LOCUS       NM_005740               1474 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens dynein axonemal light chain 4 (DNAL4), mRNA.
ACCESSION   NM_005740
VERSION     NM_005740.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1474)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1474)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1474)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1474)
  AUTHORS   Zhong,Q., Pevzner,S.J., Hao,T., Wang,Y., Mosca,R., Menche,J.,
            Taipale,M., Tasan,M., Fan,C., Yang,X., Haley,P., Murray,R.R.,
            Mer,F., Gebreab,F., Tam,S., MacWilliams,A., Dricot,A., Reichert,P.,
            Santhanam,B., Ghamsari,L., Calderwood,M.A., Rolland,T.,
            Charloteaux,B., Lindquist,S., Barabasi,A.L., Hill,D.E., Aloy,P.,
            Cusick,M.E., Xia,Y., Roth,F.P. and Vidal,M.
  TITLE     An inter-species protein-protein interaction network across vast
            evolutionary distance
  JOURNAL   Mol Syst Biol 12 (4), 865 (2016)
   PUBMED   27107014
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1474)
  AUTHORS   Meneret,A., Trouillard,O., Vidailhet,M., Depienne,C. and Roze,E.
  TITLE     Congenital mirror movements: no mutation in DNAL4 in 17 index cases
  JOURNAL   J Neurol 261 (10), 2030-2031 (2014)
   PUBMED   25236653
  REMARK    GeneRIF: No mutation in DNAL4 in Congenital mirror movements.
REFERENCE   6  (bases 1 to 1474)
  AUTHORS   Yu,H., Tardivo,L., Tam,S., Weiner,E., Gebreab,F., Fan,C.,
            Svrzikapa,N., Hirozane-Kishikawa,T., Rietman,E., Yang,X.,
            Sahalie,J., Salehi-Ashtiani,K., Hao,T., Cusick,M.E., Hill,D.E.,
            Roth,F.P., Braun,P. and Vidal,M.
  TITLE     Next-generation sequencing to generate interactome datasets
  JOURNAL   Nat Methods 8 (6), 478-480 (2011)
   PUBMED   21516116
REFERENCE   7  (bases 1 to 1474)
  AUTHORS   Iwasaki,M., Kuwata,T., Yamazaki,Y., Jenkins,N.A., Copeland,N.G.,
            Osato,M., Ito,Y., Kroon,E., Sauvageau,G. and Nakamura,T.
  TITLE     Identification of cooperative genes for NUP98-HOXA9 in myeloid
            leukemogenesis using a mouse model
  JOURNAL   Blood 105 (2), 784-793 (2005)
   PUBMED   15454493
REFERENCE   8  (bases 1 to 1474)
  AUTHORS   Collins,J.E., Goward,M.E., Cole,C.G., Smink,L.J., Huckle,E.J.,
            Knowles,S., Bye,J.M., Beare,D.M. and Dunham,I.
  TITLE     Reevaluating human gene annotation: a second-generation analysis of
            chromosome 22
  JOURNAL   Genome Res 13 (1), 27-36 (2003)
   PUBMED   12529303
REFERENCE   9  (bases 1 to 1474)
  AUTHORS   Yano,H., Lee,F.S., Kong,H., Chuang,J., Arevalo,J., Perez,P.,
            Sung,C. and Chao,M.V.
  TITLE     Association of Trk neurotrophin receptors with components of the
            cytoplasmic dynein motor
  JOURNAL   J Neurosci 21 (3), RC125 (2001)
   PUBMED   11157096
REFERENCE   10 (bases 1 to 1474)
  AUTHORS   Dunham,I., Shimizu,N., Roe,B.A., Chissoe,S., Hunt,A.R.,
            Collins,J.E., Bruskiewich,R., Beare,D.M., Clamp,M., Smink,L.J.,
            Ainscough,R., Almeida,J.P., Babbage,A., Bagguley,C., Bailey,J.,
            Barlow,K., Bates,K.N., Beasley,O., Bird,C.P., Blakey,S.,
            Bridgeman,A.M., Buck,D., Burgess,J., Burrill,W.D., O'Brien,K.P. et
            al.
  TITLE     The DNA sequence of human chromosome 22
  JOURNAL   Nature 402 (6761), 489-495 (1999)
   PUBMED   10591208
  REMARK    Erratum:[Nature 2000 Apr 20;404(6780):904]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL035366.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_005740.2.
            
            Summary: This gene encodes an axonemal dynein light chain which
            functions as a component of the outer dynein arms complex. This
            complex acts as the molecular motor that provides the force to move
            cilia in an ATP-dependent manner. The encoded protein is expressed
            in tissues with motile cilia or flagella and may be involved in the
            movement of sperm flagella. [provided by RefSeq, Dec 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL035366.1, SRR3476690.696320.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA2142586,
                                           SAMEA2145245 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000216068.9/ ENSP00000216068.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1474              AL035366.1         7-1480
FEATURES             Location/Qualifiers
     source          1..1474
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.1"
     gene            1..1474
                     /gene="DNAL4"
                     /gene_synonym="MRMV3; PIG27"
                     /note="dynein axonemal light chain 4"
                     /db_xref="GeneID:10126"
                     /db_xref="HGNC:HGNC:2955"
                     /db_xref="MIM:610565"
     exon            1..76
                     /gene="DNAL4"
                     /gene_synonym="MRMV3; PIG27"
                     /inference="alignment:Splign:2.1.0"
     exon            77..284
                     /gene="DNAL4"
                     /gene_synonym="MRMV3; PIG27"
                     /inference="alignment:Splign:2.1.0"
     CDS             216..533
                     /gene="DNAL4"
                     /gene_synonym="MRMV3; PIG27"
                     /note="dynein light chain, outer arm 4; dynein, axonemal,
                     light polypeptide 4; proliferation-inducing gene 27;
                     proliferation-inducing protein 27"
                     /codon_start=1
                     /product="dynein axonemal light chain 4"
                     /protein_id="NP_005731.1"
                     /db_xref="CCDS:CCDS13979.1"
                     /db_xref="GeneID:10126"
                     /db_xref="HGNC:HGNC:2955"
                     /db_xref="MIM:610565"
                     /translation="MGETEGKKDEADYKRLQTFPLVRHSDMPEEMRVETMELCVTACE
                     KFSNNNESAAKMIKETMDKKFGSSWHVVIGEGFGFEITHEVKNLLYLYFGGTLAVCVW
                     KCS"
     exon            285..368
                     /gene="DNAL4"
                     /gene_synonym="MRMV3; PIG27"
                     /inference="alignment:Splign:2.1.0"
     exon            369..1474
                     /gene="DNAL4"
                     /gene_synonym="MRMV3; PIG27"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1454..1459
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DNAL4"
                     /gene_synonym="MRMV3; PIG27"
                     /note="hexamer: ATTAAA"
     polyA_site      1474
                     /gene="DNAL4"
                     /gene_synonym="MRMV3; PIG27"
                     /note="major polyA site"
ORIGIN      
        1 actcttgttt cgctccttga caaccctggc gggggttcgc tggctgcggc cccggctccg
       61 gcccccgcag gagcagcacc ccccggggaa agacattttc tgctcccacc gagttggcag
      121 ggcctgcttc ctgaatctcc tgggtgtgtc ttaactgcca gtcccagcac ctcctgaaag
      181 ccccactctc ctccagtggt cacagtggaa ggatcatggg agaaacagaa gggaagaaag
      241 atgaggctga ttataagcga ctgcagacct tccctctggt caggcactcg gacatgccag
      301 aggagatgcg cgtggagacc atggagctat gtgtcacagc ctgtgagaaa ttctccaaca
      361 acaacgagag cgccgccaag atgatcaaag agacaatgga caagaagttc ggctcctcct
      421 ggcacgtggt gatcggcgag ggctttgggt ttgagatcac ccacgaggtg aagaacctcc
      481 tctacctgta cttcgggggc accctggctg tgtgcgtctg gaagtgctcc tgacactctg
      541 tcccctgccc cgtcccctgc agggcctttt cctgccactc atctggggtg gggagcagcc
      601 ctaggcaggt cctggttttt ccaaggagag ttggggtctt ttctttttgt ctttgtgtac
      661 cagtttcctg agccacgccc agtgtgtgaa cttgacatct ccatccccag gctctcaacc
      721 gtctccctcg gagtctcagg gtgtggacgg ggcagcgggc atgggtctgt gtgggagacg
      781 tggggtgggg cggtgtgaca gggtagagga ggtgggagat gagatcttcc gcacaggaac
      841 acgccagtcc ccctttctcc agggctgcct tccccttgca tcctgggagc cccactgccc
      901 tgccatcccc agtactgccg ggaagtgtcg gccgtccttg tcattagtgg tcatatgaaa
      961 atggccccaa gaaggagatg attctttcaa gggacacagg cagcttctct ccttgtcctc
     1021 tggggaggtg ctgacccctc agaaacccct tcccccaact tgaccccagg ctgaacagac
     1081 cactgcatct cactgggcca gcagcccccc cagcccccag ccttggtggg gaccaagcag
     1141 cctttcccgt cccctcctcg acccgtacag ttgagagcca ggggctggtg tgtgggagct
     1201 gctacctggc agtttctcga ggggtcaccg agcctctggt gggacacctg ggcaggagtg
     1261 ctctcaccac gaggctgctt ccgcagggaa ccctggcctg cccgcgactt cgcatcaggg
     1321 accgcatgct gatttgtact gctctctgct gggttttcta tgttcttttc gagtgtggga
     1381 aaagggtttt agtagaaggg tgaatcgtat tttacacagc ggtcttattt atataaatgt
     1441 cttggttttt acaattaaaa tgaccaaaaa ctga
//
