LOCUS       NM_139072               3257 bp    mRNA    linear   PRI 02-MAY-2024
DEFINITION  Homo sapiens delta/notch like EGF repeat containing (DNER), mRNA.
ACCESSION   NM_139072
VERSION     NM_139072.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3257)
  AUTHORS   Zhang,Q., Wu,Q., Huan,X.J., Song,S.S., Bao,X.B., Miao,Z.H. and
            Wang,Y.Q.
  TITLE     Co-inhibition of BET and NAE enhances BIM-dependent apoptosis with
            augmented cancer therapeutic efficacy
  JOURNAL   Biochem Pharmacol 223, 116198 (2024)
   PUBMED   38588830
  REMARK    GeneRIF: Co-inhibition of BET and NAE enhances BIM-dependent
            apoptosis with augmented cancer therapeutic efficacy.
REFERENCE   2  (bases 1 to 3257)
  AUTHORS   Morino,S., Mashima,T., Shirai,F., Nagayama,S., Katayama,R. and
            Seimiya,H.
  TITLE     BET protein-dependent E2F pathway activity confers bell-shaped type
            resistance to tankyrase inhibitors in APC-mutated colorectal cancer
  JOURNAL   Cancer Lett 584, 216632 (2024)
   PUBMED   38216082
  REMARK    GeneRIF: BET protein-dependent E2F pathway activity confers
            bell-shaped type resistance to tankyrase inhibitors in APC-mutated
            colorectal cancer.
REFERENCE   3  (bases 1 to 3257)
  AUTHORS   To,H.T.N., Park,J.H., Kim,J.W. and Kang,D.
  TITLE     Delta/Notch-like Epidermal Growth Factor-Related Receptor (DNER), a
            Potential Prognostic Marker of Gastric Cancer Regulates Cell
            Survival and Cell Cycle Progression
  JOURNAL   Int J Mol Sci 24 (12), 10077 (2023)
   PUBMED   37373228
  REMARK    GeneRIF: Delta/Notch-like Epidermal Growth Factor-Related Receptor
            (DNER), a Potential Prognostic Marker of Gastric Cancer Regulates
            Cell Survival and Cell Cycle Progression.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3257)
  AUTHORS   Ruiz-Otero,N. and Kuruvilla,R.
  TITLE     Role of Delta/Notch-like EGF-related receptor in blood glucose
            homeostasis
  JOURNAL   Front Endocrinol (Lausanne) 14, 1161085 (2023)
   PUBMED   37223028
  REMARK    GeneRIF: Role of Delta/Notch-like EGF-related receptor in blood
            glucose homeostasis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3257)
  AUTHORS   Kumari,A., Gesumaria,L., Liu,Y.J., Hughitt,V.K., Zhang,X.,
            Ceribelli,M., Wilson,K.M., Klumpp-Thomas,C., Chen,L., McKnight,C.,
            Itkin,Z., Thomas,C.J., Mock,B.A., Schrump,D.S. and Chen,H.
  TITLE     mTOR inhibition overcomes RSK3-mediated resistance to BET
            inhibitors in small cell lung cancer
  JOURNAL   JCI Insight 8 (5), e156657 (2023)
   PUBMED   36883564
  REMARK    GeneRIF: mTOR inhibition overcomes RSK3-mediated resistance to BET
            inhibitors in small cell lung cancer.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3257)
  AUTHORS   Park,J.R., Jung,J.W., Seo,M.S., Kang,S.K., Lee,Y.S. and Kang,K.S.
  TITLE     DNER modulates adipogenesis of human adipose tissue-derived
            mesenchymal stem cells via regulation of cell proliferation
  JOURNAL   Cell Prolif 43 (1), 19-28 (2010)
   PUBMED   20070733
  REMARK    GeneRIF: The inhibition of DNER protein resulted in an increase in
            adipocyte maturation, partly via a reduction of cell proliferation
            through elevation of CCAAT-Enhancer-Binding Protein-delta
            expression.
REFERENCE   7  (bases 1 to 3257)
  AUTHORS   Ramachandran,P., Boontheung,P., Xie,Y., Sondej,M., Wong,D.T. and
            Loo,J.A.
  TITLE     Identification of N-linked glycoproteins in human saliva by
            glycoprotein capture and mass spectrometry
  JOURNAL   J Proteome Res 5 (6), 1493-1503 (2006)
   PUBMED   16740002
REFERENCE   8  (bases 1 to 3257)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   9  (bases 1 to 3257)
  AUTHORS   Eiraku,M., Hirata,Y., Takeshima,H., Hirano,T. and Kengaku,M.
  TITLE     Delta/notch-like epidermal growth factor (EGF)-related receptor, a
            novel EGF-like repeat-containing protein targeted to dendrites of
            developing and adult central nervous system neurons
  JOURNAL   J Biol Chem 277 (28), 25400-25407 (2002)
   PUBMED   11950833
  REMARK    GeneRIF: expression in developing and mature central nervous system
REFERENCE   10 (bases 1 to 3257)
  AUTHORS   Nishizumi,H., Komiyama,T., Miyabayashi,T., Sakano,S. and Sakano,H.
  TITLE     BET, a novel neuronal transmembrane protein with multiple EGF-like
            motifs
  JOURNAL   Neuroreport 13 (6), 909-915 (2002)
   PUBMED   11997712
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA115906.1, BC035009.1, DA400901.1 and BC024766.2.
            
            On Nov 22, 2018 this sequence version replaced NM_139072.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC035009.1, AY358891.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2151887, SAMN03267753
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000341772.5/ ENSP00000345229.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-250               DA115906.1         16-265
            251-255             BC035009.1         256-260
            256-812             DA400901.1         11-567
            813-1429            BC035009.1         818-1434
            1430-3052           BC024766.2         451-2073
            3053-3254           BC035009.1         3058-3259
            3255-3257           BC024766.2         2276-2278
FEATURES             Location/Qualifiers
     source          1..3257
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q36.3"
     gene            1..3257
                     /gene="DNER"
                     /gene_synonym="bet; UNQ26"
                     /note="delta/notch like EGF repeat containing"
                     /db_xref="GeneID:92737"
                     /db_xref="HGNC:HGNC:24456"
                     /db_xref="MIM:607299"
     exon            1..408
                     /gene="DNER"
                     /gene_synonym="bet; UNQ26"
                     /inference="alignment:Splign:2.1.0"
     CDS             133..2346
                     /gene="DNER"
                     /gene_synonym="bet; UNQ26"
                     /note="delta and Notch-like epidermal growth
                     factor-related receptor; delta-notch-like EGF
                     repeat-containing transmembrane; H_NH0150O02.1;
                     WUGSC:H_NH0150O02.1"
                     /codon_start=1
                     /product="delta and Notch-like epidermal growth
                     factor-related receptor precursor"
                     /protein_id="NP_620711.3"
                     /db_xref="CCDS:CCDS33390.1"
                     /db_xref="GeneID:92737"
                     /db_xref="HGNC:HGNC:24456"
                     /db_xref="MIM:607299"
                     /translation="MQPRRAQAPGAQLLPALALLLLLLGAGPRGSSLANPVPAAPLSA
                     PGPCAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNP
                     CHHGNCSSSSSSSSDGYLCICNEGYEGPNCEQALPSLPATGWTESMAPRQLQPVPATQ
                     EPDKILPRSQATVTLPTWQPKTGQKVVEMKWDQVEVIPDIACGNASSNSSAGGRLVSF
                     EVPQNTSVKIRQDATASLILLWKVTATGFQQCSLIDGRSVTPLQASGGLVLLEEMLAL
                     GNNHFIGFVNDSVTKSIVALRLTLVVKVSTCVPGESHANDLECSGKGKCTTKPSEATF
                     SCTCEEQYVGTFCEEYDACQRKPCQNNASCIDANEKQDGSNFTCVCLPGYTGELCQSK
                     IDYCILDPCRNGATCISSLSGFTCQCPEGYFGSACEEKVDPCASSPCQNNGTCYVDGV
                     HFTCNCSPGFTGPTCAQLIDFCALSPCAHGTCRSVGTSYKCLCDPGYHGLYCEEEYNE
                     CLSAPCLNAATCRDLVNGYECVCLAEYKGTHCELYKDPCANVSCLNGATCDSDGLNGT
                     CICAPGFTGEECDIDINECDSNPCHHGGSCLDQPNGYNCHCPHGWVGANCEIHLQWKS
                     GHMAESLTNMPRHSLYIIIGALCVAFILMLIILIVGICRISRIEYQGSSRPAYEEFYN
                     CRSIDSEFSNAIASIRHARFGKKSRPAMYDVSPIAYEDYSPDDKPLVTLIKTKDL"
     exon            409..717
                     /gene="DNER"
                     /gene_synonym="bet; UNQ26"
                     /inference="alignment:Splign:2.1.0"
     exon            718..812
                     /gene="DNER"
                     /gene_synonym="bet; UNQ26"
                     /inference="alignment:Splign:2.1.0"
     exon            813..979
                     /gene="DNER"
                     /gene_synonym="bet; UNQ26"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1125
                     /gene="DNER"
                     /gene_synonym="bet; UNQ26"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1279
                     /gene="DNER"
                     /gene_synonym="bet; UNQ26"
                     /inference="alignment:Splign:2.1.0"
     exon            1280..1393
                     /gene="DNER"
                     /gene_synonym="bet; UNQ26"
                     /inference="alignment:Splign:2.1.0"
     exon            1394..1618
                     /gene="DNER"
                     /gene_synonym="bet; UNQ26"
                     /inference="alignment:Splign:2.1.0"
     exon            1619..1741
                     /gene="DNER"
                     /gene_synonym="bet; UNQ26"
                     /inference="alignment:Splign:2.1.0"
     exon            1742..1855
                     /gene="DNER"
                     /gene_synonym="bet; UNQ26"
                     /inference="alignment:Splign:2.1.0"
     exon            1856..1987
                     /gene="DNER"
                     /gene_synonym="bet; UNQ26"
                     /inference="alignment:Splign:2.1.0"
     exon            1988..2234
                     /gene="DNER"
                     /gene_synonym="bet; UNQ26"
                     /inference="alignment:Splign:2.1.0"
     exon            2235..3257
                     /gene="DNER"
                     /gene_synonym="bet; UNQ26"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3235..3240
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DNER"
                     /gene_synonym="bet; UNQ26"
                     /note="hexamer: AATAAA"
     polyA_site      3257
                     /gene="DNER"
                     /gene_synonym="bet; UNQ26"
                     /note="major polyA site"
ORIGIN      
        1 agctgcagga ggcgcccggc ccggcggagc agccctagcc gccaccgtcg ctctcgcagc
       61 tctcgtcgcc actgccaccg ccgccgccgt cactgcgtcc tggctccggc tcccgcgccc
      121 tcccggccgg ccatgcagcc ccgccgcgcc caggcgcccg gtgcgcagct gctgcccgcg
      181 ctggccctgc tgctgctgct gctcggagcg gggccccgag gcagctccct ggccaacccg
      241 gtgcccgccg cgcccctgtc tgcgcccggg ccgtgcgccg cgcagccctg ccggaatggg
      301 ggtgtgtgca cctcgcgccc tgagccggac ccgcagcacc cggcccccgc cggcgagcct
      361 ggctacagct gcacctgccc cgccgggatc tccggcgcca actgccagct tgttgcagat
      421 ccttgtgcca gcaacccttg tcaccatggc aactgcagca gcagcagcag cagcagcagc
      481 gatggctacc tctgcatttg caatgaaggc tatgaaggtc ccaactgtga acaggcactt
      541 cccagtctcc cagccactgg ctggaccgaa tccatggcac cccgacagct tcagcctgtt
      601 cctgctactc aggagcctga caaaatcctg cctcgctctc aggcaacggt gacactgcct
      661 acctggcagc cgaaaacagg gcagaaagtt gtagaaatga aatgggatca agtggaggtg
      721 atcccagata ttgcctgtgg gaatgccagt tctaacagct ctgcgggtgg ccgcctggta
      781 tcctttgaag tgccacagaa cacctcagtc aagattcggc aagatgccac tgcctcactg
      841 attttgctct ggaaggtcac ggccacagga ttccaacagt gctccctcat agatggacga
      901 agtgtgaccc cccttcaggc ttcaggggga ctggtcctcc tggaggagat gctcgccttg
      961 gggaataatc actttattgg ttttgtgaat gattctgtga ctaagtctat tgtggctttg
     1021 cgcttaactc tggtggtgaa ggtcagcacc tgtgtgccgg gggagagtca cgcaaatgac
     1081 ttggagtgtt caggaaaagg aaaatgcacc acgaagccgt cagaggcaac tttttcctgt
     1141 acctgtgagg agcagtacgt gggtactttc tgtgaagaat acgatgcttg ccagaggaaa
     1201 ccttgccaaa acaacgcgag ctgtattgat gcaaatgaaa agcaagatgg gagcaatttc
     1261 acctgtgttt gccttcctgg ttatactgga gagctttgcc agtccaagat tgattactgc
     1321 atcctagacc catgcagaaa tggagcaaca tgcatttcca gtctcagtgg attcacctgc
     1381 cagtgtccag aaggatactt cggatctgct tgtgaagaaa aggtggaccc ctgcgcctcg
     1441 tctccgtgcc agaacaacgg cacctgctat gtggacgggg tacactttac ctgcaactgc
     1501 agcccgggct tcacagggcc gacctgtgcc cagcttattg acttctgtgc cctcagcccc
     1561 tgtgctcatg gcacgtgccg cagcgtgggc accagctaca aatgcctctg tgatccaggt
     1621 taccatggcc tctactgtga ggaggaatat aatgagtgcc tctccgctcc atgcctgaat
     1681 gcagccacct gcagggacct cgttaatggc tatgagtgtg tgtgcctggc agaatacaaa
     1741 ggaacacact gtgaattgta caaggatccc tgcgctaacg tcagctgtct gaacggagcc
     1801 acctgtgaca gcgacggcct gaatggcacg tgcatctgtg cacccgggtt tacaggtgaa
     1861 gagtgcgaca ttgacataaa tgaatgtgac agtaacccct gccaccatgg tgggagctgc
     1921 ctggaccagc ccaatggtta taactgccac tgcccgcatg gttgggtggg agcaaactgt
     1981 gagatccacc tccaatggaa gtccgggcac atggcggaga gcctcaccaa catgccacgg
     2041 cactccctct acatcatcat tggagccctc tgcgtggcct tcatccttat gctgatcatc
     2101 ctgatcgtgg ggatttgccg catcagccgc attgaatacc agggttcttc caggccagcc
     2161 tatgaggagt tctacaactg ccgcagcatc gacagcgagt tcagcaatgc cattgcatcc
     2221 atccggcatg ccaggtttgg aaagaaatcc cggcctgcaa tgtatgatgt gagccccatc
     2281 gcctatgaag attacagtcc tgatgacaaa cccttggtca cactgattaa aactaaagat
     2341 ttgtaatctt tttttggatt atttttcaaa aagatgagat actacactca tttaaatatt
     2401 tttaagaaaa taaaaagctt aagaaattta aaatgctagc tgctcaagag ttttcagtag
     2461 aatatttaag aactaatttt ctgcagcttt tagtttggaa aaaatatttt aaaaacaaaa
     2521 tttgtgaaac ctatagacga tgttttaatg taccttcagc tctctaaact gtgtgcttct
     2581 actagtgtgt gctcttttca ctgtagacac tatcacgaga cccagattaa tttctgtggt
     2641 tgttacagaa taagtctaat caaggagaag tttctgtttg acgtttgagt gccggctttc
     2701 tgagtagagt taggaaaacc acgtaacgta gcatatgatg tataatagag tatacccgtt
     2761 acttaaaaag aagtctgaaa tgttcgtttt gtggaaaaga aactagttaa atttactatt
     2821 cctaacccga atgaaattag cctttgcctt attctgtgca tgggtaagta acttatttct
     2881 gcactgtttt gttgaacttt gtggaaacat tctttcgagt ttgtttttgt cattttcgta
     2941 acagtcgtcg aactaggcct caaaaacata cgtaacgaaa aggcctagcg aggcaaattc
     3001 tgattgattt gaatctatat ttttctttaa aaagtcaagg gttctatatt gtgagtaaat
     3061 taaatttaca tttgagttgt ttgttgctaa gaggtagtaa atgtaagaga gtactggttc
     3121 cttcagtagt gagtatttct catagtgcag ctttatttat ctccaggatg tttttgtggc
     3181 tgtatttgat tgatatgtgc ttcttctgat tcttgctaat ttccaaccat attgaataaa
     3241 tgtgatcaag tcaagga
//
