LOCUS       NM_001304944            4447 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens DnaJ heat shock protein family (Hsp40) member C22
            (DNAJC22), transcript variant 1, mRNA.
ACCESSION   NM_001304944 XM_005269153
VERSION     NM_001304944.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4447)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 4447)
  AUTHORS   Behr,M., Wingen,C., Wolf,C., Schuh,R. and Hoch,M.
  TITLE     Wurst is essential for airway clearance and respiratory-tube size
            control
  JOURNAL   Nat Cell Biol 9 (7), 847-853 (2007)
   PUBMED   17558392
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC125611.4 and AK055747.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001304944.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK055747.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2144835
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000549441.7/ ENSP00000446830.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                AC125611.4         100657-100685       c
            30-954              AK055747.1         1-925
            955-955             AC125611.4         99639-99639         c
            956-2472            AK055747.1         927-2443
            2473-4447           AC125611.4         93883-95857         c
FEATURES             Location/Qualifiers
     source          1..4447
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.12"
     gene            1..4447
                     /gene="DNAJC22"
                     /gene_synonym="wus"
                     /note="DnaJ heat shock protein family (Hsp40) member C22"
                     /db_xref="GeneID:79962"
                     /db_xref="HGNC:HGNC:25802"
     exon            1..664
                     /gene="DNAJC22"
                     /gene_synonym="wus"
                     /inference="alignment:Splign:2.1.0"
     exon            665..1126
                     /gene="DNAJC22"
                     /gene_synonym="wus"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..2073
                     /gene="DNAJC22"
                     /gene_synonym="wus"
                     /inference="alignment:Splign:2.1.0"
     CDS             1234..2259
                     /gene="DNAJC22"
                     /gene_synonym="wus"
                     /note="wurst homolog; DnaJ (Hsp40) homolog, subfamily C,
                     member 22"
                     /codon_start=1
                     /product="dnaJ homolog subfamily C member 22"
                     /protein_id="NP_001291873.1"
                     /db_xref="CCDS:CCDS8785.1"
                     /db_xref="GeneID:79962"
                     /db_xref="HGNC:HGNC:25802"
                     /translation="MAKGLLVTYALWAVGGPAGLHHLYLGRDSHALLWMLTLGGGGLG
                     WLWEFWKLPSFVAQANRAQGQRQSPRGVTPPLSPIRFAAQVIVGIYFGLVALISLSSM
                     VNFYIVALPLAVGLGVLLVAAVGNQTSDFKNTLGSAFLTSPIFYGRPIAILPISVAAS
                     ITAQRHRRYKALVASEPLSVRLYRLGLAYLAFTGPLAYSALCNTAATLSYVAETFGSF
                     LNWFSFFPLLGRLMEFVLLLPYRIWRLLMGETGFNSSCFQEWAKLYEFVHSFQDEKRQ
                     LAYQVLGLSEGATNEEIHRSYQELVKVWHPDHNLDQTEEAQRHFLEIQAAYEVLSQPR
                     KPWGSRR"
     exon            2074..4447
                     /gene="DNAJC22"
                     /gene_synonym="wus"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2868..2873
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DNAJC22"
                     /gene_synonym="wus"
                     /note="hexamer: AATAAA"
     polyA_site      2890
                     /gene="DNAJC22"
                     /gene_synonym="wus"
                     /note="major polyA site"
     regulatory      4419..4424
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DNAJC22"
                     /gene_synonym="wus"
                     /note="hexamer: AATAAA"
     regulatory      4427..4432
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DNAJC22"
                     /gene_synonym="wus"
                     /note="hexamer: AATAAA"
     polyA_site      4438
                     /gene="DNAJC22"
                     /gene_synonym="wus"
     polyA_site      4447
                     /gene="DNAJC22"
                     /gene_synonym="wus"
ORIGIN      
        1 agtgagccct aagaggtcat atagagagca gcatttcctc tccaggccga gatgagggct
       61 gagggcgttt ggagggaagc gctctgccta ctgccgggag gtgacacccg cgaggccgac
      121 cgtcccccga agcccccgca agtccagact gggggacctc ggagatccac gagattgcca
      181 gagaaggaaa ttgaggccca agaagctgca tgacttagcc aagttcacgg agtagaaccc
      241 gggattggag cccgggacat tgaaatgaag gcgtcttgca ttgcagctcc gttgcagcgc
      301 agaggcgcag gaaggcagac taccacgagc ctcgggctgc ggcctcgccc tcctggtcga
      361 gcctcctgcc ctccaaccct ctgctcccgt ttctccctct ggttcatagc ccgcgggaca
      421 gagcagccct ggattgggag gctcctcagg tctcaggctc aggtgcagaa gcagagcccc
      481 taactggaag gctcggaggt gggccggtga ggcaagcaag ccctgtgggg ggttgaggac
      541 agcttgggtt ggatgtccct cactgcagcc tgtccgtgga tgtctctgcc ttaagggaat
      601 tggaggtgga accatccagt cttgaaggtc aacggagcgt gaagagagga gcgtgcagct
      661 tgagcactac agataggagc gtcccttgct cctgccaggc agcccctcca taggggcagt
      721 cctgtgctgc tgtgcctcgg tacccgcaca aggtgtctgg ggaccgcccg gaccccccct
      781 tccatcggcg gcagcgccac ctggcggcca tggtgcggtg gtgtgggagg agctgggccc
      841 gggctgggca ctgagcccac cggagctgca ggcgtctgca gagccttgca ccgagtttcc
      901 ccgcgagggc gggcgggagg agtcccaggc gggaatgtga tccccagggg gccggggagg
      961 gccctgggga ggagcctggc ctggggaagc cggacttccg tgacacaaca gacacaaaag
     1021 acaaagtcca tttggatgga agtgggagca gggcgagacg ggccattttc actctgtggt
     1081 caaaggaaat gactggtctg actcggtctg ggagcggggc acccagggtc taaggataac
     1141 tctggggcca tgacagccat gagtctcaca gaggaccccg agacttctgt gctgcgagta
     1201 accggacttg ttctgagacc tttgccctag aggatggcca aggggctcct ggtgacctat
     1261 gccctctggg ctgtgggggg ccctgctggg ctccaccacc tgtacctggg aagggacagc
     1321 cacgccctgc tctggatgct gaccctgggg ggaggtgggc tgggctggct ctgggagttc
     1381 tggaagctcc caagctttgt agctcaggcc aacagagccc agggacagag gcagagcccc
     1441 agaggggtga caccccctct gagtcccatt cgctttgctg cccaggtgat agttggcatc
     1501 tattttggcc ttgtggcact gattagcctt tcttccatgg tcaacttcta tattgtggcc
     1561 ctcccactgg cagttggctt aggggtcttg ctggtggctg ctgttggcaa ccagacctca
     1621 gactttaaga acactctggg gtcagcattt ctcacttcac ctatcttcta tggccgcccc
     1681 atagccatac tgcccattag cgtggccgcc agcattacag ctcagaggca tcgccgctac
     1741 aaagctttgg tggcatcaga gccgctcagt gtgcggctct atcgtctggg cttggcttac
     1801 cttgctttca caggcccact ggcatacagt gccctctgca acacagctgc caccctcagc
     1861 tatgtggcag aaacctttgg ctccttcttg aattggttca gcttcttccc ccttcttggc
     1921 cgcctcatgg agtttgtcct ccttctgcct taccggatct ggaggctact gatgggggag
     1981 actggcttca acagcagctg ctttcaggag tgggcgaagc tctatgagtt tgttcacagt
     2041 tttcaggatg agaagcgtca gctggcttac caggttttgg gcctctcaga aggggcaaca
     2101 aatgaagaaa tacatcggag ttaccaggag ctagtgaagg tctggcaccc agaccacaac
     2161 ctggaccaga cagaggaggc acagaggcac ttcctggaga tccaggctgc gtatgaagtc
     2221 ctgagtcaac ccaggaagcc ctggggatcc cggaggtgaa aagaaacttc cccctgagga
     2281 ctgactcttc ctagcagagc tgggcaactt gtcccaaatc tagctttgcc cacgaatggc
     2341 atcccaacag agttaaagaa actgcttgca ggggctgggc gtggtggctc atgcctgtaa
     2401 tcccagcact ttgggaggcc gaggcgggca gatcacgagg tcaggagttc gagaccagca
     2461 gcctggccaa tatagtgaaa cttcgtctct actaaaaata caaaaaatta gccaggagtg
     2521 gtggcaggca cctgtagtcc cagctacttg ggaggctgag gcaggagaat cacctgaacc
     2581 tgagaggcgg aggttgcagt gagccgagat cacgccactg cactccagcc tgggcaacaa
     2641 gagtgaaact ccgtctcaaa aaaaaaaaaa agaaagaaaa actgcttgca ggggacatga
     2701 gaaaacaatg gggtgagaaa aggttgtggt agaaggatgt gtttatattc tgaatttctg
     2761 aattcttggc tattgcattc ttgacaattt ttcttaaaac cagagagtga aaggcatatt
     2821 ataaaacaat caaatatctt ttagagtatg gacaactatt atatatcaat aaaaaattaa
     2881 ttagaaaaaa tatatctttt agagaacaca ccaccttatc ccacccatga tatattgatg
     2941 tgtgatggag aaagattatt taactatttt tttaaatgtg taaagcagca gggcatagtg
     3001 gcttacgcct gtaatcccaa cactttggga agctgaggtg ggaggatcac cttaggtcag
     3061 gagttcaaga ccagcctggc caaccaacat ggtgaaaccc catctctact aaaaatacaa
     3121 aacttagcca gccatggtgg cacatgcctg tagccccagc tagtcgggag gctgaggcag
     3181 gaaaatcact tgagcctggg aggtggaggt tgcagtcaac tgagattgag ccactgcact
     3241 gtactccagc ctgggcggca gagctagatt ctgtctcaaa aattaaataa ataaataagt
     3301 aagtaaataa ataaataaat aaatgtataa agcactatgt taggagattg aaggaaaaat
     3361 atgaaggttc tagtattcac aagctgtcct gtgataagag agatttgatc ttttctgtag
     3421 atggggtgag actaggatta aatttcaaaa tttgagaaaa atattttcat tccatttatg
     3481 ggagaacttt ctagcagcta cactttctcc aaaagggaac aagctactgt ggagtggggg
     3541 gtagttcttc ctcctctgct tagaggagaa tttttggaga gctctcagac tttacatagg
     3601 tgattggact ggctgacttc tcaggtcttc ccagtatttg aggtctgatt ctgggctaca
     3661 taccctactc ctagaagcat acaatctgat gggagataat gacacaggta cacagatatc
     3721 aaagcccttg ttcagtgttt tgaactaaat gtcataagag ctgtaaatag tgtattggca
     3781 cattggagga gggacagata acattgtttt atggggactc agaaagattc attattttat
     3841 atgtcatatg tccctttggg gactttggga aaccctaggg aaccagcggc tagagcatct
     3901 caagggggcc ttattcaatt ctaggtaact agccaggtgt gaaagaaagg gcccagggtg
     3961 tctcactttg cagaggaaga ttggagacca ggaacatgat tttaaattat gtgcctttac
     4021 tgcagctttc ttgctctctt tgtgtgtgtg cattctttcc atttttttct tctttctgga
     4081 tgttaaatct gagtaatata tatcattttt aaagtggaat tatgaccagg catggtgcct
     4141 cttgcctata atcctagcac tttggcaagc caaggcagga agattgcttg agcccaggag
     4201 ttcaacacca gcctgggcaa catggcaaaa ctccatctct acaaaaagta caaaaatgag
     4261 ccaggtgttg tggggtgcgc ctgtagtccc agctaaggag gctgagattg ggaggatcac
     4321 ttgaacccaa aaggtggagg ctgcagtgag ctgagatcgt accactacac tccagcctga
     4381 gtgacacagt gacagcctgt ctcaaaaata taaaaataaa taaataaata aagtggaatt
     4441 atgttga
//
