LOCUS       NM_014787               5750 bp    mRNA    linear   PRI 07-FEB-2025
DEFINITION  Homo sapiens DnaJ heat shock protein family (Hsp40) member C6
            (DNAJC6), transcript variant 2, mRNA.
ACCESSION   NM_014787 XM_375737
VERSION     NM_014787.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5750)
  AUTHORS   Chiu,C.C., Chen,Y.L., Weng,Y.H., Liu,S.Y., Li,H.L., Yeh,T.H. and
            Wang,H.L.
  TITLE     Downregulation of Protease Cathepsin D and Upregulation of
            Pathologic alpha-Synuclein Mediate Paucity of DNAJC6-Induced
            Degeneration of Dopaminergic Neurons
  JOURNAL   Int J Mol Sci 25 (12), 6711 (2024)
   PUBMED   38928416
  REMARK    GeneRIF: Downregulation of Protease Cathepsin D and Upregulation of
            Pathologic alpha-Synuclein Mediate Paucity of DNAJC6-Induced
            Degeneration of Dopaminergic Neurons.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5750)
  AUTHORS   Benussi,L., Longobardi,A., Kocoglu,C., Carrara,M., Bellini,S.,
            Ferrari,C., Nicsanu,R., Saraceno,C., Bonvicini,C., Fostinelli,S.,
            Zanardini,R., Catania,M., Moisse,M., Van Damme,P., Di Fede,G.,
            Binetti,G., Van Broeckhoven,C., van der Zee,J. and Ghidoni,R.
  TITLE     Investigating the Endo-Lysosomal System in Major Neurocognitive
            Disorders Due to Alzheimer's Disease, Frontotemporal Lobar
            Degeneration and Lewy Body Disease: Evidence for SORL1 as a
            Cross-Disease Gene
  JOURNAL   Int J Mol Sci 22 (24), 13633 (2021)
   PUBMED   34948429
  REMARK    GeneRIF: Investigating the Endo-Lysosomal System in Major
            Neurocognitive Disorders Due to Alzheimer's Disease, Frontotemporal
            Lobar Degeneration and Lewy Body Disease: Evidence for SORL1 as a
            Cross-Disease Gene.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5750)
  AUTHORS   Wulansari,N., Darsono,W.H.W., Woo,H.J., Chang,M.Y., Kim,J.,
            Bae,E.J., Sun,W., Lee,J.H., Cho,I.J., Shin,H., Lee,S.J. and
            Lee,S.H.
  TITLE     Neurodevelopmental defects and neurodegenerative phenotypes in
            human brain organoids carrying Parkinson's disease-linked DNAJC6
            mutations
  JOURNAL   Sci Adv 7 (8) (2021)
   PUBMED   33597231
  REMARK    GeneRIF: Neurodevelopmental defects and neurodegenerative
            phenotypes in human brain organoids carrying Parkinson's
            disease-linked DNAJC6 mutations.
            Erratum:[Sci Adv. 2023 Nov 3;9(44):eadl1498. doi:
            10.1126/sciadv.adl1498.. PMID: 37922364]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5750)
  AUTHORS   Ng,J., Cortes-Saladelafont,E., Abela,L., Termsarasab,P., Mankad,K.,
            Sudhakar,S., Gorman,K.M., Heales,S.J.R., Pope,S., Biassoni,L.,
            Csanyi,B., Cain,J., Rakshi,K., Coutts,H., Jayawant,S.,
            Jefferson,R., Hughes,D., Garcia-Cazorla,A., Grozeva,D.,
            Raymond,F.L., Perez-Duenas,B., De Goede,C., Pearson,T.S., Meyer,E.
            and Kurian,M.A.
  TITLE     DNAJC6 Mutations Disrupt Dopamine Homeostasis in Juvenile
            Parkinsonism-Dystonia
  JOURNAL   Mov Disord 35 (8), 1357-1368 (2020)
   PUBMED   32472658
  REMARK    GeneRIF: DNAJC6 Mutations Disrupt Dopamine Homeostasis in Juvenile
            Parkinsonism-Dystonia.
REFERENCE   5  (bases 1 to 5750)
  AUTHORS   Shen,T., Zhao,S., Jiang,Y., Pu,J., Lai,H.Y., Yan,Y., Tian,J.,
            Chen,Y. and Zhang,B.
  TITLE     Haplotype Analysis on the Relationship of the DNAJC6 Gene with
            Early-Onset Parkinson's Disease Risk in a Chinese Population
  JOURNAL   J Parkinsons Dis 9 (1), 109-120 (2019)
   PUBMED   30373961
  REMARK    GeneRIF: Early onset Parkinson is associated with several SNPs and
            haplotypes of DNAJC6 gene.
REFERENCE   6  (bases 1 to 5750)
  AUTHORS   Scheele,U., Kalthoff,C. and Ungewickell,E.
  TITLE     Multiple interactions of auxilin 1 with clathrin and the AP-2
            adaptor complex
  JOURNAL   J Biol Chem 276 (39), 36131-36138 (2001)
   PUBMED   11470803
REFERENCE   7  (bases 1 to 5750)
  AUTHORS   Kirchhausen,T.
  TITLE     Three ways to make a vesicle
  JOURNAL   Nat Rev Mol Cell Biol 1 (3), 187-198 (2000)
   PUBMED   11252894
  REMARK    Review article
            Erratum:[Nat Rev Mol Cell Biol 2001 Mar;2(3):216]
REFERENCE   8  (bases 1 to 5750)
  AUTHORS   Ohtsuka,K. and Hata,M.
  TITLE     Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a
            proposal for their classification and nomenclature
  JOURNAL   Cell Stress Chaperones 5 (2), 98-112 (2000)
   PUBMED   11147971
REFERENCE   9  (bases 1 to 5750)
  AUTHORS   Lippincott-Schwartz,J., Roberts,T.H. and Hirschberg,K.
  TITLE     Secretory protein trafficking and organelle dynamics in living
            cells
  JOURNAL   Annu Rev Cell Dev Biol 16, 557-589 (2000)
   PUBMED   11031247
  REMARK    Review article
REFERENCE   10 (bases 1 to 5750)
  AUTHORS   Ungewickell,E., Ungewickell,H., Holstein,S.E., Lindner,R.,
            Prasad,K., Barouch,W., Martin,B., Greene,L.E. and Eisenberg,E.
  TITLE     Role of auxilin in uncoating clathrin-coated vesicles
  JOURNAL   Nature 378 (6557), 632-635 (1995)
   PUBMED   8524399
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC332732.1, AB007942.1,
            AL355487.8 and AC119800.2.
            
            On May 31, 2019 this sequence version replaced NM_014787.3.
            
            Summary: DNAJC6 belongs to the evolutionarily conserved DNAJ/HSP40
            family of proteins, which regulate molecular chaperone activity by
            stimulating ATPase activity. DNAJ proteins may have up to 3
            distinct domains: a conserved 70-amino acid J domain, usually at
            the N terminus, a glycine/phenylalanine (G/F)-rich region, and a
            cysteine-rich domain containing 4 motifs resembling a zinc finger
            domain (Ohtsuka and Hata, 2000 [PubMed 11147971]).[supplied by
            OMIM, Mar 2008].
            
            Transcript Variant: This variant (2) differs in the 5' UTR, lacks a
            portion of the 5' coding region, and initiates translation at an
            alternate start codon, compared to variant 1. The encoded isoform
            (2) has a distinct N-terminus and is shorter than isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB007942.1, SRR1660803.173779.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1970526, SAMEA2145544
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 DC332732.1         56-60
            6-1490              AB007942.1         1-1485
            1491-1491           AL355487.8         49404-49404
            1492-2000           AB007942.1         1487-1995
            2001-2001           AL355487.8         51946-51946
            2002-3447           AB007942.1         1997-3442
            3448-5750           AC119800.2         11764-14066
FEATURES             Location/Qualifiers
     source          1..5750
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p31.3"
     gene            1..5750
                     /gene="DNAJC6"
                     /gene_synonym="DJC6; PARK19"
                     /note="DnaJ heat shock protein family (Hsp40) member C6"
                     /db_xref="GeneID:9829"
                     /db_xref="HGNC:HGNC:15469"
                     /db_xref="MIM:608375"
     exon            1..184
                     /gene="DNAJC6"
                     /gene_synonym="DJC6; PARK19"
                     /inference="alignment:Splign:2.1.0"
     CDS             163..2904
                     /gene="DNAJC6"
                     /gene_synonym="DJC6; PARK19"
                     /EC_number="3.1.3.48"
                     /note="isoform 2 is encoded by transcript variant 2;
                     auxilin; DnaJ (Hsp40) homolog, subfamily B, member 6;
                     putative tyrosine-protein phosphatase auxilin; DnaJ
                     (Hsp40) homolog, subfamily C, member 6"
                     /codon_start=1
                     /product="auxilin isoform 2"
                     /protein_id="NP_055602.1"
                     /db_xref="CCDS:CCDS30739.1"
                     /db_xref="GeneID:9829"
                     /db_xref="HGNC:HGNC:15469"
                     /db_xref="MIM:608375"
                     /translation="MKDSENKGASSPDMEPSYGGGLFDMVKGGAGRLFSNLKDNLKDT
                     LKDTSSRVIQSVTSYTKGDLDFTYVTSRIIVMSFPLDNVDIGFRNQVDDIRSFLDSRH
                     LDHYTVYNLSPKSYRTAKFHSRVSECSWPIRQAPSLHNLFAVCRNMYNWLLQNPKNVC
                     VVHCLDGRAASSILVGAMFIFCNLYSTPGPAIRLLYAKRPGIGLSPSHRRYLGYMCDL
                     LADKPYRPHFKPLTIKSITVSPIPFFNKQRNGCRPYCDVLIGETKIYSTCTDFERMKE
                     YRVQDGKIFIPLNITVQGDVVVSMYHLRSTIGSRLQAKVTNTQIFQLQFHTGFIPLDT
                     TVLKFTKPELDACDVPEKYPQLFQVTLDVELQPHDKVIDLTPPWEHYCTKDVNPSILF
                     SSHQEHQDTLALGGQAPIDIPPDNPRHYGQSGFFASLCWQDQKSEKSFCEEDHAALVN
                     QESEQSDDELLTLSSPHGNANGDKPHGVKKPSKKQQEPAAPPPPEDVDLLGLEGSAMS
                     NSFSPPAAPPTNSELLSDLFGGGGAAGPTQAGQSGVEDVFHPSGPASTQSTPRRSATS
                     TSASPTLRVGEGATFDPFGAPSKPSGQDLLGSFLNTSSASSDPFLQPTRSPSPTVHAS
                     STPAVNIQPDVSGGWDWHAKPGGFGMGSKSAATSPTGSSHGTPTHQSKPQTLDPFADL
                     GTLGSSSFASKPTTPTGLGGGFPPLSSPQKASPQPMGGGWQQGGAYNWQQPQPKPQPS
                     MPHSSPQNRPNYNVSFSAMPGGQNERGKGSSNLEGKQKAADFEDLLSGQGFNAHKDKK
                     GPRTIAEMRKEEMAKEMDPEKLKILEWIEGKERNIRALLSTMHTVLWAGETKWKPVGM
                     ADLVTPEQVKKVYRKAVLVVHPDKATGQPYEQYAKMIFMELNDAWSEFENQGQKPLY"
     exon            185..335
                     /gene="DNAJC6"
                     /gene_synonym="DJC6; PARK19"
                     /inference="alignment:Splign:2.1.0"
     exon            336..385
                     /gene="DNAJC6"
                     /gene_synonym="DJC6; PARK19"
                     /inference="alignment:Splign:2.1.0"
     exon            386..534
                     /gene="DNAJC6"
                     /gene_synonym="DJC6; PARK19"
                     /inference="alignment:Splign:2.1.0"
     exon            535..657
                     /gene="DNAJC6"
                     /gene_synonym="DJC6; PARK19"
                     /inference="alignment:Splign:2.1.0"
     exon            658..791
                     /gene="DNAJC6"
                     /gene_synonym="DJC6; PARK19"
                     /inference="alignment:Splign:2.1.0"
     exon            792..986
                     /gene="DNAJC6"
                     /gene_synonym="DJC6; PARK19"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1104
                     /gene="DNAJC6"
                     /gene_synonym="DJC6; PARK19"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1184
                     /gene="DNAJC6"
                     /gene_synonym="DJC6; PARK19"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1378
                     /gene="DNAJC6"
                     /gene_synonym="DJC6; PARK19"
                     /inference="alignment:Splign:2.1.0"
     exon            1379..1459
                     /gene="DNAJC6"
                     /gene_synonym="DJC6; PARK19"
                     /inference="alignment:Splign:2.1.0"
     exon            1460..1894
                     /gene="DNAJC6"
                     /gene_synonym="DJC6; PARK19"
                     /inference="alignment:Splign:2.1.0"
     exon            1895..2029
                     /gene="DNAJC6"
                     /gene_synonym="DJC6; PARK19"
                     /inference="alignment:Splign:2.1.0"
     exon            2030..2098
                     /gene="DNAJC6"
                     /gene_synonym="DJC6; PARK19"
                     /inference="alignment:Splign:2.1.0"
     exon            2099..2218
                     /gene="DNAJC6"
                     /gene_synonym="DJC6; PARK19"
                     /inference="alignment:Splign:2.1.0"
     exon            2219..2482
                     /gene="DNAJC6"
                     /gene_synonym="DJC6; PARK19"
                     /inference="alignment:Splign:2.1.0"
     exon            2483..2625
                     /gene="DNAJC6"
                     /gene_synonym="DJC6; PARK19"
                     /inference="alignment:Splign:2.1.0"
     exon            2626..2802
                     /gene="DNAJC6"
                     /gene_synonym="DJC6; PARK19"
                     /inference="alignment:Splign:2.1.0"
     exon            2803..5750
                     /gene="DNAJC6"
                     /gene_synonym="DJC6; PARK19"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5137..5142
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DNAJC6"
                     /gene_synonym="DJC6; PARK19"
                     /note="hexamer: ATTAAA"
     polyA_site      5155
                     /gene="DNAJC6"
                     /gene_synonym="DJC6; PARK19"
                     /note="major polyA site"
     regulatory      5191..5196
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DNAJC6"
                     /gene_synonym="DJC6; PARK19"
                     /note="hexamer: AATACA"
     polyA_site      5215
                     /gene="DNAJC6"
                     /gene_synonym="DJC6; PARK19"
     regulatory      5719..5724
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DNAJC6"
                     /gene_synonym="DJC6; PARK19"
                     /note="hexamer: AATAAA"
     polyA_site      5750
                     /gene="DNAJC6"
                     /gene_synonym="DJC6; PARK19"
ORIGIN      
        1 aaccccgcac accgacttgc atgcaattat catagcccga gtgctcctcc gttgagagac
       61 ttcgcccccg agaccgctga ctgtgaatga caaatcaaaa gtcagggttg cagaatcagc
      121 cggactttcc tgctcatttg cagcagaggg aggaagcaga gaatgaaaga ttctgaaaat
      181 aaaggtgcct catctccaga catggagccc agctatgggg gaggtctctt tgacatggta
      241 aaaggaggtg cagggaggct ctttagtaac ctaaaggaca acttgaaaga caccctcaaa
      301 gacacatctt ctagagtgat acaatctgtg accagctaca caaagggaga tttagacttc
      361 acttatgtta cctccagaat tattgtgatg tcctttcctc tggacaatgt tgacatagga
      421 ttcaggaatc aggttgatga cattcgaagc tttttggatt ccagacatct tgaccactac
      481 acagtataca atctgtcacc taagtcttat cgaactgcca agtttcacag ccgggtctca
      541 gaatgcagtt ggcccattag gcaggctccc agtctgcaca acctttttgc tgtgtgtcgg
      601 aatatgtata actggctact gcagaatccc aaaaatgtct gtgttgtcca ctgcttggat
      661 ggacgggcgg catcatcaat tctggttggt gctatgttca ttttctgtaa tctctactct
      721 actcctggcc cagccattcg attgctatat gcaaagcgac caggaattgg actttcacca
      781 tcccatagga gatacctggg ctatatgtgt gacctactgg cagacaagcc ctaccgccct
      841 cacttcaagc ctctcacaat taagtcgatc actgtcagtc caataccctt tttcaacaaa
      901 cagaggaatg gatgtcgccc ttactgtgat gtactcattg gagaaaccaa aatatattcg
      961 acttgcacag attttgaacg aatgaaagaa tatcgtgtcc aagatggaaa aatcttcatt
     1021 cccttgaaca tcactgtgca aggagacgtg gttgtttcca tgtatcactt gaggtcaacc
     1081 attgggagcc ggctacaggc taaggtgacc aacacacaga tattccagct tcagtttcac
     1141 actggattca taccactgga cacaacagtt ttaaagttca ccaagcctga gttagatgca
     1201 tgtgatgtac cagaaaaata tcctcagcta tttcaggtga cactggatgt agaactacag
     1261 ccccatgaca aagtaataga cttaactcca ccatgggaac attactgcac aaaagatgtc
     1321 aatcccagca tcctcttctc ttctcaccag gaacatcaag atacgctggc cttaggagga
     1381 caggctccaa tagatatccc tccagacaac cccaggcatt acggacaaag tggtttcttt
     1441 gcctctctct gttggcaaga tcagaaatcg gagaagtcat tctgtgagga ggaccacgct
     1501 gccctagtga atcaggaaag tgagcaatca gatgatgaac ttctgacact ttccagtccg
     1561 catggcaatg ccaatggtga caagcctcat ggagtcaaga agcccagcaa aaagcagcag
     1621 gagccagcag cccctccacc ccctgaggat gtggaccttt tgggcctgga agggtctgca
     1681 atgagtaaca gcttctctcc gccagcggct cctcccacca attctgaact actgagtgac
     1741 ctgtttgggg gtggaggtgc agctggtccc acccaggctg gacagtcagg agtggaagat
     1801 gtgtttcatc ctagtggacc tgcgtctacc cagtcaacac cacgccgctc tgccacctcc
     1861 acctctgcgt ctccaaccct aagagtggga gaaggtgcca cctttgaccc atttggagca
     1921 ccttctaaac catcaggtca ggatttgctg ggttcttttc tgaacacatc cagtgcttcc
     1981 agtgacccct ttctccagcc aacaagaagt ccttcgccca cagtacatgc ttctagtacg
     2041 cctgctgtga acattcagcc agatgtttct ggaggttggg actggcatgc taaaccagga
     2101 ggctttggaa tgggaagcaa gtcagctgcc accagcccaa ccggatcctc gcatggtact
     2161 cccacccatc aaagcaaacc ccagactctg gatccttttg ccgaccttgg gacactaggt
     2221 agttcttcct ttgccagcaa acccaccaca ccaactggat tgggtggagg attcccgcct
     2281 ctcagctcgc cacagaaggc gtctccccag cctatgggtg gcgggtggca gcagggaggt
     2341 gcctacaact ggcagcagcc acagcctaag cctcagccca gcatgcccca ctcctctccc
     2401 cagaaccgac ccaactacaa cgtgagcttc tcagccatgc ctgggggcca gaacgaacgt
     2461 gggaaaggat caagtaattt ggaagggaaa caaaaagcag ctgattttga agacctactc
     2521 tctggtcaag gtttcaatgc tcacaaagac aaaaaggggc ctcggacaat agctgagatg
     2581 agaaaggagg aaatggccaa ggaaatggat cctgagaaat taaagattct ggaatggatt
     2641 gaaggcaaag aaagaaatat cagagccctt ctttccacga tgcataccgt actatgggct
     2701 ggggagacca agtggaaacc agttggcatg gcagacctgg taacaccaga gcaggtgaag
     2761 aaggtgtaca ggaaggctgt cctggtggtg cacccagata aagctactgg gcaaccctat
     2821 gaacaatacg caaagatgat tttcatggag ctcaatgatg cctggtctga atttgaaaac
     2881 caaggccaaa agcccttata ttaatttatg agcttttcca tctctgctgc agacctgtgc
     2941 taatgcttag tgtgtgtcac aattctgagg ttttcgcaga tgaaccaaaa actccagtaa
     3001 catgttttca gtactaaacc gttaagttac tcatgaatta atttctcatt gataaggaat
     3061 gtggatgttt ggtttctcca aagttcccac cataaaagat ccaaagcatg agaggaactt
     3121 ctagtcagat gaccttgcag aaccaccgca ttccaccctg ccctttgggg agcctactca
     3181 gcattctacc tggggaaatg gaaaacagag gccaccaccc atgaaggcat aacacccatc
     3241 acattgtctg agaataggat taatgagcaa aagttatgat aatagagtta tatgatggtt
     3301 taatggtttc tagatttttc ttggaaagat ataatttgag cagtggcttt atgcagactc
     3361 caagaacaaa accaccaggt attttttttt aagtaaaaat ttactaaggc ctttagcata
     3421 atactgtaaa tgtcttttgg tcaagagaac taacaaatat aaaggaactt gaaatgtggg
     3481 gagtgataat agtccagtga ttaaactaca gtccagtgat taccaccaac tttctgacta
     3541 agctaaaaat gaatgaaaat ggtggctaaa gaaaataggg actctgaaga tgtcgaaatc
     3601 tttattcctg gttaggaagg tgggccgcta cccttctttc cctttagaaa actgtgatta
     3661 attaaataaa aagtcttact actataacaa ctctaaacct ggtttaaatg aaacatctaa
     3721 ttttgctgta aggcttaatg ctcttctttt gtttagccaa gaaaacattc ttagttggaa
     3781 acaggtggta aagtagtttg gcctgttcac aacttatcag gaccaatatc tagtgtggac
     3841 tcagtgttct ctaggtttgt gagcagttgt ggtaagagaa tggaaggcaa cactgaatag
     3901 gagttaaggg aatggcacga tcacagtgag agagctgcac tcacctgcag acccagtcag
     3961 atggcttgtc agtatctgct ctgaggaacc aggtcccacc tccccacaag gcaaatctag
     4021 acccattaaa ttattacagt gggctttttt gttttaaaag tggttgggga tccacaggaa
     4081 cgacattcat acagggacat ttgtgaaagc aaagcaagaa tgaatgcttt cccgatctca
     4141 gactggctgg attcagatca gtgtgttggc tggttctcat tttaaggggt aagcagtttg
     4201 ctattctgtg actttagtag atctcttttg tgtgcacata tacaatgtgc attatacata
     4261 tatattaaat atatccacaa agcagatggg caaaaagatt ttcatgctaa tcttcaaagg
     4321 ttcatgctca atattgtgaa aagcttttaa aagttgtttt gaaaagacaa tcattttttg
     4381 tttttgtttt aactttcttg tggcaagcta taccggaaaa gcggcatgtc aaaaatactt
     4441 taggttctac atagatctct ttctctcttt tgttttgttt gtttgtttgt taaagttcat
     4501 tatttatttt accttttact gacaatgtga aactcgaaga aaatgttctc tttttaaata
     4561 tacagtcata aactgttcaa ggtaaccata acaaactagg tgttatttat taacgtatta
     4621 taaaataatg tttgatccag tatgtgcttg tcttatttaa aattggaatg tgagacatgt
     4681 tgctgtgacc tgtttttctt tctcattcac atttgtagat attgtgtgaa ctacagtata
     4741 taatgataac aattaaaagg atattctgtg gatgtcacgt attttgaaat gatagaacta
     4801 cattagcttt gtatcatgtt tggataattc atcaatgttc acagtttaaa acatcattaa
     4861 acattatgta attacaatga gaaagaatct tacttaaatt tggagatttt cccccacatc
     4921 tcttttccgg atacattata attctggacc cctatttatc tcaaaactct taatatatgc
     4981 agaccaacag gtctttgcat tccttttaaa taactggttg tgacaaagct tgttgttgat
     5041 cagattcact gtttcatcat atttattgta atatattttt tgttttgtaa atatgttaca
     5101 acaaaatgtg attggtctaa aatatttgta atgtatatta aaaggttcaa aaatatttgt
     5161 ataaatctaa gttatttggg tacttgtagg aatacaatga ggagcttgaa tgccaccttc
     5221 tgacatgatt tacttttaag gaaagttatg aggagagaat acaaaaagca tgcaccaaaa
     5281 tgtaatctga caggatttct ggatttatac gtaatcactc ctgccccaac acacacacac
     5341 acacacacac acacacacac acacatgcac gcacacatga ttttgattat gctacatgat
     5401 atatgtttca aaaagaatta gcatagaaat cctggtctcc tagccaaaaa aatcaaagga
     5461 ttttcaaaaa aacgaatctg tatgttgagg caaaaggatt gaacctggaa gtctgggact
     5521 ttatcataga aacaaagtct cagatatttt agttctttgg aaacaaatgc tgtaattcaa
     5581 aagcatttga cctgtcactg tactatctac atgtggaaga atgttcaagt tgaatcctaa
     5641 tgccgtgaat gaaacacagt ctgtgtaggg aatgagcaaa aaagttgaat tccaattgct
     5701 ttttggcctt ttggctaaaa taaatgtagc atctaatttt atcagtttaa
//
