LOCUS       NP_056106                782 aa            linear   PRI 11-FEB-2025
DEFINITION  dnaJ homolog subfamily C member 16 isoform 1 precursor [Homo
            sapiens].
ACCESSION   NP_056106 XP_497656
VERSION     NP_056106.1
DBSOURCE    REFSEQ: accession NM_015291.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 782)
  AUTHORS   Yamamoto,Y.H., Kasai,A., Omori,H., Takino,T., Sugihara,M.,
            Umemoto,T., Hamasaki,M., Hatta,T., Natsume,T., Morimoto,R.I.,
            Arai,R., Waguri,S., Sato,M., Sato,K., Bar-Nun,S., Yoshimori,T.,
            Noda,T. and Nagata,K.
  TITLE     ERdj8 governs the size of autophagosomes during the formation
            process
  JOURNAL   J Cell Biol 219 (8) (2020)
   PUBMED   32492081
  REMARK    GeneRIF: ERdj8 governs the size of autophagosomes during the
            formation process.
            GeneRIF: ERdj8 is another name for DNAJC16.
            Erratum:[J Cell Biol. 2020 Aug 3;219(8):e20190312709142020c. doi:
            10.1083/jcb.20190312709142020c.. PMID: 32968790]
REFERENCE   2  (residues 1 to 782)
  AUTHORS   Hosgood,H.D. 3rd, Zhang,L., Shen,M., Berndt,S.I., Vermeulen,R.,
            Li,G., Yin,S., Yeager,M., Yuenger,J., Rothman,N., Chanock,S.,
            Smith,M. and Lan,Q.
  TITLE     Association between genetic variants in VEGF, ERCC3 and
            occupational benzene haematotoxicity
  JOURNAL   Occup Environ Med 66 (12), 848-853 (2009)
   PUBMED   19773279
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   3  (residues 1 to 782)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC047363.1 and AB023179.2.
            
            On Dec 17, 2004 this sequence version replaced XP_497656.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB023179.2, SRR1803615.126268.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000375847.8/ ENSP00000365007.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..782
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.21"
     Protein         1..782
                     /product="dnaJ homolog subfamily C member 16 isoform 1
                     precursor"
                     /note="novel DnaJ domain-containing protein; DnaJ (Hsp40)
                     homolog, subfamily C, member 16; ER-resident protein
                     ERdj8; endoplasmic reticulum DNA J domain-containing
                     protein 8"
                     /calculated_mol_wt=87696
     sig_peptide     1..25
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2914
     mat_peptide     26..782
                     /product="DnaJ homolog subfamily C member 16.
                     /id=PRO_0000236683"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Y2G8.3)"
                     /calculated_mol_wt=87696
     Region          29..>142
                     /region_name="DnaJ_bact"
                     /note="chaperone protein DnaJ; TIGR02349"
                     /db_xref="CDD:274090"
     Region          136..245
                     /region_name="TRX_DnaJ"
                     /note="TRX domain, DnaJ domain containing protein family;
                     composed of uncharacterized proteins of about 500-800
                     amino acids, containing an N-terminal DnaJ domain followed
                     by one redox active TRX domain. DnaJ is a member of the 40
                     kDa heat-shock protein (Hsp40)...; cd02963"
                     /db_xref="CDD:239261"
     Site            order(171,174)
                     /site_type="active"
                     /note="catalytic residues [active]"
                     /db_xref="CDD:239261"
     Site            536..556
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Y2G8.3)"
     Region          562..593
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Y2G8.3)"
     Site            631
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9Y2G8.3)"
     CDS             1..782
                     /gene="DNAJC16"
                     /gene_synonym="ERdj8"
                     /coded_by="NM_015291.4:130..2478"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS30606.1"
                     /db_xref="GeneID:23341"
                     /db_xref="HGNC:HGNC:29157"
                     /db_xref="MIM:619973"
ORIGIN      
        1 mevrklsisw qflivlvlil qilsaldfdp yrvlgvsrta sqadikkayk klarewhpdk
       61 nkdpgaedkf iqiskayeil sneekrsnyd qygdagenqg yqkqqqqrey rfrhfhenfy
      121 fdesffhfpf nserrdside kyllhfshyv nevvpdsfkk pylikitsdw cfscihiepv
      181 wkeviqelee lgvgigvvha gyerrlahhl gahstpsilg iingkisffh navvrenlrq
      241 fvesllpgnl vekvtnknyv rflsgwqqen kphvllfdqt pivpllyklt afaykdylsf
      301 gyvyvglrgt eemtrrynin iyaptllvfk ehinrpadvi qargmkkqii ddfitrnkyl
      361 laarltsqkl fhelcpvkrs hrqrkycvvl ltaettklsk pfeaflsfal antqdtvrfv
      421 hvysnrqqef adtllpdsea fqgksavsil errntagrvv yktledpwig sesdkfillg
      481 yldqlrkdpa llsseavlpd ltdelapvfl lrwfysasdy isdcwdsifh nnwremmpll
      541 slifsalfil fgtvivqafs dsnderessp pekeeaqekt gktepsftke nsskipkkgf
      601 vevteltdvt ytsnlvrlrp ghmnvvlils nstktsllqk falevytftg ssclhfsfls
      661 ldkhrewley llefaqdaap ipnqydkhfm erdytgyvla lnghkkyfcl fkpqktveee
      721 eaigscsdvd sslylgesrg kpscglgsrp ikgklsklsl wmerllegsl qrfyipswpe
      781 ld
//
