LOCUS       NM_001307980            1357 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens DnaJ heat shock protein family (Hsp40) member C4
            (DNAJC4), transcript variant 1, mRNA.
ACCESSION   NM_001307980 XM_011544983
VERSION     NM_001307980.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1357)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 1357)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   3  (bases 1 to 1357)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1357)
  AUTHORS   Davila,S., Froeling,F.E., Tan,A., Bonnard,C., Boland,G.J.,
            Snippe,H., Hibberd,M.L. and Seielstad,M.
  TITLE     New genetic associations detected in a host response study to
            hepatitis B vaccine
  JOURNAL   Genes Immun 11 (3), 232-238 (2010)
   PUBMED   20237496
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 1357)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 1357)
  AUTHORS   Kaltenbach,L.S., Romero,E., Becklin,R.R., Chettier,R., Bell,R.,
            Phansalkar,A., Strand,A., Torcassi,C., Savage,J., Hurlburt,A.,
            Cha,G.H., Ukani,L., Chepanoske,C.L., Zhen,Y., Sahasrabudhe,S.,
            Olson,J., Kurschner,C., Ellerby,L.M., Peltier,J.M., Botas,J. and
            Hughes,R.E.
  TITLE     Huntingtin interacting proteins are genetic modifiers of
            neurodegeneration
  JOURNAL   PLoS Genet 3 (5), e82 (2007)
   PUBMED   17500595
REFERENCE   7  (bases 1 to 1357)
  AUTHORS   Ohtsuka,K. and Hata,M.
  TITLE     Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a
            proposal for their classification and nomenclature
  JOURNAL   Cell Stress Chaperones 5 (2), 98-112 (2000)
   PUBMED   11147971
REFERENCE   8  (bases 1 to 1357)
  AUTHORS   Silins,G., Grimmond,S. and Hayward,N.
  TITLE     Characterisation of a new human and murine member of the DnaJ
            family of proteins
  JOURNAL   Biochem Biophys Res Commun 243 (1), 273-276 (1998)
   PUBMED   9473517
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC044584.1, AP001453.6, BC032137.2 and AF036874.1.
            
            On Apr 18, 2015 this sequence version replaced XM_011544983.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC032137.2, SRR1163657.490538.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-64                BC044584.1         43-106
            65-65               AP001453.6         2678-2678
            66-326              BC044584.1         108-368
            327-1172            BC032137.2         1-846
            1173-1173           AF036874.1         724-724
            1174-1357           BC032137.2         848-1031
FEATURES             Location/Qualifiers
     source          1..1357
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.1"
     gene            1..1357
                     /gene="DNAJC4"
                     /gene_synonym="DANJC4; HSPF2; MCG18"
                     /note="DnaJ heat shock protein family (Hsp40) member C4"
                     /db_xref="GeneID:3338"
                     /db_xref="HGNC:HGNC:5271"
                     /db_xref="MIM:604189"
     exon            1..509
                     /gene="DNAJC4"
                     /gene_synonym="DANJC4; HSPF2; MCG18"
                     /inference="alignment:Splign:2.1.0"
     CDS             424..1173
                     /gene="DNAJC4"
                     /gene_synonym="DANJC4; HSPF2; MCG18"
                     /note="isoform 1 is encoded by transcript variant 1; heat
                     shock 40kD protein 2; dnaJ homolog subfamily C member 4;
                     dnaJ-like protein HSPF2; multiple endocrine neoplasia type
                     1 candidate protein number 18; DnaJ (Hsp40) homolog,
                     subfamily C, member 4"
                     /codon_start=1
                     /product="dnaJ homolog subfamily C member 4 isoform 1"
                     /protein_id="NP_001294909.1"
                     /db_xref="CCDS:CCDS76424.1"
                     /db_xref="GeneID:3338"
                     /db_xref="HGNC:HGNC:5271"
                     /db_xref="MIM:604189"
                     /translation="MPPLLPLRLCRLWPRNPPSRLLGAAAGQRSRPSTYYELLGVHPG
                     ASTEEVKRAFFSKSKELHPDRDPGNPSLHSRFVELSEAYRVLSREQSRRSYDDQLRSG
                     SPPKSPRTTVHDKSAHQTHSSSWTPPNAQYWSQFHSVRPQGPQLRQQQHKQNKQVLGY
                     CLLLMLAGMGLHYIAFRKVKQMHLNFMDEKDRIITAFYNEARARARSVPALFCSLLPV
                     QEPHFGIPIPTTQVPSPPGPTEASFSRSDNG"
     exon            510..603
                     /gene="DNAJC4"
                     /gene_synonym="DANJC4; HSPF2; MCG18"
                     /inference="alignment:Splign:2.1.0"
     exon            604..788
                     /gene="DNAJC4"
                     /gene_synonym="DANJC4; HSPF2; MCG18"
                     /inference="alignment:Splign:2.1.0"
     exon            789..953
                     /gene="DNAJC4"
                     /gene_synonym="DANJC4; HSPF2; MCG18"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1341
                     /gene="DNAJC4"
                     /gene_synonym="DANJC4; HSPF2; MCG18"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1324..1329
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DNAJC4"
                     /gene_synonym="DANJC4; HSPF2; MCG18"
                     /note="hexamer: AATAAA"
     polyA_site      1341
                     /gene="DNAJC4"
                     /gene_synonym="DANJC4; HSPF2; MCG18"
                     /note="major polyA site"
ORIGIN      
        1 gtggacgtgg tcttggcatc cacgccaatg agaatgtgag ggcggggcct gaatagacgc
       61 aggaaatggc gacggccgcg ggtctgtgag cagcgggggc ggggcctggt tgtggcccct
      121 ccttctcccg tccccaagtt ccctgggtgg gaacggggtc ttggggtccc tggctgggtg
      181 gccagacccc gaagccagcg ctgggaaggg ctgcggatgc ccgggtcaga ggaaggggca
      241 ggtccaagga cacgcgggtc tggtcctggg caagaaccgc cccctctccg ggcctgcttc
      301 agtcttcctt tgcagaacaa cgggccaggc cccttccctc tgcccccggg tgcttgaagt
      361 ctagccccat cctggtccaa tgcgctcttg gtagcctcct ttcccagctg cccgcccgcc
      421 gccatgccgc ccttactgcc cctgcgcctg tgccggctgt ggccccgcaa ccctccctcc
      481 cggctcctcg gagcggccgc cgggcagcgg tccagaccca gtacttatta tgaactgttg
      541 ggggtgcatc ctggtgccag cactgaggaa gttaaacgag ctttcttctc caagtccaaa
      601 gagctgcacc cagaccggga ccctgggaac ccaagcctgc acagccgctt tgtggagctg
      661 agcgaggcat accgtgtgct cagccgtgag cagagccgcc gcagctatga tgaccagctc
      721 cgctcaggta gtcccccaaa gtctccacga accacagtcc atgacaagtc tgcccaccaa
      781 acacacagca gctcctggac accccccaac gcacagtact ggtcccagtt tcacagcgtg
      841 aggccacagg ggccccagtt gaggcagcag caacacaaac aaaacaaaca agtgctgggg
      901 tactgcctcc tcctcatgct ggcgggcatg ggcctgcact acattgcctt caggaaggtg
      961 aagcagatgc accttaactt catggatgaa aaggatcgga tcatcacagc cttctacaac
     1021 gaagcccggg cacgggccag gtctgtccct gctctattct gctccctgct ccctgtccag
     1081 gaaccacact tcgggatccc tatcccaacc acccaggtgc cctctcctcc agggccaaca
     1141 gaggcatcct tcagcaggag cgacaacggc tagggcagcg gcagccgcca ccatccgagc
     1201 caacccaagg ccccgagatc gtgccccggg gcgccggccc ctgaggggct cacctggatg
     1261 gggcctgcag tgcgttcccg ctttgcttcc ttccctggac ggcccgctcc ccgaaacgcg
     1321 cgcaataaag tgattcgcag aaaaaaaaaa aaaaaaa
//
