LOCUS       NM_006260               5590 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens DnaJ heat shock protein family (Hsp40) member C3
            (DNAJC3), mRNA.
ACCESSION   NM_006260
VERSION     NM_006260.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5590)
  AUTHORS   Pauwels,E., Provinciael,B., Camps,A., Hartmann,E. and Vermeire,K.
  TITLE     Reduced DNAJC3 Expression Affects Protein Translocation across the
            ER Membrane and Attenuates the Down-Modulating Effect of the
            Translocation Inhibitor Cyclotriazadisulfonamide
  JOURNAL   Int J Mol Sci 23 (2), 584 (2022)
   PUBMED   35054769
  REMARK    GeneRIF: Reduced DNAJC3 Expression Affects Protein Translocation
            across the ER Membrane and Attenuates the Down-Modulating Effect of
            the Translocation Inhibitor Cyclotriazadisulfonamide.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5590)
  AUTHORS   Ocansey,S., Pullen,D., Atkinson,P., Clarke,A., Hadonou,M.,
            Crosby,C., Short,J., Lloyd,I.C., Smedley,D., Assunta,A., Shah,P.
            and McEntagart,M.
  CONSRTM   Genomics England Research Consortium
  TITLE     Biallelic DNAJC3 variants in a neuroendocrine developmental
            disorder with insulin dysregulation
  JOURNAL   Clin Dysmorphol 31 (1), 11-17 (2022)
   PUBMED   34654017
  REMARK    GeneRIF: Biallelic DNAJC3 variants in a neuroendocrine
            developmental disorder with insulin dysregulation.
REFERENCE   3  (bases 1 to 5590)
  AUTHORS   Lytrivi,M., Senee,V., Salpea,P., Fantuzzi,F., Philippi,A.,
            Abdulkarim,B., Sawatani,T., Marin-Canas,S., Pachera,N., Degavre,A.,
            Singh,P., Derbois,C., Lechner,D., Ladriere,L., Igoillo-Esteve,M.,
            Cosentino,C., Marselli,L., Deleuze,J.F., Marchetti,P.,
            Eizirik,D.L., Nicolino,M., Chaussenot,A., Julier,C. and Cnop,M.
  TITLE     DNAJC3 deficiency induces beta-cell mitochondrial apoptosis and
            causes syndromic young-onset diabetes
  JOURNAL   Eur J Endocrinol 184 (3), 455-468 (2021)
   PUBMED   33486469
  REMARK    GeneRIF: DNAJC3 deficiency induces beta-cell mitochondrial
            apoptosis and causes syndromic young-onset diabetes.
REFERENCE   4  (bases 1 to 5590)
  AUTHORS   van Huizen,R., Martindale,J.L., Gorospe,M. and Holbrook,N.J.
  TITLE     P58IPK, a novel endoplasmic reticulum stress-inducible protein and
            potential negative regulator of eIF2alpha signaling
  JOURNAL   J Biol Chem 278 (18), 15558-15564 (2003)
   PUBMED   12601012
  REMARK    GeneRIF: P58(IPK) is an important component of a negative feedback
            loop used by the cell to inhibit eIF2alpha signaling, and thus
            attenuate the unfolded protein response.
REFERENCE   5  (bases 1 to 5590)
  AUTHORS   Melville,M.W., Tan,S.L., Wambach,M., Song,J., Morimoto,R.I. and
            Katze,M.G.
  TITLE     The cellular inhibitor of the PKR protein kinase, P58(IPK), is an
            influenza virus-activated co-chaperone that modulates heat shock
            protein 70 activity
  JOURNAL   J Biol Chem 274 (6), 3797-3803 (1999)
   PUBMED   9920933
REFERENCE   6  (bases 1 to 5590)
  AUTHORS   Gale,M. Jr., Blakely,C.M., Hopkins,D.A., Melville,M.W., Wambach,M.,
            Romano,P.R. and Katze,M.G.
  TITLE     Regulation of interferon-induced protein kinase PKR: modulation of
            P58IPK inhibitory function by a novel protein, P52rIPK
  JOURNAL   Mol Cell Biol 18 (2), 859-871 (1998)
   PUBMED   9447982
REFERENCE   7  (bases 1 to 5590)
  AUTHORS   Korth,M.J., Lyons,C.N., Wambach,M. and Katze,M.G.
  TITLE     Cloning, expression, and cellular localization of the oncogenic
            58-kDa inhibitor of the RNA-activated human and mouse protein
            kinase
  JOURNAL   Gene 170 (2), 181-188 (1996)
   PUBMED   8666242
REFERENCE   8  (bases 1 to 5590)
  AUTHORS   Polyak,S.J., Tang,N., Wambach,M., Barber,G.N. and Katze,M.G.
  TITLE     The P58 cellular inhibitor complexes with the interferon-induced,
            double-stranded RNA-dependent protein kinase, PKR, to regulate its
            autophosphorylation and activity
  JOURNAL   J Biol Chem 271 (3), 1702-1707 (1996)
   PUBMED   8576172
REFERENCE   9  (bases 1 to 5590)
  AUTHORS   Korth,M.J., Edelhoff,S., Disteche,C.M. and Katze,M.G.
  TITLE     Chromosomal assignment of the gene encoding the human 58-kDa
            inhibitor (PRKRI) of the interferon-induced dsRNA-activated protein
            kinase to chromosome 13q32
  JOURNAL   Genomics 31 (2), 238-239 (1996)
   PUBMED   8824808
REFERENCE   10 (bases 1 to 5590)
  AUTHORS   Lee,T.G., Tang,N., Thompson,S., Miller,J. and Katze,M.G.
  TITLE     The 58,000-dalton cellular inhibitor of the interferon-induced
            double-stranded RNA-activated protein kinase (PKR) is a member of
            the tetratricopeptide repeat family of proteins
  JOURNAL   Mol Cell Biol 14 (4), 2331-2342 (1994)
   PUBMED   7511204
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK292947.1, BC047936.1,
            AL138955.14, AL136104.8 and AA430108.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_006260.4.
            
            Summary: This gene encodes a protein with multiple
            tetratricopeptide repeat (TPR) motifs as well as the highly
            conserved J domain found in DNAJ chaperone family members. It is a
            member of the tetratricopeptide repeat family of proteins and acts
            as an inhibitor of the interferon-induced, dsRNA-activated protein
            kinase (PKR). [provided by RefSeq, Jul 2010].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.230512.1,
                                           SRR1660807.51794.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000602402.6/ ENSP00000473631.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-680               AK292947.1         1-680
            681-1645            BC047936.1         663-1627
            1646-3824           AL138955.14        147526-149704
            3825-5528           AL136104.8         2001-3704
            5529-5590           AA430108.1         9-70                c
FEATURES             Location/Qualifiers
     source          1..5590
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q32.1"
     gene            1..5590
                     /gene="DNAJC3"
                     /gene_synonym="ACPHD; ERdj6; HP58; P58; p58(IPK); P58IPK;
                     PRKRI"
                     /note="DnaJ heat shock protein family (Hsp40) member C3"
                     /db_xref="GeneID:5611"
                     /db_xref="HGNC:HGNC:9439"
                     /db_xref="MIM:601184"
     exon            1..199
                     /gene="DNAJC3"
                     /gene_synonym="ACPHD; ERdj6; HP58; P58; p58(IPK); P58IPK;
                     PRKRI"
                     /inference="alignment:Splign:2.1.0"
     CDS             118..1632
                     /gene="DNAJC3"
                     /gene_synonym="ACPHD; ERdj6; HP58; P58; p58(IPK); P58IPK;
                     PRKRI"
                     /note="protein-kinase, interferon-inducible double
                     stranded RNA dependent inhibitor; protein kinase inhibitor
                     p58; protein kinase inhibitor of 58 kDa; DnaJ (Hsp40)
                     homolog, subfamily C, member 3; interferon-induced,
                     double-stranded RNA-activated protein kinase inhibitor;
                     ER-resident protein ERdj6; endoplasmic reticulum DNA J
                     domain-containing protein 6"
                     /codon_start=1
                     /product="dnaJ homolog subfamily C member 3 precursor"
                     /protein_id="NP_006251.1"
                     /db_xref="CCDS:CCDS9479.1"
                     /db_xref="GeneID:5611"
                     /db_xref="HGNC:HGNC:9439"
                     /db_xref="MIM:601184"
                     /translation="MVAPGSVTSRLGSVFPFLLVLVDLQYEGAECGVNADVEKHLELG
                     KKLLAAGQLADALSQFHAAVDGDPDNYIAYYRRATVFLAMGKSKAALPDLTKVIQLKM
                     DFTAARLQRGHLLLKQGKLDEAEDDFKKVLKSNPSENEEKEAQSQLIKSDEMQRLRSQ
                     ALNAFGSGDYTAAIAFLDKILEVCVWDAELRELRAECFIKEGEPRKAISDLKAASKLK
                     NDNTEAFYKISTLYYQLGDHELSLSEVRECLKLDQDHKRCFAHYKQVKKLNKLIESAE
                     ELIRDGRYTDATSKYESVMKTEPSIAEYTVRSKERICHCFSKDEKPVEAIRVCSEVLQ
                     MEPDNVNALKDRAEAYLIEEMYDEAIQDYETAQEHNENDQQIREGLEKAQRLLKQSQK
                     RDYYKILGVKRNAKKQEIIKAYRKLALQWHPDNFQNEEEKKKAEKKFIDIAAAKEVLS
                     DPEMRKKFDDGEDPLDAESQQGGGGNPFHRSWNSWQGFNPFSSGGPFRFKFHFN"
     exon            200..310
                     /gene="DNAJC3"
                     /gene_synonym="ACPHD; ERdj6; HP58; P58; p58(IPK); P58IPK;
                     PRKRI"
                     /inference="alignment:Splign:2.1.0"
     exon            311..435
                     /gene="DNAJC3"
                     /gene_synonym="ACPHD; ERdj6; HP58; P58; p58(IPK); P58IPK;
                     PRKRI"
                     /inference="alignment:Splign:2.1.0"
     exon            436..510
                     /gene="DNAJC3"
                     /gene_synonym="ACPHD; ERdj6; HP58; P58; p58(IPK); P58IPK;
                     PRKRI"
                     /inference="alignment:Splign:2.1.0"
     exon            511..663
                     /gene="DNAJC3"
                     /gene_synonym="ACPHD; ERdj6; HP58; P58; p58(IPK); P58IPK;
                     PRKRI"
                     /inference="alignment:Splign:2.1.0"
     exon            664..845
                     /gene="DNAJC3"
                     /gene_synonym="ACPHD; ERdj6; HP58; P58; p58(IPK); P58IPK;
                     PRKRI"
                     /inference="alignment:Splign:2.1.0"
     exon            846..965
                     /gene="DNAJC3"
                     /gene_synonym="ACPHD; ERdj6; HP58; P58; p58(IPK); P58IPK;
                     PRKRI"
                     /inference="alignment:Splign:2.1.0"
     exon            966..1071
                     /gene="DNAJC3"
                     /gene_synonym="ACPHD; ERdj6; HP58; P58; p58(IPK); P58IPK;
                     PRKRI"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1192
                     /gene="DNAJC3"
                     /gene_synonym="ACPHD; ERdj6; HP58; P58; p58(IPK); P58IPK;
                     PRKRI"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1325
                     /gene="DNAJC3"
                     /gene_synonym="ACPHD; ERdj6; HP58; P58; p58(IPK); P58IPK;
                     PRKRI"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..1474
                     /gene="DNAJC3"
                     /gene_synonym="ACPHD; ERdj6; HP58; P58; p58(IPK); P58IPK;
                     PRKRI"
                     /inference="alignment:Splign:2.1.0"
     exon            1475..5590
                     /gene="DNAJC3"
                     /gene_synonym="ACPHD; ERdj6; HP58; P58; p58(IPK); P58IPK;
                     PRKRI"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5563..5568
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DNAJC3"
                     /gene_synonym="ACPHD; ERdj6; HP58; P58; p58(IPK); P58IPK;
                     PRKRI"
                     /note="hexamer: AATAAA"
     polyA_site      5590
                     /gene="DNAJC3"
                     /gene_synonym="ACPHD; ERdj6; HP58; P58; p58(IPK); P58IPK;
                     PRKRI"
                     /note="major polyA site"
ORIGIN      
        1 agagccactg aggcctgagc gagagccgac ggcgggcggg cgcagctgct gccggagcgc
       61 cggcgcgtgc tggtgggcca cacacctttc ctcctcttca ctcgcgagcc ctcggacatg
      121 gtggcccccg gctccgtgac cagccggctg ggctcggtat tccccttcct gctagtcctg
      181 gtggatctgc agtacgaagg tgctgaatgt ggagtaaatg cagatgttga gaaacatctt
      241 gaattgggca agaaattact tgcagctgga cagctagctg atgctttatc tcagtttcat
      301 gctgccgtag atggtgaccc tgataactat attgcttatt atcggagggc tactgtcttt
      361 ttagctatgg gcaaatcaaa agctgcactt cctgatttaa ctaaagtgat tcaattgaag
      421 atggacttca ctgcagcaag attacagaga ggtcacttat tactcaaaca aggaaaactt
      481 gatgaagcag aagatgattt taaaaaagtg ctcaaatcta atccaagtga aaatgaagaa
      541 aaggaagcac agtctcaact tataaaatct gatgaaatgc agcgtttgcg ttcacaagca
      601 cttaacgctt ttggaagtgg agattatact gctgctatag ccttccttga taagatttta
      661 gaggtttgtg tttgggatgc agaactacgg gaacttcgag ctgaatgttt tataaaagaa
      721 ggagaaccta ggaaagctat aagtgactta aaagctgcgt caaagttgaa gaatgataat
      781 actgaagcgt tttataaaat aagcacactg tactaccaac taggagacca cgaactgtcc
      841 ctcagtgaag ttcgggaatg tcttaaactt gaccaggatc ataaaaggtg ttttgcacac
      901 tataaacaag taaagaaact taataagctg attgagtcag ctgaagagct catcagagat
      961 ggcagataca cagatgctac cagcaaatat gaatctgtca tgaaaacaga gccaagcatt
     1021 gctgaatata cagttcgttc aaaggagagg atttgccact gcttttctaa ggacgagaag
     1081 cctgttgaag ctattagggt ttgttctgaa gttttacaga tggaacctga caatgtgaat
     1141 gccctgaaag atcgagcaga ggcctatttg atagaggaaa tgtatgatga agctattcag
     1201 gattatgaaa ctgctcagga acacaatgaa aatgatcagc agattcgaga aggtctagag
     1261 aaagcacaaa gattattgaa acagtcgcag aaacgagatt attataaaat cttgggagta
     1321 aaaagaaatg ccaaaaagca agaaattatt aaagcatacc gaaaattagc actgcagtgg
     1381 cacccagata acttccagaa tgaagaagaa aagaaaaaag ctgagaaaaa gttcattgat
     1441 atagcagctg ctaaagaagt cctctctgat ccagaaatga gaaagaagtt tgacgacgga
     1501 gaagatcctt tggatgcaga gagccagcaa ggaggcggcg gcaacccttt ccacagaagc
     1561 tggaactcat ggcaagggtt caatcccttc agctcaggcg gaccatttag atttaaattc
     1621 cacttcaatt aaaccaactg tttttctgct cttcttaatt tttttaaaga ttaaaaacaa
     1681 agaaatcttg ttccgggacc ctaatgaaaa aaaatttcaa atcttttcag tttgtccatg
     1741 accaaagagt tgctttaata ggaaaaaatc tgttcttatc cctgtcagat ttatggttaa
     1801 tgggtttgca acggcaagga ggcaaggaat ggttctattt ctgacagagc agcctgcatc
     1861 tgctttatgc tgtctggagg gaagtggtct gaggcaggct cacccgtgga agtgctcacg
     1921 tattctgtat tatttttcta cactggagct gagattcttc tcttcacagc cttgcagagt
     1981 aagtcagtgc ctacaagtgt aagaaggagc tgtaatcttc atgaggatgg ttatacttca
     2041 gtattcttaa agagaacatg aacatttttg agctgtatgt tcttagggac aactgtgctt
     2101 cgatgtggtc agtctcgtca cttgtgagta gctgtgaaat ctttagtgtg catgtgtttg
     2161 cacctctgtg gtctgtcaac gtggctgtca ctgaaggagc aagagaccat cttttaggaa
     2221 ccctgccacc aaataataat atatccaggc ttagactttg gattaatgtt aaatgtacat
     2281 ttttttggtt cagtacctga agaagaatac tgaaacttga atctataaat tcctatggac
     2341 ccttttaata ttaaacacaa caaattaaaa gttgttatag gtaaaataag ttcagataaa
     2401 atagtggtgg tatttaaaat aatattgctg aagtgcagat tgaaatactt tttaaacaac
     2461 tgaagttctg agtttttata gggaatttca tgtaacaaga ctggtttaga aacgtaaagt
     2521 tgcgcagtca acataaataa atacagaatg ccatgttctc cacttctaag taaagacagt
     2581 gggcagcttc tgtttctcct tctatcaagg cttcacccta tcttaaaggt ctgtggtgcc
     2641 tcccacgtgg gacctgtctg ctggtatgtg ttaaacagca gaccggccct tctaccagat
     2701 cttgatgcct ctgattttct cctgcctaca agaaaataca ggcaaggtta gtcaggtctg
     2761 gctatatttc cactgttgtt tcatttaata agatggcatc tcctcttgag atatgttctt
     2821 cttacctttt aagaagatac tatttaagaa gtgaactatt cagtctttgt atactgaatg
     2881 ctttttccct aaaaaatgtt aatcaagaat attgaatatt tatggcactc ttgatgctgc
     2941 atttgaaagc tgaaggaatt actttagata gataggaatt gctaccttta ttctggaaag
     3001 gttttgtttc tgcctcaaag cattttgaag tgttttaacc attaaagggt ctaatttttt
     3061 tttcttaatg aaatcaagca ttttaattca ctgtgggagg catcctgacc acggacatcc
     3121 ataacagcaa agcacaaatc gttttcgtct gtagtcatat cctgaaacat aggtggacaa
     3181 atttttaact gagagacaaa aatcacatag ttgaattgag cagaacactt aagtgctttc
     3241 tgcatctatt taggagtcta tttcttacca ataaacttga caacgcattt ggaaaactag
     3301 tgaacacctt acagctttca ttttgcttta atgtttcaat tcaagccggt gtaaaaataa
     3361 tttccaaggc atttctgttt attctttagt aatctcacta ctggctatgt cagcaatatc
     3421 tttttcaatc tggttccttt tgtatatgat gtcactgtga cctctttgaa atatagtgat
     3481 ggcttttacc tactttgaaa agaattttca catagagtca gaaaaaaaag gaaatatcaa
     3541 atcacttgcc tttccacttg gagagcacga cagttgccaa caacaagggg tcaagggccg
     3601 cacaggagat gtgtgggggc ctggccacct cccacctgct gcccagaggc ttgtttgcat
     3661 tttcattttt tctccacttg taacaaccat agtttcagct cctaaattct tatcatggat
     3721 ttacttagtc atcttaactg acctgcagtt acttgcctgt tttcagtgaa gagagagaag
     3781 cagctctggt gccacatgcc agtgccatgg agggaaatga attctctgca atctgttgtt
     3841 tcgctgattc atgaagaaag taacaactgt tgagtttcag ccttgatggc tgtcggcagt
     3901 tttctggtgt ccacccaaac ggagagacag tcactcctgc ttaccctaat gtgtgactga
     3961 gaagcagcct gggtgtgtaa agagatagtc attccccctg cctgtctcac tgtagggtag
     4021 cattatccac tgtaaaacca tactactttc attttccctt ggggactaca ggtgccaggt
     4081 aacctttttt tttttttttt tttttttttg agacagaatc ttgctctgtt gcccaggctg
     4141 gagtgcaggg acacctcccg ggttcaagca gttctcctgc ctcagcctcc aagtagctgg
     4201 gactataggc acgcaccacc atgcctggct aatttttgta tttttagtag aaatggggtt
     4261 tcactgtgtt agccaggatg gtcttgatct cctgaccttg tgatctgccc gccttggcct
     4321 tccaaagtgt tgggattaca ggcgtgagcc actgcgcctg gccatcaggt aacctttatg
     4381 gctctttcag gaaaagtgaa atcagagagg cgtaccctag ccacagctgt tgtattctgc
     4441 tcttctttcc tttttggtga gcttcatggg tggagttatc agtggtctgt actttgtgga
     4501 tattttgccc agcaggaagt attagacaca tcagtctaga agcattgtga aaaggttcca
     4561 aaacgggaga caaaatttaa ttcattcctc agttctgaaa gtttgtgctt tcttaccatg
     4621 aatagatgaa aacttgaaaa aaatcttgac agtttactaa tgtgaatcag atgtaacgta
     4681 ctactaattc tacaatgcct ttctctttag tcagtattaa aaatcttttt taaagtattg
     4741 gtatgaaaac aaatttttgt tgccctgata atggaatttt aaaactaccc acagtttaag
     4801 agaaaacata acttggtaaa aaaggtagcc aataaaacca caatttgaaa ttgataccat
     4861 tttctactca caatggatga tgaaaaattt cacctttaaa tgggtcagaa gttgtctttg
     4921 acatttacca tgaaaaaact acataaaatg gctccctggt gaggttacag acacggccct
     4981 ggtgatgggc gttgcaaagt tttcactgag cacacagcaa tggtatcacc tagagaagtt
     5041 cacgcaactt tgttgaatgt agttgacttt tccaaattta taaaggaagg aagaaggcaa
     5101 atgttaattt gccaacaacg aatatccttt ttctaaatca gatcattcct tttttgttag
     5161 tggcagttta tcctgtaatt tcaaatgacg ttaagaggtg ggattatttg ggggtttttt
     5221 ttgtttgttt acagatgatc tcatttgctg aatgattgat ttaagagtaa aattagccac
     5281 tgcgtggctt tgtgtatagt aaccggtttt gttgcacttg tctgtggctg aaacacttac
     5341 ctgcagtgga aagccgagca aggaggaggt aaacattgga gatgtttgtg aaaatattac
     5401 tcttgctgtg aggttttagt ttgttttgaa tgagaaaaga ctaagtaact taatccatct
     5461 caatgtagtg ttttaataaa aaaggaacct aatatttgaa atgggtctca gacatgtcta
     5521 caaatatggg tactattttt atgcccgtgt attttcacat ttaataaaaa tatttatggt
     5581 catatcagta
//
