LOCUS       NM_194249               1595 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens DND microRNA-mediated repression inhibitor 1 (DND1),
            mRNA.
ACCESSION   NM_194249
VERSION     NM_194249.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1595)
  AUTHORS   Zhang,W., Xu,Q., Shi,C., Chen,X., Shen,C., Zhang,Y., Zheng,B. and
            Zhu,H.
  TITLE     RNA-binding protein DND1 participates in migration, invasion, and
            EMT of prostate cancer cells by degrading CLIC4
  JOURNAL   Histol Histopathol 39 (10), 1343-1358 (2024)
   PUBMED   38390782
  REMARK    GeneRIF: RNA-binding protein DND1 participates in migration,
            invasion, and EMT of prostate cancer cells by degrading CLIC4.
REFERENCE   2  (bases 1 to 1595)
  AUTHORS   Yang,Y., Li,J., Wei,C., Wang,L., Gao,Z., Shen,K., Li,Y., Ren,M.,
            Zhu,Y., Ding,Y., Wei,C., Zhang,T., Zheng,S., Lu,N. and Gu,J.
  TITLE     Circular RNA circFCHO2(hsa_circ_0002490) promotes the proliferation
            of melanoma by directly binding to DND1
  JOURNAL   Cell Biol Toxicol 40 (1), 9 (2024)
   PUBMED   38311675
  REMARK    GeneRIF: Circular RNA circFCHO2(hsa_circ_0002490) promotes the
            proliferation of melanoma by directly binding to DND1.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1595)
  AUTHORS   Hirano,T., Wright,D., Suzuki,A. and Saga,Y.
  TITLE     A cooperative mechanism of target RNA selection via
            germ-cell-specific RNA-binding proteins NANOS2 and DND1
  JOURNAL   Cell Rep 39 (11), 110894 (2022)
   PUBMED   35705038
  REMARK    GeneRIF: A cooperative mechanism of target RNA selection via
            germ-cell-specific RNA-binding proteins NANOS2 and DND1.
REFERENCE   4  (bases 1 to 1595)
  AUTHORS   Xu,G., Yang,X., Li,C., Wang,F., Cui,J., Li,B., Xiao,H., Tang,K. and
            Cui,Z.
  TITLE     High DND1 Level Indicates a Poor Prognostic Factor in Prostate
            Cancer
  JOURNAL   Dis Markers 2021, 9948241 (2021)
   PUBMED   34721738
  REMARK    GeneRIF: High DND1 Level Indicates a Poor Prognostic Factor in
            Prostate Cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1595)
  AUTHORS   Kumari,P. and Bhavesh,N.S.
  TITLE     Human DND1-RRM2 forms a non-canonical domain swapped dimer
  JOURNAL   Protein Sci 30 (6), 1184-1195 (2021)
   PUBMED   33860980
  REMARK    GeneRIF: Human DND1-RRM2 forms a non-canonical domain swapped
            dimer.
REFERENCE   6  (bases 1 to 1595)
  AUTHORS   Linger,R., Dudakia,D., Huddart,R., Tucker,K., Friedlander,M.,
            Phillips,K.A., Hogg,D., Jewett,M.A., Lohynska,R., Daugaard,G.,
            Richard,S., Chompret,A., Stoppa-Lyonnet,D., Bonaiti-Pellie,C.,
            Heidenreich,A., Albers,P., Olah,E., Geczi,L., Bodrogi,I.,
            Daly,P.A., Guilford,P., Fossa,S.D., Heimdal,K., Tjulandin,S.A.,
            Liubchenko,L., Stoll,H., Weber,W., Einhorn,L., McMaster,M.,
            Korde,L., Greene,M.H., Nathanson,K.L., Cortessis,V., Easton,D.F.,
            Bishop,D.T., Stratton,M.R. and Rapley,E.A.
  TITLE     Analysis of the DND1 gene in men with sporadic and familial
            testicular germ cell tumors
  JOURNAL   Genes Chromosomes Cancer 47 (3), 247-252 (2008)
   PUBMED   18069663
  REMARK    GeneRIF: The variant, p. Glu86Ala, found in only one case of
            testiciular germ cell tumor, is within a known functional domain of
            DND1 and is highly conserved through evolution; mutations in DND1
            make, at most, a very small contribution to TGCT susceptibility
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 1595)
  AUTHORS   Kedde,M., Strasser,M.J., Boldajipour,B., Oude Vrielink,J.A.,
            Slanchev,K., le Sage,C., Nagel,R., Voorhoeve,P.M., van Duijse,J.,
            Orom,U.A., Lund,A.H., Perrakis,A., Raz,E. and Agami,R.
  TITLE     RNA-binding protein Dnd1 inhibits microRNA access to target mRNA
  JOURNAL   Cell 131 (7), 1273-1286 (2007)
   PUBMED   18155131
  REMARK    GeneRIF: Unravels a novel role of Dnd1 in protecting certain mRNAs
            from miRNA-mediated repression.
REFERENCE   8  (bases 1 to 1595)
  AUTHORS   Matin,A.
  TITLE     What leads from dead-end?
  JOURNAL   Cell Mol Life Sci 64 (11), 1317-1322 (2007)
   PUBMED   17464447
  REMARK    Review article
REFERENCE   9  (bases 1 to 1595)
  AUTHORS   Youngren,K.K., Coveney,D., Peng,X., Bhattacharya,C., Schmidt,L.S.,
            Nickerson,M.L., Lamb,B.T., Deng,J.M., Behringer,R.R., Capel,B.,
            Rubin,E.M., Nadeau,J.H. and Matin,A.
  TITLE     The Ter mutation in the dead end gene causes germ cell loss and
            testicular germ cell tumours
  JOURNAL   Nature 435 (7040), 360-364 (2005)
   PUBMED   15902260
REFERENCE   10 (bases 1 to 1595)
  AUTHORS   Weidinger,G., Stebler,J., Slanchev,K., Dumstrei,K., Wise,C.,
            Lovell-Badge,R., Thisse,C., Thisse,B. and Raz,E.
  TITLE     dead end, a novel vertebrate germ plasm component, is required for
            zebrafish primordial germ cell migration and survival
  JOURNAL   Curr Biol 13 (16), 1429-1434 (2003)
   PUBMED   12932328
  REMARK    GeneRIF: Cloning of zebrafish dnd1 and identification of human DND1
            by database analysis.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC033496.1 and AC116353.2.
            
            On Nov 22, 2018 this sequence version replaced NM_194249.2.
            
            Summary: This gene encodes a protein that binds to
            microRNA-targeting sequences of mRNAs, inhibiting microRNA-mediated
            repression. Reduced expression of this gene has been implicated in
            tongue squamous cell carcinoma. Two pseudogenes of this gene are
            located on the long arm of chromosome 17. [provided by RefSeq, Dec
            2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC033496.1, AY321065.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000542735.2/ ENSP00000445366.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1267              BC033496.1         11-1277
            1268-1268           AC116353.2         126832-126832       c
            1269-1593           BC033496.1         1279-1603
            1594-1595           AC116353.2         126505-126506       c
FEATURES             Location/Qualifiers
     source          1..1595
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.3"
     gene            1..1595
                     /gene="DND1"
                     /gene_synonym="RBMS4"
                     /note="DND microRNA-mediated repression inhibitor 1"
                     /db_xref="GeneID:373863"
                     /db_xref="HGNC:HGNC:23799"
                     /db_xref="MIM:609385"
     exon            1..58
                     /gene="DND1"
                     /gene_synonym="RBMS4"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..1096
                     /gene="DND1"
                     /gene_synonym="RBMS4"
                     /note="dead end homolog 1; RNA-binding motif,
                     single-stranded-interacting protein 4"
                     /codon_start=1
                     /product="dead end protein homolog 1"
                     /protein_id="NP_919225.1"
                     /db_xref="CCDS:CCDS4236.1"
                     /db_xref="GeneID:373863"
                     /db_xref="HGNC:HGNC:23799"
                     /db_xref="MIM:609385"
                     /translation="MQSKRDCELWCERVNPENKAALEAWVRETGIRLVQVNGQRKYGG
                     PPPGWVGSPPPAGSEVFIGRLPQDVYEHQLIPLFQRVGRLYEFRLMMTFSGLNRGFAY
                     ARYSSRRGAQAAIATLHNHPLRPSCPLLVCRSTEKCELSVDGLPPNLTRSALLLALQP
                     LGPGLQEARLLPSPGPAPGQIALLKFSSHRAAAMAKKALVEGQSHLCGEQVAVEWLKP
                     DLKQRLRQQLVGPFLRSPQPEGSQLALARDKLGFQGARATLQLLCQRMKLGSPVFLTK
                     CLGIGPAGWHRFWYQVVIPGHPVPFSGLIWVVLTLDGRDGHEVAKDAVSVRLLQALSE
                     SGANLLWSAGAEAGTMVKQ"
     exon            59..176
                     /gene="DND1"
                     /gene_synonym="RBMS4"
                     /inference="alignment:Splign:2.1.0"
     exon            177..638
                     /gene="DND1"
                     /gene_synonym="RBMS4"
                     /inference="alignment:Splign:2.1.0"
     exon            639..1595
                     /gene="DND1"
                     /gene_synonym="RBMS4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1573..1578
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DND1"
                     /gene_synonym="RBMS4"
                     /note="hexamer: ATTAAA"
     polyA_site      1595
                     /gene="DND1"
                     /gene_synonym="RBMS4"
                     /note="major polyA site"
ORIGIN      
        1 ataaagaggg tacgaggggg ccagctggag agccatgcag tccaagcggg attgtgagct
       61 gtggtgtgag agggtgaatc cagagaacaa ggcggcgctg gaggcgtggg tcagggagac
      121 aggcatccgc ctggtgcagg tgaacgggca gaggaagtat ggcgggccac ccccaggctg
      181 ggtgggcagc ccgccgccag ctgggtcaga ggtgttcatc gggcggctgc ctcaggacgt
      241 gtacgagcac cagcttatcc cgctgttcca gcgcgtgggc cgcctctacg agttccgcct
      301 gatgatgacc ttcagcggcc tgaaccgcgg cttcgcctat gcccgctaca gctcgaggcg
      361 cggcgcgcag gccgccatcg ccacgctgca caaccatccg ctgcggccgt cctgcccgct
      421 gctcgtgtgc cgcagcaccg agaagtgtga gctgagcgtt gacggcctgc cgccgaatct
      481 gacccgcagc gcgctgctgc tcgcgctgca gccgctgggt cccggcttgc aggaggcgcg
      541 gctgctgccc agccccggac cggcgcccgg gcagatcgct ctgctcaaat tcagctcgca
      601 ccgggccgct gccatggcca aaaaggccct ggtggaaggg cagtcacacc tctgtggaga
      661 gcaggtggct gtggagtggc tcaagccaga cctgaagcag cgacttcgcc agcagcttgt
      721 gggtcccttc ttgcggtccc cacagccaga gggcagccag ttggctttgg caagggacaa
      781 gttagggttc caaggggctc gggctaccct gcagttgctg tgccaacgaa tgaagctggg
      841 cagccctgtg ttcctcacca agtgtttggg cataggacct gctggctggc accgcttctg
      901 gtaccaggtg gtgattcctg ggcatccggt gcccttcagc ggcctcatct gggttgtgct
      961 gaccctagat ggccgggatg ggcatgaggt ggccaaggat gctgtgtctg tacggctgct
     1021 gcaggcactc agtgagtctg gggccaacct cctgtggtct gctggggctg aggcaggtac
     1081 catggttaaa cagtgactcc attctttctc cacaggcacc ctgaatgggc atgcagagcc
     1141 tgtgtcaggc cccatcccag caggcctggg tggccacttt ctgaccccca aaggtgggga
     1201 ggggcatggg cccaggccca tcagcctccc tgctgggaca gggacctatg gcacctgggg
     1261 gcagcttagg tttgggttaa gttgtggtga ggggccttgc cctcccgctc ccagcccagg
     1321 gtccaacctg acccagtgat cttccatggc cgttccttgt cccaccccca cccgatcata
     1381 ccttcccccc tctgccacag cttagcatga atcttcttta ttgtcctgat ttgtcctctt
     1441 tgttggtttt tatttgtggg gaagggcagc tgagccaaag gggtcagaaa ttctgccctt
     1501 tgcctccacc acatggcatt ctggttttgg tttctgtata gttttgggtc tttctatgct
     1561 ggttgtattt atattaaacc cctggttagt atata
//
