga gcgccggcaa gagctcggtg
      301 ctcgagaact tcgtgggcag ggactttctc cctcgagggt cgggcattgt aacaagacga
      361 cctcttgtgc tgcagcttgt tacttctaaa gcagaatatg ccgagtttct acattgcaaa
      421 ggaaagaaat ttacagattt tgatgaagtt cgccttgaga ttgaagcaga aacagatcgc
      481 gtgactggaa tgaataaagg catttcctcc atacccatta atttacgagt ctattcccca
      541 cacgtgttaa atctaaccct tattgatcta cctggaataa ctaaagtgcc tgtgggagat
      601 cagccaccag atatcgagta tcagatcaga gaaatgatta tgcagttcat cacgagggag
      661 aactgtctga ttttagctgt tactccagcc aacactgatc ttgcaaactc agatgcgctg
      721 aagctagcta aagaagttga tcctcaaggt ctgagaacca ttggagttat caccaaactg
      781 gaccttatgg atgaaggaac ggatgccagg gatgttctag agaacaaact gttgcctctt
      841 cgcaggggtt acgtgggggt ggtaaacaga agccagaagg acatagatgg gaagaaggac
      901 ataaaggcag ccatgctggc agagaggaag tttttccttt cccacccggc ttacagacat
      961 atcgctgacc gaatgggaac cccacacctg cagaaggtcc ttaatcagca acttaccaac
     1021 cacattcggg ataccctacc aaacttcagg aacaaactac agggacagtt gctctccata
     1081 gaacatgaag tagaagccta caaaaatttc aaaccagaag acccaacaag gaagaccaaa
     1141 gcattgctgc agatggttca gcaatttgct gtggactttg agaagagaat tgaagggtca
     1201 ggggatcaag tagataccct ggaactctca ggtggtgcta aaatcaatcg tatttttcat
     1261 gaacgctttc cttttgagat agtaaagatg gagttcaatg agaaagaatt gcgaagagaa
     1321 ataagctatg caatcaaaaa catacatggt atcaggacag ggttgtttac tccagacatg
     1381 gcatttgaag cgatagtcaa gaaacagatt gtaaagttga aagggccttc cttgaagagt
     1441 gtggatctgg taatacaaga attaatcaac actgtgaaga agtgtaccaa aaaactggca
     1501 aacttcccca gactctgcga ggaaacggaa aggattgttg ctaaccacat tcgtgagcga
     1561 gaagggaaga caaaggacca ggtattgcta ttgattgaca ttcaagtctc ttacatcaac
     1621 accaaccatg aagacttcat tggcttcgca aatgctcagc agaggagcag tcaggttcac
     1681 aagaaaacca cagttggaaa tcaggtgatt cgcaaggggt ggctcaccat cagcaacatt
     1741 ggcatcatga aaggcggctc gaagggatac tggttcgtcc ttactgcgga aagcttgtcc
     1801 tggtataaag atgatgagga aaaagaaaag aagtacatgc ttcccttgga caacctgaaa
     1861 gttcgggatg tggaaaagag ctttatgtct agcaagcaca tctttgcact ctttaataca
     1921 gagcaaagga atgtatacaa agactatcgc ttccttgagc tggcatgtga ttcccaggag
     1981 gatgtcgaca gctggaaggc atctctacta agagctgggg tctatcctga caaatctgta
     2041 gggaacaaca aagctgaaaa tgatgagaat ggacaagcag aaaacttttc catggaccca
     2101 caattggaga ggcaagtgga gaccattcgc aacctcgtag actcctacat gtccattatc
     2161 aacaaatgta tccgagatct aattccaaaa acaataatgc accttatgat caataacgtt
     2221 aaagatttca taaattccga gctcctagca cagttgtatt cttcagagga ccaaaatacc
     2281 ctgatggagg aatctgctga gcaggctcag cgccgggatg agatgcttcg aatgtatcaa
     2341 gcactgaaag aagcccttgg gataattggg gacatcagca cagccaccgt gtccactccg
     2401 gcaccccctc cagtggatga ctcctggata cagcactctc gcaggtcacc tcctccaagc
     2461 cccacaaccc aaaggaggcc aacactaagt gctcccctcg caaggcccac atccggccga
     2521 ggaccagctc ctgccattcc ctctcctggc ccccactctg gggctcctcc agtcccattc
     2581 cgtccaggcc cattacctcc tttccccagc agcagtgact ccttcggagc ccctccacaa
     2641 gttccatcta ggcctacgag ggccccgccc agtgtcccaa gccggagacc acccccatca
     2701 ccaactcgtc ccactataat ccgcccacta gaatcctccc tgttagacta aacgaagtgt
     2761 ctggcatggc aattaatcac taatgaatta tgcgaaagca acatatttga taaccgttgc
     2821 agtaaatcat gagtagtcgc atgtgtggac atcagtaggc aagtaaccag ttttactaat
     2881 gcattcatcg ctcatcttca ttgctcatgg tatgtcaaac ctttggggtt tgactcagaa
     2941 actgctaacc ttttagaggc tttatatgtt gtactgacca aggtaggttt gtatagcagc
     3001 cctatacttt ggggatcatt tgcctaccat ggcatatatt tgaaattgct ttggacaagt
     3061 tttctaggct atctaccagg tagctcatta aacgtaattc ttcagatatg agatagtggg
     3121 cttagaccta agccatacat atttcttttc ccacattctg tttaggatga cagtaattct
     3181 gttgtctacc attaatgcta ctacctactc cataattgcc tatttagctc ctcttttctt
     3241 cctttttatt tcataagact gctaggaagt gattttttaa aattaggact ccttaagaat
     3301 aaacttttcc agaagcacga ggtagtttgc aaaggaaaag tctgcactgt ttgctctaaa
     3361 gagcttctcc tcattccaat gtgttttgct tcatgctaga agcatatgca acagtgaata
     3421 aaagcttctt tttttgttaa tcagtcaata aatttggcta attagtttca gagttcaagg
     3481 aagaagcaaa atatcacatc tctagaagtg ttgggaaaaa tataatttct ttctttactt
     3541 atattcacct catggtaggt tatattgaag gctgacatgg agaatgttta cttttctatt
     3601 tggcatagct aactacactt tgatactaac tccagtttta ctattattat tttggttgga
     3661 aaaaaaattc actctttacg tgctaatttg taatcttgtt ttgtaagaat ttatcctacc
     3721 cttgaaacag gctcagtgta actgtatatc cattctaggc tttcttaata aatcttgagg
     3781 ctatgggata atcacattta aagaatggtt cctgaaatga agtcagtaga aatggcatgg
     3841 gataagagca gagctcacac ttttacagtt gcagtatttc aaagtcccta tccaggtcac
     3901 tccagaaaag ggtattgaaa cgttgaaatc taaagcaaat ttgcaatttc ttaagatttc
     3961 taaaatttac cagaacagtt tagcctgggg gttaatagtt aagtcttgag gctaagtttt
     4021 ggactaccaa ggaccagatg attcacatgt aggaaacagc cagaagccaa ctggaatttt
     4081 gtgtgctaac tgttcccaga cagcagagca agtattcact gagtaggggt gtcccatgac
     4141 actatttcat attctacaga agtaaatcag gtttcaccaa ctgaaatgtc tccctttgaa
     4201 agtagcaaac atgatttgta tgttaactta actttaattt cctgtgtagt ttacacccag
     4261 agcagatact cataaagtat aaagtaaaaa cttttaacca ttattaaaca gagaacttgc
     4321 catgttgagt gccattgtat tgaacttatt ctaaaggctt atgctaaccc atttataatt
     4381 ggtaaaaatc agaaaataca agatttacat aaaggtcatt tcaactttta aggttaccag
     4441 tgattgtata aaaacatcac aatcctaaat cctctcgtat ctcaccccaa accccaaact
     4501 gggggaaaaa aagttaactc tttgtgaatg gaaccaatgt gcaagataca tactgcattt
     4561 ttaaaatagt gtctcagcta aatggaaaac tgttaagcaa acatccatag taaaacaaat
     4621 aatcttcagt gagatctttt tataaaactt cttgttttta ggattccctt tgcttcttcc
     4681 tttgaattct ctaaaatagg cagctaacgg attatatact tcagggtttg gctttgtgct
     4741 aaatgtggtt ttgtgttttg ctgtatttca aaattttcct tctgttaaag gaaaatattg
     4801 tgaataacca ctggtgtgtt cttagatcag cacaaaccat gtcaaaaaaa attggagatt
     4861 tttttccaat tttccttcca ctgatcttag gcagtaataa acaatggcat ttgtcatctt
     4921 tggcacttgc ttttagatta tagtcccaca gttgcactgc cccaattgtc tacctttgtg
     4981 ggtacatttt tgttctttac tcctaagtta tttctcatag aacccagcct actctagaat
     5041 ttcagcagtg acattggaga atatttttaa tttgctgcag tactatgtca tattattagt
     5101 atgaatctca tttcccaaag ggtttgtatt ctgctaaaag gagatgccaa tgttgaatga
     5161 agtctgaaac tctagtatgt gcatagtttg acgtgcagca tgcacaccag gccttaagat
     5221 gggaatgtag cttaatgatt ttctgtttcc cataccattt ctaatctttt gtgtaatttt
     5281 ctcttaactg attgctctga tattgtaaac acaatagatg tagctctatc atgtctagca
     5341 taatttaaaa aatcagtgtt tttaggattt gggaaaataa actgtaaatg tttatttgat
     5401 aggtaaatat agttttattg tcacatgcta aatattgcat gcatattgac taattggaat
     5461 aaccatttac tcaattatgg acagcttatt gaaatagtat tgatttagaa aaagtatatt
     5521 gcatttctaa aaaacatcta ccaaggttac tcgtctgaat attgctttta gccgtgtttt
     5581 ataacataga cgagcagtag ggtctgttta ttagcaaatt tcctatttgt tccaatacaa
     5641 actcacttta ttctaaagta tattaatgaa accagttcct gtgatgtaac tgtaagcctt
     5701 ctcgacttag acttaaaaag tggtcacata gattaatttt gtgacttttt agtatagact
     5761 gtagccataa ttctcaaata tgaaatggga cctaatacca gtatgtgata aatgttgatg
     5821 ttttctgtgt acaaacacat tttctatgca tgtgtctctg tgtatatggc atatacctag
     5881 taagtatgtt tctgtaagta tgtgtatttt atgtccattt gagtaggtag gtaggtttta
     5941 aaaatactag ttaaaatgcc acaagcatga gtgtgattgt atgtgcactg tgtgtatata
     6001 tataaatata tgtatatgta tggttgtaaa tatctatgta tacatgtact tagtatgtgt
     6061 ggtatcagga tattttttaa actgtgataa tacaacagat agctttgaat gatctgccat
     6121 aacatgtggt aacaatagtt catttctcat aacatatatg aggtatacaa aattttctaa
     6181 ctccagattg tagtcatttt gagaggtaca aagctcataa ttaccatgac aacatggtaa
     6241 tgtccataga catttgtatc tgaatccaca agaagatctg aatctaagaa ggaattacct
     6301 ttgacaatat ttttcggtaa gaagtaaaac ctctggagac ctatctttaa gatctctaat
     6361 tggaattata aattattttt ggattgctga gctgaatctt aaaaagccaa gttgatatac
     6421 atagtcattt ttcctctatg gtagaagtaa aaaaaaaaaa aaaggacata gcaacattaa
     6481 agtagtggat ttttctgagt aaatttgctg aaaatataag agagaagcta tctaatacct
     6541 tggaggtagg tcatccactt tttcaggtaa acatttttca tttggcaaat ggcataatta
     6601 tttgaaagtg acaggaatct cctcagaatg aagaataaag cctactaggt ctctaactgt
     6661 tgaactcatg aaagaagata gtgtatgaga cttaagccat gagttttgta tcatttcaat
     6721 tagaagacta ctagctgtga gctcagagtt taatgtaaat gaatctagat gattttgaag
     6781 aaatgattat tcgttcacca gatcactcat tgtacattct aaaaagctca aatgagtctt
     6841 ctagatactc ttactcatcc tgtctggttg ctatgtttaa aattatgtgg tgctgtgtag
     6901 gtgaaacttt aagaatattt ttgaagcata tgtaatatat gcactgctat ttgtgtgtgt
     6961 gtgtgtgtct ttgtatatat gtaagaatgt gtgtatgtgt gagagcaaga gagaggaaac
     7021 tcaaagagga gtgtttgtct taagacctgt tcatactggt atattggtga gacttctcac
     7081 ttctggttgg aggtttcaca tatggctcaa ctcaagtcat taatctcttt ttaattttta
     7141 ctcttgaatt ccttaaactt cgctcattat gaaatgtttt aaaattatga caaaaattac
     7201 tctgtctaac cacttgcctt gtctgctacc agtttgttaa aaattattcc ccccaaccag
     7261 taattccacc agtactactt gatttgtgtt atatttccta tgtacatgta cagcctttgt
     7321 tttgcttgct tgtctatttt tactttccct tttttgggtc aaatttttct tttgctttgt
     7381 ttgaagaagg aatatacaga agtaaaatct tgtcttctct gctgattctt taattaatat
     7441 gagccggata ctttccactg tcttcttggc actttcagga tttcttaatg ctgatatatg
     7501 gactcttaga atggaatttt tgaagaaaaa tctcaaagcc tgtatcgttc ttgaaggtca
     7561 catgtaccta ttgtgaaaat gtgaagctgt atttctgaag ctgaaataaa ttataacatt
     7621 tgaagga
//
