LOCUS       NM_032364               3256 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens DnaJ heat shock protein family (Hsp40) member C14
            (DNAJC14), transcript variant 1, mRNA.
ACCESSION   NM_032364
VERSION     NM_032364.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3256)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 3256)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   3  (bases 1 to 3256)
  AUTHORS   Jung,J., Kim,J., Roh,S.H., Jun,I., Sampson,R.D., Gee,H.Y.,
            Choi,J.Y. and Lee,M.G.
  TITLE     The HSP70 co-chaperone DNAJC14 targets misfolded pendrin for
            unconventional protein secretion
  JOURNAL   Nat Commun 7, 11386 (2016)
   PUBMED   27109633
  REMARK    GeneRIF: Hsc70 and DNAJC14 are required for the unconventional
            trafficking of H723R-pendrin.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3256)
  AUTHORS   Bozzacco,L., Yi,Z., Andreo,U., Conklin,C.R., Li,M.M., Rice,C.M. and
            MacDonald,M.R.
  TITLE     Chaperone-Assisted Protein Folding Is Critical for Yellow Fever
            Virus NS3/4A Cleavage and Replication
  JOURNAL   J Virol 90 (6), 3212-3228 (2016)
   PUBMED   26739057
  REMARK    GeneRIF: This suggests that DNAJC14's folding activity normally
            modulates yellow fever virus NS3/4A/2K cleavage events to liberate
            appropriate levels of NS3 and NS4A and promote replication complex
            formation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3256)
  AUTHORS   Yi,Z., Yuan,Z., Rice,C.M. and MacDonald,M.R.
  TITLE     Flavivirus replication complex assembly revealed by DNAJC14
            functional mapping
  JOURNAL   J Virol 86 (21), 11815-11832 (2012)
   PUBMED   22915803
  REMARK    GeneRIF: These findings support a novel model of DNAJC14 action
            that includes specific membrane targeting of both DNAJC14 and
            yellow fever virus replication proteins.
REFERENCE   6  (bases 1 to 3256)
  AUTHORS   Chen,J., Huang,Y., Wu,H., Ni,X., Cheng,H., Fan,J., Gu,S., Gu,X.,
            Cao,G., Ying,K., Mao,Y., Lu,Y. and Xie,Y.
  TITLE     Molecular cloning and characterization of a novel human J-domain
            protein gene (HDJ3) from the fetal brain
  JOURNAL   J Hum Genet 48 (5), 217-221 (2003)
   PUBMED   12768437
REFERENCE   7  (bases 1 to 3256)
  AUTHORS   Leclerc,P.C., Auger-Messier,M., Lanctot,P.M., Escher,E., Leduc,R.
            and Guillemette,G.
  TITLE     A polyaromatic caveolin-binding-like motif in the cytoplasmic tail
            of the type 1 receptor for angiotensin II plays an important role
            in receptor trafficking and signaling
  JOURNAL   Endocrinology 143 (12), 4702-4710 (2002)
   PUBMED   12446598
REFERENCE   8  (bases 1 to 3256)
  AUTHORS   Tchernev,V.T., Mansfield,T.A., Giot,L., Kumar,A.M., Nandabalan,K.,
            Li,Y., Mishra,V.S., Detter,J.C., Rothberg,J.M., Wallace,M.R.,
            Southwick,F.S. and Kingsmore,S.F.
  TITLE     The Chediak-Higashi protein interacts with SNARE complex and signal
            transduction proteins
  JOURNAL   Mol Med 8 (1), 56-64 (2002)
   PUBMED   11984006
REFERENCE   9  (bases 1 to 3256)
  AUTHORS   Bermak,J.C. and Zhou,Q.Y.
  TITLE     Accessory proteins in the biogenesis of G protein-coupled receptors
  JOURNAL   Mol Interv 1 (5), 282-287 (2001)
   PUBMED   14993367
  REMARK    Review article
REFERENCE   10 (bases 1 to 3256)
  AUTHORS   Bermak,J.C., Li,M., Bullock,C. and Zhou,Q.Y.
  TITLE     Regulation of transport of the dopamine D1 receptor by a new
            membrane-associated ER protein
  JOURNAL   Nat Cell Biol 3 (5), 492-498 (2001)
   PUBMED   11331877
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA127901.1, AY188447.1 and BC080655.1.
            
            On Aug 13, 2020 this sequence version replaced NM_032364.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY188447.1, BC117148.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000678005.2/ ENSP00000504134.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-99                DA127901.1         130-228
            100-1007            AY188447.1         66-973
            1008-2935           BC080655.1         9-1936
            2936-3256           BC080655.1         1939-2259
FEATURES             Location/Qualifiers
     source          1..3256
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.2"
     gene            1..3256
                     /gene="DNAJC14"
                     /gene_synonym="DNAJ; DRIP78; HDJ3; LIP6"
                     /note="DnaJ heat shock protein family (Hsp40) member C14"
                     /db_xref="GeneID:85406"
                     /db_xref="HGNC:HGNC:24581"
                     /db_xref="MIM:606092"
     exon            1..99
                     /gene="DNAJC14"
                     /gene_synonym="DNAJ; DRIP78; HDJ3; LIP6"
                     /inference="alignment:Splign:2.1.0"
     exon            100..1562
                     /gene="DNAJC14"
                     /gene_synonym="DNAJ; DRIP78; HDJ3; LIP6"
                     /inference="alignment:Splign:2.1.0"
     CDS             156..2264
                     /gene="DNAJC14"
                     /gene_synonym="DNAJ; DRIP78; HDJ3; LIP6"
                     /note="isoform 1 is encoded by transcript variant 1; dnaJ
                     homolog subfamily C member 14; dopamine receptor
                     interacting protein; LYST-interacting protein LIP6; human
                     DnaJ protein 3; dnaJ protein homolog 3; dopamine
                     receptor-interacting protein of 78 kDa; DnaJ (Hsp40)
                     homolog, subfamily C, member 14"
                     /codon_start=1
                     /product="dnaJ homolog subfamily C member 14 isoform 1"
                     /protein_id="NP_115740.5"
                     /db_xref="CCDS:CCDS8894.1"
                     /db_xref="GeneID:85406"
                     /db_xref="HGNC:HGNC:24581"
                     /db_xref="MIM:606092"
                     /translation="MAQKHPGERGLYGAHHSGGASLRTLGPSVDPEIPSFSGLRDSAG
                     TAPNGTRCLTEHSGPKHTQHPNPAHWLDPSHGPPGGPGPPRDAEDPDQSETSSEEESG
                     VDQELSKENETGNQKDGNSFLSIPSACNCQGTPGIPEGPYSEGGNGSSSNFCHHCTSP
                     ALGEDELEEEYDDEESLKFPSDFSRVSSGKKPPSRRQRHRFPTKEDTREGGRRDPRSP
                     GRHRLGRKRSQADKRKGLGLWGAEELCQLGQAGFWWLIELLVLVGEYVETCGHLIYAC
                     RQLKSSDLDLFRVWMGVWTGRLGGWAQVMFQFLSQGFYCGVGLFTRFLKLLGALLLLA
                     LALFLGFLQLGWRFLVGLGDRLGWRDKATWLFSWLDSPALQRCLTLLRDSRPWQRLVR
                     IVQWGWLELPWVKQNINRQGNAPVASGRYCQPEEEVARLLTMAGVPEDELNPFHVLGV
                     EATASDVELKKAYRQLAVMVHPDKNHHPRAEEAFKVLRAAWDIVSNAEKRKEYEMKRM
                     AENELSRSVNEFLSKLQDDLKEAMNTMMCSRCQGKHRRFEMDREPKSARYCAECNRLH
                     PAEEGDFWAESSMLGLKITYFALMDGKVYDITEWAGCQRVGISPDTHRVPYHISFGSR
                     IPGTRGRQRATPDAPPADLQDFLSRIFQVPPGQMPNGNFFAAPQPAPGAAAASKPNST
                     VPKGEAKPKRRKKVRRPFQR"
     exon            1563..1669
                     /gene="DNAJC14"
                     /gene_synonym="DNAJ; DRIP78; HDJ3; LIP6"
                     /inference="alignment:Splign:2.1.0"
     exon            1670..1789
                     /gene="DNAJC14"
                     /gene_synonym="DNAJ; DRIP78; HDJ3; LIP6"
                     /inference="alignment:Splign:2.1.0"
     exon            1790..1950
                     /gene="DNAJC14"
                     /gene_synonym="DNAJ; DRIP78; HDJ3; LIP6"
                     /inference="alignment:Splign:2.1.0"
     exon            1951..2053
                     /gene="DNAJC14"
                     /gene_synonym="DNAJ; DRIP78; HDJ3; LIP6"
                     /inference="alignment:Splign:2.1.0"
     exon            2054..3256
                     /gene="DNAJC14"
                     /gene_synonym="DNAJ; DRIP78; HDJ3; LIP6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3237..3242
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DNAJC14"
                     /gene_synonym="DNAJ; DRIP78; HDJ3; LIP6"
                     /note="hexamer: TATAAA"
     polyA_site      3256
                     /gene="DNAJC14"
                     /gene_synonym="DNAJ; DRIP78; HDJ3; LIP6"
                     /note="major polyA site"
ORIGIN      
        1 agagcgtgag cgggaggcgg agccgggaga gcggctctcg tagctcaccc tggccccagg
       61 ccgggcggct cgagggggag gagttaccgc cgttcttcgg catcagaaca caccatgatg
      121 gctgtgacct aagaccctca ggaagccccg gggtcatggc ccagaagcac cccggagaaa
      181 gagggttgta tggagcccac cacagtggtg gtgcctccct caggacttta ggaccctccg
      241 tggaccctga aataccttca ttctcaggac tcagggactc agcagggact gctcctaatg
      301 gtacccgctg cctcacagag cactctggtc ctaagcacac acagcaccca aacccagccc
      361 attggttgga cccaagccat ggccccccag ggggtccagg accacctaga gatgcagagg
      421 accctgatca gagtgagacg tcttcagaag aagaatcagg agtggaccag gaactctcaa
      481 aagaaaacga gactgggaac cagaaggatg ggaactcttt tctttccatt ccatctgctt
      541 gcaactgcca gggaacacct ggaattccag aagggcctta ctctgaggga ggaaatggtt
      601 cttctagcaa cttttgccac cactgtacct ctccagcttt gggggaagat gagttggaag
      661 aggaatatga tgatgaagaa tctctcaagt tccccagtga tttttcacgt gtgtccagcg
      721 gaaagaaacc cccatcccgg agacagcggc accgctttcc aacgaaggag gatactcggg
      781 agggtggacg tagggatccc aggtcccctg gtcgacatcg gctgggtcgg aaacgaagtc
      841 aggcagataa gcgcaaaggc ctgggattgt ggggagccga ggaactatgt caacttggac
      901 aggcaggctt ttggtggctg attgaactgc tggtattggt gggagagtac gtagaaactt
      961 gtggccatct catctatgcc tgcaggcaac tgaaaagcag tgatttggac ctttttcgag
     1021 tttggatggg agtgtggaca gggcggttag ggggctgggc ccaggtcatg tttcagtttc
     1081 taagccaggg gttttactgt ggagtaggac tgtttactcg ttttcttaag ctgctgggtg
     1141 ctttgctgct cctggctctg gccctctttt tgggctttct acagttggga tggcggtttc
     1201 tggtgggact aggtgaccgg ttaggctgga gggataaggc tacctggctc ttctcttggc
     1261 tggattctcc agccttgcag cgttgcttga ctctgctgag agatagcagg ccatggcagc
     1321 ggctggtaag aatagttcag tggggctggc tggagttgcc ttgggtcaag cagaatatta
     1381 ataggcaggg gaatgcacct gtagctagtg ggcgctactg ccagcctgaa gaggaagtgg
     1441 ctcgactctt gaccatggct ggggttcctg aggatgagct aaaccctttc catgtactgg
     1501 gggttgaggc cacagcatca gatgttgaac tgaagaaggc ctatagacag ctggcagtga
     1561 tggttcatcc tgacaaaaat catcatcccc gggctgagga ggccttcaag gttttgcgag
     1621 cagcttggga cattgtcagc aatgctgaaa agcgaaagga gtatgagatg aaacgaatgg
     1681 cagagaatga gctgagccgg tcagtaaatg agtttctgtc caagctgcaa gatgacctca
     1741 aggaggcaat gaatactatg atgtgtagcc gatgccaagg aaagcatagg aggtttgaaa
     1801 tggaccggga acctaagagt gccagatact gtgctgagtg taataggctg catcctgctg
     1861 aggaaggaga cttttgggca gagtcaagca tgttgggcct caagatcacc tactttgcac
     1921 tgatggatgg aaaggtgtat gacatcacag agtgggctgg atgccagcgt gtaggtatct
     1981 ccccagatac ccacagagtc ccctatcaca tctcatttgg ttctcggatt ccaggcacca
     2041 gagggcggca gagagccacc ccagatgccc ctcctgctga tcttcaggat ttcttgagtc
     2101 ggatctttca agtaccccca gggcagatgc ccaatgggaa cttctttgca gctcctcagc
     2161 ctgcccctgg agccgctgca gcctctaagc ccaacagcac agtacccaag ggagaagcca
     2221 aacctaagcg gcggaagaaa gtgaggaggc ccttccaacg ttgatgcccc ttctctttcc
     2281 tcaaatcaat gtcagggagt caaaagggct gtagcacagg atggagtttg atttatccct
     2341 cctcccccaa cacctaggaa ctgaatcttt ttctttttat tttttgagat ggagtcttgc
     2401 tctgttgccc agctggagtg cagtggtgtg atctcagctt actgcaacct ctgtctcccg
     2461 ggttcaagca attctcccat ctcagcctcc tgagtagctg ggattacagg cacacaccac
     2521 cacacctggc ccagctaatt cttttttgta tttttagtag agacggggtt tcaccatgtt
     2581 gcccaggctg gtctcgaact cctgagctca ggtgatccac ccgtcttggc ctcccaaagt
     2641 gctggattac aggcataagc cactgtgccc ggcctgaatc ttgtcttttg acaataccaa
     2701 agaaataggg ggtagctaga gtaaagaacc tagggcctgg acctgggctg gacagtgtat
     2761 ccctttaggt gtgggaactg ggtatttccc tggggtctgt atgcctttgt cttgtcattt
     2821 gcttttaggg cagatgacac tttttcccac ccttttaaag ctacaagtct atcttctttc
     2881 ttgacccatt tcaggaggga gccctctcct ttatcctgat ataatattta aaagagaaca
     2941 agaaagcatg tagccctaat gataggagat tatcgcatag agttcagaga ctggaaactg
     3001 aattttccct cgactttcac tttgtgggta aatcacccaa ttttaggctc ttttctgcaa
     3061 ggatggccaa aattaatcat ttttaaaaag tagattcatg cccactgccc ttgggtgagg
     3121 gggaagaata cgggggttcc cagaagcccc catgtgatcc aagggtttgt attttttttt
     3181 taagtttgtt catatttgta tgtacatgac tatttaaagc caggggatta tctttctata
     3241 aatgtataac tggcaa
//
