LOCUS       NM_001080849            3096 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens DNL-type zinc finger (DNLZ), transcript variant 1,
            mRNA.
ACCESSION   NM_001080849 XM_001127552
VERSION     NM_001080849.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3096)
  AUTHORS   Moritz,M.N.O., Dores-Silva,P.R., Coto,A.L.S.,
            Selistre-de-Araujo,H.S., Leitao,A., Cauvi,D.M., De Maio,A.,
            Carra,S. and Borges,J.C.
  TITLE     Human HSP70-escort protein 1 (hHep1) interacts with negatively
            charged lipid bilayers and cell membranes
  JOURNAL   Cell Stress Chaperones 28 (6), 1001-1012 (2023)
   PUBMED   38001371
  REMARK    GeneRIF: Human HSP70-escort protein 1 (hHep1) interacts with
            negatively charged lipid bilayers and cell membranes.
REFERENCE   2  (bases 1 to 3096)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (bases 1 to 3096)
  AUTHORS   Dores-Silva,P.R., Kiraly,V.T.R., Moritz,M.N.O., Serrao,V.H.B., Dos
            Passos,P.M.S., Spagnol,V., Teixeira,F.R., Gava,L.M., Cauvi,D.M.,
            Ramos,C.H.I., De Maio,A. and Borges,J.C.
  TITLE     New insights on human Hsp70-escort protein 1: Chaperone activity,
            interaction with liposomes, cellular localizations and HSPA's
            self-assemblies remodeling
  JOURNAL   Int J Biol Macromol 182, 772-784 (2021)
   PUBMED   33857516
  REMARK    GeneRIF: New insights on human Hsp70-escort protein 1: Chaperone
            activity, interaction with liposomes, cellular localizations and
            HSPA's self-assemblies remodeling.
REFERENCE   4  (bases 1 to 3096)
  AUTHORS   Dores-Silva,P.R., Minari,K., Ramos,C.H., Barbosa,L.R. and
            Borges,J.C.
  TITLE     Structural and stability studies of the human mtHsp70-escort
            protein 1: an essential mortalin co-chaperone
  JOURNAL   Int J Biol Macromol 56, 140-148 (2013)
   PUBMED   23462535
  REMARK    GeneRIF: The results indicate that hHep1 shares some structural
            similarities with the yeast ortholog despite the low identity and
            functional differences.
REFERENCE   5  (bases 1 to 3096)
  AUTHORS   Vu,M.T., Zhai,P., Lee,J., Guerra,C., Liu,S., Gustin,M.C. and
            Silberg,J.J.
  TITLE     The DNLZ/HEP zinc-binding subdomain is critical for regulation of
            the mitochondrial chaperone HSPA9
  JOURNAL   Protein Sci 21 (2), 258-267 (2012)
   PUBMED   22162012
  REMARK    GeneRIF: DNLZ/HEP zinc-binding subdomain is critical for regulation
            of the mitochondrial chaperone HSPA9. Human DNLZ partially
            complements the growth of Deltazim17 Saccharomyces cerevisiae.
REFERENCE   6  (bases 1 to 3096)
  AUTHORS   Zhai,P., Vu,M.T., Hoff,K.G. and Silberg,J.J.
  TITLE     A conserved histidine in human DNLZ/HEP is required for stimulation
            of HSPA9 ATPase activity
  JOURNAL   Biochem Biophys Res Commun 408 (4), 589-594 (2011)
   PUBMED   21530495
  REMARK    GeneRIF: These findings implicate a conserved histidine as critical
            for DNLZ regulation of mitochondrial HSPA9 catalytic activity.
REFERENCE   7  (bases 1 to 3096)
  AUTHORS   Zhai,P., Stanworth,C., Liu,S. and Silberg,J.J.
  TITLE     The human escort protein Hep binds to the ATPase domain of
            mitochondrial hsp70 and regulates ATP hydrolysis
  JOURNAL   J Biol Chem 283 (38), 26098-26106 (2008)
   PUBMED   18632665
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC146915.1, AI435052.1, AI696701.1 and AL592301.14.
            
            On Nov 23, 2018 this sequence version replaced NM_001080849.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the a protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163658.513955.1, BI827090.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371738.4/ ENSP00000360803.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-604               BC146915.1         68-671
            605-623             AI435052.1         55-73               c
            624-679             AI696701.1         5-60                c
            680-3096            AL592301.14        3107-5523           c
FEATURES             Location/Qualifiers
     source          1..3096
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.3"
     gene            1..3096
                     /gene="DNLZ"
                     /gene_synonym="bA413M3.2; C9orf151; HEP; HEP1; TIMM15;
                     ZIM17"
                     /note="DNL-type zinc finger"
                     /db_xref="GeneID:728489"
                     /db_xref="HGNC:HGNC:33879"
                     /db_xref="MIM:620797"
     exon            1..258
                     /gene="DNLZ"
                     /gene_synonym="bA413M3.2; C9orf151; HEP; HEP1; TIMM15;
                     ZIM17"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..567
                     /gene="DNLZ"
                     /gene_synonym="bA413M3.2; C9orf151; HEP; HEP1; TIMM15;
                     ZIM17"
                     /note="HSP70 escort protein; translocase of inner
                     mitochondrial membrane 15 homolog; hsp70-escort protein 1;
                     mtHsp70-escort protein; RP11-413M3.2"
                     /codon_start=1
                     /product="DNL-type zinc finger protein"
                     /protein_id="NP_001074318.1"
                     /db_xref="CCDS:CCDS35179.1"
                     /db_xref="GeneID:728489"
                     /db_xref="HGNC:HGNC:33879"
                     /db_xref="MIM:620797"
                     /translation="MLRTALRGAPRLLSRVQPRAPCLRRLWGRGARPEVAGRRRAWAW
                     GWRRSSSEQGPGPAAALGRVEAAHYQLVYTCKVCGTRSSKRISKLAYHQGVVIVTCPG
                     CQNHHIIADNLGWFSDLNGKRNIEEILTARGEQVHRVAGEGALELVLEAAGAPTSTAA
                     PEAGEDEGPPSPGKTEPS"
     exon            259..398
                     /gene="DNLZ"
                     /gene_synonym="bA413M3.2; C9orf151; HEP; HEP1; TIMM15;
                     ZIM17"
                     /inference="alignment:Splign:2.1.0"
     exon            399..3096
                     /gene="DNLZ"
                     /gene_synonym="bA413M3.2; C9orf151; HEP; HEP1; TIMM15;
                     ZIM17"
                     /inference="alignment:Splign:2.1.0"
     regulatory      656..661
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DNLZ"
                     /gene_synonym="bA413M3.2; C9orf151; HEP; HEP1; TIMM15;
                     ZIM17"
                     /note="hexamer: AATAAA"
     polyA_site      676
                     /gene="DNLZ"
                     /gene_synonym="bA413M3.2; C9orf151; HEP; HEP1; TIMM15;
                     ZIM17"
                     /note="major polyA site"
     polyA_site      3021
                     /gene="DNLZ"
                     /gene_synonym="bA413M3.2; C9orf151; HEP; HEP1; TIMM15;
                     ZIM17"
     regulatory      3074..3079
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DNLZ"
                     /gene_synonym="bA413M3.2; C9orf151; HEP; HEP1; TIMM15;
                     ZIM17"
                     /note="hexamer: AATAAA"
     polyA_site      3096
                     /gene="DNLZ"
                     /gene_synonym="bA413M3.2; C9orf151; HEP; HEP1; TIMM15;
                     ZIM17"
ORIGIN      
        1 ggggcagggc ggacggagcc ggcgagcggg atgctgcgga ctgcgctgcg cggcgcgccg
       61 aggttgctga gtcgcgtgca gccccgggcg ccctgcctga ggcggctgtg gggccgcggg
      121 gcccgtccag aggtcgcggg gaggcggcgg gcctgggcct ggggctggcg gcgctcaagc
      181 tccgagcagg ggccggggcc cgcggcggct ctggggcgcg tggaggcggc gcactaccag
      241 ctcgtctaca cctgcaaggt ctgcgggact aggtcctcca agcgcatctc caagctggcc
      301 tatcaccaag gcgtggtcat tgtgacctgc cccggctgcc agaaccacca tatcatcgct
      361 gacaacctgg gctggttctc ggacctgaat gggaagagaa atatcgaaga gatcctgacg
      421 gccagaggcg agcaggtgca ccgtgtggcg ggcgaggggg ccctggaact ggttctggag
      481 gctgcagggg cccccacatc cactgcagct ccggaagcgg gtgaggatga gggtcccccc
      541 agccctggca agacggagcc gagctgactc ctgcgctccc cggcactgtg ggacttcggc
      601 cttccagaag gaggttttgg ccctgggcct ctctggacgt ggcctgtttt ctatcaataa
      661 acagacatta cttccagatg ctggggcctg tggccctcgt ggcctttctt tttctggagt
      721 tagaacgatt gctctgaatc cctggtgctg ctgggtggga cataggagcc gcaggacctc
      781 tcgcctcacc acagttcctt ctacacagag tcacccagct cttgcccaca gaggccacag
      841 tcgcgtggaa agggggctgg atgtggcgtc agagcccttc ctggctgtcg ctgcgtgact
      901 ttgagcaggt caccacccct gtgagcctca gccttcctct gcaaggccct tgccgccccc
      961 ctggccagct ctggcggcct cccttccgtg agccagtgca gacctgagcc ctggtcctcg
     1021 gccgccggcc gtcggcgaaa cagtgagcaa accaggctgc ctgctggccc aggcaggacg
     1081 agcagctatg gcgtggccgt gtgttaggag ctccagaccc ctcccggggg agccacctgg
     1141 gcctccttcc ctcggtggac agcgctctgg acgtccccag ggccctccga ggtgtgtggg
     1201 gtttgtctcc cagccttgtc tgtgcgcagg atgttcccgt gtttatgaaa gcgagcaaac
     1261 acagcagcct gtttatttgc agaagcgttc tgggcagcgt aaccttcagc attcatcacc
     1321 cgccacactc cggcagggaa gagaatgggg cgaggtggga ggtggaggca ggactgagca
     1381 cgacagggac ccagtgcggc ccctcccagc gggacacggc caggactgcc agctcacatc
     1441 cggcccgtgg gaggccgggg cgcggcggca tcgttcccag tgtgcttgtg gcgtgggctt
     1501 tgcctcgatt accccctgtc cttctttcag ccaacaaccc tctattattc ccacccagag
     1561 ccttctgtgc catttgtgga aactgtcctc ttctcggctg agccaccggc acccaggcct
     1621 gctcctccat ggaggcactg gctgggggtc tcttgggggc ttggaagtgc agtggggctg
     1681 ggcttggctt ggctgcctca ctgcctccag agggcctgga ccagcatgtg gggaggtcca
     1741 gggagccgtc tggacctgga agtgcagaat tagagcaagg agagccgctt gggccaaccc
     1801 ctcctcttac ggatggggag atggcggctg gtagttggga tgtggacgtt accatgtctt
     1861 ttctgtctga tgccagcacc tctgggccca ggctggccct ggagggaaat ccttcccaag
     1921 gctggcacgt tcctagagaa gacctatggc taccccccgc gtgccagaag catcccgcca
     1981 gctcctgcct gaggccccct ggaccctgtc tccctccgcc cttccctccc cgcagcccca
     2041 atcccacagc caggtttctg caaggggctt tgccatccta atctcctgcc actctacacc
     2101 cccccgcccc aggacatccc tgcctcccgg gcacggttgc tggcctgggc atccctcgtc
     2161 acagcgtctc tccaagcagg ttcctcggcc gcaccttcag aggctgtccc agccagtagc
     2221 gtgggcggca ctgctgcgct tccctggctg tgcgcggtcc tgggccctgc acggttactt
     2281 ggaccctgtg tgcgtgtacc accacacgca agctggctgg gaccctggac ctggagtaca
     2341 cgttgattct ggttcccaag gccccttctg gggtggagga ggcaacggag tcaaccagca
     2401 cagaggctgt ggctgccaac atggccaggt gggctgtggc gaggggcagc aggactgccc
     2461 ggcgcacctg tgtgtcccct gacgggggcc ccgtgggggt gccacccacc acaagcagcg
     2521 cccagacaag ccccaagact gcagatctgc cgtcggctcc tccactgtgg ctcagtgtcc
     2581 agaccctgag cccagccgga tcagactcca ggaaaggacc tccctccccc gggtgctggg
     2641 tgggcggcag caggctgggt cctcaggggg tcgtggggct gacctggggg ctgctgcttc
     2701 tgggggctgg tcccggccac gtgagtgtca gctcagagca tgctctgttt ccctaggggc
     2761 tgggagcgtg aggaggtagg ggtgcaggaa tcagtggtga cagcaggcag ccacttcacc
     2821 cctctgtgcc ccagctcccc cgtggttaaa tgcagtggga actccatctc tctgaggtct
     2881 cagagggccc agacagtggg tatctgtgga cactttgcac agtgcagcct cttaccgggt
     2941 taggccccca cccgggacta agcccatacg gaccacactc acttggccga ctttattttt
     3001 caggaaaaac agaaaaacaa atgtacctct tgggttggaa aggacccatt gacaacatgg
     3061 cacagacgtg agcaataaat acgcacatac attcaa
//
