LOCUS       NM_001040192            1485 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens DnaJ heat shock protein family (Hsp40) member C28
            (DNAJC28), transcript variant 2, mRNA.
ACCESSION   NM_001040192
VERSION     NM_001040192.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1485)
  AUTHORS   Rietveld,C.A., Esko,T., Davies,G., Pers,T.H., Turley,P.,
            Benyamin,B., Chabris,C.F., Emilsson,V., Johnson,A.D., Lee,J.J., de
            Leeuw,C., Marioni,R.E., Medland,S.E., Miller,M.B., Rostapshova,O.,
            van der Lee,S.J., Vinkhuyzen,A.A., Amin,N., Conley,D.,
            Derringer,J., van Duijn,C.M., Fehrmann,R., Franke,L., Glaeser,E.L.,
            Hansell,N.K., Hayward,C., Iacono,W.G., Ibrahim-Verbaas,C.,
            Jaddoe,V., Karjalainen,J., Laibson,D., Lichtenstein,P.,
            Liewald,D.C., Magnusson,P.K., Martin,N.G., McGue,M., McMahon,G.,
            Pedersen,N.L., Pinker,S., Porteous,D.J., Posthuma,D.,
            Rivadeneira,F., Smith,B.H., Starr,J.M., Tiemeier,H., Timpson,N.J.,
            Trzaskowski,M., Uitterlinden,A.G., Verhulst,F.C., Ward,M.E.,
            Wright,M.J., Davey Smith,G., Deary,I.J., Johannesson,M., Plomin,R.,
            Visscher,P.M., Benjamin,D.J., Cesarini,D. and Koellinger,P.D.
  TITLE     Common genetic variants associated with cognitive performance
            identified using the proxy-phenotype method
  JOURNAL   Proc Natl Acad Sci U S A 111 (38), 13790-13794 (2014)
   PUBMED   25201988
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2015 Jan 27;112(4):E380. doi:
            10.1073/pnas.1424631112.. PMID: 25572966]
REFERENCE   2  (bases 1 to 1485)
  AUTHORS   Dowling,J.K., Becker,C.E., Bourke,N.M., Corr,S.C., Connolly,D.J.,
            Quinn,S.R., Pandolfi,P.P., Mansell,A. and O'Neill,L.A.J.
  TITLE     Promyelocytic leukemia protein interacts with the
            apoptosis-associated speck-like protein to limit inflammasome
            activation
  JOURNAL   J Biol Chem 289 (10), 6429-6437 (2014)
   PUBMED   24407287
REFERENCE   3  (bases 1 to 1485)
  AUTHORS   Gardiner,K., Slavov,D., Bechtel,L. and Davisson,M.
  TITLE     Annotation of human chromosome 21 for relevance to Down syndrome:
            gene structure and expression analysis
  JOURNAL   Genomics 79 (6), 833-843 (2002)
   PUBMED   12036298
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC029509.1, CB241459.1 and
            AI825667.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Feb 27, 2020 this sequence version replaced NM_001040192.2.
            
            Summary: This gene encodes a member of the DnaJ heat shock protein
            family. The encoded protein, which contains a conserved N-terminal
            DnaJ domain, is thought to play a role in protein folding or act as
            a molecular chaperone protein. [provided by RefSeq, Oct 2016].
            
            Transcript Variant: This variant (2) differs in the 5' UTR,
            compared to variant 1. Variants 1, 2, and 3 encode the same
            protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC029509.1, DA234338.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000381947.4/ ENSP00000371373.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-822               BC029509.1         1-822
            823-1313            CB241459.1         18-508              c
            1314-1485           AI825667.1         1-172               c
FEATURES             Location/Qualifiers
     source          1..1485
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q22.11"
     gene            1..1485
                     /gene="DNAJC28"
                     /gene_synonym="C21orf55; C21orf78"
                     /note="DnaJ heat shock protein family (Hsp40) member C28"
                     /db_xref="GeneID:54943"
                     /db_xref="HGNC:HGNC:1297"
     exon            1..115
                     /gene="DNAJC28"
                     /gene_synonym="C21orf55; C21orf78"
                     /inference="alignment:Splign:2.1.0"
     exon            116..1485
                     /gene="DNAJC28"
                     /gene_synonym="C21orf55; C21orf78"
                     /inference="alignment:Splign:2.1.0"
     CDS             147..1313
                     /gene="DNAJC28"
                     /gene_synonym="C21orf55; C21orf78"
                     /note="DnaJ (Hsp40) homolog, subfamily C, member 28"
                     /codon_start=1
                     /product="dnaJ homolog subfamily C member 28"
                     /protein_id="NP_001035282.1"
                     /db_xref="CCDS:CCDS13626.1"
                     /db_xref="GeneID:54943"
                     /db_xref="HGNC:HGNC:1297"
                     /translation="MNTMYVMMAQILRSHLIKATVIPNRVKMLPYFGIIRNRMMSTHK
                     SKKKIREYYRLLNVEEGCSADEVRESFHKLAKQYHPDSGSNTADSATFIRIEKAYRKV
                     LSHVIEQTNASQSKGEEEEDVEKFKYKTPQHRHYLSFEGIGFGTPTQREKHYRQFRAD
                     RAAEQVMEYQKQKLQSQYFPDSVIVKNIRQSKQQKITQAIERLVEDLIQESMAKGDFD
                     NLSGKGKPLKKFSDCSYIDPMTHNLNRILIDNGYQPEWILKQKEISDTIEQLREAILV
                     SRKKLGNPMTPTEKKQWNHVCEQFQENIRKLNKRINDFNLIVPILTRQKVHFDAQKEI
                     VRAQKIYETLIKTKEVTDRNPNNLDQGEGEKTPEIKKGFLNWMNLWKFIKIRSF"
     regulatory      1293..1298
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DNAJC28"
                     /gene_synonym="C21orf55; C21orf78"
                     /note="hexamer: ATTAAA"
     polyA_site      1313
                     /gene="DNAJC28"
                     /gene_synonym="C21orf55; C21orf78"
                     /note="major polyA site"
     regulatory      1324..1329
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DNAJC28"
                     /gene_synonym="C21orf55; C21orf78"
                     /note="hexamer: CATAAA"
     polyA_site      1350
                     /gene="DNAJC28"
                     /gene_synonym="C21orf55; C21orf78"
     regulatory      1381..1386
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DNAJC28"
                     /gene_synonym="C21orf55; C21orf78"
                     /note="hexamer: AATACA"
     polyA_site      1401
                     /gene="DNAJC28"
                     /gene_synonym="C21orf55; C21orf78"
ORIGIN      
        1 ggtggtcccc ggtcgggacg aaggctcccg aggtgccctg cctgggtcct ccggggtaaa
       61 gttcgtttgg cggaagattg tccgttttcc tggtaaggtc acctgtccca atcaggtcat
      121 tgctaggaag aactctgggt acaataatga atacaatgta tgtgatgatg gctcagatct
      181 taagatctca cctgataaag gctacagtga ttcctaatcg agtgaaaatg cttccatatt
      241 ttggtatcat tagaaataga atgatgtcaa cccataaatc caaaaagaag atcagagaat
      301 attatagact gctgaacgtg gaggaaggat gctctgcaga tgaagtcagg gaatcttttc
      361 ataagcttgc caagcaatat catcctgaca gtggctctaa tactgctgat tctgcaacat
      421 ttataaggat tgaaaaagct tatagaaagg tgctctccca tgtgatagaa caaacaaatg
      481 ccagtcagag taaaggtgaa gaagaagaag atgtagaaaa attcaaatat aaaacacccc
      541 aacaccgaca ttatttaagt tttgaaggta ttggttttgg gactccaact caacgagaga
      601 agcattatag gcaatttagg gcagaccgtg ctgctgaaca agtgatggaa tatcaaaagc
      661 agaaactaca aagccagtat tttcctgata gtgtaattgt taaaaatata agacagagca
      721 aacagcaaaa gataacgcaa gctatagaac gtttagtgga ggacctcatt caagaatcca
      781 tggcaaaagg agactttgac aatctcagtg ggaaaggaaa acctctgaaa aagttttctg
      841 actgttctta cattgatccc atgactcaca acctgaaccg aatactgatc gataatggat
      901 accaaccaga atggatcctt aagcaaaagg aaataagcga tactattgag caactcagag
      961 aggcaatttt agtgtctagg aaaaaacttg ggaatccaat gacaccaact gaaaagaaac
     1021 agtggaacca tgtttgtgag cagtttcaag aaaacatcag aaaattaaac aagcgaatta
     1081 atgattttaa tttaattgtt cccatcctga ccaggcaaaa agtccatttt gatgctcaga
     1141 aagaaattgt cagagcccag aaaatatacg agacccttat aaaaacaaaa gaagtcacag
     1201 atagaaaccc aaataacctt gatcaaggag aaggagagaa aacacctgaa atcaagaaag
     1261 gttttttaaa ctggatgaat ctgtggaaat ttattaaaat acgatcattt tgatgtttac
     1321 tatcataaat cattcttagt tccactgaca ctttacatgg aaaatgagat ttattgctat
     1381 aatacaagaa tttaagaatt gtgccattgt acttatcaca aaactaatca catagccaat
     1441 gatgtgtgag tgagaaacct atcaggtttg tcctgaggat atagc
//
