LOCUS       NM_012062               4514 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens dynamin 1 like (DNM1L), transcript variant 1, mRNA.
ACCESSION   NM_012062
VERSION     NM_012062.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4514)
  AUTHORS   Peng,Y., Zhao,T., Rong,S., Yang,S., Teng,W., Xie,Y. and Wang,Y.
  TITLE     Young small extracellular vesicles rejuvenate replicative
            senescence by remodeling Drp1 translocation-mediated mitochondrial
            dynamics
  JOURNAL   J Nanobiotechnology 22 (1), 543 (2024)
   PUBMED   39238005
  REMARK    GeneRIF: Young small extracellular vesicles rejuvenate replicative
            senescence by remodeling Drp1 translocation-mediated mitochondrial
            dynamics.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4514)
  AUTHORS   Kaur,S., Khullar,N., Navik,U., Bali,A., Bhatti,G.K. and Bhatti,J.S.
  TITLE     Multifaceted role of dynamin-related protein 1 in cardiovascular
            disease: From mitochondrial fission to therapeutic interventions
  JOURNAL   Mitochondrion 78, 101904 (2024)
   PUBMED   38763184
  REMARK    GeneRIF: Multifaceted role of dynamin-related protein 1 in
            cardiovascular disease: From mitochondrial fission to therapeutic
            interventions.
            Review article
REFERENCE   3  (bases 1 to 4514)
  AUTHORS   Kadier,T., Zhang,Y.G., Jing,Y.X., Weng,Z.Y., Liao,S.S., Luo,J.,
            Ding,K., Cao,C., Chen,R. and Meng,Q.T.
  TITLE     MCU inhibition protects against intestinal ischemia-reperfusion by
            inhibiting Drp1-dependent mitochondrial fission
  JOURNAL   Free Radic Biol Med 221, 111-124 (2024)
   PUBMED   38763207
  REMARK    GeneRIF: MCU inhibition protects against intestinal
            ischemia-reperfusion by inhibiting Drp1-dependent mitochondrial
            fission.
REFERENCE   4  (bases 1 to 4514)
  AUTHORS   Ghani,M., Szabo,B., Alkhatibe,M., Amsalu,H., Zohar,P., Janka,E.A.,
            Motyan,J.A. and Tar,K.
  TITLE     Serine 39 in the GTP-binding domain of Drp1 is involved in shaping
            mitochondrial morphology
  JOURNAL   FEBS Open Bio 14 (7), 1147-1165 (2024)
   PUBMED   38760979
  REMARK    GeneRIF: Serine 39 in the GTP-binding domain of Drp1 is involved in
            shaping mitochondrial morphology.
REFERENCE   5  (bases 1 to 4514)
  AUTHORS   Chen,Y., Li,S., Guan,B., Yan,X., Huang,C., Du,Y., Yang,F.,
            Zhang,N., Li,Y., Lu,J., Wang,J., Zhang,J., Chen,Z., Chen,C. and
            Kong,X.
  TITLE     MAP4K4 exacerbates cardiac microvascular injury in diabetes by
            facilitating S-nitrosylation modification of Drp1
  JOURNAL   Cardiovasc Diabetol 23 (1), 164 (2024)
   PUBMED   38724987
  REMARK    GeneRIF: MAP4K4 exacerbates cardiac microvascular injury in
            diabetes by facilitating S-nitrosylation modification of Drp1.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4514)
  AUTHORS   Waterham,H.R., Koster,J., van Roermund,C.W., Mooyer,P.A.,
            Wanders,R.J. and Leonard,J.V.
  TITLE     A lethal defect of mitochondrial and peroxisomal fission
  JOURNAL   N Engl J Med 356 (17), 1736-1741 (2007)
   PUBMED   17460227
REFERENCE   7  (bases 1 to 4514)
  AUTHORS   Imoto,M., Tachibana,I. and Urrutia,R.
  TITLE     Identification and functional characterization of a novel human
            protein highly related to the yeast dynamin-like GTPase Vps1p
  JOURNAL   J Cell Sci 111 (Pt 10), 1341-1349 (1998)
   PUBMED   9570752
REFERENCE   8  (bases 1 to 4514)
  AUTHORS   Yoon,Y., Pitts,K.R., Dahan,S. and McNiven,M.A.
  TITLE     A novel dynamin-like protein associates with cytoplasmic vesicles
            and tubules of the endoplasmic reticulum in mammalian cells
  JOURNAL   J Cell Biol 140 (4), 779-793 (1998)
   PUBMED   9472031
REFERENCE   9  (bases 1 to 4514)
  AUTHORS   Kamimoto,T., Nagai,Y., Onogi,H., Muro,Y., Wakabayashi,T. and
            Hagiwara,M.
  TITLE     Dymple, a novel dynamin-like high molecular weight GTPase lacking a
            proline-rich carboxyl-terminal domain in mammalian cells
  JOURNAL   J Biol Chem 273 (2), 1044-1051 (1998)
   PUBMED   9422767
REFERENCE   10 (bases 1 to 4514)
  AUTHORS   Shin,H.W., Shinotsuka,C., Torii,S., Murakami,K. and Nakayama,K.
  TITLE     Identification and subcellular localization of a novel mammalian
            dynamin-related protein homologous to yeast Vps1p and Dnm1p
  JOURNAL   J Biochem 122 (3), 525-530 (1997)
   PUBMED   9348079
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK302565.1, AB006965.1 and
            AC087588.10.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_012062.4.
            
            Summary: This gene encodes a member of the dynamin superfamily of
            GTPases. The encoded protein mediates mitochondrial and peroxisomal
            division, and is involved in developmentally regulated apoptosis
            and programmed necrosis. Dysfunction of this gene is implicated in
            several neurological disorders, including Alzheimer's disease.
            Mutations in this gene are associated with the autosomal dominant
            disorder, encephalopathy, lethal, due to defective mitochondrial
            and peroxisomal fission (EMPF). Alternative splicing results in
            multiple transcript variants encoding different isoforms. [provided
            by RefSeq, Jun 2013].
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.224930.1,
                                           SRR1803614.83130.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000549701.6/ ENSP00000450399.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                AK302565.1         102-130
            30-2477             AB006965.1         2-2449
            2478-4514           AC087588.10        138112-140148       c
FEATURES             Location/Qualifiers
     source          1..4514
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p11.21"
     gene            1..4514
                     /gene="DNM1L"
                     /gene_synonym="DLP1; DRP1; DVLP; DYMPLE; EMPF; EMPF1;
                     HDYNIV; OPA5"
                     /note="dynamin 1 like"
                     /db_xref="GeneID:10059"
                     /db_xref="HGNC:HGNC:2973"
                     /db_xref="MIM:603850"
     exon            1..165
                     /gene="DNM1L"
                     /gene_synonym="DLP1; DRP1; DVLP; DYMPLE; EMPF; EMPF1;
                     HDYNIV; OPA5"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..2274
                     /gene="DNM1L"
                     /gene_synonym="DLP1; DRP1; DVLP; DYMPLE; EMPF; EMPF1;
                     HDYNIV; OPA5"
                     /EC_number="3.6.5.5"
                     /note="isoform 1 is encoded by transcript variant 1;
                     Dnm1p/Vps1p-like protein; dynamin family member
                     proline-rich carboxyl-terminal domain less; dynamin-like
                     protein 4; dynamin-like protein IV; dynamin-related
                     protein 1"
                     /codon_start=1
                     /product="dynamin-1-like protein isoform 1"
                     /protein_id="NP_036192.2"
                     /db_xref="CCDS:CCDS8729.1"
                     /db_xref="GeneID:10059"
                     /db_xref="HGNC:HGNC:2973"
                     /db_xref="MIM:603850"
                     /translation="MEALIPVINKLQDVFNTVGADIIQLPQIVVVGTQSSGKSSVLES
                     LVGRDLLPRGTGIVTRRPLILQLVHVSQEDKRKTTGEENGVEAEEWGKFLHTKNKLYT
                     DFDEIRQEIENETERISGNNKGVSPEPIHLKIFSPNVVNLTLVDLPGMTKVPVGDQPK
                     DIELQIRELILRFISNPNSIILAVTAANTDMATSEALKISREVDPDGRRTLAVITKLD
                     LMDAGTDAMDVLMGRVIPVKLGIIGVVNRSQLDINNKKSVTDSIRDEYAFLQKKYPSL
                     ANRNGTKYLARTLNRLLMHHIRDCLPELKTRINVLAAQYQSLLNSYGEPVDDKSATLL
                     QLITKFATEYCNTIEGTAKYIETSELCGGARICYIFHETFGRTLESVDPLGGLNTIDI
                     LTAIRNATGPRPALFVPEVSFELLVKRQIKRLEEPSLRCVELVHEEMQRIIQHCSNYS
                     TQELLRFPKLHDAIVEVVTCLLRKRLPVTNEMVHNLVAIELAYINTKHPDFADACGLM
                     NNNIEEQRRNRLARELPSAVSRDKSSKVPSALAPASQEPSPAASAEADGKLIQDSRRE
                     TKNVASGGGGVGDGVQEPTTGNWRGMLKTSKAEELLAEEKSKPIPIMPASPQKGHAVN
                     LLDVPVPVARKLSAREQRDCEVIERLIKSYFLIVRKNIQDSVPKAVMHFLVNHVKDTL
                     QSELVGQLYKSSLLDDLLTESEDMAQRRKEAADMLKALQGASQIIAEIRETHLW"
     exon            166..313
                     /gene="DNM1L"
                     /gene_synonym="DLP1; DRP1; DVLP; DYMPLE; EMPF; EMPF1;
                     HDYNIV; OPA5"
                     /inference="alignment:Splign:2.1.0"
     exon            314..360
                     /gene="DNM1L"
                     /gene_synonym="DLP1; DRP1; DVLP; DYMPLE; EMPF; EMPF1;
                     HDYNIV; OPA5"
                     /inference="alignment:Splign:2.1.0"
     exon            361..432
                     /gene="DNM1L"
                     /gene_synonym="DLP1; DRP1; DVLP; DYMPLE; EMPF; EMPF1;
                     HDYNIV; OPA5"
                     /inference="alignment:Splign:2.1.0"
     exon            433..519
                     /gene="DNM1L"
                     /gene_synonym="DLP1; DRP1; DVLP; DYMPLE; EMPF; EMPF1;
                     HDYNIV; OPA5"
                     /inference="alignment:Splign:2.1.0"
     exon            520..682
                     /gene="DNM1L"
                     /gene_synonym="DLP1; DRP1; DVLP; DYMPLE; EMPF; EMPF1;
                     HDYNIV; OPA5"
                     /inference="alignment:Splign:2.1.0"
     exon            683..803
                     /gene="DNM1L"
                     /gene_synonym="DLP1; DRP1; DVLP; DYMPLE; EMPF; EMPF1;
                     HDYNIV; OPA5"
                     /inference="alignment:Splign:2.1.0"
     exon            804..935
                     /gene="DNM1L"
                     /gene_synonym="DLP1; DRP1; DVLP; DYMPLE; EMPF; EMPF1;
                     HDYNIV; OPA5"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1142
                     /gene="DNM1L"
                     /gene_synonym="DLP1; DRP1; DVLP; DYMPLE; EMPF; EMPF1;
                     HDYNIV; OPA5"
                     /inference="alignment:Splign:2.1.0"
     exon            1143..1263
                     /gene="DNM1L"
                     /gene_synonym="DLP1; DRP1; DVLP; DYMPLE; EMPF; EMPF1;
                     HDYNIV; OPA5"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..1419
                     /gene="DNM1L"
                     /gene_synonym="DLP1; DRP1; DVLP; DYMPLE; EMPF; EMPF1;
                     HDYNIV; OPA5"
                     /inference="alignment:Splign:2.1.0"
     exon            1420..1509
                     /gene="DNM1L"
                     /gene_synonym="DLP1; DRP1; DVLP; DYMPLE; EMPF; EMPF1;
                     HDYNIV; OPA5"
                     /inference="alignment:Splign:2.1.0"
     exon            1510..1602
                     /gene="DNM1L"
                     /gene_synonym="DLP1; DRP1; DVLP; DYMPLE; EMPF; EMPF1;
                     HDYNIV; OPA5"
                     /inference="alignment:Splign:2.1.0"
     exon            1603..1659
                     /gene="DNM1L"
                     /gene_synonym="DLP1; DRP1; DVLP; DYMPLE; EMPF; EMPF1;
                     HDYNIV; OPA5"
                     /inference="alignment:Splign:2.1.0"
     exon            1660..1737
                     /gene="DNM1L"
                     /gene_synonym="DLP1; DRP1; DVLP; DYMPLE; EMPF; EMPF1;
                     HDYNIV; OPA5"
                     /inference="alignment:Splign:2.1.0"
     exon            1738..1770
                     /gene="DNM1L"
                     /gene_synonym="DLP1; DRP1; DVLP; DYMPLE; EMPF; EMPF1;
                     HDYNIV; OPA5"
                     /inference="alignment:Splign:2.1.0"
     exon            1771..1947
                     /gene="DNM1L"
                     /gene_synonym="DLP1; DRP1; DVLP; DYMPLE; EMPF; EMPF1;
                     HDYNIV; OPA5"
                     /inference="alignment:Splign:2.1.0"
     exon            1948..2057
                     /gene="DNM1L"
                     /gene_synonym="DLP1; DRP1; DVLP; DYMPLE; EMPF; EMPF1;
                     HDYNIV; OPA5"
                     /inference="alignment:Splign:2.1.0"
     exon            2058..2217
                     /gene="DNM1L"
                     /gene_synonym="DLP1; DRP1; DVLP; DYMPLE; EMPF; EMPF1;
                     HDYNIV; OPA5"
                     /inference="alignment:Splign:2.1.0"
     exon            2218..4514
                     /gene="DNM1L"
                     /gene_synonym="DLP1; DRP1; DVLP; DYMPLE; EMPF; EMPF1;
                     HDYNIV; OPA5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2457..2462
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DNM1L"
                     /gene_synonym="DLP1; DRP1; DVLP; DYMPLE; EMPF; EMPF1;
                     HDYNIV; OPA5"
                     /note="hexamer: AATAAA"
     polyA_site      2479
                     /gene="DNM1L"
                     /gene_synonym="DLP1; DRP1; DVLP; DYMPLE; EMPF; EMPF1;
                     HDYNIV; OPA5"
                     /note="major polyA site"
     regulatory      4386..4391
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DNM1L"
                     /gene_synonym="DLP1; DRP1; DVLP; DYMPLE; EMPF; EMPF1;
                     HDYNIV; OPA5"
                     /note="hexamer: AATAAA"
     polyA_site      4411
                     /gene="DNM1L"
                     /gene_synonym="DLP1; DRP1; DVLP; DYMPLE; EMPF; EMPF1;
                     HDYNIV; OPA5"
                     /note="major polyA site"
ORIGIN      
        1 gtgggccccg gccccattca ttgccgtggc cggcgggcac tggggccccg tgttttcaga
       61 gtcatggagg cgctaattcc tgtcataaac aagctccagg acgtcttcaa cacggtgggc
      121 gccgacatca tccagctgcc tcaaatcgtc gtagtgggaa cgcagagcag cggaaagagc
      181 tcagtgctag aaagcctggt ggggagggac ctgcttccca gaggtactgg aattgtcacc
      241 cggagacctc tcattctgca actggtccat gtttcacaag aagataaacg gaaaacaaca
      301 ggagaagaaa atggggtgga agcagaagaa tggggtaaat ttcttcacac caaaaataag
      361 ctttacacgg attttgatga aattcgacaa gaaattgaaa atgaaacaga aagaatttca
      421 ggaaataata agggagtaag ccctgaacca attcatctta agattttttc acccaacgtt
      481 gtcaatttga cacttgtgga tttgccagga atgaccaagg tgcctgtagg tgatcaacct
      541 aaggatattg agcttcaaat cagagagctc attcttcggt tcatcagtaa tcctaattcc
      601 attatcctcg ctgtcactgc tgctaataca gatatggcaa catcagaggc acttaaaatt
      661 tcaagagagg tagatccaga tggtcgcaga accctagctg taatcactaa acttgatctc
      721 atggatgcgg gtactgatgc catggatgta ttgatgggaa gggttattcc agtcaaactt
      781 ggaataattg gagtagttaa caggagccag ctagatatta acaacaagaa gagtgtaact
      841 gattcaatcc gtgatgagta tgcttttctt caaaagaaat atccatctct ggccaataga
      901 aatggaacaa agtatcttgc taggactcta aacaggttac tgatgcatca catcagagat
      961 tgtttaccag agttgaaaac aagaataaat gttctagctg ctcagtatca gtctcttcta
     1021 aatagctacg gtgaacccgt ggatgataaa agtgctactt tactccaact tattaccaaa
     1081 tttgccacag aatattgtaa cactattgaa ggaactgcaa aatatattga aacttcggag
     1141 ctatgcggtg gtgctagaat ttgttatatt ttccatgaga cttttgggcg aaccttagaa
     1201 tctgttgatc cacttggtgg ccttaacact attgacattt tgactgccat tagaaatgct
     1261 actggtcctc gtcctgcttt atttgtgcct gaggtttcat ttgagttact ggtgaagcgg
     1321 caaatcaaac gtctagaaga gcccagcctc cgctgtgtgg aactggttca tgaggaaatg
     1381 caaaggatca ttcagcactg tagcaattac agtacacagg aattgttacg atttcctaaa
     1441 cttcatgatg ccatagttga agtggtgact tgtcttcttc gtaaaaggtt gcctgttaca
     1501 aatgaaatgg tccataactt agtggcaatt gaactggctt atatcaacac aaaacatcca
     1561 gactttgctg atgcttgtgg gctaatgaac aataatatag aggaacaaag gagaaacagg
     1621 ctagccagag aattaccttc agctgtatca cgagacaagt cttctaaagt tccaagtgct
     1681 ttggcacctg cctcccagga gccctccccc gctgcttctg ctgaggctga tggcaagtta
     1741 attcaggaca gcagaagaga aactaaaaat gttgcatctg gaggtggtgg ggttggagat
     1801 ggtgttcaag aaccaaccac aggcaactgg agaggaatgc tgaaaacttc aaaagctgaa
     1861 gagttattag cagaagaaaa atcaaaaccc attccaatta tgccagccag tccacaaaaa
     1921 ggtcatgccg tgaacctgct agatgtgcca gttcctgttg cacgaaaact atctgctcgg
     1981 gaacagcgag attgtgaggt tattgaacga ctcattaaat catattttct cattgtcaga
     2041 aagaatattc aagacagtgt gccaaaggca gtaatgcatt ttttggttaa tcatgtgaaa
     2101 gacactcttc agagtgagct agtaggccag ctgtataaat catccttatt ggatgatctt
     2161 ctgacagaat ctgaggacat ggcacagcgc aggaaagaag cagctgatat gctaaaggca
     2221 ttacaaggag ccagtcaaat tattgctgaa atccgggaga ctcatctttg gtgaagagaa
     2281 ctatgtaata ctgagacttt gttgactcaa aacttgctag ttactgccta cctgagtaga
     2341 atcttattta tgaactcctg tgtattgcaa tggtatgaat ctgctcatgt ggagactggc
     2401 tataaactga aaagtgtatt ccaaattgca gaacacatca cacatttaat ccaaataata
     2461 aatggctgtt tctaaagttt cccagtatat ataaaataca tcaagtctgt cttgtgacag
     2521 tttcatctga acttaactta aaaacaactg ttaatgttct agttgtgcaa agcagtttgc
     2581 ctgtggataa gatgacctgt gtaataatct ttgttagtag tcttaaagct gctgccatag
     2641 tcctccaaga agaaagcacc aagacaacat ttcatatgac tataatgcat gtactatata
     2701 agctgatctg gctttgaaag atgtgagttg gcaagttcct cacatagagt cattgtattc
     2761 cacctgtcct tcaatttagt tttttctgag cttctttgca gcctttgatg tgtttttaag
     2821 aaagctgaat gcacaagagg atctgtgaca ctgacatggc tgtggtgtgc atactgtgta
     2881 gttacatagc ccttccaatt ctgggtccat ttgcactagc aaattaaaat atgctttgat
     2941 tcatacttaa acctgaaagc aggaatgcct acattaattc ctacattaaa aacagccatc
     3001 tacccttgat tatctagaaa gacttggtaa tgatggtcag ttccttttag atttcagaaa
     3061 atcaaatgat gacctaaatt tcccttaatt tgcaaataca gtagtaatta aggtacatct
     3121 ctaaagtgga gcacttacac caggctctaa gattcacttt gaggtggaac ttaaaaccag
     3181 tgtactgtat gtatgcattg gtaatagcta cttttgcttc atagcttcat accaacaaaa
     3241 tatatttatt agaatagtat gaaagtactg gaggagctga aagaaaaaca cccaaggctg
     3301 ggcgtggtgg cacacgcctg taatcccagc actttgggag gccgaggcag gtggatcacc
     3361 tgaggttggg agttggagac cagcttgacc aacatggaga aaccccgtct ctactaaaaa
     3421 tacaaaattg gccgggcgtg gtggcgcatg cctgtaatcc cagctactcg ggagggtgag
     3481 gcaggagaat tgcttgaccc tgggaggtgg aggttgtggt gagctaagat cgtgccattg
     3541 cactccagcc ttggcaacaa gagcgaaact ccgtctcaaa aaaaaaaaat aaaacaacac
     3601 ccagatagat acacatactc cttcagactt acagacctaa gctgcattta tggggtagtg
     3661 atgaggttta gaacatatac atattttgtt aaaattcccc agatgattct tggtatgaac
     3721 gactatatta taaattttaa gatgtactta gaaatcctta agacatctag ccccgtctct
     3781 aatagacaac acatttatat tgcagatatt actttttttt cagtttatga ccaggtattt
     3841 atgaaggact attggcaggg aaaatatgaa tatgttaact ttagcttatg gcatcaattt
     3901 actaaggaac aacaggctca ccaactgatg tcaaacataa aaacccccac atcagtctga
     3961 tacgatatgg tactactttg aatctgttac tagtaccatc ttgacagagg atacatgctc
     4021 ccaaaacgtt tgttaccaca cttaaaaatc actgccatca ttaagcatca gtttcaaaat
     4081 tatagccatt catgatttac tttttccaga tgactatcat tattctagtc ctttgaattt
     4141 gtaaggggaa aaaaaacaaa aacaaaaact tacgatgcac ttttctccag cacatcagat
     4201 ttcaaattga aaattaaaga catgctatgg taatgcactt gctagtacta cacactttgt
     4261 acaacaaaaa acagaggcaa gaaacaacgg aaagagaaaa gccttccttt gttggccctt
     4321 aaactgagtc aagatctgaa atgtagagat gatctctgac gatacctgta tgttcttatt
     4381 gtgtaaataa aattgctggt atgaaatgac actaaagttt gtcaaaaaat gaattcttaa
     4441 cttttctccc agagaaaggg agacaaaagg agctttttaa tacctaatct actttggaac
     4501 ataaccgtat agag
//
