LOCUS       NM_014377               2291 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens DnaJ heat shock protein family (Hsp40) member C2
            (DNAJC2), transcript variant 1, mRNA.
ACCESSION   NM_014377
VERSION     NM_014377.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2291)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 2291)
  AUTHORS   Yang,F., Hu,A., Guo,Y., Wang,J., Li,D., Wang,X., Jin,S., Yuan,B.,
            Cai,S., Zhou,Y., Li,Q., Chen,G., Gao,H., Zheng,L. and Tong,Q.
  TITLE     p113 isoform encoded by CUX1 circular RNA drives tumor progression
            via facilitating ZRF1/BRD4 transactivation
  JOURNAL   Mol Cancer 20 (1), 123 (2021)
   PUBMED   34579723
  REMARK    GeneRIF: p113 isoform encoded by CUX1 circular RNA drives tumor
            progression via facilitating ZRF1/BRD4 transactivation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2291)
  AUTHORS   Liu,H., Li,J., Zhao,H., Liu,X. and Ye,X.
  TITLE     DNAJC2 is reversely regulated by miR-627-3p, promoting the
            proliferation of colorectal cancer
  JOURNAL   Mol Med Rep 24 (2) (2021)
   PUBMED   34165158
  REMARK    GeneRIF: DNAJC2 is reversely regulated by miR6273p, promoting the
            proliferation of colorectal cancer.
REFERENCE   4  (bases 1 to 2291)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 2291)
  AUTHORS   Imamura,T., Komatsu,S., Ichikawa,D., Miyamae,M., Okajima,W.,
            Ohashi,T., Kiuchi,J., Nishibeppu,K., Kosuga,T., Konishi,H.,
            Shiozaki,A., Fujiwara,H., Okamoto,K., Tsuda,H. and Otsuji,E.
  TITLE     Overexpression of ZRF1 is related to tumor malignant potential and
            a poor outcome of gastric carcinoma
  JOURNAL   Carcinogenesis 39 (2), 263-271 (2018)
   PUBMED   29228320
  REMARK    GeneRIF: These findings suggest that ZRF1 plays a crucial role in
            tumor malignant potential through its overexpression and highlight
            its usefulness as a prognostic factor and potential therapeutic
            target in gastric cancer
REFERENCE   6  (bases 1 to 2291)
  AUTHORS   Hundley,H.A., Walter,W., Bairstow,S. and Craig,E.A.
  TITLE     Human Mpp11 J protein: ribosome-tethered molecular chaperones are
            ubiquitous
  JOURNAL   Science 308 (5724), 1032-1034 (2005)
   PUBMED   15802566
  REMARK    GeneRIF: concluded that Mpp11, an ortholog of yeast Zuo, is a
            ribosome-associated J protein; proposed that in metazoans,
            ribosome-associated Zuo and Mpp11 orthologs recruit cytosolic Hsc70
            to short ribosome-bound nascent chains as they exit the ribosome
REFERENCE   7  (bases 1 to 2291)
  AUTHORS   Greiner,J., Ringhoffer,M., Taniguchi,M., Li,L., Schmitt,A.,
            Shiku,H., Dohner,H. and Schmitt,M.
  TITLE     mRNA expression of leukemia-associated antigens in patients with
            acute myeloid leukemia for the development of specific
            immunotherapies
  JOURNAL   Int J Cancer 108 (5), 704-711 (2004)
   PUBMED   14696097
REFERENCE   8  (bases 1 to 2291)
  AUTHORS   Greiner,J., Ringhoffer,M., Taniguchi,M., Hauser,T., Schmitt,A.,
            Dohner,H. and Schmitt,M.
  TITLE     Characterization of several leukemia-associated antigens inducing
            humoral immune responses in acute and chronic myeloid leukemia
  JOURNAL   Int J Cancer 106 (2), 224-231 (2003)
   PUBMED   12800198
REFERENCE   9  (bases 1 to 2291)
  AUTHORS   Resto,V.A., Caballero,O.L., Buta,M.R., Westra,W.H., Wu,L.,
            Westendorf,J.M., Jen,J., Hieter,P. and Sidransky,D.
  TITLE     A putative oncogenic role for MPP11 in head and neck squamous cell
            cancer
  JOURNAL   Cancer Res 60 (19), 5529-5535 (2000)
   PUBMED   11034098
REFERENCE   10 (bases 1 to 2291)
  AUTHORS   Matsumoto-Taniura,N., Pirollet,F., Monroe,R., Gerace,L. and
            Westendorf,J.M.
  TITLE     Identification of novel M phase phosphoproteins by expression
            cloning
  JOURNAL   Mol Biol Cell 7 (9), 1455-1469 (1996)
   PUBMED   8885239
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA272314.1, DA691752.1,
            BC012376.1, AI621015.1, BC000859.1, X98260.1 and AI140595.1.
            
            On Nov 22, 2018 this sequence version replaced NM_014377.2.
            
            Summary: This gene is a member of the M-phase phosphoprotein (MPP)
            family. The gene encodes a phosphoprotein with a J domain and a Myb
            DNA-binding domain which localizes to both the nucleus and the
            cytosol. The protein is capable of forming a heterodimeric complex
            that associates with ribosomes, acting as a molecular chaperone for
            nascent polypeptide chains as they exit the ribosome. This protein
            was identified as a leukemia-associated antigen and expression of
            the gene is upregulated in leukemic blasts. Also, chromosomal
            aberrations involving this gene are associated with primary head
            and neck squamous cell tumors. This gene has a pseudogene on
            chromosome 6. Alternatively spliced variants which encode different
            protein isoforms have been described. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.1166810.1,
                                           SRR1803614.23994.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000379263.8/ ENSP00000368565.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 DA272314.1         107-109
            4-13                DA691752.1         95-104
            14-925              BC012376.1         1-912
            926-1180            AI621015.1         1-255               c
            1181-2061           BC000859.1         131-1011
            2062-2106           X98260.1           1802-1846
            2107-2291           AI140595.1         14-198              c
FEATURES             Location/Qualifiers
     source          1..2291
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q22.1"
     gene            1..2291
                     /gene="DNAJC2"
                     /gene_synonym="MPHOSPH11; MPP11; ZRF1; ZUO1"
                     /note="DnaJ heat shock protein family (Hsp40) member C2"
                     /db_xref="GeneID:27000"
                     /db_xref="HGNC:HGNC:13192"
                     /db_xref="MIM:605502"
     exon            1..209
                     /gene="DNAJC2"
                     /gene_synonym="MPHOSPH11; MPP11; ZRF1; ZUO1"
                     /inference="alignment:Splign:2.1.0"
     CDS             146..2011
                     /gene="DNAJC2"
                     /gene_synonym="MPHOSPH11; MPP11; ZRF1; ZUO1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     M-phase phosphoprotein 11; dnaJ homolog subfamily C member
                     2; zuotin-related factor 1; DnaJ (Hsp40) homolog,
                     subfamily C, member 2"
                     /codon_start=1
                     /product="dnaJ homolog subfamily C member 2 isoform 1"
                     /protein_id="NP_055192.1"
                     /db_xref="CCDS:CCDS43628.1"
                     /db_xref="GeneID:27000"
                     /db_xref="HGNC:HGNC:13192"
                     /db_xref="MIM:605502"
                     /translation="MLLLPSAADGRGTAITHALTSASTLCQVEPVGRWFEAFVKRRNR
                     NASASFQELEDKKELSEESEDEELQLEEFPMLKTLDPKDWKNQDHYAVLGLGHVRYKA
                     TQRQIKAAHKAMVLKHHPDKRKAAGEPIKEGDNDYFTCITKAYEMLSDPVKRRAFNSV
                     DPTFDNSVPSKSEAKDNFFEVFTPVFERNSRWSNKKNVPKLGDMNSSFEDVDIFYSFW
                     YNFDSWREFSYLDEEEKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSC
                     DPRIKKFKEEEKAKKEAEKKAKAEAKRKEQEAKEKQRQAELEAARLAKEKEEEEVRQQ
                     ALLAKKEKDIQKKAIKKERQKLRNSCKTWNHFSDNEAERVKMMEEVEKLCDRLELASL
                     QCLNETLTSCTKEVGKAALEKQIEEINEQIRKEKEEAEARMRQASKNTEKSTGGGGNG
                     SKNWSEDDLQLLIKAVNLFPAGTNSRWEVIANYMNIHSSSGVKRTAKDVIGKAKSLQK
                     LDPHQKDDINKKAFDKFKKEHGVVPQADNATPSERFEGPYTDFTPWTTEEQKLLEQAL
                     KTYPVNTPERWEKIAEAVPGRTKKDCMKRYKELVEMVKAKKAAQEQVLNASRAKK"
     exon            210..400
                     /gene="DNAJC2"
                     /gene_synonym="MPHOSPH11; MPP11; ZRF1; ZUO1"
                     /inference="alignment:Splign:2.1.0"
     exon            401..476
                     /gene="DNAJC2"
                     /gene_synonym="MPHOSPH11; MPP11; ZRF1; ZUO1"
                     /inference="alignment:Splign:2.1.0"
     exon            477..575
                     /gene="DNAJC2"
                     /gene_synonym="MPHOSPH11; MPP11; ZRF1; ZUO1"
                     /inference="alignment:Splign:2.1.0"
     exon            576..717
                     /gene="DNAJC2"
                     /gene_synonym="MPHOSPH11; MPP11; ZRF1; ZUO1"
                     /inference="alignment:Splign:2.1.0"
     exon            718..798
                     /gene="DNAJC2"
                     /gene_synonym="MPHOSPH11; MPP11; ZRF1; ZUO1"
                     /inference="alignment:Splign:2.1.0"
     exon            799..864
                     /gene="DNAJC2"
                     /gene_synonym="MPHOSPH11; MPP11; ZRF1; ZUO1"
                     /inference="alignment:Splign:2.1.0"
     exon            865..956
                     /gene="DNAJC2"
                     /gene_synonym="MPHOSPH11; MPP11; ZRF1; ZUO1"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1078
                     /gene="DNAJC2"
                     /gene_synonym="MPHOSPH11; MPP11; ZRF1; ZUO1"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1228
                     /gene="DNAJC2"
                     /gene_synonym="MPHOSPH11; MPP11; ZRF1; ZUO1"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1317
                     /gene="DNAJC2"
                     /gene_synonym="MPHOSPH11; MPP11; ZRF1; ZUO1"
                     /inference="alignment:Splign:2.1.0"
     exon            1318..1387
                     /gene="DNAJC2"
                     /gene_synonym="MPHOSPH11; MPP11; ZRF1; ZUO1"
                     /inference="alignment:Splign:2.1.0"
     exon            1388..1572
                     /gene="DNAJC2"
                     /gene_synonym="MPHOSPH11; MPP11; ZRF1; ZUO1"
                     /inference="alignment:Splign:2.1.0"
     exon            1573..1673
                     /gene="DNAJC2"
                     /gene_synonym="MPHOSPH11; MPP11; ZRF1; ZUO1"
                     /inference="alignment:Splign:2.1.0"
     exon            1674..1781
                     /gene="DNAJC2"
                     /gene_synonym="MPHOSPH11; MPP11; ZRF1; ZUO1"
                     /inference="alignment:Splign:2.1.0"
     exon            1782..1936
                     /gene="DNAJC2"
                     /gene_synonym="MPHOSPH11; MPP11; ZRF1; ZUO1"
                     /inference="alignment:Splign:2.1.0"
     exon            1937..2291
                     /gene="DNAJC2"
                     /gene_synonym="MPHOSPH11; MPP11; ZRF1; ZUO1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2039..2044
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DNAJC2"
                     /gene_synonym="MPHOSPH11; MPP11; ZRF1; ZUO1"
                     /note="hexamer: AATAAA"
     polyA_site      2061
                     /gene="DNAJC2"
                     /gene_synonym="MPHOSPH11; MPP11; ZRF1; ZUO1"
                     /note="major polyA site"
     regulatory      2078..2083
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DNAJC2"
                     /gene_synonym="MPHOSPH11; MPP11; ZRF1; ZUO1"
                     /note="hexamer: ATTATA"
     polyA_site      2103
                     /gene="DNAJC2"
                     /gene_synonym="MPHOSPH11; MPP11; ZRF1; ZUO1"
     regulatory      2273..2278
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DNAJC2"
                     /gene_synonym="MPHOSPH11; MPP11; ZRF1; ZUO1"
                     /note="hexamer: AATACA"
     polyA_site      2291
                     /gene="DNAJC2"
                     /gene_synonym="MPHOSPH11; MPP11; ZRF1; ZUO1"
ORIGIN      
        1 actggtcgtc tccatgcgcc ggttcctggg cgtcttagag ccaaggcgcg aggctcggag
       61 tgagaggtag agctggaggg gaccctaagc gccctccgcc cgggacgtga gccgctgcgc
      121 ccaccgggct agacccggcg ccatcatgct gcttctgcca agcgccgcgg acggccgggg
      181 caccgccatc acccacgctc tgacctctgc ctctacactc tgtcaagttg aacctgtggg
      241 aagatggttt gaagcttttg ttaagaggag aaacagaaat gcttctgcct cttttcagga
      301 actggaggat aagaaagagt tatccgagga atcagaagat gaagaattgc agttggaaga
      361 gtttcccatg ctgaaaacac ttgatcccaa agactggaag aaccaagatc attatgcagt
      421 tcttggactt ggccatgtga gatacaaggc tacacagaga cagatcaaag cagctcataa
      481 agcaatggtt ttaaaacatc acccagacaa acggaaagca gctggtgaac caataaaaga
      541 aggagataat gactacttca cttgcataac taaagcttat gaaatgttat ctgatccagt
      601 gaaaagacga gcatttaaca gtgtagatcc tacttttgat aactcagttc cttctaaaag
      661 tgaagcaaag gataatttct tcgaagtgtt taccccagtg tttgaaagga attccagatg
      721 gtcaaataaa aaaaatgttc ctaaacttgg tgatatgaat tcatcatttg aagatgtaga
      781 tatattttat tctttctggt ataattttga ttcttggaga gaattttctt atttagatga
      841 agaagaaaaa gaaaaagcag aatgtcgtga tgagaggaga tggattgaaa agcagaacag
      901 agcaacaaga gcacaaagaa aaaaagaaga aatgaacaga ataagaacat tagttgacaa
      961 tgcatacagc tgtgatccaa ggataaaaaa gttcaaggaa gaagaaaaag ccaagaaaga
     1021 agcagaaaag aaagcaaaag cagaagctaa acggaaggag caagaagcta aagaaaaaca
     1081 aagacaagct gaattagaag ctgctcggtt agctaaggag aaagaagagg aggaagtcag
     1141 acagcaagca ttgctggcaa agaaggaaaa agatatccag aaaaaagcca ttaagaagga
     1201 aaggcaaaaa cttcgaaact catgcaagac ctggaatcat ttttctgata atgaggcaga
     1261 gcgggttaaa atgatggaag aagtggaaaa actttgtgat cggcttgaac tggcaagctt
     1321 acagtgcttg aatgaaacac tcacatcatg cacaaaagaa gtaggaaagg ctgctttgga
     1381 aaaacagata gaagaaataa atgagcaaat cagaaaagag aaagaggaag ctgaggctcg
     1441 tatgcgacaa gcatctaaga acacagagaa atcaactggt ggaggtggaa atggaagtaa
     1501 aaattggtca gaagatgatc tacaattact aattaaagct gtgaatctgt tccctgctgg
     1561 aacaaattca agatgggaag ttattgctaa ttacatgaac atacattctt cctctggagt
     1621 caaaagaact gccaaagatg ttattggcaa agcaaagagt ctccaaaaac ttgaccctca
     1681 tcaaaaagat gacataaata aaaaggcatt tgataagttc aaaaaagaac atggagtggt
     1741 acctcaagca gacaacgcaa cgccttcaga acgatttgaa ggtccatata cagacttcac
     1801 cccttggaca acagaagaac agaagctttt ggaacaagct ttgaaaacat acccagtaaa
     1861 tacacctgaa agatgggaaa aaatagcaga agcggtgcct ggcaggacaa agaaggactg
     1921 catgaaacga tacaaggaac ttgtcgagat ggtaaaagca aagaaagctg ctcaagaaca
     1981 agtgctgaat gcaagtagag ccaagaaatg acaatctttg ttgtgtgtgc atttttataa
     2041 taaaactgaa aatactgtaa acattttcat tcttaaaatt atactcatgg taataatttg
     2101 aaagtatgct gcttccaaca taatttctca gagaacaaag actgaccatt aatacaaaac
     2161 aaccttcaga ggggtagtct ttttatcctt tgaaagtatg atacagtatt taattcaaat
     2221 ttccaaatgt atatacatgt tcatttttat ttttctctag ctctgtttta taaatacatg
     2281 tgttcaaaca a
//
