LOCUS       NM_015291               6034 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens DnaJ heat shock protein family (Hsp40) member C16
            (DNAJC16), transcript variant 1, mRNA.
ACCESSION   NM_015291 XM_497656
VERSION     NM_015291.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6034)
  AUTHORS   Yamamoto,Y.H., Kasai,A., Omori,H., Takino,T., Sugihara,M.,
            Umemoto,T., Hamasaki,M., Hatta,T., Natsume,T., Morimoto,R.I.,
            Arai,R., Waguri,S., Sato,M., Sato,K., Bar-Nun,S., Yoshimori,T.,
            Noda,T. and Nagata,K.
  TITLE     ERdj8 governs the size of autophagosomes during the formation
            process
  JOURNAL   J Cell Biol 219 (8) (2020)
   PUBMED   32492081
  REMARK    GeneRIF: ERdj8 governs the size of autophagosomes during the
            formation process.
            GeneRIF: ERdj8 is another name for DNAJC16.
            Erratum:[J Cell Biol. 2020 Aug 3;219(8):e20190312709142020c. doi:
            10.1083/jcb.20190312709142020c.. PMID: 32968790]
REFERENCE   2  (bases 1 to 6034)
  AUTHORS   Hosgood,H.D. 3rd, Zhang,L., Shen,M., Berndt,S.I., Vermeulen,R.,
            Li,G., Yin,S., Yeager,M., Yuenger,J., Rothman,N., Chanock,S.,
            Smith,M. and Lan,Q.
  TITLE     Association between genetic variants in VEGF, ERCC3 and
            occupational benzene haematotoxicity
  JOURNAL   Occup Environ Med 66 (12), 848-853 (2009)
   PUBMED   19773279
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   3  (bases 1 to 6034)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC047363.1 and AB023179.2.
            
            On Nov 22, 2018 this sequence version replaced NM_015291.3.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB023179.2, SRR1803615.126268.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000375847.8/ ENSP00000365007.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 BC047363.1         36-44
            10-6034             AB023179.2         1-6025
FEATURES             Location/Qualifiers
     source          1..6034
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.21"
     gene            1..6034
                     /gene="DNAJC16"
                     /gene_synonym="ERdj8"
                     /note="DnaJ heat shock protein family (Hsp40) member C16"
                     /db_xref="GeneID:23341"
                     /db_xref="HGNC:HGNC:29157"
                     /db_xref="MIM:619973"
     exon            1..111
                     /gene="DNAJC16"
                     /gene_synonym="ERdj8"
                     /inference="alignment:Splign:2.1.0"
     exon            112..296
                     /gene="DNAJC16"
                     /gene_synonym="ERdj8"
                     /inference="alignment:Splign:2.1.0"
     CDS             130..2478
                     /gene="DNAJC16"
                     /gene_synonym="ERdj8"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; novel DnaJ domain-containing protein; DnaJ
                     (Hsp40) homolog, subfamily C, member 16; ER-resident
                     protein ERdj8; endoplasmic reticulum DNA J
                     domain-containing protein 8"
                     /codon_start=1
                     /product="dnaJ homolog subfamily C member 16 isoform 1
                     precursor"
                     /protein_id="NP_056106.1"
                     /db_xref="CCDS:CCDS30606.1"
                     /db_xref="GeneID:23341"
                     /db_xref="HGNC:HGNC:29157"
                     /db_xref="MIM:619973"
                     /translation="MEVRKLSISWQFLIVLVLILQILSALDFDPYRVLGVSRTASQAD
                     IKKAYKKLAREWHPDKNKDPGAEDKFIQISKAYEILSNEEKRSNYDQYGDAGENQGYQ
                     KQQQQREYRFRHFHENFYFDESFFHFPFNSERRDSIDEKYLLHFSHYVNEVVPDSFKK
                     PYLIKITSDWCFSCIHIEPVWKEVIQELEELGVGIGVVHAGYERRLAHHLGAHSTPSI
                     LGIINGKISFFHNAVVRENLRQFVESLLPGNLVEKVTNKNYVRFLSGWQQENKPHVLL
                     FDQTPIVPLLYKLTAFAYKDYLSFGYVYVGLRGTEEMTRRYNINIYAPTLLVFKEHIN
                     RPADVIQARGMKKQIIDDFITRNKYLLAARLTSQKLFHELCPVKRSHRQRKYCVVLLT
                     AETTKLSKPFEAFLSFALANTQDTVRFVHVYSNRQQEFADTLLPDSEAFQGKSAVSIL
                     ERRNTAGRVVYKTLEDPWIGSESDKFILLGYLDQLRKDPALLSSEAVLPDLTDELAPV
                     FLLRWFYSASDYISDCWDSIFHNNWREMMPLLSLIFSALFILFGTVIVQAFSDSNDER
                     ESSPPEKEEAQEKTGKTEPSFTKENSSKIPKKGFVEVTELTDVTYTSNLVRLRPGHMN
                     VVLILSNSTKTSLLQKFALEVYTFTGSSCLHFSFLSLDKHREWLEYLLEFAQDAAPIP
                     NQYDKHFMERDYTGYVLALNGHKKYFCLFKPQKTVEEEEAIGSCSDVDSSLYLGESRG
                     KPSCGLGSRPIKGKLSKLSLWMERLLEGSLQRFYIPSWPELD"
     exon            297..363
                     /gene="DNAJC16"
                     /gene_synonym="ERdj8"
                     /inference="alignment:Splign:2.1.0"
     exon            364..703
                     /gene="DNAJC16"
                     /gene_synonym="ERdj8"
                     /inference="alignment:Splign:2.1.0"
     exon            704..888
                     /gene="DNAJC16"
                     /gene_synonym="ERdj8"
                     /inference="alignment:Splign:2.1.0"
     exon            889..993
                     /gene="DNAJC16"
                     /gene_synonym="ERdj8"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1152
                     /gene="DNAJC16"
                     /gene_synonym="ERdj8"
                     /inference="alignment:Splign:2.1.0"
     exon            1153..1283
                     /gene="DNAJC16"
                     /gene_synonym="ERdj8"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..1467
                     /gene="DNAJC16"
                     /gene_synonym="ERdj8"
                     /inference="alignment:Splign:2.1.0"
     exon            1468..1650
                     /gene="DNAJC16"
                     /gene_synonym="ERdj8"
                     /inference="alignment:Splign:2.1.0"
     exon            1651..1727
                     /gene="DNAJC16"
                     /gene_synonym="ERdj8"
                     /inference="alignment:Splign:2.1.0"
     exon            1728..1808
                     /gene="DNAJC16"
                     /gene_synonym="ERdj8"
                     /inference="alignment:Splign:2.1.0"
     exon            1809..1907
                     /gene="DNAJC16"
                     /gene_synonym="ERdj8"
                     /inference="alignment:Splign:2.1.0"
     exon            1908..2078
                     /gene="DNAJC16"
                     /gene_synonym="ERdj8"
                     /inference="alignment:Splign:2.1.0"
     exon            2079..6034
                     /gene="DNAJC16"
                     /gene_synonym="ERdj8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6010..6015
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DNAJC16"
                     /gene_synonym="ERdj8"
                     /note="hexamer: AATAAA"
     polyA_site      6034
                     /gene="DNAJC16"
                     /gene_synonym="ERdj8"
                     /note="major polyA site"
ORIGIN      
        1 ctctttcccc tccccaggcc caggcgagcg ctggtgtgga cgggaagctc ccggcccggc
       61 gaactaactg gagcacggag ctgcagccgg ttgggccggt gtactttccc gctctggaaa
      121 ggaagagaaa tggaagtgag aaagttgagc atttcctggc agttcttgat agttctggtt
      181 ctgatcctgc aaattctgtc tgcgttggat tttgacccat acagagtcct aggggtcagc
      241 cgaacagcca gtcaggctga tattaaaaag gcttataaga agctcgcccg ggaatggcat
      301 cctgacaaaa acaaagatcc tggagcagaa gacaagttca ttcaaatcag taaggcttac
      361 gagattcttt caaatgaaga aaagagatca aattatgatc aatatggaga cgctggagag
      421 aaccagggct accagaagca gcaacagcag cgagagtatc gcttccgcca tttccatgaa
      481 aatttttatt ttgatgaatc cttttttcac ttccctttta attctgaacg gcgggactca
      541 attgacgaaa agtatttatt gcacttttca cattatgtga atgaagtggt tccagatagc
      601 ttcaagaaac cctacctcat caagatcacc tccgattggt gctttagctg cattcatatc
      661 gagcctgtgt ggaaagaagt cattcaagaa ctggaagaat tgggtgtagg aattggcgtg
      721 gtccatgctg ggtatgagag acgcctggcc catcacctag gggcacacag cacgccctct
      781 atcctaggaa tcattaacgg gaaaatctcc ttcttccaca atgcagttgt ccgtgaaaat
      841 ctgcgacaat ttgtagaaag tcttcttcca gggaacttgg tggagaaagt tacaaataaa
      901 aattacgtca gattcctctc tggctggcag caagagaata agcctcatgt ccttctgttt
      961 gaccaaacgc ccattgtgcc actgttatac aagttgactg cctttgcata caaagattat
     1021 ttatcatttg gatatgtata tgtgggtttg agagggacgg aagagatgac aaggcggtac
     1081 aacatcaata tctacgcccc taccctcttg gtctttaaag aacatataaa caggcctgcc
     1141 gatgttatcc aggcccgagg tatgaagaag caaatcattg acgacttcat cacccgaaac
     1201 aaatatctat tggcagccag gctcaccagc cagaagttgt tccatgaact ctgccctgtg
     1261 aaacggtcgc atcgacagag gaagtactgt gtggttttat tgactgctga gactaccaag
     1321 ttgagcaaac cctttgaggc tttcctgtcc tttgccctgg caaacactca agacacagtg
     1381 agatttgtgc atgtctacag caatcggcag caggagtttg ccgacacctt actaccagac
     1441 agtgaggcgt ttcaagggaa atcagcggtg tctattttag aaaggcgcaa cacagcagga
     1501 agggtggtgt ataaaaccct ggaagaccct tggattggga gtgagagtga caaatttatc
     1561 ctcttgggct atctcgacca gctgcgtaaa gatccagctc ttctgtcctc tgaagcagtg
     1621 cttcctgacc tgaccgatga acttgcccct gtttttctcc ttcgatggtt ctactctgct
     1681 tctgactaca tctcagactg ctgggatagc atttttcaca acaactggag ggaaatgatg
     1741 cccctgctgt ccctgatctt ctctgccctc ttcatcctct tcggcactgt catcgttcag
     1801 gctttcagcg actctaatga tgagcgagag tcaagccctc cagaaaaaga ggaagcccaa
     1861 gagaagactg ggaaaactga gccaagcttc accaaagaaa acagcagcaa gattcctaaa
     1921 aaaggctttg tggaggtaac tgaactcaca gatgtaacat acaccagtaa cttggtacgt
     1981 ctgaggccag gccacatgaa tgtggtcctc atcctgtcga attctaccaa gaccagccta
     2041 ctacagaaat ttgctttgga ggtctacaca tttactggga gcagctgcct acacttctcc
     2101 ttcctgagtc tagataaaca cagagaatgg ctagaatact tactagaatt tgctcaagat
     2161 gcagctccaa tcccaaacca atatgataag catttcatgg agcgtgacta cactggttat
     2221 gtactggctc tgaatggcca caagaaatac ttctgcctct tcaagcccca aaagacagtc
     2281 gaagaggagg aagccatagg gtcgtgcagt gatgttgact cttccctcta cctgggtgaa
     2341 tctcgaggga aaccttcctg tggccttgga tccaggccca tcaaaggaaa gttgagcaag
     2401 ctctctttat ggatggaacg cctgctggag ggctccttac agaggtttta tatcccatca
     2461 tggcctgaac tagactgaga ggattttcca aagagatttg aactcttcag actttttaac
     2521 atgcccctgt gaacaggtat tttcaggact caaactacca caatgaacag agtatagatt
     2581 ttagattgct cttctagaac catggctaga agaatctttc ctttgtcctg ttctaaccta
     2641 ggaatgaaaa acaccaccag tttgaatcgc ctagatgaaa atcttttcct ctgggtgtta
     2701 tttttcccca ctgaatgcca caccattgaa aatagactgc tcatcccctc ttcctttctt
     2761 gtccttgtcc catgctcacc ccaccctcct gtcctgtgtc ttggagaagc acagggctcc
     2821 accctgcaag cggcatctgg cggaccctca tgagcctgtc gtgcaggcca ggtcattggc
     2881 cccttcccca atcccggccc tgctgtgctg ctgccatggc gcatgctcct aactctgaac
     2941 aacccacggc agcttctagc cccgcatctg gaaaaaggcc cctttccaag caatctcacg
     3001 tttactggtt gttctgggag taagtggcta aatgtatatt ttgggggtat cccccaacaa
     3061 cagtttgttg gccacaggtt gaaaaggaaa ggaataaacg ggagttctgc atgtgagttc
     3121 tcaagaaaag gaaagggagg ctgagcagtg gctgaagcga tgcagccttg agacacgctg
     3181 tgagcatccc atccgccgcc ccagcgctgc tggtagccag gggaggggtc tgcacagcga
     3241 gaagtactgt gatgactttg agccgttgac atgtatgtct tcagatgcct ttctgcctct
     3301 gtcgatttta gggtatggat attaggagcc ataacttgta atcttgttct ctgaacgtag
     3361 agataagctg ctataaagcc agtagatgtt aaactgaaga gaaattattc ccacctgcta
     3421 tgagtcaggc ttaaggaatc tcttcaatag tgtctcttta gtaaaatacc aaacatgtct
     3481 ttgtatcaag gaacttaaaa tttctcaaca attgtatttt gaacactgtt accctaaaag
     3541 tgctgtctct tcaagtcatc ttttgcagga agtgagccaa gatttgttct agactcccat
     3601 tttgcaaaag gcttactttc cacttctggg ctgtattttg atgtctcatc ttcattgttt
     3661 tcactcttaa cttagagctg cttcaccagt attggggtca gactggccat cagcacctga
     3721 gcgtgctgag ctccaggtat agtggacccc agggtgcctc ataccagcca gttagagagc
     3781 atacctttta tttttcaggg cagaatgacc agtggttctg agtttgagtt tggacagctt
     3841 caaagagtgg tccgttcaaa tgtcaaagca aggtgccttt ggtggctttg tgaagggtga
     3901 aaatcagtga tgggacattt actaagtatt tctttttttt tttttttttt tagttgttga
     3961 gacagagttt cactcttgtt gcccaggctg gagtgaaatg gtgcgatctc ggttcaccgc
     4021 aacctccaca tcccaggttc aagtgattct cctgcctcag cctcctgagt agctaggatt
     4081 acaggcatgt gccaccatgt aattagcccg gctaattttg tatttttagt agagacggga
     4141 tttctccatg ttgatcaggc tggtcatgaa ctcctgacct caggtgatct gcctgcctca
     4201 gcctcccaaa gtgctgctgg gattacaggc gtgagccacc actcccggct aagttagtat
     4261 ttctttaatc ttaatgcttt aaactaagcc acttggatcc tgaataattt aaatcttgag
     4321 ctacattggt aagtaataaa ttatttaagg ccaggaattc ctgtagtttt catggagtct
     4381 gtagctttat taaaaaataa atcactgcca ggcttcattc ttccatatga tcctctaaaa
     4441 atggacactt cctctgaatg ctgtatctca tggcacctgg tccaactaga aatggtcaag
     4501 gaattcattt ggctccttga tacatcagtc ctcaatatta ctttctaggt attttatggc
     4561 cagattgctt atatgagtgg tcttttggtt tggtagtagg tttttatttt taatttctgt
     4621 actaatgaaa ttcctgactt taatttctga aaaccaaaaa ctctccaagt gtatttattt
     4681 atattttttt taatagagac gaggtcttgc tatgttgccc aggctggtcc caaactcctg
     4741 gcctcaagca gtccttccac cttggcctcc caaagtgctg ggattatcaa tatgagccac
     4801 catgccagat ttgttcattt ttaaacattt ttatctcttc aagtcatctt ttgatctttt
     4861 aaaaagcacc ttcaaacagc tgcaccttcc atttgcacta ggaaatgaag gtagtgatgg
     4921 gattggcaat gttcctggca gatgtttcag cccaaaagct cttctacaga ccggtttaga
     4981 gctggtgccc tatgagaata ttagggagct tttattttaa attgaacttt acccttgtcc
     5041 atgcaaggca ttcctcctga atgcatccat gaatttgttt acttttgcgt caaacatatg
     5101 agccattgtc atgctcagcc tgtgccacca ttgctctgtc tgatgtatgt aatcatacaa
     5161 gacctgattt tggttctaac acagtggtct ttgactatca acattgatgt ttttagagat
     5221 gggttcttct ggttgataca gactatgcat tgcgtttagc agatggggta aaactggcct
     5281 aaaacaagtc tttgcagaat acatgccaat ttccaaaaaa aaaaaaaaat ttgttgctca
     5341 ggtgttgcac aatttttatc taacactgag gctatcagct ccaactaaac aacatttcag
     5401 tgggtgaggc tgccctaact tccattaggg gccatggtct cactgccatc acttattagc
     5461 catgagaatt tggttgtagt tttcaggtag gttggtttct tcctcatttg cagcttgttg
     5521 atacttgttc ctttttattt attaacatcc caatcaattt gcagctgcca tcattacata
     5581 aatatttttc tgttataaaa agaagtgtga tctgtttttt tagtgatttc ctttgtttgg
     5641 gaatagagat tggaagcaca tactcagacc tgttttgtta actagaattc tttaaaagct
     5701 gatgccaaac atctttacag aggaactgta gttcacatcc acctgtctga cattgtcccc
     5761 taaaaacaag tgcagtgtgg cagctgctga atctgtctgt tcagtttgtc aaggaggata
     5821 attatgcttg ggagagatct gaaaagaagg tgaatatttt gcacttttga tactcttagg
     5881 aacaaataac ttatttggca aattgtttct tttttatgtt ttgggtgttg tttttgtttt
     5941 ttgacttttt ttgtattgtg aacaggcact gaagctgatg ttattttaag attacagaat
     6001 ggaaaaagaa ataaactatt ttaatgtctg ataa
//
