LOCUS       NM_152686               5102 bp    mRNA    linear   PRI 25-FEB-2025
DEFINITION  Homo sapiens DnaJ heat shock protein family (Hsp40) member C18
            (DNAJC18), mRNA.
ACCESSION   NM_152686
VERSION     NM_152686.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5102)
  AUTHORS   Bagchi,P., Walczak,C.P. and Tsai,B.
  TITLE     The endoplasmic reticulum membrane J protein C18 executes a
            distinct role in promoting simian virus 40 membrane penetration
  JOURNAL   J Virol 89 (8), 4058-4068 (2015)
   PUBMED   25631089
REFERENCE   2  (bases 1 to 5102)
  AUTHORS   Hosgood,H.D. 3rd, Menashe,I., He,X., Chanock,S. and Lan,Q.
  TITLE     PTEN identified as important risk factor of chronic obstructive
            pulmonary disease
  JOURNAL   Respir Med 103 (12), 1866-1870 (2009)
   PUBMED   19625176
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA497858.1, BC030162.2, AC142391.2 and BU735127.1.
            
            On Nov 23, 2018 this sequence version replaced NM_152686.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.11751.1,
                                           SRR1660803.91775.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000302060.10/ ENSP00000302843.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-575               DA497858.1         1-575
            576-3533            BC030162.2         501-3458
            3534-5093           AC142391.2         1393-2952           c
            5094-5102           BU735127.1         12-20               c
FEATURES             Location/Qualifiers
     source          1..5102
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.2"
     gene            1..5102
                     /gene="DNAJC18"
                     /note="DnaJ heat shock protein family (Hsp40) member C18"
                     /db_xref="GeneID:202052"
                     /db_xref="HGNC:HGNC:28429"
                     /db_xref="MIM:621108"
     exon            1..120
                     /gene="DNAJC18"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..1157
                     /gene="DNAJC18"
                     /note="DnaJ (Hsp40) homolog, subfamily C, member 18"
                     /codon_start=1
                     /product="dnaJ homolog subfamily C member 18"
                     /protein_id="NP_689899.1"
                     /db_xref="CCDS:CCDS4214.1"
                     /db_xref="GeneID:202052"
                     /db_xref="HGNC:HGNC:28429"
                     /db_xref="MIM:621108"
                     /translation="MAATLGSGERWTEAYIDAVRRNKYPEDTPPESHDPCGCCNCMKA
                     QKEKKSENEWTQTRQGEGNSTYSEEQLLGVQRIKKCRNYYEILGVSRDASDEELKKAY
                     RKLALKFHPDKNCAPGATDAFKAIGNAFAVLSNPDKRLRYDEYGDEQVTFTAPRARPY
                     NYYRDFEADITPEELFNVFFGGHFPTGNIHMFSNVTDDTYYYRRRHRHERTQTQKEEE
                     EEKPQTTYSAFIQLLPVLVIVIISVITQLLATNPPYSLFYKSTLGYTISRETQNLQVP
                     YFVDKNFDKAYRGASLHDLEKTIEKDYIDYIQTSCWKEKQQKSELTNLAGLYRDERLK
                     QKAESLKLENCEKLSKLIGLRRGG"
     exon            121..307
                     /gene="DNAJC18"
                     /inference="alignment:Splign:2.1.0"
     exon            308..453
                     /gene="DNAJC18"
                     /inference="alignment:Splign:2.1.0"
     exon            454..639
                     /gene="DNAJC18"
                     /inference="alignment:Splign:2.1.0"
     exon            640..749
                     /gene="DNAJC18"
                     /inference="alignment:Splign:2.1.0"
     exon            750..859
                     /gene="DNAJC18"
                     /inference="alignment:Splign:2.1.0"
     exon            860..1032
                     /gene="DNAJC18"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..5102
                     /gene="DNAJC18"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1229..1234
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DNAJC18"
                     /note="hexamer: AATACA"
     polyA_site      1252
                     /gene="DNAJC18"
                     /note="major polyA site"
     regulatory      3580..3585
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DNAJC18"
                     /note="hexamer: ATTAAA"
     polyA_site      3614
                     /gene="DNAJC18"
                     /note="major polyA site"
     regulatory      5078..5083
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DNAJC18"
                     /note="hexamer: ATTAAA"
     polyA_site      5102
                     /gene="DNAJC18"
ORIGIN      
        1 gtgccccgcg ctccgcgccc ccttctcttt cagcctcggg cacgggggag gctcggcgga
       61 cctgctgatt gggaaccgat atggcggcga ctctgggcag cggggagcgc tggacggaag
      121 cttacattga cgcagttaga agaaacaaat acccagaaga cacacctcct gagagtcatg
      181 acccctgtgg ctgctgtaac tgcatgaagg cacaaaagga aaagaagtct gagaatgagt
      241 ggactcagac ccggcagggt gaggggaact ccacgtatag tgaggaacag ctgcttgggg
      301 tacaaaggat caagaaatgc agaaattact atgaaattct gggagtttct cgagatgcta
      361 gtgacgaaga gcttaagaaa gcttacagaa aactcgccct gaaatttcac cctgacaaga
      421 actgtgctcc tggagcaaca gatgctttca aagcaatagg aaatgcattt gcagtcctga
      481 gcaatcctga taagagactt cgctatgatg aatacggaga tgaacaggtg actttcactg
      541 cccctcgagc cagaccttat aattattaca gggattttga agctgacatc actccagaag
      601 agctgttcaa cgtcttcttt ggaggacatt ttcctacagg aaatattcat atgttttcaa
      661 atgtgacaga tgacacttac tattaccgtc gacggcaccg acatgagagg acacagactc
      721 agaaggagga ggaagaagag aaacctcaga ctacatattc tgcatttatt cagctacttc
      781 cagttcttgt gattgtgatt atatctgtca ttactcagct gctggctact aatcccccat
      841 atagtctgtt ctataaatcg accttgggct acaccatttc tagagaaact cagaacctgc
      901 aggtgcctta ctttgtggat aaaaactttg acaaggccta cagaggagct tctctgcatg
      961 acttggagaa aacaatagag aaggattaca ttgattatat ccagactagt tgttggaagg
     1021 agaaacaaca aaagtcagag ctgacaaatt tggcaggatt atacagagat gaacgattga
     1081 aacagaaagc agagtcgctg aaacttgaaa actgtgagaa actttccaaa ctcattggcc
     1141 tacgcagagg tggctgagag gataatggtc ctacgcaggg ctggggtttt gctacttgtt
     1201 cctatttatg ttcctgattc cattttataa tacaaaacta ggtaatgatg aacactttac
     1261 tatttgctaa cttcgttggt tgggcagagt ggcaggagca tgggcacgag agccagatgt
     1321 gtcttcacag gatccttcct ggggagtggc tccagggacc aggagtagtt catctaagtt
     1381 aaattaatgg caaggcattg gattccgtct ccctgctcca tgcctaccct gcctatgtga
     1441 atggagttca gggcatccca gagcagatcc atgctttctt ccttcttccc ttcttcagtg
     1501 aagtcttaag aaccaggcat tcctaggctt agccaaagct taatattagt tatttacact
     1561 gtctaccaag aattatacct ctcccttcat tagagtcatc atctccgcca agatttagcc
     1621 tttggaacat gttcctgccc agctttccat tttctagggg aatatggaga aatttaaact
     1681 attgtagtca atagttttct attattccaa tctctgctca gttagtagca ttagcaaact
     1741 gcctaatttg agattccttt atttccttaa ccctctctcc tttagagagt ccagaaatta
     1801 aaactactga gcagcatctg gaggcggggg ccagggcgaa ggtataatgc aagaccgagc
     1861 ctcatctcct ccacgaagcc tccctactcc atcatagaac ccagagaatg tcccttcggt
     1921 catttcccct cagtatcatc attggtgtca tcgcacttag gctgagttcc tacatcccac
     1981 agaggcagat ggtcagaccc aggaggaggc attgccagct ctccaggctg tttgctcaag
     2041 cctagagata gaggagacag atcctctctc cttggatatg ggggtctagc tttggcccca
     2101 gcagccactt tgtttaaccc agtatcctat agtttgtgat ttgagatgat ttttcattca
     2161 ttcaacattt attgagtgcc tactataaaa gcaggggctc tcacacatat tttcttactt
     2221 aaacctcctc acaactctga agtagatgta ttatccctgg ttctatgaat gagaacattg
     2281 gcccagagag gatgacccag gtcttgtagt ggcagagcaa gacggtaggc tgagtgtcaa
     2341 gtagaaagtg ggagagcatc ctcatgtctc aggtgattct agccagactg gcaaagcaga
     2401 acctttcccg aggatgcctc cgtcctcccc aaccccatga cccctcatct tttctgtggc
     2461 aatcttgcat ctgttcagga caacatccct gctgctcttt aggaagcagg accctgtcta
     2521 acataaattc tgtacacaaa ataagaggtc cctcacaggc aggcagccct ccactggtga
     2581 ctaggaagaa ttcagtcact gcctgggctg tgtggttctg ggccttcctg tggagctgag
     2641 ctgcctgaat tatcatgact ctgaacttgg aaggatcatt aagtgactgt agcctacact
     2701 ccatgcttcc ttcatattgg aagaaaagtt tctggtagag agtcggccgg gtgcactggc
     2761 tcaagcctgt aatcccagca ctttgggagg ctgtggcagg tggatcacct gaggtcagga
     2821 gttcaagacc agcctggcca acacagtgaa accccatctc tactaataat acaaaaatta
     2881 gccaggtgtg gtggcacatg cctgtagtcc cagctactcg ggaggctgag gcatgagaat
     2941 cgctgcaact tgcaaggtgg aggttacagt gagctgaaat cacgccactg cactccactc
     3001 catctcaaaa aaaaaaagag tctacattaa acagattcca aagtaaagtt tcttcatccc
     3061 aatgcatggc catgatttac acagacgtgc ctagcatggc tcatcaacat ctgaacggtt
     3121 gttccctacc atgcctctgc aggcattcca cagagtcagg agatgggttc acaggtaaag
     3181 attgggggct ttagtggctt gtaggggaca actgctcagt tgcagggaga gggagcattt
     3241 ctagaaatag ccagattttg ctgcccaact agatctgtcc tcctggtttt agggggccct
     3301 tcttgatccc ctctgagtga ctgagggagg ttacattgta aaatatgtcc atgagccaaa
     3361 caggcttatg gaaagttctt ctacacacaa aaaaatcaaa gctctcctct ccccatcccc
     3421 aaccactgct agaaaattgg ccataatgaa actgacttga caggttaaaa gaccctgtcc
     3481 tagatgccca ggaatcaggt agtcacacat tttatggact tcatggcagc gataagtaat
     3541 ctgtgatgat actaaataga agcaataata actaactcca ttaaatgtca cgctgattgt
     3601 ctgtttttat agcaccgatg gtactgtttt atttattgcc aatagaccac aacattcaca
     3661 tctgtttttc ctcaagggaa ccgtatttgc ttttggttga aggatttatc tatttgatac
     3721 tatccagaat attgtgaagc tataatttcc tgggttatat tttagatggg ttgtctgcat
     3781 ggtggtaaaa taagcttttt cctctcgcct acgtcctttg gaagatctcc tgatcataca
     3841 taactaggta gggcttattc ttgctgccgg agcttggcac ccagctctag actgtttctt
     3901 tgagcattac tgcagattgg agacgtgtgt gagaggagca gcgctcagaa atagggcttg
     3961 aggctcaagc agaaactgaa gctctcattc aaatgaagat gctctctcta ccgcacgatc
     4021 ggcagtgaga aaaggaggat gaaaatcctt ctcatcacaa agagcttgaa ggaacccacg
     4081 tccccagatt agcaacccta gagttcatct gctcaggccg ggaaatgtgt aagcttcctt
     4141 gatcagctcc aggcctcaca gcacgggagc agtgaccagt aaggaaacgt cactgctgtg
     4201 ctttctgttg gaaattgttc gaaaatacag tgaactggcc aggcccagta gctcatgcct
     4261 gtaatcccag cactttgaaa ggctgaggca ggcagatcat ttgaggtcag gagttccaga
     4321 ccagcctggc caacatggtg aaaccctgtc tgtactaaaa atacaaaaat taggcgggca
     4381 tggtagcacg tgtctgtaat cccagctcct caggaggctg aggcagaaga atctcttgag
     4441 cctgggaggc agaggttgca gtaagctgag atcacatcat tgcactccag cctgggtgac
     4501 agagcaagac tctgtctcaa aaaaaaaaaa agaaagaaaa aagaaaatac agtgaactcc
     4561 agatgccact ggaacatggg ttccagcagc ctggccaagc tatgtgtcat tctttttcct
     4621 catgataccc aggatgggct ttgtgaggag gcactgtgcc gttccagtgg ctttctgtta
     4681 cagctggcca caccatacaa gcaagtacat catctgcatg cactgctcct cacaggagct
     4741 tgcacttcat tcatatttat tctgccctca tttaaggtat aagcttagtg tcctaatata
     4801 tttatttttg gaaagggcca agttacaaaa catctttttt ttgaggctgc actgttgata
     4861 tgtcatgcag tggccaccaa gaaagtatat actcgtgtta gatactgatt acatcattta
     4921 catcacgctc agtatttgga attaaagatg tgaatgttct gtgaccagag tagggatgac
     4981 acaaatggaa tcagctcctg gtggactaag aatcttgaaa aaatctggcc acctcatcca
     5041 ctacatctgg attgagtgta ctgcaacaaa gaaaaacatt aaacaatttt atattaaaag
     5101 aa
//
