LOCUS       NM_031427               8417 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens dynein axonemal light chain 1 (DNAL1), transcript
            variant 1, mRNA.
ACCESSION   NM_031427
VERSION     NM_031427.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8417)
  AUTHORS   Poplawska,K., Griffiths,A., Temme,R., Adamko,D.J., Nykamp,K. and
            Shapiro,A.J.
  TITLE     Deletions in DNAL1 Cause Primary Ciliary Dyskinesia Across North
            American Indigenous Populations
  JOURNAL   J Pediatr 261, 113362 (2023)
   PUBMED   36841509
  REMARK    GeneRIF: Deletions in DNAL1 Cause Primary Ciliary Dyskinesia Across
            North American Indigenous Populations.
REFERENCE   2  (bases 1 to 8417)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 8417)
  AUTHORS   Cho,K.J., Noh,S.H., Han,S.M., Choi,W.I., Kim,H.Y., Yu,S., Lee,J.S.,
            Rim,J.H., Lee,M.G., Hildebrandt,F. and Gee,H.Y.
  TITLE     ZMYND10 stabilizes intermediate chain proteins in the cytoplasmic
            pre-assembly of dynein arms
  JOURNAL   PLoS Genet 14 (3), e1007316 (2018)
   PUBMED   29601588
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8417)
  AUTHORS   Gallo,D.E. and Hope,T.J.
  TITLE     Knockdown of MAP4 and DNAL1 produces a post-fusion and pre-nuclear
            translocation impairment in HIV-1 replication
  JOURNAL   Virology 422 (1), 13-21 (2012)
   PUBMED   22018492
  REMARK    GeneRIF: DNAL1 and MAP4 may exert their functions in the HIV life
            cycle at reverse transcription, prior to nuclear translocation.
REFERENCE   5  (bases 1 to 8417)
  AUTHORS   Mazor,M., Alkrinawi,S., Chalifa-Caspi,V., Manor,E., Sheffield,V.C.,
            Aviram,M. and Parvari,R.
  TITLE     Primary ciliary dyskinesia caused by homozygous mutation in DNAL1,
            encoding dynein light chain 1
  JOURNAL   Am J Hum Genet 88 (5), 599-607 (2011)
   PUBMED   21496787
  REMARK    GeneRIF: DNAL1 mutation could help to elucidate the interaction
            between the DNAL1 to dynein heavy chain and to tubulin.
REFERENCE   6  (bases 1 to 8417)
  AUTHORS   Horvath,J., Fliegauf,M., Olbrich,H., Kispert,A., King,S.M.,
            Mitchison,H., Zariwala,M.A., Knowles,M.R., Sudbrak,R., Fekete,G.,
            Neesen,J., Reinhardt,R. and Omran,H.
  TITLE     Identification and analysis of axonemal dynein light chain 1 in
            primary ciliary dyskinesia patients
  JOURNAL   Am J Respir Cell Mol Biol 33 (1), 41-47 (2005)
   PUBMED   15845866
  REMARK    GeneRIF: identification of the human (DNAL1) ortholog of the
            Chlamydomonas LC1-gene; protein interaction studies demonstrated
            binding of DNAL1 and DNAH5; DNAL1 considered a candidate for
            primary ciliary dyskinesia
REFERENCE   7  (bases 1 to 8417)
  AUTHORS   Zariwala,M.A., Knowles,M.R. and Leigh,M.W.
  TITLE     Primary Ciliary Dyskinesia
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301301
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AI242197.1, AF542071.1,
            BJ996719.1, AC006146.2 and BQ267448.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_031427.3.
            
            Summary: This gene encodes an axonemal dynein light chain which
            functions as a component of the outer dynein arms complex. This
            complex acts as the molecular motor that provides the force to move
            cilia in an ATP-dependent manner. The encoded protein is expressed
            in tissues with motile cilia or flagella and may be involved in the
            movement of sperm flagella. Alternate splicing results in multiple
            transcript variants.[provided by RefSeq, Jan 2011].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.663198.1,
                                           SRR3476690.1014941.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000553645.7/ ENSP00000452037.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                AI242197.1         112-124
            14-671              AF542071.1         1-658
            672-841             BJ996719.1         379-548
            842-7977            AC006146.2         61024-68159         c
            7978-8413           BQ267448.1         15-450              c
            8414-8417           AC006146.2         60584-60587         c
FEATURES             Location/Qualifiers
     source          1..8417
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q24.3"
     gene            1..8417
                     /gene="DNAL1"
                     /gene_synonym="C14orf168; CILD16; LC1"
                     /note="dynein axonemal light chain 1"
                     /db_xref="GeneID:83544"
                     /db_xref="HGNC:HGNC:23247"
                     /db_xref="MIM:610062"
     exon            1..57
                     /gene="DNAL1"
                     /gene_synonym="C14orf168; CILD16; LC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..627
                     /gene="DNAL1"
                     /gene_synonym="C14orf168; CILD16; LC1"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="dynein axonemal light chain 1 isoform 1"
                     /protein_id="NP_113615.2"
                     /db_xref="CCDS:CCDS45134.1"
                     /db_xref="GeneID:83544"
                     /db_xref="HGNC:HGNC:23247"
                     /db_xref="MIM:610062"
                     /translation="MAKATTIKEALARWEEKTGQRPSEAKEIKLYAQIPPIEKMDASL
                     SMLANCEKLSLSTNCIEKIANLNGLKNLRILSLGRNNIKNLNGLEAVGDTLEELWISY
                     NFIEKLKGIHIMKKLKILYMSNNLVKDWAEFVKLAELPCLEDLVFVGNPLEEKHSAEN
                     NWIEEATKRVPKLKKLDGTPVIKGDEEEDN"
     exon            58..96
                     /gene="DNAL1"
                     /gene_synonym="C14orf168; CILD16; LC1"
                     /inference="alignment:Splign:2.1.0"
     exon            97..206
                     /gene="DNAL1"
                     /gene_synonym="C14orf168; CILD16; LC1"
                     /inference="alignment:Splign:2.1.0"
     exon            207..262
                     /gene="DNAL1"
                     /gene_synonym="C14orf168; CILD16; LC1"
                     /inference="alignment:Splign:2.1.0"
     exon            263..318
                     /gene="DNAL1"
                     /gene_synonym="C14orf168; CILD16; LC1"
                     /inference="alignment:Splign:2.1.0"
     exon            319..445
                     /gene="DNAL1"
                     /gene_synonym="C14orf168; CILD16; LC1"
                     /inference="alignment:Splign:2.1.0"
     exon            446..586
                     /gene="DNAL1"
                     /gene_synonym="C14orf168; CILD16; LC1"
                     /inference="alignment:Splign:2.1.0"
     exon            587..8417
                     /gene="DNAL1"
                     /gene_synonym="C14orf168; CILD16; LC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      737..742
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DNAL1"
                     /gene_synonym="C14orf168; CILD16; LC1"
                     /note="hexamer: GATAAA"
     polyA_site      760
                     /gene="DNAL1"
                     /gene_synonym="C14orf168; CILD16; LC1"
                     /note="major polyA site"
     regulatory      2815..2820
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DNAL1"
                     /gene_synonym="C14orf168; CILD16; LC1"
                     /note="hexamer: AATATA"
     polyA_site      2837
                     /gene="DNAL1"
                     /gene_synonym="C14orf168; CILD16; LC1"
     regulatory      8391..8396
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DNAL1"
                     /gene_synonym="C14orf168; CILD16; LC1"
                     /note="hexamer: AATAAA"
     polyA_site      8417
                     /gene="DNAL1"
                     /gene_synonym="C14orf168; CILD16; LC1"
ORIGIN      
        1 gcactgaccc cgcgggccct agcaaccaga gcagtgacag tagcaaccgc cggaatggcg
       61 aaagcaacaa caatcaaaga agccttagcg agatgggaag agaaaactgg ccagaggcca
      121 tctgaagcca aagagataaa actttatgcc cagattcccc ctatagagaa gatggatgca
      181 tccttgtcca tgcttgctaa ttgcgagaag ctttcactgt ctacaaactg cattgaaaaa
      241 attgccaacc tgaatggctt aaaaaacttg aggatattat ctttaggaag aaacaacata
      301 aagaacttaa atggactgga ggcagtaggg gacacattag aagaactgtg gatctcctac
      361 aattttattg agaagttgaa agggatccac ataatgaaga aattgaagat tctctacatg
      421 tctaataacc tggtaaaaga ctgggctgag tttgtgaagc tggcagaact gccatgcctc
      481 gaagacctgg tgtttgtagg caatcccttg gaagagaaac attctgctga gaataactgg
      541 attgaagaag caaccaagag agtgcccaaa ctgaaaaagc tggatggtac tccagtaatt
      601 aaaggggatg aggaagaaga caactaatgc cacgctttcc actgtgtgtt aacttattta
      661 aatgtcataa gaacaataga taaattttat ataattgtct attttaaaga ttctgtatgg
      721 gacaaaagtt tcttaagata aaacagatca ctcattctca tctttttttt tcctttaact
      781 tattcagtgt ttctccccaa aactggtaat gccaacctta tatatcctat ttctcttttt
      841 agaaaccaca aattttcgat ttttgtcttc agtctcagtt acgtactgtg tagccccatc
      901 tactaaaaca aaacctttgt agaccagtca tttttaataa caaaggaaca aatgtttttt
      961 tcagtttgtt catttttttt aggttagaca ttttaaaaga tgtacatttg aaaattcaga
     1021 acatttttcc tgaaggtctg tctctgtaca attcagaagc acatgccttt agctcagaag
     1081 gcagcatggt gatgggaaga gttcctctta gaaatacagc aggtccggaa ccaagactcc
     1141 aaagttccat tggaaaagat atggtgaaaa aaggaaaaag tagtatctca gagaccttct
     1201 agtctatatt atacttattt gtttttccaa aaatgtgcac attgtcaact ggaatttagg
     1261 ttgtttttat atgcatggcc acttgagtca ttgtgtacag tcattctgtg atctcagtta
     1321 gtggttaaaa tgactgtcat gatcatttct ttgactgata atgtggcaat gttactcatg
     1381 tggacctcgc cttaagcaca cattttggtt ttatagttcc ttatgtgttt aaagcattag
     1441 ttatatttga attcctagac taaatgctgg ccattgatgt atgtcaaaat ttaccctaat
     1501 tatttggtct ggtgaccctc attgttggga aaagtgacta ccatggttat aagtaagggt
     1561 ataatgaaac ttagtatttc aaaatatatt ttttgagaag ttctaagtta aacagctctt
     1621 aaaatgtatt atgtacgtgg ttgtggaggg aagggagatg tttcattatg agatcccagg
     1681 caaatggcaa tatgtttgag gattgtctcc tacataaagc agtgtaggtg atttaacctc
     1741 aaaattgcaa agcaatagtt agatgcagag gttagaattt atcatgtaaa caaaaaatcc
     1801 ttcaggaaaa tgtaagacat tgtagtcagt aagcagatga ggtcatagga ggccatggct
     1861 ggatcactat tagattgcag aaaagaagtc aggggccctc tgccaaattg tgcctaaagt
     1921 ccctcagaga ctgttgattc tggtttcccc atctacttgt gtgattttac ttgcataaaa
     1981 tcacagtgaa agagggaaga atcatcttta aaaagtgatt gcataagtag tcctgggttt
     2041 cagaagattt cagctatcat ttacatagga attacttgat ttttctaagt tactctgatc
     2101 aaaagggacc actgctttga caatcaactc taaatacaaa caagaggcca ggcgtggtgg
     2161 ctcatgcctg tcatcccagc actttgggag gccgaggcgg gcggatcatc tgagatcagg
     2221 agttcaagac cagcctgacc aacatggtga aaccccgtct ctactaaaaa tacaaaaatt
     2281 agccagtcct ggtggtgggc gcctgtagtc ccaactactc gggaggctga ggcaggagaa
     2341 tcatttgaac ccgggaggcg gaggttgcag tgagccgaga ttgcgccatt gcactccagc
     2401 ctgggcaata gagcgagact ccatatttaa aaaaaaaaaa aaaaaaaaaa gaggaaaact
     2461 tggtctaaca cccttttagt tttcttttct ctcttctttt caatctgata ggaagaaacc
     2521 ttattctact ctagctggtt tatgcattca aagcctttgg acatttcttt tatgaaccat
     2581 aggcaatgag ccttcattct ccttggtgat gttttaagtt ccataaactg agagggaaga
     2641 tgatcttctt aaagtttgca cttccttcag taggcaagct tgaagccatg ttgatatgga
     2701 tatgttttct aaaagtaacc ctggaagtga atataatagg aagtaagtga tttcatattg
     2761 aatttatttg taaaatggct tagagttttg gtgtttgttt tttctgaatt ctgtaatata
     2821 gaaactggtt ctctttctcc ttgtttctca atgactttta attacaggta gttctcagac
     2881 aaatgtaaga tacttttctc tgtccatttc atgcaaaatt catattcagt atcattcaac
     2941 aaatctttga atgacttcta tgcatccctg ttcatggaac ccatgccatt agaaaatggc
     3001 agttgggatg tatgaagaaa tgtaggatat tctctcaaat cattccctaa attatccttt
     3061 actgctgcaa atttagctga taaaactgcc tttggtttat gcctcttgga tcagatattt
     3121 gacctatgtg gaatagatta tctctgtgct tccggtttaa gacattacgc cattttagtg
     3181 gatcatttaa attttttcta ttctgttttt ttttgtttgt ttgtttgttt gttttaaaca
     3241 gagtctcact cccgagtagc tgggaccaca ggcacgtgcc atcatgcctg gcctattttt
     3301 gtatttttag tagagatggg gtttcaccat gttggccagg cttgtcttga actcctaact
     3361 tcagatgacc tgcccacatc ggcctcccaa agtgctggga ttacaggcat gagccaccgt
     3421 gcctggccaa atttcttcta ttcttgtaag tgatggtaaa actctggaat cagtccagta
     3481 ttttagtttt tcacagcaaa tttgatttta gtctaccaag gagtttaact tttctatgtt
     3541 ccctaactct aagattaggg ctgtattacc tagacaggcc ttaaaaggtt tttgtgttgt
     3601 tctctgttaa taagaatttg ttcctttaaa ccagaggatc aaccttggaa ctattaacat
     3661 tttgggattg ataattcatt gttgttgggg gctgtcctgt gtgcttagga tgttcagctg
     3721 cagccctggc ctctacccac tagattccag tagaccccct cctcagccat gacaacaaag
     3781 atatctccag acattgccat ctgtcccttg ggtaggaggg tgggaacaaa ttctccctta
     3841 gttgtacttt ttataccaac atcacttgtg tccagggtcc atttattttc agtctgtagc
     3901 catgtgccac ttgaattgtt atatgagaga aggtgatgta ttcagtaatc atggatggaa
     3961 agaaatggtc actggtattt tttgtaatgc tcattttttt ttttttttga gacagagtct
     4021 cgctctgtta cctaggctgg agtgcagtgg cgcaatctca gctcactgca acctccgtct
     4081 cccgggttca agcaattctt ctgcctccgc ctcccaagta gctgggacta caggcacgcg
     4141 ccaccatgcc tggctaattt ttgtattttt agtacagacg gcgtttcacc atattggcca
     4201 ggctggtctc aaactcctga cctcgtgatc cgcctgcctc agcctcccaa agtgctggga
     4261 ttacagacgt gagccactgc gactggctta atgctcattt tcataatttt catgtaatat
     4321 tagaaactca gggctggaag gttcaacttc tcttttttga agcagggtct caacttttat
     4381 ttctaagcat tcttgcttat cttaggacag tgattattaa cctacctctc tgtttctatc
     4441 aacagaagcc aactttatga tagattttgc tttgtctcta aagtttaata ttttgagtgt
     4501 actttagaaa ataggtcatc attctttaag cgtcattcat tgtctaatca cataattttg
     4561 cagaccatgg cagtcattaa atacagaaaa atactgtgta aaatttgata atcttgtagg
     4621 aaagttagct gatgtagaca tcaattttgg atgtgatcag aagaatgtct gcttaagata
     4681 actggtcaat aacttggtat ggctactgga ttcattccac atatggtagt ataaggcact
     4741 taaatgtgtt tcctgattgg gcactgtggc tcatgcctgt aatcccagca ctttgggagg
     4801 ccgtggtggg cagatcactt gaggtcagga gttcgaggcc agcctggcca acgtggtgaa
     4861 accccatgtc taccaaaaat ataaaaagat agccgggcgt ggtggcgcat gcctgtaatc
     4921 ccagctactc gggaggctga ggcaggagaa ttgcttgaac ccgggaggca gaggcttcag
     4981 tgagccgaaa tagtgtgact gtactccagc ctgggtgaca gagtaagtct ccgtctcaaa
     5041 aagaaaaaaa aaaatgtggt tcttttgtgg aaagaggaat ttgaacttga ataaacactt
     5101 cttttgacac cttttaccag tggtctgaag cagaataagg aagaataaga aatgaatctt
     5161 gactgttgac ttattctgag aattggtgat gtgtaaagag agttggaatc ttctacctgg
     5221 gtttttctca gggctaaatg gaaaagcaca gggcccagaa aggttggagt taatcattca
     5281 cttaaaagca ttaggaggaa gtgtcaaagc atcagtcatg aatagattat gtctctctga
     5341 ctacagtcag accatcaatt cactaagacc ttatactctg taagtgttgg taaaggaaga
     5401 aaactgctaa attgcatgtt accctttact agaaattcat tcctttggca cagattttat
     5461 ttatttgggg ctgtttaatg tgtctgtaaa tcatgaaata taaaagcaag attcagtgta
     5521 gcagagttgg tgcttcttct gacaagctaa cttgaccata tttctttatc tgtgctctaa
     5581 catgtgtcat attgttttct ttttgtaaac cataaaatgg gtgaacttcc aaaaatcaag
     5641 ggtcatgttt taaaatcatg gaacttttag aaataccata tctgtatctc tattcctgca
     5701 ttttataaat ctgtaaagga agaaaactga aaggaagaac tagactgagt cttacctttc
     5761 tctgacctaa gataaactga taaaactttt tacttgatat ttggagaagt cattaactgg
     5821 attctagtta atttcccata ttgggcagtt tagaggagac ccagccaacc aaattatgat
     5881 ctagcaaatt taacataggg gaagagggat agtaaactat ttttcagtag atttgcactt
     5941 taaacttagg aactggatgt tggtggaaag gacttccata gggcagatgg gtaaatatct
     6001 agcctgcact tggatgttag agaatcaaac ctcacccttg ctcgttctaa acccacatga
     6061 gtagttaact gtcttttgac ataatcagag tcaggatttc cctttttccc tacttgagtc
     6121 gtcttccatg tctgttacat ccaagatcat ccctctgggg gatgtgtcaa gtagttctcc
     6181 tactcagaat agaagctttg cgaattatca ttcccacctc tagattttaa atgaatgtag
     6241 agttgtctaa cattatatgg gtgggaggct ctttgcctct gtgatcagta gggtacctgc
     6301 ctctgaggtg ctactgcctg gagggatcac tcccatcaaa agactggtga gttggaagct
     6361 aagagcacat gcgcatagcc agctcctctc ccaggctggc agtcatgatt acgagcatca
     6421 ttccagaatc tttggcttct agaaccaact ccattctgaa gaacatttta acatctatga
     6481 ataccttggt aataatcttt tatacacagg agttttgtag catgacttta tgactaaact
     6541 tattgtgaat taagttattt agaaatgttg agtttctgaa tgttattttg tgatttgttt
     6601 caaaatggta ataaattgtg ttattttgta aaaaaaaaaa aaagtatatt tttggtacat
     6661 gattattagt tttagctaat atagagcaat tatataaact tctagtgata ttcagtccaa
     6721 agaaattcag cctttggata acatgtacca tgcagtttgt gtggtgtgtg tgtgtgtgtg
     6781 tgtgtgtgtg cacgtgcatg agagagagtg aaagagagag gtgttttttg ttttgttttt
     6841 tttgagacgg agtctcactc tgttgcccag gctggagtgc actggcacaa tctcggctta
     6901 ctgcaacctc cacctcccgt gttcaagcga gtctcctgcc tcagcctccc gagtactggg
     6961 actacaggcg cacaccacca tgcttggcta atttttgtat ttttagtaga gacgaagttt
     7021 caccatgctg gccaggttgg tctcgaactc ttgacctcgt gatctgcccg ccacagcctc
     7081 ccaaagagct aggattacag gcacgagcca ccgcgcacgg ccagaggcat tcatttcttt
     7141 agctaagttt ttttttctta gtaggttttt ttctcccagg cttgtaactc ttccccagtt
     7201 ctttgggcac tatttcaaat tattaggctt ctggaaagag tgcttccagg gacagcaagt
     7261 tactactgca cttgaccatt cctagtcctc acctgattac cagaaggtac gcaaggtaaa
     7321 agttagctga taggccctga attgagaaaa aggaatcacc aagcaatatc cgtaacatta
     7381 cacattttgc cagcacattt tctatgctat cagctaaaac gtaattttgg tcacaaaata
     7441 gggctgtagt gtagtttcta cttcttattc cagttgtttg attatgagga tacatttctt
     7501 gctgctgtcc tccactaaac agcagacaaa ttgccaggtg tgctggctca tgcctgtaat
     7561 cccagtgctt tgggaggcca aggcaggagt ttgagaccag cctaggcaac atcgtgagac
     7621 cccatctcta caaaaaaaaa aaaagaaaaa aaaaattagt tgggcatggc aatgccgcct
     7681 gtggtcctag ctactgggga ggctgaggca ggattgcttg aacccagaag tttgaggtta
     7741 cagtgagcta tgatcatgtc actgcaagac cctgtcccta aaaaaaggaa aaacaaatag
     7801 aagacaaatt tcaatttctg agtttataca aagaaagcct taattcagat cataaatatc
     7861 ccattgttat ttttagttca ttgtttccta gaacaaagga tggacattta ggatcctcac
     7921 attgatttat gtcatatata tgtattgcat tgaatatata tatacgcatg tagatacata
     7981 caattgttat atataattaa aagtcagaat cttaggtgat aactgtcaga cctctgagcc
     8041 caagctaagc catcgcatcc cctgtgactt gcacgtatac atccagatgg cctgaagtaa
     8101 ctgaagatcc acaaaagaag taaaaatagc cttaactgat gacattccac cattgtgatt
     8161 tgttcctgcc ccaccctaac tgatcaatgt actttgtaat ctcccccacc cttaagaagg
     8221 ttctttttaa ttctccccac ccttgagaat gtactttgtg agctccaccc actgtctgca
     8281 aaacattgct cttaacttca gcgcctatcc caaaacctat aagaactgat gataatccac
     8341 caccctttgc tgactctctt ttcggactca gcccgcctgc acccaggtga aataaacagc
     8401 catgttactc acacaaa
//
