LOCUS       NP_060668                559 aa            linear   PRI 20-SEP-2024
DEFINITION  dnaJ homolog subfamily C member 11 [Homo sapiens].
ACCESSION   NP_060668
VERSION     NP_060668.2
DBSOURCE    REFSEQ: accession NM_018198.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 559)
  AUTHORS   Wang,B., Chen,H., Deng,Y., Chen,H., Xing,L., Guo,Y., Wang,M. and
            Chen,J.
  TITLE     CircDNAJC11 interacts with TAF15 to promote breast cancer
            progression via enhancing MAPK6 expression and activating the MAPK
            signaling pathway
  JOURNAL   J Transl Med 21 (1), 186 (2023)
   PUBMED   36895010
  REMARK    GeneRIF: CircDNAJC11 interacts with TAF15 to promote breast cancer
            progression via enhancing MAPK6 expression and activating the MAPK
            signaling pathway.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 559)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (residues 1 to 559)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (residues 1 to 559)
  AUTHORS   Huynen,M.A., Muhlmeister,M., Gotthardt,K., Guerrero-Castillo,S. and
            Brandt,U.
  TITLE     Evolution and structural organization of the mitochondrial contact
            site (MICOS) complex and the mitochondrial intermembrane space
            bridging (MIB) complex
  JOURNAL   Biochim Biophys Acta 1863 (1), 91-101 (2016)
   PUBMED   26477565
REFERENCE   5  (residues 1 to 559)
  AUTHORS   Guarani,V., McNeill,E.M., Paulo,J.A., Huttlin,E.L., Frohlich,F.,
            Gygi,S.P., Van Vactor,D. and Harper,J.W.
  TITLE     QIL1 is a novel mitochondrial protein required for MICOS complex
            stability and cristae morphology
  JOURNAL   Elife 4, e06265 (2015)
   PUBMED   25997101
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 559)
  AUTHORS   Kneissl,J., Wachtler,V., Chua,N.H. and Bolle,C.
  TITLE     OWL1: an Arabidopsis J-domain protein involved in perception of
            very low light fluences
  JOURNAL   Plant Cell 21 (10), 3212-3225 (2009)
   PUBMED   19808946
REFERENCE   7  (residues 1 to 559)
  AUTHORS   Xie,J., Marusich,M.F., Souda,P., Whitelegge,J. and Capaldi,R.A.
  TITLE     The mitochondrial inner membrane protein mitofilin exists as a
            complex with SAM50, metaxins 1 and 2, coiled-coil-helix
            coiled-coil-helix domain-containing protein 3 and 6 and DnaJC11
  JOURNAL   FEBS Lett 581 (18), 3545-3549 (2007)
   PUBMED   17624330
  REMARK    GeneRIF: mitofilin helps regulate mitochondrial morphology and at
            least four of the associated proteins (metaxins 1 and 2, SAM50 and
            CHCHD3) have been implicated in protein import; DnaJC11 is a
            chaperone-like protein that may have a similar role
REFERENCE   8  (residues 1 to 559)
  AUTHORS   Kaltenbach,L.S., Romero,E., Becklin,R.R., Chettier,R., Bell,R.,
            Phansalkar,A., Strand,A., Torcassi,C., Savage,J., Hurlburt,A.,
            Cha,G.H., Ukani,L., Chepanoske,C.L., Zhen,Y., Sahasrabudhe,S.,
            Olson,J., Kurschner,C., Ellerby,L.M., Peltier,J.M., Botas,J. and
            Hughes,R.E.
  TITLE     Huntingtin interacting proteins are genetic modifiers of
            neurodegeneration
  JOURNAL   PLoS Genet 3 (5), e82 (2007)
   PUBMED   17500595
REFERENCE   9  (residues 1 to 559)
  AUTHORS   Henrich,K.O., Claas,A., Praml,C., Benner,A., Mollenhauer,J.,
            Poustka,A., Schwab,M. and Westermann,F.
  TITLE     Allelic variants of CAMTA1 and FLJ10737 within a commonly deleted
            region at 1p36 in neuroblastoma
  JOURNAL   Eur J Cancer 43 (3), 607-616 (2007)
   PUBMED   17222547
  REMARK    GeneRIF: no evidence for somatic mutations in CAMTA1 in
            neuroblastoma
REFERENCE   10 (residues 1 to 559)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     Identification and characterization of FLJ10737 and CAMTA1 genes on
            the commonly deleted region of neuroblastoma at human chromosome
            1p36.31-p36.23
  JOURNAL   Int J Oncol 23 (4), 1219-1224 (2003)
   PUBMED   12964007
  REMARK    GeneRIF: FLJ10737 and CAMTA1 genes on 1p36.31-p36.23 are candidate
            tumor suppressor genes of neuroblastoma
            GeneRIF: FLJ10737 protein consists of the DnaJ domain, bipartite
            NLS, FADH domain, and FEMCA domain.  Mouse E030019A03, zebrafish
            MGC55845, Drosophila CG8531 and Arabidopsis At2g35720 were homologs
            of human FLJ10737.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB461237.1, AL159177.13, AL031447.4 and AF306695.1.
            
            On Dec 10, 2008 this sequence version replaced NP_060668.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC006086.1, AL833841.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000377577.10/ ENSP00000366800.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..559
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.31"
     Protein         1..559
                     /product="dnaJ homolog subfamily C member 11"
                     /note="novel DnaJ domain-containing protein; DnaJ (Hsp40)
                     homolog, subfamily C, member 11"
                     /calculated_mol_wt=63147
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylalanine.
                     /evidence=ECO:0007744|PubMed:22814378; propagated from
                     UniProtKB/Swiss-Prot (Q9NVH1.2)"
     Region          14..79
                     /region_name="DnaJ"
                     /note="DnaJ domain; pfam00226"
                     /db_xref="CDD:395170"
     Site            order(42..44,56,59..60,63..64)
                     /site_type="other"
                     /note="HSP70 interaction site [polypeptide binding]"
                     /db_xref="CDD:99751"
     Site            204
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q5U458; propagated from
                     UniProtKB/Swiss-Prot (Q9NVH1.2)"
     Region          410..549
                     /region_name="DnaJ-like_C11_C"
                     /note="DnaJ-like protein C11, C-terminal; pfam11875"
                     /db_xref="CDD:463378"
     CDS             1..559
                     /gene="DNAJC11"
                     /gene_synonym="dJ126A5.1"
                     /coded_by="NM_018198.4:17..1696"
                     /db_xref="CCDS:CCDS87.1"
                     /db_xref="GeneID:55735"
                     /db_xref="HGNC:HGNC:25570"
                     /db_xref="MIM:614827"
ORIGIN      
        1 matalseeel dnedyyslln vrreasseel kaayrrlcml yhpdkhrdpe lksqaerlfn
       61 lvhqayevls dpqtraiydi ygkrglemeg wevverrrtp aeireeferl qrereerrlq
      121 qrtnpkgtis vgvdatdlfd rydeeyedvs gssfpqiein kmhisqsiea pltatdtail
      181 sgslstqngn gggsinfalr rvtsakgwge lefgagdlqg plfglklfrn ltprcfvttn
      241 calqfssrgi rpglttvlar nldkntvgyl qwrwgiqsam ntsivrdtkt shftvalqlg
      301 iphsfalisy qhkfqdddqt rvkgslkagf fgtvveygae rkisrhsvlg aavsvgvpqg
      361 vslkvklnra sqtyffpihl tdqllpsamf yatvgplvvy famhrliikp ylraqkekel
      421 ekqresaatd vlqkkqeaes avrlmqesvr riieaeesrm gliivnawyg kfvndksrks
      481 ekvkvidvtv plqclvkdsk lilteaskag lpgfydpcvg eeknlkvlyq frgvlhqvmv
      541 ldsealripk qshridtdg
//
