LOCUS       NM_013238               7459 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens DnaJ heat shock protein family (Hsp40) member C15
            (DNAJC15), mRNA.
ACCESSION   NM_013238
VERSION     NM_013238.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7459)
  AUTHORS   Santamans,A.M., Cicuendez,B., Mora,A., Villalba-Orero,M.,
            Rajlic,S., Crespo,M., Vo,P., Jerome,M., Macias,A., Lopez,J.A.,
            Leiva,M., Rocha,S.F., Leon,M., Rodriguez,E., Leiva,L., Pintor
            Chocano,A., Garcia Lunar,I., Garcia-Alvarez,A.,
            Hernansanz-Agustin,P., Peinado,V.I., Barbera,J.A., Ibanez,B.,
            Vazquez,J., Spinelli,J.B., Daiber,A., Oliver,E. and Sabio,G.
  TITLE     MCJ: A mitochondrial target for cardiac intervention in pulmonary
            hypertension
  JOURNAL   Sci Adv 10 (3), eadk6524 (2024)
   PUBMED   38241373
  REMARK    GeneRIF: MCJ: A mitochondrial target for cardiac intervention in
            pulmonary hypertension.
REFERENCE   2  (bases 1 to 7459)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (bases 1 to 7459)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 7459)
  AUTHORS   Barbier-Torres,L., Fortner,K.A., Iruzubieta,P., Delgado,T.C.,
            Giddings,E., Chen,Y., Champagne,D., Fernandez-Ramos,D., Mestre,D.,
            Gomez-Santos,B., Varela-Rey,M., de Juan,V.G., Fernandez-Tussy,P.,
            Zubiete-Franco,I., Garcia-Monzon,C., Gonzalez-Rodriguez,A., Oza,D.,
            Valenca-Pereira,F., Fang,Q., Crespo,J., Aspichueta,P., Tremblay,F.,
            Christensen,B.C., Anguita,J., Martinez-Chantar,M.L. and Rincon,M.
  TITLE     Silencing hepatic MCJ attenuates non-alcoholic fatty liver disease
            (NAFLD) by increasing mitochondrial fatty acid oxidation
  JOURNAL   Nat Commun 11 (1), 3360 (2020)
   PUBMED   32620763
  REMARK    GeneRIF: Silencing hepatic MCJ attenuates non-alcoholic fatty liver
            disease (NAFLD) by increasing mitochondrial fatty acid oxidation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7459)
  AUTHORS   Pascual-Itoiz,M.A., Pena-Cearra,A., Martin-Ruiz,I., Lavin,J.L.,
            Simo,C., Rodriguez,H., Atondo,E., Flores,J.M.,
            Carreras-Gonzalez,A., Tomas-Cortazar,J., Barriales,D., Palacios,A.,
            Garcia-Canas,V., Pellon,A., Fullaondo,A., Aransay,A.M.,
            Prados-Rosales,R., Martin,R., Anguita,J. and Abecia,L.
  TITLE     The mitochondrial negative regulator MCJ modulates the interplay
            between microbiota and the host during ulcerative colitis
  JOURNAL   Sci Rep 10 (1), 572 (2020)
   PUBMED   31953445
  REMARK    GeneRIF: The mitochondrial negative regulator MCJ modulates the
            interplay between microbiota and the host during ulcerative
            colitis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7459)
  AUTHORS   Strathdee,G., Davies,B.R., Vass,J.K., Siddiqui,N. and Brown,R.
  TITLE     Cell type-specific methylation of an intronic CpG island controls
            expression of the MCJ gene
  JOURNAL   Carcinogenesis 25 (5), 693-701 (2004)
   PUBMED   14729589
  REMARK    GeneRIF: loss of expression of MCJ by DNA methylation is associated
            with drug-resistance in ovarian cancer
REFERENCE   7  (bases 1 to 7459)
  AUTHORS   Dunham,A., Matthews,L.H., Burton,J., Ashurst,J.L., Howe,K.L.,
            Ashcroft,K.J., Beare,D.M., Burford,D.C., Hunt,S.E.,
            Griffiths-Jones,S., Jones,M.C., Keenan,S.J., Oliver,K., Scott,C.E.,
            Ainscough,R., Almeida,J.P., Ambrose,K.D., Andrews,D.T.,
            Ashwell,R.I., Babbage,A.K., Bagguley,C.L., Bailey,J., Bannerjee,R.,
            Barlow,K.F., Bates,K., Beasley,H., Bird,C.P., Bray-Allen,S.,
            Brown,A.J., Brown,J.Y., Burrill,W., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M.E., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S.C., Cobley,V., Collins,J.E., Corby,N., Coville,G.J.,
            Deloukas,P., Dhami,P., Dunham,I., Dunn,M., Earthrowl,M.E.,
            Ellington,A.G., Faulkner,L., Frankish,A.G., Frankland,J.,
            French,L., Garner,P., Garnett,J., Gilbert,J.G., Gilson,C.J.,
            Ghori,J., Grafham,D.V., Gribble,S.M., Griffiths,C., Hall,R.E.,
            Hammond,S., Harley,J.L., Hart,E.A., Heath,P.D., Howden,P.J.,
            Huckle,E.J., Hunt,P.J., Hunt,A.R., Johnson,C., Johnson,D., Kay,M.,
            Kimberley,A.M., King,A., Laird,G.K., Langford,C.J., Lawlor,S.,
            Leongamornlert,D.A., Lloyd,D.M., Lloyd,C., Loveland,J.E.,
            Lovell,J., Martin,S., Mashreghi-Mohammadi,M., McLaren,S.J.,
            McMurray,A., Milne,S., Moore,M.J., Nickerson,T., Palmer,S.A.,
            Pearce,A.V., Peck,A.I., Pelan,S., Phillimore,B., Porter,K.M.,
            Rice,C.M., Searle,S., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Steward,C.A., Sycamore,N., Tester,J., Thomas,D.W.,
            Tracey,A., Tromans,A., Tubby,B., Wall,M., Wallis,J.M., West,A.P.,
            Whitehead,S.L., Willey,D.L., Wilming,L., Wray,P.W., Wright,M.W.,
            Young,L., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E., Beck,S.,
            Bentley,D.R., Rogers,J. and Ross,M.T.
  TITLE     The DNA sequence and analysis of human chromosome 13
  JOURNAL   Nature 428 (6982), 522-528 (2004)
   PUBMED   15057823
REFERENCE   8  (bases 1 to 7459)
  AUTHORS   Shridhar,V., Bible,K.C., Staub,J., Avula,R., Lee,Y.K., Kalli,K.,
            Huang,H., Hartmann,L.C., Kaufmann,S.H. and Smith,D.I.
  TITLE     Loss of expression of a new member of the DNAJ protein family
            confers resistance to chemotherapeutic agents used in the treatment
            of ovarian cancer
  JOURNAL   Cancer Res 61 (10), 4258-4265 (2001)
   PUBMED   11358853
REFERENCE   9  (bases 1 to 7459)
  AUTHORS   Grottke,C., Mantwill,K., Dietel,M., Schadendorf,D. and Lage,H.
  TITLE     Identification of differentially expressed genes in human melanoma
            cells with acquired resistance to various antineoplastic drugs
  JOURNAL   Int J Cancer 88 (4), 535-546 (2000)
   PUBMED   11058868
REFERENCE   10 (bases 1 to 7459)
  AUTHORS   Bauer,M.F., Gempel,K., Reichert,A.S., Rappold,G.A., Lichtner,P.,
            Gerbitz,K.D., Neupert,W., Brunner,M. and Hofmann,S.
  TITLE     Genetic and structural characterization of the human mitochondrial
            inner membrane translocase
  JOURNAL   J Mol Biol 289 (1), 69-82 (1999)
   PUBMED   10339406
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF126743.1, AL445217.3 and CA444534.1.
            
            On May 17, 2019 this sequence version replaced NM_013238.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7346977.2533127.1,
                                           SRR7346977.2736747.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000379221.4/ ENSP00000368523.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-48                AF126743.1         383-430
            49-149              AL445217.3         68490-68590
            150-201             AL445217.3         110542-110593
            202-275             AL445217.3         113786-113859
            276-352             AL445217.3         123468-123544
            353-423             AL445217.3         130624-130694
            424-1949            AL445217.3         152034-153559
            1950-2391           CA444534.1         43-484              c
            2392-2416           CA444534.1         17-41               c
            2417-7459           AL445217.3         154027-159069
FEATURES             Location/Qualifiers
     source          1..7459
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q14.11"
     gene            1..7459
                     /gene="DNAJC15"
                     /gene_synonym="DNAJD1; HSD18; MCJ"
                     /note="DnaJ heat shock protein family (Hsp40) member C15"
                     /db_xref="GeneID:29103"
                     /db_xref="HGNC:HGNC:20325"
                     /db_xref="MIM:615339"
     exon            1..149
                     /gene="DNAJC15"
                     /gene_synonym="DNAJD1; HSD18; MCJ"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..494
                     /gene="DNAJC15"
                     /gene_synonym="DNAJD1; HSD18; MCJ"
                     /note="DNAJ domain-containing; methylation-controlled J
                     protein; DnaJ (Hsp40) homolog, subfamily D, member 1; cell
                     growth-inhibiting gene 22 protein; DnaJ (Hsp40) homolog,
                     subfamily C, member 15"
                     /codon_start=1
                     /product="dnaJ homolog subfamily C member 15"
                     /protein_id="NP_037370.2"
                     /db_xref="CCDS:CCDS9388.1"
                     /db_xref="GeneID:29103"
                     /db_xref="HGNC:HGNC:20325"
                     /db_xref="MIM:615339"
                     /translation="MAARGVIAPVGESLRYAEYLQPSAKRPDADVDQQRLVRSLIAVG
                     LGVAALAFAGRYAFRIWKPLEQVITETAKKISTPSFSSYYKGGFEQKMSRREAGLILG
                     VSPSAGKAKIRTAHRRVMILNHPDKGGSPYVAAKINEAKDLLETTTKH"
     exon            150..201
                     /gene="DNAJC15"
                     /gene_synonym="DNAJD1; HSD18; MCJ"
                     /inference="alignment:Splign:2.1.0"
     exon            202..275
                     /gene="DNAJC15"
                     /gene_synonym="DNAJD1; HSD18; MCJ"
                     /inference="alignment:Splign:2.1.0"
     exon            276..352
                     /gene="DNAJC15"
                     /gene_synonym="DNAJD1; HSD18; MCJ"
                     /inference="alignment:Splign:2.1.0"
     exon            353..423
                     /gene="DNAJC15"
                     /gene_synonym="DNAJD1; HSD18; MCJ"
                     /inference="alignment:Splign:2.1.0"
     exon            424..7459
                     /gene="DNAJC15"
                     /gene_synonym="DNAJD1; HSD18; MCJ"
                     /inference="alignment:Splign:2.1.0"
     regulatory      637..642
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DNAJC15"
                     /gene_synonym="DNAJD1; HSD18; MCJ"
                     /note="hexamer: AATAAA"
     polyA_site      654
                     /gene="DNAJC15"
                     /gene_synonym="DNAJD1; HSD18; MCJ"
                     /note="major polyA site"
     regulatory      2392..2397
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DNAJC15"
                     /gene_synonym="DNAJD1; HSD18; MCJ"
                     /note="hexamer: AATAAA"
     polyA_site      2416
                     /gene="DNAJC15"
                     /gene_synonym="DNAJD1; HSD18; MCJ"
     regulatory      7433..7438
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DNAJC15"
                     /gene_synonym="DNAJD1; HSD18; MCJ"
                     /note="hexamer: AATAAA"
     polyA_site      7459
                     /gene="DNAJC15"
                     /gene_synonym="DNAJD1; HSD18; MCJ"
ORIGIN      
        1 agtcactgcc gcggcgcctt gagtctccgg gccgccttgc catggctgcc cgtggtgtca
       61 tcgctccagt tggcgagagt ttgcgctacg ctgagtactt gcagccctcg gccaaacggc
      121 cagacgccga cgtcgaccag cagagactgg taagaagttt gatagctgta ggactgggtg
      181 ttgcagctct tgcatttgca ggtcgctacg catttcggat ctggaaacct ctagaacaag
      241 ttatcacaga aactgcaaag aagatttcaa ctcctagctt ttcatcctac tataaaggag
      301 gatttgaaca gaaaatgagt aggcgagaag ctggtcttat tttaggtgta agcccatctg
      361 ctggcaaggc taagattaga acagctcata ggagagtcat gattttgaat cacccagata
      421 aaggtggatc tccttacgta gcagccaaaa taaatgaagc aaaagacttg ctagaaacaa
      481 ccaccaaaca ttgatgctta aggaccacac tgaaggaaaa aaaaagaggg gacttcgaaa
      541 aaaaaaaaag ccctgcaaaa tattctaaaa catggtcttc ttaattttct atatggattg
      601 accacagtct tatcttccac cattaagctg tataacaata aaatgttaat agtcttgctt
      661 tttattatct tttaaagatc tccttaaatt ctataactga tcttttttct tattttgttt
      721 gtgacattca tacattttta agatttttgt tatgttctga attcccccct acacacacac
      781 acacacacac acacacacac acgtgcaaaa aatatgatca agaatgcaat tgggatttgt
      841 gagcaatgag tagacctctt attgtttata tttgtaccct cattgtcaat ttttttttag
      901 ggaatttggg actctgccta tataaggtgt tttaaatgtc ttgagaacaa gcactggctg
      961 atacctcttg gagatatgat ctgaaatgta atggaattta ttaaatggtg tttagtaaag
     1021 taggggttaa ggacttgtta aagaacccca ctatctctga gaccctatag ccaaagcatg
     1081 aggacttgga gagctactaa aatgattcag gtttacaaaa tgagccctgt gaggaaaggt
     1141 tgagagaagt ctgaggagtt tgtatttaat tatagtcttc cagtactgta tattcattca
     1201 ttactcattc tacaaatatt tattgacccc ttttgatgtg caaggcacta tcgtgcgtcc
     1261 cctgagagtt gcaagtatga agcagtcatg gatcatgaac caaaggaact tatatgtaga
     1321 ggaaggataa atcacaaata gtgaatactg ttagatacag atgatatatt ttaaaagttc
     1381 aaaggaagaa aagaatgtgt taaacactgc atgagaggag gaataagtgg catagagcta
     1441 ggctttagaa aagaaaaata ttccgatacc atatgattgg tgaggtaagt gttattctga
     1501 gatgagaatt agcagaaata gatatatcaa tcggagtgat tagagtgcag ggtttctgga
     1561 aagcaaggtt tggacagagt ggtcatcaaa ggccagccct gtgacttaca ctgcattaaa
     1621 ttaatttctt agaacatagt ccctgatcat tatcacttta ctattccaaa ggtgagagaa
     1681 cagattcaga tagagtgcca gcattgtttc ccagtattcc tttacaaatc ttgggttcat
     1741 tccaggtaaa ctgaactact gcattgtttc tatcttaaaa tactttttag atatcctaga
     1801 tgcatctttc aacttctaac attctgtagt ttaggagttc tcaaccttgg cattattgac
     1861 atgttaggcc aaataatttt ttttgtggga ggtctcttgt gcgttttaga tgattagcaa
     1921 taatccctga cctgttatct actaaagact agtcgtttct catcagttgt gacaacaaaa
     1981 atggttccag atattgccaa atgcccttta gaggacagta atcgccccca gttgagaacc
     2041 atttcagtaa aactttaatt actatttttt cttttggttt ataaaataat gatcctgaat
     2101 taaattgatg gaaccttgaa gtcgataaaa tatatttctt gctttaaagt ccccatacgt
     2161 gtcctactaa ttttctcatg ctttagtgtt ttcacttttc tcctgttatc cttgtaccta
     2221 agaatgccat cccaatcccc agatgtccac ctgcccaaag tctaggcata gctgaaggcc
     2281 aagctaaaat gtatccctct ttttctggta catgcagcaa aagtaatatg aattatcagc
     2341 tttctgagag caggcattgt atctgtcttg tttggtgtta cattggcacc caataaatat
     2401 ttgttgagtg aatgaataaa ttcccatagc actttattct tcacatggta cataactata
     2461 ggggctatag cttggtacct tgtgaagcaa ctcttggtgt aacatacctt atttctcata
     2521 ctaaaatgca agaaccttta gagcaaggat cttgccattc atctttgtaa cctctttact
     2581 ctggagcact tgcatttagc aggcatcata aagttttacg taccaagaaa atgttgctgt
     2641 tttctgaata ctatgcatca aaaaatgtta ccactaattt ttaaagctct gctaaggaat
     2701 attggggcac cctcagatgc accttttaat tgatgtcata ttttcctaat ccatacttta
     2761 ttcatgagaa tttgagtcac cccagcatta gcttggaatt tccttatttc ccatttgctt
     2821 tgcaggtgcc ttggagtcag atctggtttt gaatactatc ttcctgttat gtgatcttgg
     2881 gcagttactt aattttctag tcaataaccc gtatctataa aatagagaaa ataatcctac
     2941 acaccggggc ctgttgtggg gcggggagag gggggaggga tcgcatttgg agatatacta
     3001 atgtaaatga caagttaatt ggtgcagcac accaacatgg ctcatgtcta catatgtaac
     3061 aaacctgcac gttgtgcaca tgtgccctag aacttaaagt ataataaaaa gaaattttaa
     3121 aaaatcctgt caaataaggt tatagtagag aataaggatg tgtaaagcat ttagtcacgt
     3181 aaatgcttaa aaaaatgtaa tttttacttc tttcactgcc tcatttaatt agttttatct
     3241 ttaataatac cttggattca gggtaaagtt tcagttatgt cccagtaatc atttatttta
     3301 ccctcgaatc tgcaatttgg atagaacatg gtggggacag ctcgtctcta ttccttgcag
     3361 cattaacagg ctggaggcac cacttctctg gccagcaagt tgggcctggt tgttggctga
     3421 gagcctcagt tcctttctgc acaggttcct ctttacatag gcttctcaac agggctacta
     3481 gagcatcgtc accatagcag ctgtcttata acagagagtg gtcggtctga gagacaaaaa
     3541 atggaagctg ccaaattgtt ctgggtctgg aaactgtcag ggcatcactt gtgccatatt
     3601 cagttggcct aagaattaca gagcctgcct cgattcaaag ggagaggata gagaggactg
     3661 aaggaatcag tgctcatctt taatatgcag caggacaggt ttgggatttt ttttccccct
     3721 tgagtctgtg aaggcattac ttaagaacaa agtcaggcat gtataattga actacagtta
     3781 cttgaaatat aagcccagaa agtttcagat aataaataca actatttttc tgctgttacc
     3841 cttgtaccta aagatgccat cctaatcccc agatctccac aactatacct acatagtaga
     3901 aggttaaaat gtatccctct ttttctggtg catccagcaa aagtaatatc atgaattatg
     3961 agctctctga gagcaaggat catatcagtc ttgtttattg ttgcagtgaa caagtacagt
     4021 tgcagatatt caggagtaat tatctaaatg gcagtaggct tataaaactg aattttcacc
     4081 agccacaccc tccccccaac tccttatctg taaaaagctt atttgagtgg ttacctgtct
     4141 tcagtaaaga ttgcgcttgc atatttgctg tcattgcata ttctgcttaa ttaagctctg
     4201 ttgatattgc agtttctgtg catacttaca tcttagatgc aatctgaggg cctaggaagg
     4261 ccttttaaaa ataaaacaat tccgattgca gagaaagtgt aagtcaagga cagttaattc
     4321 aaggggaaca tagaaagcta tttagatttt agttgatggt gccagtcttc agcgtaaagt
     4381 caaaagtgga gggaagttta gtaaggaaaa aatgttgggc ttggaataca ttgtttagtc
     4441 ttcaaagcac tttacttttt atgaaatata ttttagacat tcagcaaata ttgaatactt
     4501 actatatcag gcagtaaaga tataaattca ttcttaaaat gtgcaacatg ttcaaactga
     4561 aaaaaataca ttcttaaaca ggaaactttt tccttcatac tttttaatta acaagacata
     4621 taagagttgc attaatgggc gtgcttatga ttgatcaccc agcagcatca ttagaaataa
     4681 tatattttat tcatgtgcag aaatcttttg gttgtcctgg ggaaccttga acacagaaaa
     4741 gagcttttat tgataaggta attgaacaca cttgacaatt agcttaatat ggtttaatac
     4801 catttgtggg agaagatgaa tcagccaggc tctttacgtc aagaatatga agtttctctt
     4861 gagtcaacca acttaagatg agctacggag actgcagtga aaagttaaat atccaagtac
     4921 accagccaat ttcacacagt ggaaccatgc tgtcctcggg caccctgcac ctcgcccaac
     4981 agtcatcaac tagatggagg ctcctggctg caaggaggat ttgatgggaa tgagtaaatg
     5041 tgtcagcata gtccgtccct tctaatggaa aagcaaccca aagagcaaat cctattaatg
     5101 gctggatcag tatcatctac ttgtcaaaaa cattccatga attatgagtc aaaattttat
     5161 ttatggtggc attacacaca ttaagagatg aggacttctg ttagcataat ttattagctg
     5221 gaaaagttga gaaggttctc tggactcatt tttataggtg gaacctaagt gatctggata
     5281 attgcccacc agcaaaattg ctgggcatgg tggacaaaga aaatgttcct tctaatgatt
     5341 ttttatgagc tgagtagcta ttgttcccag ctgagtgctc ttttcctctt tttattgttg
     5401 ctgagcaaaa gaatttataa aaagctcttt cttttgtatt aaaaaccctg ctcaattgaa
     5461 atgcaagttc attaagtaat cttcatttct cttcctgcca taataaccct ttccctctct
     5521 gttcgattca acagtatcta gcagcactgc tccaaatttt aagtctgaac agactatatt
     5581 acatagatgt agagaaatac tcaatcttca gcattaagag ggagcttaat ttcacacggg
     5641 tggaatatga tcactcaggc tagatgttgg ccataaattt caaattagta tctcaactta
     5701 gcagggggga tcaacagtgg caaacttcaa ttatgacagg ataaaaatca catagagata
     5761 ttggttcaat atggacatct aaactataat gctaaaagcc aataattaga ataagttcat
     5821 tttaagaaaa gcattaataa tattagctaa cgtttagtac ctgtgccaaa cattctacct
     5881 atgttacctt gattttcata gccagcctaa gaggtactat tatgtatccc cattttacag
     5941 gttaagaaac aggctcagag gagtttagga tcttttccaa gattacatag ccagtaagtg
     6001 gtggcactag gaaccaaatt cagactctga atcgcatgct gtttatatta tattgcactc
     6061 attctaaata tgtgggaatc agaatgaagg ggcttgtatg acttttggct cattttttga
     6121 tgcatgtgac ctgggattat aaatgtgaaa ttaggtttac gaaaggatcc agtgtcattg
     6181 tgcatcatgg gcaaggagta cctaatctct ttaattcttc cctggaagct tacgatgtcc
     6241 atccaagtgc acatagcaaa agttctgttg taaagtttag cagagtgact ttctttgact
     6301 cagagtgatg acggaggaag ctttgataag attttatctg aaatgttcat ggacaagagc
     6361 tttcaaggag aacatccaga gcaaggttct gaagacagct catgaaggtg aagcagcaga
     6421 cctggcacaa gaaatgaaga gagagctcag tgtattaaag atgaaaacaa gaaaaccgaa
     6481 tatattgaaa ggagcagaga ggcaatgaaa acaagacaac tgaaatgagg taacttgcag
     6541 caattgaaag ggaatttcag tacttttata gaattcttaa aaattgtttc ctgctgttta
     6601 ttttcaattt tgaacagggt tatttgtcca tgccatactt tttttgccaa attccaaaat
     6661 tgtgtatagt tctatagttg tctggtggag tcaatggaac tttagttacc agtctaagaa
     6721 tgtgtctttg agattgtcca gttaattctc tatttccagt agctgtaata aatggtgaaa
     6781 aggtttctga ctcctggaga aagtttctaa ctccttatga ctaatattca taacagactt
     6841 gtgagttcct tgaacatgga tacacctata tgcaagagtg tattccaaag ctaactcagt
     6901 gatctttcca tttatctatt cttggattag tggtgccttt gctctttcct tctgtaaatg
     6961 tgaatagtta agagttgact gcagaagtgt ttacactttg gcttccatgc ctctggaatg
     7021 tttgtgcttt ggtggtgaga tgtgagacta tatttgtata gtctgcatct ctcaggctgc
     7081 cccagaatgt tgtacagtgc agtgctgaag aaagcagcag gtacacacag aaatgcagcc
     7141 tttcctggtt aaccctgctt ggatctgagt tacactttgt ttcctgactt cttgggactt
     7201 aggtaatcag tttgccttct actctatctc attttgtact cgcttacata ctacattctt
     7261 gtttgggctt tcgtttcttc ttgtaagcag agatttttta aaatccaata tgtgaaaata
     7321 cggatgcact acaattaaat aaataaaatg ctgttgtgtt tgttttgctt taaaattgta
     7381 aaggataaac aataagatag ttttatctat gtggttttcc cgatgcagtt aaaataaaac
     7441 ctaatctgct aaaattgaa
//
