LOCUS       NM_018198               3201 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens DnaJ heat shock protein family (Hsp40) member C11
            (DNAJC11), mRNA.
ACCESSION   NM_018198
VERSION     NM_018198.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3201)
  AUTHORS   Wang,B., Chen,H., Deng,Y., Chen,H., Xing,L., Guo,Y., Wang,M. and
            Chen,J.
  TITLE     CircDNAJC11 interacts with TAF15 to promote breast cancer
            progression via enhancing MAPK6 expression and activating the MAPK
            signaling pathway
  JOURNAL   J Transl Med 21 (1), 186 (2023)
   PUBMED   36895010
  REMARK    GeneRIF: CircDNAJC11 interacts with TAF15 to promote breast cancer
            progression via enhancing MAPK6 expression and activating the MAPK
            signaling pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3201)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (bases 1 to 3201)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3201)
  AUTHORS   Huynen,M.A., Muhlmeister,M., Gotthardt,K., Guerrero-Castillo,S. and
            Brandt,U.
  TITLE     Evolution and structural organization of the mitochondrial contact
            site (MICOS) complex and the mitochondrial intermembrane space
            bridging (MIB) complex
  JOURNAL   Biochim Biophys Acta 1863 (1), 91-101 (2016)
   PUBMED   26477565
REFERENCE   5  (bases 1 to 3201)
  AUTHORS   Guarani,V., McNeill,E.M., Paulo,J.A., Huttlin,E.L., Frohlich,F.,
            Gygi,S.P., Van Vactor,D. and Harper,J.W.
  TITLE     QIL1 is a novel mitochondrial protein required for MICOS complex
            stability and cristae morphology
  JOURNAL   Elife 4, e06265 (2015)
   PUBMED   25997101
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3201)
  AUTHORS   Kneissl,J., Wachtler,V., Chua,N.H. and Bolle,C.
  TITLE     OWL1: an Arabidopsis J-domain protein involved in perception of
            very low light fluences
  JOURNAL   Plant Cell 21 (10), 3212-3225 (2009)
   PUBMED   19808946
REFERENCE   7  (bases 1 to 3201)
  AUTHORS   Xie,J., Marusich,M.F., Souda,P., Whitelegge,J. and Capaldi,R.A.
  TITLE     The mitochondrial inner membrane protein mitofilin exists as a
            complex with SAM50, metaxins 1 and 2, coiled-coil-helix
            coiled-coil-helix domain-containing protein 3 and 6 and DnaJC11
  JOURNAL   FEBS Lett 581 (18), 3545-3549 (2007)
   PUBMED   17624330
  REMARK    GeneRIF: mitofilin helps regulate mitochondrial morphology and at
            least four of the associated proteins (metaxins 1 and 2, SAM50 and
            CHCHD3) have been implicated in protein import; DnaJC11 is a
            chaperone-like protein that may have a similar role
REFERENCE   8  (bases 1 to 3201)
  AUTHORS   Kaltenbach,L.S., Romero,E., Becklin,R.R., Chettier,R., Bell,R.,
            Phansalkar,A., Strand,A., Torcassi,C., Savage,J., Hurlburt,A.,
            Cha,G.H., Ukani,L., Chepanoske,C.L., Zhen,Y., Sahasrabudhe,S.,
            Olson,J., Kurschner,C., Ellerby,L.M., Peltier,J.M., Botas,J. and
            Hughes,R.E.
  TITLE     Huntingtin interacting proteins are genetic modifiers of
            neurodegeneration
  JOURNAL   PLoS Genet 3 (5), e82 (2007)
   PUBMED   17500595
REFERENCE   9  (bases 1 to 3201)
  AUTHORS   Henrich,K.O., Claas,A., Praml,C., Benner,A., Mollenhauer,J.,
            Poustka,A., Schwab,M. and Westermann,F.
  TITLE     Allelic variants of CAMTA1 and FLJ10737 within a commonly deleted
            region at 1p36 in neuroblastoma
  JOURNAL   Eur J Cancer 43 (3), 607-616 (2007)
   PUBMED   17222547
  REMARK    GeneRIF: no evidence for somatic mutations in CAMTA1 in
            neuroblastoma
REFERENCE   10 (bases 1 to 3201)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     Identification and characterization of FLJ10737 and CAMTA1 genes on
            the commonly deleted region of neuroblastoma at human chromosome
            1p36.31-p36.23
  JOURNAL   Int J Oncol 23 (4), 1219-1224 (2003)
   PUBMED   12964007
  REMARK    GeneRIF: FLJ10737 and CAMTA1 genes on 1p36.31-p36.23 are candidate
            tumor suppressor genes of neuroblastoma
            GeneRIF: FLJ10737 protein consists of the DnaJ domain, bipartite
            NLS, FADH domain, and FEMCA domain.  Mouse E030019A03, zebrafish
            MGC55845, Drosophila CG8531 and Arabidopsis At2g35720 were homologs
            of human FLJ10737.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB461237.1, AL159177.13, AL031447.4 and AF306695.1.
            
            On Nov 23, 2018 this sequence version replaced NM_018198.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC006086.1, AL833841.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000377577.10/ ENSP00000366800.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                DB461237.1         93-115
            24-88               AL159177.13        2845-2909           c
            89-218              AL031447.4         19848-19977
            219-292             AL031447.4         22418-22491
            293-394             AL031447.4         33075-33176
            395-523             AL031447.4         46846-46974
            524-646             AL031447.4         47934-48056
            647-720             AL031447.4         49283-49356
            721-910             AL031447.4         54907-55096
            911-996             AL031447.4         55759-55844
            997-1113            AL031447.4         56211-56327
            1114-1269           AL031447.4         60828-60983
            1270-1339           AL031447.4         62521-62590
            1340-1397           AL031447.4         63381-63438
            1398-1540           AL031447.4         63545-63687
            1541-1670           AL031447.4         64639-64768
            1671-3169           AL031447.4         65185-66683
            3170-3201           AF306695.1         3174-3205
FEATURES             Location/Qualifiers
     source          1..3201
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.31"
     gene            1..3201
                     /gene="DNAJC11"
                     /gene_synonym="dJ126A5.1"
                     /note="DnaJ heat shock protein family (Hsp40) member C11"
                     /db_xref="GeneID:55735"
                     /db_xref="HGNC:HGNC:25570"
                     /db_xref="MIM:614827"
     exon            1..88
                     /gene="DNAJC11"
                     /gene_synonym="dJ126A5.1"
                     /inference="alignment:Splign:2.1.0"
     CDS             17..1696
                     /gene="DNAJC11"
                     /gene_synonym="dJ126A5.1"
                     /note="novel DnaJ domain-containing protein; DnaJ (Hsp40)
                     homolog, subfamily C, member 11"
                     /codon_start=1
                     /product="dnaJ homolog subfamily C member 11"
                     /protein_id="NP_060668.2"
                     /db_xref="CCDS:CCDS87.1"
                     /db_xref="GeneID:55735"
                     /db_xref="HGNC:HGNC:25570"
                     /db_xref="MIM:614827"
                     /translation="MATALSEEELDNEDYYSLLNVRREASSEELKAAYRRLCMLYHPD
                     KHRDPELKSQAERLFNLVHQAYEVLSDPQTRAIYDIYGKRGLEMEGWEVVERRRTPAE
                     IREEFERLQREREERRLQQRTNPKGTISVGVDATDLFDRYDEEYEDVSGSSFPQIEIN
                     KMHISQSIEAPLTATDTAILSGSLSTQNGNGGGSINFALRRVTSAKGWGELEFGAGDL
                     QGPLFGLKLFRNLTPRCFVTTNCALQFSSRGIRPGLTTVLARNLDKNTVGYLQWRWGI
                     QSAMNTSIVRDTKTSHFTVALQLGIPHSFALISYQHKFQDDDQTRVKGSLKAGFFGTV
                     VEYGAERKISRHSVLGAAVSVGVPQGVSLKVKLNRASQTYFFPIHLTDQLLPSAMFYA
                     TVGPLVVYFAMHRLIIKPYLRAQKEKELEKQRESAATDVLQKKQEAESAVRLMQESVR
                     RIIEAEESRMGLIIVNAWYGKFVNDKSRKSEKVKVIDVTVPLQCLVKDSKLILTEASK
                     AGLPGFYDPCVGEEKNLKVLYQFRGVLHQVMVLDSEALRIPKQSHRIDTDG"
     exon            89..218
                     /gene="DNAJC11"
                     /gene_synonym="dJ126A5.1"
                     /inference="alignment:Splign:2.1.0"
     exon            219..292
                     /gene="DNAJC11"
                     /gene_synonym="dJ126A5.1"
                     /inference="alignment:Splign:2.1.0"
     exon            293..394
                     /gene="DNAJC11"
                     /gene_synonym="dJ126A5.1"
                     /inference="alignment:Splign:2.1.0"
     exon            395..523
                     /gene="DNAJC11"
                     /gene_synonym="dJ126A5.1"
                     /inference="alignment:Splign:2.1.0"
     exon            524..646
                     /gene="DNAJC11"
                     /gene_synonym="dJ126A5.1"
                     /inference="alignment:Splign:2.1.0"
     exon            647..720
                     /gene="DNAJC11"
                     /gene_synonym="dJ126A5.1"
                     /inference="alignment:Splign:2.1.0"
     exon            721..910
                     /gene="DNAJC11"
                     /gene_synonym="dJ126A5.1"
                     /inference="alignment:Splign:2.1.0"
     exon            911..996
                     /gene="DNAJC11"
                     /gene_synonym="dJ126A5.1"
                     /inference="alignment:Splign:2.1.0"
     exon            997..1113
                     /gene="DNAJC11"
                     /gene_synonym="dJ126A5.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..1269
                     /gene="DNAJC11"
                     /gene_synonym="dJ126A5.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..1339
                     /gene="DNAJC11"
                     /gene_synonym="dJ126A5.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1340..1397
                     /gene="DNAJC11"
                     /gene_synonym="dJ126A5.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1398..1540
                     /gene="DNAJC11"
                     /gene_synonym="dJ126A5.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1541..1670
                     /gene="DNAJC11"
                     /gene_synonym="dJ126A5.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1671..3201
                     /gene="DNAJC11"
                     /gene_synonym="dJ126A5.1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3181..3186
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DNAJC11"
                     /gene_synonym="dJ126A5.1"
                     /note="hexamer: AATAAA"
     polyA_site      3201
                     /gene="DNAJC11"
                     /gene_synonym="dJ126A5.1"
                     /note="major polyA site"
ORIGIN      
        1 gtgaaaggtt gcgaagatgg cgacggcctt gagcgaggag gagctggaca atgaagacta
       61 ttactcgttg ctgaacgtgc gcagggaggc ctcttctgaa gagctgaaag ctgcctaccg
      121 gaggctctgt atgctctacc atccagacaa gcacagagac ccagagctca agtcacaggc
      181 ggaacgactg tttaaccttg ttcaccaggc ttatgaagtg cttagtgacc cccaaaccag
      241 ggccatctat gatatatatg ggaagagagg actggaaatg gaaggatggg aggttgtgga
      301 aaggaggaga acccctgctg aaattcgaga ggagtttgag cggctgcaga gagagagaga
      361 agagaggaga ttgcagcagc gaaccaatcc caagggaacg atcagcgttg gagtagatgc
      421 caccgacctt tttgatcgct atgatgagga gtatgaagat gtgtccggca gtagctttcc
      481 gcagattgaa attaataaaa tgcacatatc ccagtccatt gaggcaccct tgacagcgac
      541 agacacagcc atcctctctg gaagcctctc aacccagaat ggaaatggag gaggttccat
      601 taactttgcg ctcagacgag taacttcggc aaagggatgg ggagagttgg aatttggagc
      661 tggagaccta caggggcctt tgttcggtct caagctgttc cgtaatctca caccaagatg
      721 ctttgtgaca acaaactgtg ctctgcagtt ttcatcccgt ggaatccgac ccggcctgac
      781 cactgtccta gctcggaacc tagacaagaa caccgtgggc tacctgcagt ggcgatgggg
      841 tatccagtca gccatgaaca ctagcatcgt ccgagacact aaaaccagcc acttcactgt
      901 ggccctgcag ctgggaatcc ctcactcctt tgcactgatc agctatcagc acaaattcca
      961 agatgacgat cagactcgtg tgaaaggatc cctcaaagca ggcttctttg ggacggtggt
     1021 ggagtacgga gctgagagga agatctccag gcacagcgtt ttgggtgcag ctgtcagcgt
     1081 tggagttcca cagggtgttt ctctcaaagt caagctcaac agggccagtc agacatactt
     1141 cttccctatt cacttgacgg accagcttct gcccagcgcc atgttctatg ccaccgtggg
     1201 gcctctagtg gtctactttg ccatgcaccg tctgatcatc aaaccatacc tcagggctca
     1261 gaaagagaag gaattggaga agcagaggga aagcgccgcc accgatgtgc tgcagaagaa
     1321 gcaagaggcg gagtccgctg tccggctgat gcaggaatct gtccgaagga taattgaggc
     1381 agaagagtcc agaatgggcc tcatcatcgt caatgcctgg tacgggaagt ttgtcaatga
     1441 caagagcagg aagagcgaga aggtgaaggt gattgacgtg actgtgcccc tgcagtgcct
     1501 ggtgaaggac tcgaagctca tcctcacgga ggcctccaag gctgggctgc ctggctttta
     1561 tgacccgtgt gtgggggaag agaagaacct gaaagtgctc tatcagttcc ggggcgtcct
     1621 gcatcaggtg atggtgctgg acagtgaggc cctccggata ccaaagcagt cccacaggat
     1681 cgatacagat ggataaactg ccaagaacca gatttttaaa aggccgcaaa aaatcttttc
     1741 ctgggagtct acaaatttgg aaatgaaaaa acccagacat cagatgtttt tattttatat
     1801 tattattata gaaggtggta ccattatcaa ttatgtgaag ggacatgcag acaccccagc
     1861 ttttgagggt gctgggggta ggactgaggc agccccactg ggaaccagac tgcagcctgg
     1921 cccatggctg ttttcccaag gatcagttcc tggagggaag ggctctggcc ctgactccgc
     1981 tgtgtcccga gcacacgtgc tgaccgcagc ccgccgccct gtagttcttg gctgggtctg
     2041 gaggtgtctg tggagcaccc tgccctcacc acaggagcgt gagccacttc tgcagtccac
     2101 gctgaacatg ggaaacaacc tgaaaagcag gcaggcctcc cggtcaggga gcctctgctg
     2161 tgctggcttc ccatgaccac ctcctcttgc tgaaatatta ctgcttgaat ctggagcaga
     2221 ttgcgggttt ataaaactgc tttttatctg agaacaaacg ggtttggaaa ttagtcgtct
     2281 tttttcccca ctcccagagc tgctcaagtc attccaccgg ccccctcggc ttgggacagg
     2341 gtagtgtaac tcccgatccc agggcctagc cctgacacag gtggcttccc gtatcccggt
     2401 gggaaaacgc cctgccacca gcgggcttga gctggcctgt gtccctccac cgcctgcacc
     2461 acccacctcc agagtgcagt gctgggcaag ggcagctcaa gaggacagga ccaggcgctt
     2521 ggcaagacat cagacacacc caacccaaag gcgtggaccc caggcccggc ccgtggtacc
     2581 cagcaggtgg cactgcagct ccccgctcct gcaggtccag cgtcctcaca ggaacaccag
     2641 ggcctgtgct ccggagcctt ccttcagacc cttcctccac gtgcccactt gggatgcaga
     2701 atgcagcgga gctaggaccc cctccacggc ctggacctcg gctgcagtaa agttacgtga
     2761 ggcctgtctc tcggggcctg gaagtggcag ccatcagttg ctcttgctga cccctcggag
     2821 caagcgccgc acaggtggtg gctgagacag ctggcgcggg gggccccaag ctgcgccggc
     2881 ctccagccca cccacagctg ttgctgaagt caggcctccc tccccagcac tggtatctga
     2941 gtaacggcta agaacctcct tcctctggtt ttgaaaagca gttcgggttg tccaattctg
     3001 taacattcat ctccattttt taaaaaggtt tctctgacgg ccccacggcc cgagccgcgg
     3061 tgagcgtcgt gttgcatgag cctgggcccc gggcttcccg tgcgcctctg ccgcaggtgc
     3121 ttctgggcac ccatcctctg cgtttcattt gcagtcgact gtacagaagg cactcaccac
     3181 aataaacctt tcctgaaagc a
//
