LOCUS       NM_015268               7754 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens DnaJ heat shock protein family (Hsp40) member C13
            (DNAJC13), transcript variant 2, mRNA.
ACCESSION   NM_015268 XM_039828
VERSION     NM_015268.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7754)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 7754)
  AUTHORS   Saini,P., Rudakou,U., Yu,E., Ruskey,J.A., Asayesh,F., Laurent,S.B.,
            Spiegelman,D., Fahn,S., Waters,C., Monchi,O., Dauvilliers,Y.,
            Dupre,N., Greenbaum,L., Hassin-Baer,S., Espay,A.J., Rouleau,G.A.,
            Alcalay,R.N., Fon,E.A., Postuma,R.B. and Gan-Or,Z.
  TITLE     Association study of DNAJC13, UCHL1, HTRA2, GIGYF2, and EIF4G1 with
            Parkinson's disease
  JOURNAL   Neurobiol Aging 100, 119 (2021)
   PUBMED   33239198
  REMARK    GeneRIF: Association study of DNAJC13, UCHL1, HTRA2, GIGYF2, and
            EIF4G1 with Parkinson's disease.
REFERENCE   3  (bases 1 to 7754)
  AUTHORS   Besemer,A.S., Maus,J., Ax,M.D.A., Stein,A., Vo,S., Freese,C.,
            Nalbach,K., von Hilchen,C., Pfalzgraf,I.F., Koziollek-Drechsler,I.,
            Silva,B., Huesmann,H., Boukhallouk,F., Florin,L., Kern,A., Behl,C.
            and Clement,A.M.
  TITLE     Receptor-mediated endocytosis 8 (RME-8)/DNAJC13 is a novel positive
            modulator of autophagy and stabilizes cellular protein homeostasis
  JOURNAL   Cell Mol Life Sci 78 (2), 645-660 (2021)
   PUBMED   32322926
  REMARK    GeneRIF: Receptor-mediated endocytosis 8 (RME-8)/DNAJC13 is a novel
            positive modulator of autophagy and stabilizes cellular protein
            homeostasis.
REFERENCE   4  (bases 1 to 7754)
  AUTHORS   Follett,J., Fox,J.D., Gustavsson,E.K., Kadgien,C., Munsie,L.N.,
            Cao,L.P., Tatarnikov,I., Milnerwood,A.J. and Farrer,M.J.
  TITLE     DNAJC13 p.Asn855Ser, implicated in familial parkinsonism, alters
            membrane dynamics of sorting nexin 1
  JOURNAL   Neurosci Lett 706, 114-122 (2019)
   PUBMED   31082451
REFERENCE   5  (bases 1 to 7754)
  AUTHORS   Gagliardi,M., Annesi,G., Procopio,R., Morelli,M., Iannello,G.,
            Bonapace,G., Mancini,M., Nicoletti,G. and Quattrone,A.
  TITLE     DNAJC13 mutation screening in patients with Parkinson's disease
            from South Italy
  JOURNAL   Parkinsonism Relat Disord 55, 134-137 (2018)
   PUBMED   29887357
  REMARK    GeneRIF: This study showed the DNAJC13 mutation screening in
            patients with Parkinson's disease.
REFERENCE   6  (bases 1 to 7754)
  AUTHORS   Girard,M., Poupon,V., Blondeau,F. and McPherson,P.S.
  TITLE     The DnaJ-domain protein RME-8 functions in endosomal trafficking
  JOURNAL   J Biol Chem 280 (48), 40135-40143 (2005)
   PUBMED   16179350
  REMARK    GeneRIF: RME-8 functions in intracellular trafficking and provides
            the first evidence of a functional role for a DnaJ domain-bearing
            co-chaperone on endosomes
REFERENCE   7  (bases 1 to 7754)
  AUTHORS   Foster,L.J., Zeemann,P.A., Li,C., Mann,M., Jensen,O.N. and
            Kassem,M.
  TITLE     Differential expression profiling of membrane proteins by
            quantitative proteomics in a human mesenchymal stem cell line
            undergoing osteoblast differentiation
  JOURNAL   Stem Cells 23 (9), 1367-1377 (2005)
   PUBMED   16210410
REFERENCE   8  (bases 1 to 7754)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   9  (bases 1 to 7754)
  AUTHORS   Chang,H.C., Hull,M. and Mellman,I.
  TITLE     The J-domain protein Rme-8 interacts with Hsc70 to control
            clathrin-dependent endocytosis in Drosophila
  JOURNAL   J Cell Biol 164 (7), 1055-1064 (2004)
   PUBMED   15051737
REFERENCE   10 (bases 1 to 7754)
  AUTHORS   Volz,A., Melkaoui,R., Hildebrandt,F. and Omran,H.
  TITLE     Candidate gene analysis of KIAA0678 encoding a DnaJ-like protein
            for adolescent nephronophthisis and Senior-Loken syndrome type 3
  JOURNAL   Cytogenet Genome Res 97 (3-4), 163-166 (2002)
   PUBMED   12438707
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC020633.3, AY779857.1 and
            AI189887.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_015268.3.
            
            Summary: This gene encodes a member of the Dnaj protein family
            whose members act as co-chaperones of a partner heat-shock protein
            by binding to the latter and stimulating ATP hydrolysis. The
            encoded protein associates with the heat-shock protein Hsc70 and
            plays a role in clathrin-mediated endocytosis. It may also be
            involved in post-endocytic transport mechanisms via its
            associations with other proteins, including the sorting nexin SNX1.
            Mutations in this gene are associated with Parkinson's disease.
            [provided by RefSeq, Jun 2016].
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon in the 5' coding region, compared to variant 1. It encodes
            isoform 2, which is shorter than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.120148.1,
                                           SRR1803613.137071.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000260818.11/ ENSP00000260818.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-207               AC020633.3         28135-28341         c
            208-7751            AY779857.1         1-7544
            7752-7754           AI189887.1         5-7                 c
FEATURES             Location/Qualifiers
     source          1..7754
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q22.1"
     gene            1..7754
                     /gene="DNAJC13"
                     /gene_synonym="PARK21; RME8"
                     /note="DnaJ heat shock protein family (Hsp40) member C13"
                     /db_xref="GeneID:23317"
                     /db_xref="HGNC:HGNC:30343"
                     /db_xref="MIM:614334"
     exon            1..259
                     /gene="DNAJC13"
                     /gene_synonym="PARK21; RME8"
                     /inference="alignment:Splign:2.1.0"
     exon            260..340
                     /gene="DNAJC13"
                     /gene_synonym="PARK21; RME8"
                     /inference="alignment:Splign:2.1.0"
     CDS             273..7004
                     /gene="DNAJC13"
                     /gene_synonym="PARK21; RME8"
                     /note="isoform 2 is encoded by transcript variant 2; dnaJ
                     homolog subfamily C member 13; DnaJ domain-containing
                     protein RME-8; required for receptor-mediated endocytosis
                     8; DnaJ (Hsp40) homolog, subfamily C, member 13"
                     /codon_start=1
                     /product="dnaJ homolog subfamily C member 13 isoform 2"
                     /protein_id="NP_056083.3"
                     /db_xref="CCDS:CCDS33857.1"
                     /db_xref="GeneID:23317"
                     /db_xref="HGNC:HGNC:30343"
                     /db_xref="MIM:614334"
                     /translation="MNIIRENKDLACFYTTKHSWRGKYKRVFSVGTHAITTYNPNTLE
                     VTNQWPYGDICSISPVGKGQGTEFNLTFRKGSGKKSETLKFSTEHRTELLTEALRFRT
                     DFSEGKITGRRYNCYKHHWSDSRKPVILEVTPGGFDQINPATNRVLCSYDYRNIEGFV
                     DLSDYQGGFCILYGGFSRLHLFASEQREEIIKSAIDHAGNYIGISLRIRKEPLEFEQY
                     LNLRFGKYSTDESITSLAEFVVQKISPRHSEPVKRVLALTETCLVERDPATYNIATLK
                     PLGEVFALVCDSENPQLFTIEFIKGQVRKYSSTERDSLLASLLDGVRASGNRDVCVKM
                     TPTHKGQRWGLLSMPVDEEVESLHLRFLATPPNGNFADAVFRFNANISYSGVLHAVTQ
                     DGLFSENKEKLINNAITALLSQEGDVVASNAELESQFQAVRRLVASKAGFLAFTQLPK
                     FRERLGVKVVKALKRSNNGIIHAAVDMLCALMCPMHDDYDLRQEQLNKASLLSSKKFL
                     ENLLEKFNSHVDHGTGALVISSLLDFLTFALCAPYSETTEGQQFDMLLEMVASNGRTL
                     FKLFQHPSMAIIKGAGLVMKAIIEEGDKEIATKMQELALSEGALPRHLHTAMFTISSD
                     QRMLTNRQLSRHLVGLWTADNATATNLLKRILPPGLLAYLESSDLVPEKDADRMHVRD
                     NVKIAMDQYGKFNKVPEWQRLAGKAAKEVEKFAKEKVDLVLMHWRDRMGIAQKENINQ
                     KPVVLRKRRQRIKIEANWDLFYYRFGQDHARSNLIWNFKTREELKDTLESEMRAFNID
                     RELGSANVISWNHHEFEVKYECLAEEIKIGDYYLRLLLEEDENEESGSIKRSYEFFNE
                     LYHRFLLTPKVNMKCLCLQALAIVYGRCHEEIGPFTDTRYIIGMLERCTDKLERDRLI
                     LFLNKLILNKKNVKDLMDSNGIRILVDLLTLAHLHVSRATVPLQSNVIEAAPDMKRES
                     EKEWYFGNADKERSGPYGFHEMQELWTKGMLNAKTRCWAQGMDGWRPLQSIPQLKWCL
                     LASGQAVLNETDLATLILNMLITMCGYFPSRDQDNAIIRPLPKVKRLLSDSTCLPHII
                     QLLLTFDPILVEKVAILLYHIMQDNPQLPRLYLSGVFFFIMMYTGSNVLPVARFLKYT
                     HTKQAFKSEETKGQDIFQRSILGHILPEAMVCYLENYEPEKFSEIFLGEFDTPEAIWS
                     SEMRRLMIEKIAAHLADFTPRLQSNTRALYQYCPIPIINYPQLENELFCNIYYLKQLC
                     DTLRFPDWPIKDPVKLLKDTLDAWKKEVEKKPPMMSIDDAYEVLNLPQGQGPHDESKI
                     RKAYFRLAQKYHPDKNPEGRDMFEKVNKAYEFLCTKSAKIVDGPDPENIILILKTQSI
                     LFNRHKEDLQPYKYAGYPMLIRTITMETSDDLLFSKESPLLPAATELAFHTVNCSALN
                     AEELRRENGLEVLQEAFSRCVAVLTRASKPSDMSVQVCGYISKCYSVAAQFEECREKI
                     TEMPSIIKDLCRVLYFGKSIPRVAALGVECVSSFAVDFWLQTHLFQAGILWYLLGFLF
                     NYDYTLEESGIQKSEETNQQEVANSLAKLSVHALSRLGGYLAEEQATPENPTIRKSLA
                     GMLTPYVARKLAVASVTEILKMLNSNTESPYLIWNNSTRAELLEFLESQQENMIKKGD
                     CDKTYGSEFVYSDHAKELIVGEIFVRVYNEVPTFQLEVPKAFAASLLDYIGSQAQYLH
                     TFMAITHAAKVESEQHGDRLPRVEMALEALRNVIKYNPGSESECIGHFKLIFSLLRVH
                     GAGQVQQLALEVVNIVTSNQDCVNNIAESMVLSSLLALLHSLPSSRQLVLETLYALTS
                     STKIIKEAMAKGALIYLLDMFCNSTHPQVRAQTAELFAKMTADKLIGPKVRITLMKFL
                     PSVFMDAMRDNPEAAVHIFEGTHENPELIWNDNSRDKVSTTVREMMLEHFKNQQDNPE
                     ANWKLPEDFAVVFGEAEGELAVGGVFLRIFIAQPAWVLRKPREFLIALLEKLTELLEK
                     NNPHGETLETLTMATVCLFSAQPQLADQVPPLGHLPKVIQAMNHRNNAIPKSAIRVIH
                     ALSENELCVRAMASLETIGPLMNGMKKRADTVGLACEAINRMFQKEQSELVAQALKAD
                     LVPYLLKLLEGIGLENLDSPAATKAQIVKALKAMTRSLQYGEQVNEILCRSSVWSAFK
                     DQKHDLFISESQTAGYLTGPGVAGYLTAGTSTSVMSNLPPPVDHEAGDLGYQT"
     exon            341..416
                     /gene="DNAJC13"
                     /gene_synonym="PARK21; RME8"
                     /inference="alignment:Splign:2.1.0"
     exon            417..566
                     /gene="DNAJC13"
                     /gene_synonym="PARK21; RME8"
                     /inference="alignment:Splign:2.1.0"
     exon            567..608
                     /gene="DNAJC13"
                     /gene_synonym="PARK21; RME8"
                     /inference="alignment:Splign:2.1.0"
     exon            609..809
                     /gene="DNAJC13"
                     /gene_synonym="PARK21; RME8"
                     /inference="alignment:Splign:2.1.0"
     exon            810..1016
                     /gene="DNAJC13"
                     /gene_synonym="PARK21; RME8"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1112
                     /gene="DNAJC13"
                     /gene_synonym="PARK21; RME8"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1204
                     /gene="DNAJC13"
                     /gene_synonym="PARK21; RME8"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..1371
                     /gene="DNAJC13"
                     /gene_synonym="PARK21; RME8"
                     /inference="alignment:Splign:2.1.0"
     exon            1372..1451
                     /gene="DNAJC13"
                     /gene_synonym="PARK21; RME8"
                     /inference="alignment:Splign:2.1.0"
     exon            1452..1621
                     /gene="DNAJC13"
                     /gene_synonym="PARK21; RME8"
                     /inference="alignment:Splign:2.1.0"
     exon            1622..1721
                     /gene="DNAJC13"
                     /gene_synonym="PARK21; RME8"
                     /inference="alignment:Splign:2.1.0"
     exon            1722..1829
                     /gene="DNAJC13"
                     /gene_synonym="PARK21; RME8"
                     /inference="alignment:Splign:2.1.0"
     exon            1830..1985
                     /gene="DNAJC13"
                     /gene_synonym="PARK21; RME8"
                     /inference="alignment:Splign:2.1.0"
     exon            1986..2042
                     /gene="DNAJC13"
                     /gene_synonym="PARK21; RME8"
                     /inference="alignment:Splign:2.1.0"
     exon            2043..2164
                     /gene="DNAJC13"
                     /gene_synonym="PARK21; RME8"
                     /inference="alignment:Splign:2.1.0"
     exon            2165..2240
                     /gene="DNAJC13"
                     /gene_synonym="PARK21; RME8"
                     /inference="alignment:Splign:2.1.0"
     exon            2241..2336
                     /gene="DNAJC13"
                     /gene_synonym="PARK21; RME8"
                     /inference="alignment:Splign:2.1.0"
     exon            2337..2480
                     /gene="DNAJC13"
                     /gene_synonym="PARK21; RME8"
                     /inference="alignment:Splign:2.1.0"
     exon            2481..2563
                     /gene="DNAJC13"
                     /gene_synonym="PARK21; RME8"
                     /inference="alignment:Splign:2.1.0"
     exon            2564..2717
                     /gene="DNAJC13"
                     /gene_synonym="PARK21; RME8"
                     /inference="alignment:Splign:2.1.0"
     exon            2718..2821
                     /gene="DNAJC13"
                     /gene_synonym="PARK21; RME8"
                     /inference="alignment:Splign:2.1.0"
     exon            2822..2981
                     /gene="DNAJC13"
                     /gene_synonym="PARK21; RME8"
                     /inference="alignment:Splign:2.1.0"
     exon            2982..3044
                     /gene="DNAJC13"
                     /gene_synonym="PARK21; RME8"
                     /inference="alignment:Splign:2.1.0"
     exon            3045..3146
                     /gene="DNAJC13"
                     /gene_synonym="PARK21; RME8"
                     /inference="alignment:Splign:2.1.0"
     exon            3147..3251
                     /gene="DNAJC13"
                     /gene_synonym="PARK21; RME8"
                     /inference="alignment:Splign:2.1.0"
     exon            3252..3454
                     /gene="DNAJC13"
                     /gene_synonym="PARK21; RME8"
                     /inference="alignment:Splign:2.1.0"
     exon            3455..3539
                     /gene="DNAJC13"
                     /gene_synonym="PARK21; RME8"
                     /inference="alignment:Splign:2.1.0"
     exon            3540..3694
                     /gene="DNAJC13"
                     /gene_synonym="PARK21; RME8"
                     /inference="alignment:Splign:2.1.0"
     exon            3695..3740
                     /gene="DNAJC13"
                     /gene_synonym="PARK21; RME8"
                     /inference="alignment:Splign:2.1.0"
     exon            3741..3895
                     /gene="DNAJC13"
                     /gene_synonym="PARK21; RME8"
                     /inference="alignment:Splign:2.1.0"
     exon            3896..4097
                     /gene="DNAJC13"
                     /gene_synonym="PARK21; RME8"
                     /inference="alignment:Splign:2.1.0"
     exon            4098..4213
                     /gene="DNAJC13"
                     /gene_synonym="PARK21; RME8"
                     /inference="alignment:Splign:2.1.0"
     exon            4214..4292
                     /gene="DNAJC13"
                     /gene_synonym="PARK21; RME8"
                     /inference="alignment:Splign:2.1.0"
     exon            4293..4428
                     /gene="DNAJC13"
                     /gene_synonym="PARK21; RME8"
                     /inference="alignment:Splign:2.1.0"
     exon            4429..4613
                     /gene="DNAJC13"
                     /gene_synonym="PARK21; RME8"
                     /inference="alignment:Splign:2.1.0"
     exon            4614..4688
                     /gene="DNAJC13"
                     /gene_synonym="PARK21; RME8"
                     /inference="alignment:Splign:2.1.0"
     exon            4689..4808
                     /gene="DNAJC13"
                     /gene_synonym="PARK21; RME8"
                     /inference="alignment:Splign:2.1.0"
     exon            4809..4988
                     /gene="DNAJC13"
                     /gene_synonym="PARK21; RME8"
                     /inference="alignment:Splign:2.1.0"
     exon            4989..5156
                     /gene="DNAJC13"
                     /gene_synonym="PARK21; RME8"
                     /inference="alignment:Splign:2.1.0"
     exon            5157..5270
                     /gene="DNAJC13"
                     /gene_synonym="PARK21; RME8"
                     /inference="alignment:Splign:2.1.0"
     exon            5271..5387
                     /gene="DNAJC13"
                     /gene_synonym="PARK21; RME8"
                     /inference="alignment:Splign:2.1.0"
     exon            5388..5565
                     /gene="DNAJC13"
                     /gene_synonym="PARK21; RME8"
                     /inference="alignment:Splign:2.1.0"
     exon            5566..5657
                     /gene="DNAJC13"
                     /gene_synonym="PARK21; RME8"
                     /inference="alignment:Splign:2.1.0"
     exon            5658..5757
                     /gene="DNAJC13"
                     /gene_synonym="PARK21; RME8"
                     /inference="alignment:Splign:2.1.0"
     exon            5758..5832
                     /gene="DNAJC13"
                     /gene_synonym="PARK21; RME8"
                     /inference="alignment:Splign:2.1.0"
     exon            5833..5945
                     /gene="DNAJC13"
                     /gene_synonym="PARK21; RME8"
                     /inference="alignment:Splign:2.1.0"
     exon            5946..6115
                     /gene="DNAJC13"
                     /gene_synonym="PARK21; RME8"
                     /inference="alignment:Splign:2.1.0"
     exon            6116..6158
                     /gene="DNAJC13"
                     /gene_synonym="PARK21; RME8"
                     /inference="alignment:Splign:2.1.0"
     exon            6159..6332
                     /gene="DNAJC13"
                     /gene_synonym="PARK21; RME8"
                     /inference="alignment:Splign:2.1.0"
     exon            6333..6512
                     /gene="DNAJC13"
                     /gene_synonym="PARK21; RME8"
                     /inference="alignment:Splign:2.1.0"
     exon            6513..6653
                     /gene="DNAJC13"
                     /gene_synonym="PARK21; RME8"
                     /inference="alignment:Splign:2.1.0"
     exon            6654..6797
                     /gene="DNAJC13"
                     /gene_synonym="PARK21; RME8"
                     /inference="alignment:Splign:2.1.0"
     exon            6798..6897
                     /gene="DNAJC13"
                     /gene_synonym="PARK21; RME8"
                     /inference="alignment:Splign:2.1.0"
     exon            6898..7754
                     /gene="DNAJC13"
                     /gene_synonym="PARK21; RME8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7723..7728
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DNAJC13"
                     /gene_synonym="PARK21; RME8"
                     /note="hexamer: AATAAA"
     polyA_site      7754
                     /gene="DNAJC13"
                     /gene_synonym="PARK21; RME8"
                     /note="major polyA site"
ORIGIN      
        1 agagcgcgct cgctcaaagc ctgagcgaag atggcggcct ccagagtgaa actctgagag
       61 gcagagggag gaggcggagg gggcggggag gcagcgccgc ggcggcacca ggaacccgcg
      121 gcagcggagc tgcagggccc cggcggggga aaggggaagt ggtgagggtg aggaggccgg
      181 agggcgcctc atcccactct ggaagctgag ccggcggcgg gaggagctag ggctggagcc
      241 tctccagcct cccgcgaagg tttgagcaca aaatgaacat aattagggaa aataaggatc
      301 tggcatgttt ctacacaaca aaacattcat ggagggggaa gtataagcgt gtcttttcag
      361 ttggaactca tgcgattact acatataatc ccaatacctt agaagtaaca aatcagtggc
      421 cttatggaga catttgcagc atcagccctg ttggaaaagg acaaggaacg gagttcaacc
      481 tcacatttcg taaaggcagt ggaaaaaagt cagaaacttt aaaattttct acagagcaca
      541 gaacagaact tcttacagaa gcattgagat ttagaactga tttttcagag ggaaaaatca
      601 caggaaggag atacaactgc tataagcatc actggagtga ctcaagaaaa cctgtaattt
      661 tggaagtaac tccaggaggc tttgaccaaa ttaatcctgc aaccaacaga gtactctgtt
      721 cctatgacta tagaaatatt gaaggatttg tagatctctc agattatcaa ggaggatttt
      781 gtatacttta tggaggattt agtagattgc atttatttgc gtcagagcaa agagaagaga
      841 ttattaaaag tgcaatagac catgctggta actacatagg tatttcattg cggatcagga
      901 aagagccttt agaattcgag caatatttga atcttcgctt tggaaaatac agcactgatg
      961 aatccatcac atctttagca gagtttgtag tccaaaaaat atcacctaga cattcggagc
     1021 ctgttaaaag agttctagca cttacagaaa catgtttagt agaacgtgat ccggcaacct
     1081 ataatattgc aacattgaag cctttaggag aagtatttgc gttggtctgt gactcagaaa
     1141 atccacaact ttttaccatt gaatttataa aagggcaagt acggaaatat tcttcaacag
     1201 agagagattc cttattagca agtttgctgg atggagtaag agcctctggt aatagagatg
     1261 tttgtgtaaa aatgacacca acccataaag gtcagcgatg ggggttactc agcatgcctg
     1321 ttgatgagga agtagagagc cttcacctca ggttcttagc tacgcctcca aatggcaact
     1381 ttgcagatgc tgtattcagg ttcaatgcta atatttcata cagtggagtc ctacatgcag
     1441 taacacaaga tggtctcttc tcagaaaaca aagaaaaact gatcaataat gccataacag
     1501 cattactgtc ccaagaaggg gatgtcgttg cttcaaatgc ggaacttgag agtcagttcc
     1561 aggctgtgag gaggcttgtg gcatccaaag ctggtttcct ggctttcact cagcttccaa
     1621 agtttcgcga gcgtctaggg gtgaaggtag taaaagcact caaaagaagc aacaacggaa
     1681 taatccatgc agcagttgat atgctttgtg cccttatgtg tcccatgcat gatgactatg
     1741 acttaagaca agaacagttg aacaaagctt ctcttctctc gtcaaagaag tttctggaaa
     1801 acttactgga gaaatttaat tcccatgtgg atcatgggac tggtgcccta gttattagtt
     1861 cgctcttgga cttccttacc tttgccctct gtgctccata tagtgagaca actgaagggc
     1921 agcagtttga tatgctcttg gagatggtag catccaatgg aagaaccctt tttaaacttt
     1981 ttcagcatcc ttccatggca ataataaaag gagctgggtt ggttatgaag gcaataatag
     2041 aggaaggtga taaagaaatt gctacaaaaa tgcaggagct tgccctaagt gaaggtgcct
     2101 tacctcgaca cttgcatact gcgatgttta caataagctc agatcaaagg atgcttacaa
     2161 atagacagct aagtagacat ttagtgggac tctggacagc tgataatgca actgcaacaa
     2221 acttgttgaa acgcattttg ccgccaggct tgctggcata cttggaaagc tcagatctcg
     2281 tacctgagaa ggatgctgat cggatgcatg ttagagacaa tgtgaaaata gcaatggatc
     2341 agtatggaaa atttaataaa gttccagagt ggcaaagact agctggaaaa gctgctaaag
     2401 aagttgaaaa atttgccaaa gaaaaagtgg atcttgtatt gatgcactgg agggatagga
     2461 tgggcattgc tcaaaaagag aatataaatc agaagccagt ggttcttcga aagagaagac
     2521 aaagaataaa aatagaagca aattgggatc tcttctatta taggtttggt caagaccatg
     2581 ccaggtcaaa ccttatttgg aatttcaaaa cacgagaaga actgaaagat actcttgaat
     2641 ctgaaatgag agcatttaat attgacagag aacttggaag tgcaaatgtg atctcctgga
     2701 accaccatga gtttgaggtt aaatatgagt gcctggcaga ggaaattaaa ataggagact
     2761 attacctgag attactattg gaggaagatg agaatgaaga aagtggatca attaagagat
     2821 cgtatgaatt tttcaatgag ctttatcatc gcttcttgct caccccaaaa gtaaacatga
     2881 agtgtttatg tttacaagcc cttgctattg tttatggcag atgtcacgaa gaaataggac
     2941 cttttacaga taccagatat atcattggaa tgttagagag gtgcacagat aaacttgaac
     3001 gagataggtt gattctcttc cttaacaagt tgatccttaa taagaaaaat gttaaggatc
     3061 tcatggattc aaatggaata agaatccttg tggacttgct tacccttgca catctccatg
     3121 taagccgagc tacagtacca ctgcaaagca atgtaattga agctgctcca gatatgaaaa
     3181 gagagagtga aaaggaatgg tattttggca acgcagacaa agaaaggagt ggcccgtatg
     3241 gatttcatga gatgcaagaa ttgtggacca aaggaatgtt aaatgcaaaa accagatgct
     3301 gggctcaagg catggatgga tggcgaccac ttcagtccat accccagctt aagtggtgtc
     3361 tcttagccag tggacaggct gtcctgaatg aaactgacct tgctaccctt atattgaaca
     3421 tgttgatcac aatgtgtgga tattttccaa gcagggatca agacaatgcc atcattcggc
     3481 ctctacccaa agtgaaaaga ctgctgtcag atagcacttg ccttccccat attattcagc
     3541 tactgctgac ctttgaccct atccttgttg agaaggttgc tattttgtta taccatatca
     3601 tgcaagataa cccacagtta ccccgccttt atctgagtgg agtatttttc tttatcatga
     3661 tgtacacagg ttccaatgtg cttcctgttg ctcgattttt gaaatacaca cataccaaac
     3721 aggctttcaa gtcagaagag acaaaaggac aagatatttt tcagagaagt atacttgggc
     3781 acattctacc tgaagcaatg gtttgttact tagaaaatta tgaacctgaa aagttttctg
     3841 agatttttct aggagaattt gatactccag aagcaatctg gagcagtgaa atgaggcgcc
     3901 tgatgataga gaagattgct gcccatctcg cggatttcac acctcgtctt cagagtaaca
     3961 caagagcact ttatcagtat tgccccattc ctataatcaa ctatccacaa ctcgaaaatg
     4021 aactattttg taatatttat tacctcaaac aactgtgtga tacactccgg tttccagatt
     4081 ggccaattaa agacccggtt aagcttctaa aagataccct tgatgcctgg aagaaagaag
     4141 tagaaaagaa gccacctatg atgtcaatag atgatgctta tgaagtgctt aatctgcctc
     4201 aaggacaggg accgcatgat gagagcaaga ttaggaaagc ttacttcaga cttgcacaaa
     4261 agtaccaccc tgataagaat ccagaaggga gggacatgtt tgaaaaagta aataaagcat
     4321 atgaattttt atgtaccaaa tcagcaaaaa tagtggatgg gccagatcca gagaatataa
     4381 ttttaattct aaaaacacag agcatcctct tcaaccgtca taaagaagat ttacagcctt
     4441 ataaatatgc aggatacccc atgcttattc ggactataac aatggaaact tcagatgacc
     4501 tccttttctc aaaagaatca ccattgttgc ctgcggctac agagctagct ttccatactg
     4561 tcaactgttc agccctcaat gctgaagagc tcagaagaga gaatggacta gaggtgttac
     4621 aagaggcatt tagtcgctgt gtggctgtct tgactcgtgc tagtaaacca agtgacatgt
     4681 cagtacaggt gtgtggatac ataagtaaat gctacagtgt ggctgctcag tttgaggaat
     4741 gccgagagaa gatcacggaa atgcctagca tcatcaagga tctctgtcgg gtactatatt
     4801 ttggcaagag tattccccgc gtagctgctc ttggggtaga atgtgtcagt tcttttgctg
     4861 tggatttctg gctacagaca cacctatttc aggctggaat tttgtggtat ctccttggtt
     4921 ttctgtttaa ttatgactac acactagaag agagtggcat tcagaaaagt gaagaaacaa
     4981 accagcagga ggtagcaaac agccttgcca aactgagtgt ccatgctctg agtcgccttg
     5041 gagggtattt ggctgaagaa caagcaactc cagaaaatcc aaccataagg aaaagcttag
     5101 ctggcatgct gacaccctat gttgctagaa aacttgctgt ggctagtgtg actgagattt
     5161 tgaagatgct taacagcaac acagaaagtc catatttgat atggaacaat tctacaagag
     5221 cagaattact tgaatttctt gaatcccaac aagaaaacat gattaaaaaa ggtgattgtg
     5281 acaaaactta tggatcagaa tttgtctaca gtgatcatgc caaagaactt attgtagggg
     5341 agatttttgt tagggtgtat aatgaagttc ctactttcca actggaggtt ccaaaagcat
     5401 ttgctgcaag tctcttggat tatataggct cgcaggccca atacttgcac acattcatgg
     5461 ccatcacaca cgcggcaaaa gtggagtcag agcaacatgg agatcgctta ccgagagtag
     5521 aaatggcttt ggaggctctg agaaatgtca taaaatacaa tccaggttct gagagtgaat
     5581 gcattgggca ctttaagttg atattttctc ttctccgagt tcatggagct ggtcaagtgc
     5641 agcagttggc tttagaggtt gtgaatatag tgacatctaa ccaagactgt gtcaacaata
     5701 ttgctgaatc aatggttttg tccagtttat tggctcttct acattcattg ccatcaagtc
     5761 gtcagcttgt tctggaaact ctttatgctt tgacatcgag tacaaaaata atcaaagaag
     5821 caatggcaaa gggtgctttg atctatttac tggatatgtt ctgcaattca acacatccac
     5881 aggttcgagc ccaaacagca gaactttttg ccaaaatgac agcagataaa ctgataggtc
     5941 caaaggttcg aattacgtta atgaaatttc taccaagcgt tttcatggat gctatgagag
     6001 acaatcctga agctgctgta catatttttg aaggaactca tgaaaatcct gagttaattt
     6061 ggaatgataa ttccagagat aaagtgtcca caacagttag ggaaatgatg ctagagcact
     6121 ttaaaaatca gcaggacaac cctgaggcaa actggaagtt gcctgaagat tttgctgtgg
     6181 tgtttggaga agcagagggt gaacttgctg ttggaggagt cttcttgagg atctttattg
     6241 cacaaccagc ctgggttcta agaaagccta gagaatttct tattgccctg ttagaaaaat
     6301 taactgagct cctagagaag aacaatcctc atggagaaac tctggaaacc ttgacaatgg
     6361 caacagtgtg tctcttcagc gcacaacctc agctggcaga tcaggtcccg ccattgggcc
     6421 atcttcccaa agttatccag gcaatgaatc ataggaacaa tgccattcct aagagtgcca
     6481 ttcgggttat ccatgccttg tctgaaaatg agctgtgtgt tcgagccatg gcatctttag
     6541 agaccattgg cccactgatg aatggaatga aaaagcgagc agatactgtt ggtctagcct
     6601 gtgaagcaat taatcgaatg tttcagaagg agcagagtga attagtagca caagccctga
     6661 aagcagattt ggttccatac ctcttaaaat tactcgaagg cattggcctt gaaaacctgg
     6721 acagcccagc agccactaag gctcagattg ttaaagctct caaggcaatg actcgaagtt
     6781 tgcagtatgg agaacaggtg aatgaaatcc tgtgccgttc ttcagtctgg agtgccttca
     6841 aagatcagaa acatgatttg ttcatttctg agtcacaaac agcaggatac ctcacaggac
     6901 ctggagttgc tggctacctt accgcaggta catctacatc agtcatgtct aacctgccac
     6961 ctcctgtaga ccatgaggca ggcgaccttg gctatcagac ttgaaatatt cacgagagac
     7021 aataaacgct gaaaggccag tgccaagtcc acattcctcc agctgatacg ttgaagcaaa
     7081 ctcttactgc ctttctcctg gtttcatgac agtgttattc ctttttctat aaatatattt
     7141 ttaggaaaaa aagtcagtga tcctaattgt atcacattat aagaaagcac tctgtggatc
     7201 aacataagtg ggtacacaag aatttttttt ttcttggtgt atgtaagcac atttgttcct
     7261 ttatatctgt ttacaaaact gtgaatcaaa aagacaaaac tttcttccta gtttttgtaa
     7321 tttttttttt gaactagcat gactgtaggg ttgagctaca gtcaacaaaa attgggctaa
     7381 gtcacttttc cccaggaaag aatatttccc tctcctgcat caagtctgcg tggccatcct
     7441 ccccccacca tccaagacta ttaggttttg tccctgcacc cttcactggc atcctcaatc
     7501 attaaccttc tgaaagctca cagtacacat tagtatgtat aactggcttt accaaattga
     7561 atgaaaagga gcttgtgcaa aaaaatttaa aaatggatgt caagatgtta tgtaaaagat
     7621 gagtgtaatt gtgaaatgtt ctatacacta tcaaatatat aaagctttct atattgaatg
     7681 tacattatac agatcattca tatgtgtaca taaaatttta aaaataaagg gaattgactg
     7741 ctttgttaat gaga
//
