LOCUS       NM_018981              20144 bp    mRNA    linear   PRI 10-OCT-2024
DEFINITION  Homo sapiens DnaJ heat shock protein family (Hsp40) member C10
            (DNAJC10), transcript variant 1, mRNA.
ACCESSION   NM_018981
VERSION     NM_018981.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 20144)
  AUTHORS   Cao,L., Liu,H., Han,Z., Huang,C., Guo,C., Zhao,L., Gao,C., Xu,Y.,
            Wang,G., Feng,Z. and Li,S.
  TITLE     MCM8 promotes lung cancer progression through upregulating DNAJC10
  JOURNAL   J Cell Mol Med 28 (12), e18488 (2024)
   PUBMED   39031896
  REMARK    GeneRIF: MCM8 promotes lung cancer progression through upregulating
            DNAJC10.
REFERENCE   2  (bases 1 to 20144)
  AUTHORS   Li,M., Wu,X., Chen,M., Hao,S., Yu,Y., Li,X., Zhao,E., Xu,M., Yu,Z.,
            Wang,Z., Xu,N., Jin,C. and Yin,Y.
  TITLE     DNAJC10 maintains survival and self-renewal of leukemia stem cells
            through PERK branch of the unfolded protein response
  JOURNAL   Haematologica 109 (3), 751-764 (2024)
   PUBMED   37496439
  REMARK    GeneRIF: DNAJC10 maintains survival and self-renewal of leukemia
            stem cells through PERK branch of the unfolded protein response.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 20144)
  AUTHORS   Cai,X., Ito,S., Noi,K., Inoue,M., Ushioda,R., Kato,Y., Nagata,K.
            and Inaba,K.
  TITLE     Mechanistic characterization of disulfide bond reduction of an ERAD
            substrate mediated by cooperation between ERdj5 and BiP
  JOURNAL   J Biol Chem 299 (11), 105274 (2023)
   PUBMED   37739037
  REMARK    GeneRIF: Mechanistic characterization of disulfide bond reduction
            of an ERAD substrate mediated by cooperation between ERdj5 and BiP.
REFERENCE   4  (bases 1 to 20144)
  AUTHORS   Liu,F., Tu,Z., Liu,J., Long,X., Xiao,B., Fang,H., Huang,K. and
            Zhu,X.
  TITLE     DNAJC10 correlates with tumor immune characteristics and predicts
            the prognosis of glioma patients
  JOURNAL   Biosci Rep 42 (1) (2022)
   PUBMED   34988580
  REMARK    GeneRIF: DNAJC10 correlates with tumor immune characteristics and
            predicts the prognosis of glioma patients.
REFERENCE   5  (bases 1 to 20144)
  AUTHORS   Aguila,M., Bellingham,J., Athanasiou,D., Bevilacqua,D., Duran,Y.,
            Maswood,R., Parfitt,D.A., Iwawaki,T., Spyrou,G., Smith,A.J.,
            Ali,R.R. and Cheetham,M.E.
  TITLE     AAV-mediated ERdj5 overexpression protects against P23H rhodopsin
            toxicity
  JOURNAL   Hum Mol Genet 29 (8), 1310-1318 (2020)
   PUBMED   32196553
  REMARK    GeneRIF: AAV-mediated ERdj5 overexpression protects against P23H
            rhodopsin toxicity.
REFERENCE   6  (bases 1 to 20144)
  AUTHORS   Dong,M., Bridges,J.P., Apsley,K., Xu,Y. and Weaver,T.E.
  TITLE     ERdj4 and ERdj5 are required for endoplasmic reticulum-associated
            protein degradation of misfolded surfactant protein C
  JOURNAL   Mol Biol Cell 19 (6), 2620-2630 (2008)
   PUBMED   18400946
  REMARK    GeneRIF: ERdj4 and ERdj5 promote turnover of misfolded SP-C and
            this activity is dependent on their ability to stimulate BiP ATPase
            activity.
REFERENCE   7  (bases 1 to 20144)
  AUTHORS   Corazzari,M., Lovat,P.E., Armstrong,J.L., Fimia,G.M., Hill,D.S.,
            Birch-Machin,M., Redfern,C.P. and Piacentini,M.
  TITLE     Targeting homeostatic mechanisms of endoplasmic reticulum stress to
            increase susceptibility of cancer cells to fenretinide-induced
            apoptosis: the role of stress proteins ERdj5 and ERp57
  JOURNAL   Br J Cancer 96 (7), 1062-1071 (2007)
   PUBMED   17353921
REFERENCE   8  (bases 1 to 20144)
  AUTHORS   Gu,S.H., Chen,J.Z., Ying,K., Wang,S., Jin,W., Qian,J., Zhao,E.P.,
            Xie,Y. and Mao,Y.M.
  TITLE     Cloning and identification of a novel cDNA which encodes a putative
            protein with a DnaJ domain and a thioredoxin active motif, human
            macrothioredoxin
  JOURNAL   Biochem Genet 41 (7-8), 245-253 (2003)
   PUBMED   14587667
  REMARK    GeneRIF: The organization of the functional motifs of hMTHr
            suggests that the protein might be a member of a molecular
            chaperone family.
REFERENCE   9  (bases 1 to 20144)
  AUTHORS   Hosoda,A., Kimata,Y., Tsuru,A. and Kohno,K.
  TITLE     JPDI, a novel endoplasmic reticulum-resident protein containing
            both a BiP-interacting J-domain and thioredoxin-like motifs
  JOURNAL   J Biol Chem 278 (4), 2669-2676 (2003)
   PUBMED   12446677
  REMARK    GeneRIF: JPDI may have roles in folding of some proteins in the ER,
            chaperoning by BiP and formation of proper disulfide bonds
REFERENCE   10 (bases 1 to 20144)
  AUTHORS   Cunnea,P.M., Miranda-Vizuete,A., Bertoli,G., Simmen,T.,
            Damdimopoulos,A.E., Hermann,S., Leinonen,S., Huikko,M.P.,
            Gustafsson,J.A., Sitia,R. and Spyrou,G.
  TITLE     ERdj5, an endoplasmic reticulum (ER)-resident protein containing
            DnaJ and thioredoxin domains, is expressed in secretory cells or
            following ER stress
  JOURNAL   J Biol Chem 278 (2), 1059-1066 (2003)
   PUBMED   12411443
  REMARK    GeneRIF: ERdj5 is a ubiquitous protein localized in the ER and is
            particularly abundant in secretory cells. Its transcription is
            induced during ER stress, suggesting potential roles for ERdj5 in
            protein folding and translocation across the ER membrane.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC073951.5, AC105396.2 and
            KF456753.1.
            
            On May 17, 2019 this sequence version replaced NM_018981.3.
            
            Summary: This gene encodes an endoplasmic reticulum co-chaperone
            which is part of the endoplasmic reticulum-associated degradation
            complex involved in recognizing and degrading misfolded proteins.
            The encoded protein reduces incorrect disulfide bonds in misfolded
            glycoproteins. Alternatively spliced transcript variants encoding
            multiple isoforms have been observed for this gene. [provided by
            RefSeq, Oct 2012].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.191882.1,
                                           SRR1803616.221825.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000264065.12/ ENSP00000264065.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-227               AC073951.5         143285-143511
            228-284             AC073951.5         144044-144100
            285-634             AC073951.5         144969-145318
            635-797             AC073951.5         147035-147197
            798-848             AC073951.5         149053-149103
            849-931             AC073951.5         155604-155686
            932-1063            AC073951.5         155891-156022
            1064-1157           AC073951.5         156876-156969
            1158-1235           AC073951.5         158058-158135
            1236-1279           AC073951.5         159527-159570
            1280-1417           AC073951.5         163277-163414
            1418-1507           AC105396.2         3397-3486
            1508-1621           AC105396.2         4341-4454
            1622-1736           AC105396.2         6696-6810
            1737-1752           AC105396.2         14756-14771
            1753-1864           KF456753.1         277-388             c
            1865-1981           AC105396.2         15170-15286
            1982-2083           AC105396.2         18101-18202
            2084-2239           AC105396.2         19412-19567
            2240-2373           AC105396.2         20790-20923
            2374-2427           AC105396.2         21935-21988
            2428-2575           AC105396.2         22258-22405
            2576-2695           AC105396.2         25780-25899
            2696-2800           AC105396.2         38414-38518
            2801-20144          AC105396.2         40219-57562
FEATURES             Location/Qualifiers
     source          1..20144
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q32.1"
     gene            1..20144
                     /gene="DNAJC10"
                     /gene_synonym="ERdj5; JPDI; MTHr; PDIA19"
                     /note="DnaJ heat shock protein family (Hsp40) member C10"
                     /db_xref="GeneID:54431"
                     /db_xref="HGNC:HGNC:24637"
                     /db_xref="MIM:607987"
     exon            1..227
                     /gene="DNAJC10"
                     /gene_synonym="ERdj5; JPDI; MTHr; PDIA19"
                     /inference="alignment:Splign:2.1.0"
     exon            228..284
                     /gene="DNAJC10"
                     /gene_synonym="ERdj5; JPDI; MTHr; PDIA19"
                     /inference="alignment:Splign:2.1.0"
     exon            285..634
                     /gene="DNAJC10"
                     /gene_synonym="ERdj5; JPDI; MTHr; PDIA19"
                     /inference="alignment:Splign:2.1.0"
     CDS             431..2812
                     /gene="DNAJC10"
                     /gene_synonym="ERdj5; JPDI; MTHr; PDIA19"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; J-domain-containing protein disulfide
                     isomerase-like protein; ER-resident protein ERdj5; dnaJ
                     homolog subfamily C member 10; macrothioredoxin; protein
                     disulfide isomerase family A, member 19; endoplasmic
                     reticulum DNA J domain-containing protein 5; DnaJ (Hsp40)
                     homolog, subfamily C, member 10"
                     /codon_start=1
                     /product="dnaJ homolog subfamily C member 10 isoform 1
                     precursor"
                     /protein_id="NP_061854.1"
                     /db_xref="CCDS:CCDS33345.1"
                     /db_xref="GeneID:54431"
                     /db_xref="HGNC:HGNC:24637"
                     /db_xref="MIM:607987"
                     /translation="MGVWLNKDDYIRDLKRIILCFLIVYMAILVGTDQDFYSLLGVSK
                     TASSREIRQAFKKLALKLHPDKNPNNPNAHGDFLKINRAYEVLKDEDLRKKYDKYGEK
                     GLEDNQGGQYESWNYYRYDFGIYDDDPEIITLERREFDAAVNSGELWFVNFYSPGCSH
                     CHDLAPTWRDFAKEVDGLLRIGAVNCGDDRMLCRMKGVNSYPSLFIFRSGMAPVKYHG
                     DRSKESLVSFAMQHVRSTVTELWTGNFVNSIQTAFAAGIGWLITFCSKGGDCLTSQTR
                     LRLSGMLDGLVNVGWMDCATQDNLCKSLDITTSTTAYFPPGATLNNKEKNSILFLNSL
                     DAKEIYLEVIHNLPDFELLSANTLEDRLAHHRWLLFFHFGKNENSNDPELKKLKTLLK
                     NDHIQVGRFDCSSAPDICSNLYVFQPSLAVFKGQGTKEYEIHHGKKILYDILAFAKES
                     VNSHVTTLGPQNFPANDKEPWLVDFFAPWCPPCRALLPELRRASNLLYGQLKFGTLDC
                     TVHEGLCNMYNIQAYPTTVVFNQSNIHEYEGHHSAEQILEFIEDLMNPSVVSLTPTTF
                     NELVTQRKHNEVWMVDFYSPWCHPCQVLMPEWKRMARTLTGLINVGSIDCQQYHSFCA
                     QENVQRYPEIRFFPPKSNKAYHYHSYNGWNRDAYSLRIWGLGFLPQVSTDLTPQTFSE
                     KVLQGKNHWVIDFYAPWCGPCQNFAPEFELLARMIKGKVKAGKVDCQAYAQTCQKAGI
                     RAYPTVKFYFYERAKRNFQEEQINTRDAKAIAALISEKLETLRNQGKRNKDEL"
     exon            635..797
                     /gene="DNAJC10"
                     /gene_synonym="ERdj5; JPDI; MTHr; PDIA19"
                     /inference="alignment:Splign:2.1.0"
     exon            798..848
                     /gene="DNAJC10"
                     /gene_synonym="ERdj5; JPDI; MTHr; PDIA19"
                     /inference="alignment:Splign:2.1.0"
     exon            849..931
                     /gene="DNAJC10"
                     /gene_synonym="ERdj5; JPDI; MTHr; PDIA19"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1063
                     /gene="DNAJC10"
                     /gene_synonym="ERdj5; JPDI; MTHr; PDIA19"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1157
                     /gene="DNAJC10"
                     /gene_synonym="ERdj5; JPDI; MTHr; PDIA19"
                     /inference="alignment:Splign:2.1.0"
     exon            1158..1235
                     /gene="DNAJC10"
                     /gene_synonym="ERdj5; JPDI; MTHr; PDIA19"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..1279
                     /gene="DNAJC10"
                     /gene_synonym="ERdj5; JPDI; MTHr; PDIA19"
                     /inference="alignment:Splign:2.1.0"
     exon            1280..1417
                     /gene="DNAJC10"
                     /gene_synonym="ERdj5; JPDI; MTHr; PDIA19"
                     /inference="alignment:Splign:2.1.0"
     exon            1418..1507
                     /gene="DNAJC10"
                     /gene_synonym="ERdj5; JPDI; MTHr; PDIA19"
                     /inference="alignment:Splign:2.1.0"
     exon            1508..1621
                     /gene="DNAJC10"
                     /gene_synonym="ERdj5; JPDI; MTHr; PDIA19"
                     /inference="alignment:Splign:2.1.0"
     exon            1622..1736
                     /gene="DNAJC10"
                     /gene_synonym="ERdj5; JPDI; MTHr; PDIA19"
                     /inference="alignment:Splign:2.1.0"
     exon            1737..1864
                     /gene="DNAJC10"
                     /gene_synonym="ERdj5; JPDI; MTHr; PDIA19"
                     /inference="alignment:Splign:2.1.0"
     exon            1865..1981
                     /gene="DNAJC10"
                     /gene_synonym="ERdj5; JPDI; MTHr; PDIA19"
                     /inference="alignment:Splign:2.1.0"
     exon            1982..2083
                     /gene="DNAJC10"
                     /gene_synonym="ERdj5; JPDI; MTHr; PDIA19"
                     /inference="alignment:Splign:2.1.0"
     exon            2084..2239
                     /gene="DNAJC10"
                     /gene_synonym="ERdj5; JPDI; MTHr; PDIA19"
                     /inference="alignment:Splign:2.1.0"
     exon            2240..2373
                     /gene="DNAJC10"
                     /gene_synonym="ERdj5; JPDI; MTHr; PDIA19"
                     /inference="alignment:Splign:2.1.0"
     exon            2374..2427
                     /gene="DNAJC10"
                     /gene_synonym="ERdj5; JPDI; MTHr; PDIA19"
                     /inference="alignment:Splign:2.1.0"
     exon            2428..2575
                     /gene="DNAJC10"
                     /gene_synonym="ERdj5; JPDI; MTHr; PDIA19"
                     /inference="alignment:Splign:2.1.0"
     exon            2576..2695
                     /gene="DNAJC10"
                     /gene_synonym="ERdj5; JPDI; MTHr; PDIA19"
                     /inference="alignment:Splign:2.1.0"
     exon            2696..2800
                     /gene="DNAJC10"
                     /gene_synonym="ERdj5; JPDI; MTHr; PDIA19"
                     /inference="alignment:Splign:2.1.0"
     exon            2801..20144
                     /gene="DNAJC10"
                     /gene_synonym="ERdj5; JPDI; MTHr; PDIA19"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4166..4171
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DNAJC10"
                     /gene_synonym="ERdj5; JPDI; MTHr; PDIA19"
                     /note="hexamer: ATTAAA"
     polyA_site      4193
                     /gene="DNAJC10"
                     /gene_synonym="ERdj5; JPDI; MTHr; PDIA19"
                     /note="major polyA site"
     regulatory      5264..5269
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DNAJC10"
                     /gene_synonym="ERdj5; JPDI; MTHr; PDIA19"
                     /note="hexamer: AATAAA"
     polyA_site      5287
                     /gene="DNAJC10"
                     /gene_synonym="ERdj5; JPDI; MTHr; PDIA19"
     regulatory      6190..6195
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DNAJC10"
                     /gene_synonym="ERdj5; JPDI; MTHr; PDIA19"
                     /note="hexamer: AATAAA"
     polyA_site      6214
                     /gene="DNAJC10"
                     /gene_synonym="ERdj5; JPDI; MTHr; PDIA19"
     regulatory      7095..7100
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DNAJC10"
                     /gene_synonym="ERdj5; JPDI; MTHr; PDIA19"
                     /note="hexamer: AATAAA"
     polyA_site      7116
                     /gene="DNAJC10"
                     /gene_synonym="ERdj5; JPDI; MTHr; PDIA19"
     regulatory      9654..9659
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DNAJC10"
                     /gene_synonym="ERdj5; JPDI; MTHr; PDIA19"
                     /note="hexamer: AATAAA"
     polyA_site      9679
                     /gene="DNAJC10"
                     /gene_synonym="ERdj5; JPDI; MTHr; PDIA19"
     regulatory      10944..10949
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DNAJC10"
                     /gene_synonym="ERdj5; JPDI; MTHr; PDIA19"
                     /note="hexamer: AATAAA"
     polyA_site      10962
                     /gene="DNAJC10"
                     /gene_synonym="ERdj5; JPDI; MTHr; PDIA19"
     regulatory      20120..20125
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DNAJC10"
                     /gene_synonym="ERdj5; JPDI; MTHr; PDIA19"
                     /note="hexamer: AATAAA"
     polyA_site      20144
                     /gene="DNAJC10"
                     /gene_synonym="ERdj5; JPDI; MTHr; PDIA19"
ORIGIN      
        1 cccggctcgc cgtggagacc ggcgcgtgag gaacctaccg gtaccggccg cgcgctggta
       61 gtcgccggtg tggctgcacc tcaccaatcc cgtgcgccgc ggctgggccg tcggagagtg
      121 cgtgtgcttc tctcctgcac gcggtgcttg ggctcggcca ggcggggtcc gccgccaggg
      181 tttgaggatg ggggagtagc tacaggaagc gaccccgcga tggcaaggta tatttttgtg
      241 gaatgaaaag gaagtattag aaatgagctg aagaccattc acagattaat atttttgggg
      301 acagatttgt gatgcttgat tcacccttga agtaatgtag acagaagttc tcaaatttgc
      361 atattacatc aactggaacc agcagtgaat cttaatgttc acttaaatca gaacttgcat
      421 aagaaagaga atgggagtct ggttaaataa agatgactat atcagagact tgaaaaggat
      481 cattctctgt tttctgatag tgtatatggc cattttagtg ggcacagatc aggattttta
      541 cagtttactt ggagtgtcca aaactgcaag cagtagagaa ataagacaag ctttcaagaa
      601 attggcattg aagttacatc ctgataaaaa cccgaataac ccaaatgcac atggcgattt
      661 tttaaaaata aatagagcat atgaagtact caaagatgaa gatctacgga aaaagtatga
      721 caaatatgga gaaaagggac ttgaggataa tcaaggtggc cagtatgaaa gctggaacta
      781 ttatcgttat gattttggta tttatgatga tgatcctgaa atcataacat tggaaagaag
      841 agaatttgat gctgctgtta attctggaga actgtggttt gtaaattttt actccccagg
      901 ctgttcacac tgccatgatt tagctcccac atggagagac tttgctaaag aagtggatgg
      961 gttacttcga attggagctg ttaactgtgg tgatgataga atgctttgcc gaatgaaagg
     1021 agtcaacagc tatcccagcc tcttcatttt tcggtctgga atggccccag tgaaatatca
     1081 tggagacaga tcaaaggaga gtttagtgag ttttgcaatg cagcatgtta gaagtacagt
     1141 gacagaactt tggacaggaa attttgtcaa ctccatacaa actgcttttg ctgctggtat
     1201 tggctggctg atcacttttt gttcaaaagg aggagattgt ttgacttcac agacacgact
     1261 caggcttagt ggcatgttgg atggtcttgt taatgtagga tggatggact gtgccaccca
     1321 ggataacctt tgtaaaagct tagatattac aacaagtact actgcttatt ttcctcctgg
     1381 agccacttta aataacaaag agaaaaacag tattttgttt ctcaactcat tggatgctaa
     1441 agaaatatat ttggaagtaa tacataatct tccagatttt gaactacttt cggcaaacac
     1501 actagaggat cgtttggctc atcatcggtg gctgttattt tttcattttg gaaaaaatga
     1561 aaattcaaat gatcctgagc tgaaaaaact aaaaactcta cttaaaaatg atcatattca
     1621 agttggcagg tttgactgtt cctctgcacc agacatctgt agtaatctgt atgtttttca
     1681 gccgtctcta gcagtattta aaggacaagg aaccaaagaa tatgaaattc atcatggaaa
     1741 gaagattcta tatgatatac ttgcctttgc caaagaaagt gtgaattctc atgttaccac
     1801 gcttggacct caaaattttc ctgccaatga caaagaacca tggcttgttg atttctttgc
     1861 cccctggtgt ccaccatgtc gagctttact accagagtta cgaagagcat caaatcttct
     1921 ttatggtcag cttaagtttg gtacactaga ttgtacagtt catgagggac tctgtaacat
     1981 gtataacatt caggcttatc caacaacagt ggtattcaac cagtccaaca ttcatgagta
     2041 tgaaggacat cactctgctg aacaaatctt ggagttcata gaggatctta tgaatccttc
     2101 agtggtctcc cttacaccca ccaccttcaa cgaactagtt acacaaagaa aacacaacga
     2161 agtctggatg gttgatttct attctccgtg gtgtcatcct tgccaagtct taatgccaga
     2221 atggaaaaga atggcccgga cattaactgg actgatcaac gtgggcagta tagattgcca
     2281 acagtatcat tctttttgtg cccaggaaaa cgttcaaaga taccctgaga taagattttt
     2341 tcccccaaaa tcaaataaag cttatcatta tcacagttac aatggttgga atagggatgc
     2401 ttattccctg agaatctggg gtctaggatt tttacctcaa gtatccacag atctaacacc
     2461 tcagactttc agtgaaaaag ttctacaagg gaaaaatcat tgggtgattg atttctatgc
     2521 tccttggtgt ggaccttgcc agaattttgc tccagaattt gagctcttgg ctaggatgat
     2581 taaaggaaaa gtgaaagctg gaaaagtaga ctgtcaggct tatgctcaga catgccagaa
     2641 agctgggatc agggcctatc caactgttaa attttatttc tacgaaagag caaagagaaa
     2701 ttttcaagaa gagcagataa ataccagaga tgcaaaagca atcgctgcct taataagtga
     2761 aaaattggaa actctccgaa atcaaggcaa gaggaataag gatgaacttt gataatgttg
     2821 aagatgaaga aaaagtttaa aagaaattct gacagatgac atcagaagac acctatttag
     2881 aatgttacat ttatgatggg aatgaatgaa cattatctta gacttgcagt tgtactgcca
     2941 gaattatcta cagcactggt gtaaaagaag ggtctgcaaa ctttttctgt aaagggccgg
     3001 tttataaata ttttagactt tgcaggctat aatatatggt tcacacatga gaacaagaat
     3061 agagtcatca tgtattcttt gttatttgct tttaacaacc tttaaaaaat attaaaacga
     3121 ttcttagctc agagccatac aaaagtaggc tggattcagt ccatggacca tagattgctg
     3181 tccccctcga cggacttata atgtttcagg tggctggctt gaacatgagt ctgctgtgct
     3241 atctacataa atgtctaagt tgtataaagt ccactttccc ttcacgtttt ttggctgacc
     3301 tgaaaagagg taacttagtt tttggtcact tgttctccta aaaatgctat ccctaaccat
     3361 atatttatat ttcgttttaa aaacacccat gatgtggcac agtaaacaaa ccctgttatg
     3421 ctgtattatt atgaggagat tcttcattgt tttctttcct tctcaaaggt tgaaaaaatg
     3481 cttttaattt ttcacagccg agaaacagtg cagcagtata tgtgcacaca gtaagtacac
     3541 aaatttgagc aacagtaagt gcacaaattc tgtagtttgc cgtatcatcc aggaaaacct
     3601 gagggaaaaa aattatagca attaactggg cattgtagag tatcctaaat atgttatcaa
     3661 gtatttagag ttctatattt taaagatata tgtgttcatg tattttctga aattgctttc
     3721 atagaaattt tcccactgat agttgatttt tgaggcatct aatatttaca tatttgcctt
     3781 ctgaactttg ttttgacctg tatcctttat ttacattggg tttttctttc gtagttttgg
     3841 tttttcactc ctgtccagtc tatttattat tcaaatagga aaaattactt tacaggttgt
     3901 tttactgtag cttataatga tactgtagtt attccagtta ctagtttact gtcagagggc
     3961 tgcctttttc agataaatat tgacataata actgaagtta tttttataag aaaatcaagt
     4021 atataaatct aggaaaggga tcttctagtt tctgtgttgt ttagactcaa agaatcacaa
     4081 atttgtcagt aacatgtagt tgtttagtta taattcagag tgtacagaat ggtaaaaatt
     4141 ccaatcagtc aaaagaggtc aatgaattaa aaggcttgca actttttcaa aaacctgtta
     4201 gaatatgctt tattgtgttt tgaggagttt tccttttttt cttttcaata tcactttatc
     4261 ctgctcacca gtatttcctc ataagggtta ttatagccat aattaatgtt aaaatagact
     4321 ttgttcttca tattctccca tctttttcgc tactatatac tctgtctgga ttctgctgta
     4381 tgcctgttgg catatatgga acagtcacca cttgtcacac ttaacaccag ctttttgaat
     4441 tatgatcagt aatggcaaga gcctttcatt ctcgaatgtt taaagcctag gagttctaca
     4501 aaattggctt ctttctacaa gaatcccaaa atggaatgcc taaagaagtc ttacttgggt
     4561 aaatacttac taaaatatac tggttatgtg catatcacca cactggacac tgaggagtgt
     4621 tcaaaaggaa tctaagacat ggtccccatc ttccaactgt ctgtaattca ctgttttgtc
     4681 attgagctca taaggtactt acattactac ctataaatgt ttcctgtact tgttagttgt
     4741 tgagaaacat tttaggcagt aaataaaata gtaaatatta tgtgtcctat aatttgacct
     4801 aagctgtgtg cctttggaat cagctctaag ccagggcccc ctgggagtca tgttaagaaa
     4861 cacgtatcat aaagtgacat acatcaaggt tatcttatat agtcataaca gtattattgg
     4921 gtctttcaaa aacagctggc agattgagct tttaatggct atattgatac agtagataga
     4981 gcacctctaa ggagtaccag gtataatgtg ccatttctct cagcaacacc atttttgtgt
     5041 gcagctgacc ctctaacatg gtatcaattc tagctgacca aagcacattc tatcaggcag
     5101 ccaggcttgg aaattaggtc catttaaagt atgtggctta cagtcaggta tggtggtgtg
     5161 cgcctattgt cccatctact tgagaggctg aggcaggagg gattgcttgg gctcaggatt
     5221 ttgaatccag cctgggcaac atagcaagac cccatctcta ataaataaat tatgttttgg
     5281 gcattaatga tgtttgtcta ttctgatttc tcaaatttta tttaggtctt tcatagcttt
     5341 tttatttaaa ggtatatgat taagataaag gaaaagtaaa atgaaatgtt tatgtaattt
     5401 tatattctca aaattttctt taaatttgct ctgttttctg acagtgctca aagtgggaat
     5461 ttttttagaa gtacggttat caaaaaaaca catttcctat gggacacaca tttcaaagat
     5521 gtttagtacg ataaaatttt tagtaaaagg gtagcacttt taagtcattt gaatagaata
     5581 tttgtgtaat atttagtcta gtgttagtcc ttaaatctgc caacaaaacc agatagatgt
     5641 cttaaagtag gcacatttat tccattgtga ctgttaagaa ataataaaag attaaattaa
     5701 caaaatgcat tttaaatttt tatgatacct atagaaaatt gataatgaag atgaaaagta
     5761 aataaccttt ctgataatat tctactttac acatatactg aaaacttact tacatatacc
     5821 caaattcttc tagtgaagaa gtttgtaata tggtttgagt atttgtcccc tccaaatctc
     5881 atgttgaaat atgatcccca gtgttggata tggggcctgg tgggaggtgt ttgggtgatg
     5941 ggggctgatc cctcataaat ggctttgtgc cttccccagt ggtaatgagt tcctgctgtg
     6001 tttattcctg caagagctgg ttgttaaaag gaacttggca ccaccacctc ctctctttct
     6061 cgctccttct ctgtgtgaca tgccttctcc ccccgtgcct tctgccatga gtaaaagctc
     6121 cctgagacct caccagaagc tgagcagatg ctggtgccat gtttttacag cctgcagaac
     6181 tgcaagtcaa ataaacgttt tctttataag gtaaccagtc ccaggtattc cttcattgca
     6241 atgcaaaaca gactaataca gtttcttttc agtaagaatt acaaaattta ggccaatgac
     6301 caagctgagt ataaattact aatcatacac aaaaatgtgt ttcactggct tgagtcattt
     6361 ttctgtttaa cactgaattt acacttagat tcttgtactg tcactgagtc cccttgtaaa
     6421 cagctaggta tattttgtga atggaaacta gccaaaaata cagccaaagt ctcaacgcca
     6481 aactggtcta catcagtatg gactccagaa atgcatcttt caaccacttg attgcattaa
     6541 gtagtcattt gagtgcatca cctagtggcc tttggtcctg aaagttagca atcatcccca
     6601 aaaaggtctg tgttaataac tgatagacaa tcttcattaa gcaactgctg tttttttttt
     6661 ttaatacttc aagttctgca atacatgtgc agaacatgca ggtttgttac ataggtatac
     6721 atgtgccatg gtggtttgct gcacccatca acctgtcatc tacattagct atttcttcta
     6781 atgttgtcct tccccttgcc ccctaccccg ccgacaggcc ccattgttga tgttcccctc
     6841 cctgtgtcca tatgttctca ttgttcaact cccacttacg agtgacaaca tgtggtgttt
     6901 ggttttctgt tcctgttagt ttgctgagaa taatggtttc cggcttcatc cctgtccctg
     6961 caaaggacat gaacgcatcc ttttttatgg ctgcatagta ttccatggtg tgtttgtgcc
     7021 cgtttcttta tccagtctaa cattgatggg cattttggtt ggttccaagt gtttcctatt
     7081 gtgaatagtg ctccaataaa catacgtgtg catgtgtctt tatagtaaaa ttatttataa
     7141 tcctttaggt atatacccag taacgggatt gctgggtcaa atggtatttc tatttctaga
     7201 tccttgagga atcgccacac tgtcttccac aatggttgaa caaatttaca ctcccactaa
     7261 cagtgtaaaa gcattcctat ttctccacat cctctccagc atctgttgtt tcctcacttt
     7321 ttaatgatcg ccattctaac tgatgtgaca tggtatctca ttgtgttttt gatttgcatt
     7381 tctctaatga ccactgatga tgagcttttt ttcatatctt tgttggccac ctaaatgtct
     7441 tcttttgaga agtgtctgtt catatccttt gcccactttt aatgggattt ttttcttgta
     7501 aatttaagtt ccttgtagat tctggatatt agccctttgt cagatggata gattgcaaaa
     7561 agtttctccc attctgtagg ttgcctgttc actctgatca tagtttcttt tgccatgcag
     7621 aagctcttta attagatccc atttatctgt tttggctttt attgccattg cttttggtgt
     7681 tctagtcatg aagtctttgc ccatgcctat gtcctgaatg gtgttgccta ggttttcttc
     7741 taggtttttt atggtttcag accttacatt taagtcttta atctatcaac ttaattttta
     7801 tataaggtgt aaggaagggg tcccagtttc agttttctac atgtggctag cctgttttcc
     7861 caacatcatt tattaaatag ggaatccttt ccccattgct tgtttttgtc aggtttgtca
     7921 aagatcagat ggttgtagaa gtgtggcgtt atttctgagg gctgtgttct gttccattgg
     7981 tctatagctc tgttttggta ccagtaccat gctgttttgg ttactgagcc ttgtagtata
     8041 gttcgttctt tttgcttagg attgccttgg ctatatgggc tctttttttt ttggttccat
     8101 atgaaattta aagtagtttt ttccaattct gtgaagaaag tcaatggtag cttgatggga
     8161 atagcattga atctataaat tactttgggc agtatgacta tttcacaata ttaattcttc
     8221 ctatccatga gcatggaatg ctttttccat ttgtttctgt cctctctcat ttccttgagc
     8281 agtggtttgt agttcttgaa gaggtccttc acgtcccttg taagttgtat tcctaggtat
     8341 ttaattctct ttgtagcaat tgtgaatggg agttcactca cgatttggct ctctgtttgt
     8401 caattattgg tgtataggaa tgcttgtgat ttttgcacat taattttgta tcctgagact
     8461 ttgctgaagt tgcttatcag cttaaggagt ttttgggctg agatgatggg gttttctaaa
     8521 tatacaatta tgtcatctgc aaacagagat aatttgactt cctctcttcc tgtttgaata
     8581 cgctttcttt ctcttgcctg attgtcctgg ccagaacttc cagtacatag gagtggtgag
     8641 agagggcatc cttgtcttgt gccggttttc aaagggaatg cttgcagctt ttgcccattc
     8701 agtatgatat tggctgtggt tttgtcataa atagctctta ttattttgag atatgttcca
     8761 tcatatctag ttttttgagt gtttttagca tgaaagggtg ttaattttat cgaaggcctt
     8821 ttctgcatct attgagataa tcatgttttt gtcataactg ctatttcaaa tgtttggagg
     8881 aagtaaaatg tctttaaaag aataagtgtt gatttttgga aaatatgaaa ttggaaactt
     8941 agaaaacttg aattctaagt ggctatttat attaccaagc ggtaaaacat tagctaacta
     9001 aaacatggtt ctgaagccag ttaactagca aaaagtccca cctatgcatt gaaatatctt
     9061 tctcaagtca ttagataaag tatatggcgt taaggcaaaa aatacatata cacacacaaa
     9121 aaaaatattt cagcagccac tgccaactga aagtaataaa atgaaacaat ttgttggctt
     9181 taatgtattt aggaaaaatc atttatttac aaaacatctt ccctttctta tcatgaaaat
     9241 tatgaagatg aggtaaagtc tgttccattt ttcctctatt tttgagaaat cttagattta
     9301 tctttaccag tctgtaaccc agctttcttg ttttatattt taaatatact ttctattttg
     9361 tgacaggagt gaaaaaatgt ttaatgattt taaacatgtt tatatatatt tttcagactt
     9421 ggaacagcag tatctcatgt tttactataa aaacttgggt atattacttg aagatcaact
     9481 atattgttat ttttagtatg ttagcaattc atctgtcaat aatcaccaaa gaactcaaga
     9541 atgaataaca tgatctatca aaaggcctat aatctcaatc ttcatgttaa gactttggaa
     9601 agttaatttg tattaattaa ctaatataaa ttaatcctat caagttaatt tgtaataaat
     9661 tcaagatgca aaaagaaaac ctatttcact accgaaatta aataaacttt aaaattcatt
     9721 ttgttggctg ggtgcagtag ctcacgccca taatcccagc actttgggag gccaagtgga
     9781 aggatcactt aaggccagga gttcaagacc agcctagcca acatagtgaa accccatctc
     9841 tactaaaaat acaaaaacta gctgggcatg gaggtgtgtg cctgtaatca tctaccctgg
     9901 aggctgagac aggagaattg catgaacccg gaggcaaagg ttgcagtgag cagagatcac
     9961 accactgccc tccagcctgg gtgacggagt aagaccctgt ctaaaaaaaa acaaaacaac
    10021 aaaaaaaatc attttgttgg tattttatat aaacttaaga aacctcccca cacaaacaca
    10081 cacagccata ttgtcatctc tgaagacagc agccacatgt gtcttattcc ctgcagtgtt
    10141 ggcagaacct agcacattgt tgacccgtag aagcacagtg tgtatttcaa ttgacaaaca
    10201 gccagaagta ttatactgtt gactgtgttt aaaactaatt tgccagagct ctactgtgat
    10261 aagaatttct gactagaaat tataaattca ttgttttatg ccttaaaaat tataaataat
    10321 gataagttta atttgcagcc cttatagctt agaggcattg tagttgatat tatagtaacc
    10381 cttttagatg ttagtaactt ttattgtaaa atttaaggta gctctacctg ctaaagtagc
    10441 acctattctt ttgaaaggaa ctttctcaaa ggatttttag ggcttcataa tttcttgttg
    10501 ctctgtgtaa atccctctga taggcttccc tgaaggattt taagcagaaa taacatcagg
    10561 taccagtaga tggcagtgaa aaataagcag acacattttt ctgataaaat gccatttcta
    10621 cctcagtact tgataagaat cacacagtct agctggcctt tgtgttttca ctaaaaatat
    10681 cctgaattat cagtcagtta tgtttgacta tgagaaattg cagaaaagtt aaaagtattt
    10741 cgcatccaaa agtttgtaat ctagtgtaat aaataggaca gatactcaaa gtgtatgaat
    10801 ggtatgacaa taaatttaga aaatcataca ggcacacaca ctgctataga catgtaaaga
    10861 tacatacatg tattggagct cagcagattc ccattcatga agaatggtgc ctgtgtaaca
    10921 gtataaatgg atcacttcta ataaataaaa cataaaattg gactaatagc ttaatttttt
    10981 tttttaattc aaaaatctca gggttttctg gggcttttag tactcctttg tgaaataaga
    11041 cacatagtct tcaggtaaaa agaaagagct cttggtcaca gaaatgggtg tactgaattc
    11101 tcgccctgta gtcaagtact tactatgagt ttggaaaaat tgcttacttc atatctgtat
    11161 cctaattatc ctaattaact cgtttgttaa gtggaaaaaa tatttcagta ggtagtcata
    11221 taaataagat gaggtaatgt gtttagaaaa acaaatcaat gtgcaggcaa gaatcgggaa
    11281 tgtgggaaat tttgtaggac aaatggtatg atttctttaa tgaaaaagac agagaaaggt
    11341 atcgtatagc ttaaaaggaa aaagaaaaag aggcttttca gtcatgagcc aaatgcagta
    11401 tgtgggctat atttgcatct tgatttgaac agactattgt atacatttat atatacatag
    11461 atctatagag acagtaggat atatttcata tatatatgaa acagttgggg aaatcagaat
    11521 atttgaattt gatattaact aagaattgtt tgcaggggat gttgttgcat attctaatga
    11581 ctttttttaa taatgaaaat gtttggcatt tgctttaaaa taatccagta accaggatct
    11641 gagagaaacc aaaaaaaagt ggggagataa taatccaggg actttgggta gttgttaaat
    11701 ggatggctgt atcataagta ttgaagctga taagggatag atatgggttg attatatatt
    11761 tgttttgctg gaaaatgttc catgatacag ttttaataac agttttaatt tcagaaacgc
    11821 aaaatattgt ttttacaact aagataacat tgaaatttat acagaacccc aaatgacaag
    11881 tgtataatca actgccagga aatcagttta cctgttagag gtagaaaagt tacaggataa
    11941 aaatggaatt ggttggcact aagtaggacc actttcgaag agaatgggta gaattcattt
    12001 tcttttcatt acttcctttc agcgtggagc ctgagcatca tttcaccatt ttgagcctca
    12061 agctctcaat atactggaaa attgtaatcc tgttcccttc actgaggtca taatactgaa
    12121 ttctgaaatg gaaataattg actagagatt gtctagtcaa actagactga tgaggtctca
    12181 ccattttctt caaggaagat caactgaacc tgcctgaagg cacagggtac accatcttcc
    12241 taaggtgtga cctcctgttc ccaaaggaat agacctaggt gaccaaccag cagcacctag
    12301 cttttgccag ctacgcagct ttgaatagcc ttccaccctt gtgtccttca aaccccattc
    12361 ttgccaaagc caagttctct ccctccctct caacagattt ctcagcacac atcagatttc
    12421 acaccgatct atgaaaaact atttttagag attattacta tggtccgaat gtttatatcc
    12481 cctcctgctc tccctaaaat tatgttgaaa tcctaacccc caaggtaatg gtattaggaa
    12541 tgtgaggcct ttgggaaggg tttaagtcat gagggcagag acctcctttt tgagattggt
    12601 acacttataa aagagacccc agtatcttgc tcgtcccttc tgccatggga gaacacggtg
    12661 agagcgagcc atctgtaaac caacaaacaa ggccctcacc aggcactcaa tctgccagca
    12721 ctttgatagt ggacttccca gcctccagaa ctatgagaaa taaatgtgtt tttttaagcc
    12781 agccagttca ttttgttata gcagcctgga cagacaatat attgaaaaaa atcagttttg
    12841 cagttccact ggtcaggtga atgccagagg agctggtcca cagtcatagg cgttaaactt
    12901 cttttggaaa ctatactggc ttgacagtct ccccatactg attcagactc cagcaaggtg
    12961 cacatcaccc gctagtcatt gtggcttctg ctgctttaag gttctggaat tatggaagaa
    13021 aatagggtgg gcctactgtc tcttcccact gtttacctgg tgttttgatt ctgaatagtt
    13081 tataagctct gctattcaag aagtttatac aaacccgtaa tgtactacca aaccgttcat
    13141 tcattatgac aaaactgcct accaaagcca cagactttaa gtctttgcag gattaccact
    13201 gaaagttcac atgcttggtt agcagtctta acctctaacc aactgaacaa atcgaagaca
    13261 tttaatttag tcaaaatagg catgggaatg aaagtgagac ttagaggcaa agaatgaggc
    13321 caggtgcggt ggctcacacc tgtaactcca gcactttgga aggcccaggc agaaggattc
    13381 ctgcagacca ggatttcaag accagcctgg acaacctggt gaaacctcct ctctacaaga
    13441 aaattcaaaa attagccagg cgtggtaggg tatgcctgta gtcccagcta cttgggaggc
    13501 tgaggtggga ggactgcttg agcccaggag gtccaggctg cagtgagccg tgatcacacc
    13561 actgcactcc agactgggag gcagaggaag accccgtctc aaaaaacaaa aggtaaagaa
    13621 tgattttagg aattaggtgt ctctaaattg aagtaatgct cacatagaaa aattaaggca
    13681 tattatttta ctgtactctc agaaagatgt ttaacaaata cttgaagagc cactatttaa
    13741 gataaatgag agtcctttcc aatttgagcc tcgcagagtg gttcctacag agaagggtgg
    13801 caagaagggc tgttctgcca tcaatgaggt ggtgacccga gaatatgcca tcagcgtcca
    13861 caagcccatc catggagtgg gattcaagaa gcatacccct cagagcactc aaagagatcc
    13921 ggaagtgtgc cacaaaggaa atgcgcgttg ataccagcct ctacaaagct gtcggggcca
    13981 ggcgaataaa ggatgtccca tgtcttatcc ataagcagta gtccagaaaa catagcgagg
    14041 atgaaaattc accaaacgag ctcttatact ttggttacct atgtacctgt taccacttgc
    14101 agaaatcaac agacaaggtg gatgagaact gtaaatcatc aaataagtta taaaaccacc
    14161 aaaaaatagg agaaaatggg agtaaaaaca aaatgtataa aaagtattaa aatttgaaaa
    14221 atatcttgga aataaggatg gacagtttaa gtacttatct caaaaggaaa aatgttagca
    14281 attggttgta gcaatacgtc cgtctgtaag tgatggtcat atttgtgttc ttttgtccca
    14341 gagaacaaaa ggaagtgagc ttatcccaca gcacaagtaa cgtctattta tctcagagga
    14401 aatccaggga agttcctact tgggaaaacg gaaaggtaga ctattcagaa gttttctaaa
    14461 atggacttca agctctatga ctttatgatc acttagtatg tctacggatt ttttggggaa
    14521 gagagatttc acgttaaagg tcattttgtg tcttctttaa aactcttgat tccttttaga
    14581 gttttttaaa ttgtgataaa gtacatgtaa caaaatttat taatcatttt aaagtagcat
    14641 acagttcagt agtgttaagt aatttcacat tgttcaaccc atctccgtga ctttatcttg
    14701 caaaactgaa attttatatc cataaagcaa aaccttttta tttaccaatg ctgctagacc
    14761 ctgacaacca ccaccctact ttctatcaat atgactacca tagatattta atgtaagtga
    14821 aatcatacac catttatctt tttgtgattc cttattttac ttagcgtaag tcctcgagac
    14881 tcacccatgt tgtagcatgt gtcataattt tcttgttttg agacggagtc ttactctgtc
    14941 cccctggctg gagtgcagtg gtgtgatctc agctcactgc aacctccacc tcccaggttc
    15001 aagcgattct cctgcctcac cctcccaagt agctgggact gcaggcatgt gccaccacgc
    15061 tggctaattt ttgtatgttt aacggagaca aggttttagt gtgttggcca ggctggtctc
    15121 gaactcttga cctcaggtga tccgcctgcc ttggtctccc aaagtgctgg gattacaggc
    15181 gtgagccacc gcacccagcc aattttcttc ctttttaagg ctgaataata ttcaattata
    15241 tatacattct acattttgtt attcgtccgt tgataggctg ccttcaccct ttggccattg
    15301 caaataatgc tgctataaac atgggtgtac aaatatcaga aaccctgctt tcagttcttt
    15361 cagctatata cctagaagtg taagtctata tcatagtaat tctattttta atatgggggg
    15421 acctccatac tgtttttcat agcagctgca ccattttaca ttcccaccaa tagtgcacaa
    15481 gagttctgat ttttccacat cctcaccaac actcattttt tttaaatagt aggtatccca
    15541 atgagtgtgc gttcatatcc cattggagtt ttgatttgta cttttagagt ctttaaatta
    15601 ttactttttc catatcaaag tactttgtgg gaagttggtt attttacatt ctcataccat
    15661 gctttgtatt actttcccat ttggatgccc ttttcatcct tcacctcatc ctgtaaaccc
    15721 aaaatctaac ttaaatccca aatccaactt ccactgtaaa gcctttgctg acttctttac
    15781 ttcacattga tttctgaatt tctaaaagtt cctcattgtc taccacaaaa ctaagtattt
    15841 gtttataaga aaaagcttta tttagtccta tattattctc tgattattcc atatgttatc
    15901 ttccaaacta gattgttagg tcttcaagag cagaagaaat ttattttata cttataaact
    15961 tcaagatttg ctgaagtact ttgggtgcta aatgcttcta gcttattcgt ttagtttaca
    16021 tgactttctg catgtgaaac ttgagaaaac tgcaaatcta ataccttggt cttacagaac
    16081 tgaacaatac ttaaatgtgt ttaaacctgc tatataaaat gtcagatgta aaagcgaata
    16141 tctaatgaag caccttttcc cttttctaaa attcaatagt aagggccagg cacagtggct
    16201 cacacctgaa atcccagcgc tttgggaggc cgaggcgggt ggatcccttg aggttaagag
    16261 ttcaagacca gcctggccaa catggtgaaa cgccgtctct actaaaaata caaaaaaaaa
    16321 tggccaggcg tggtggtgca cgcctgtaat cccagctact tgggagtctg agacaggaaa
    16381 atcgcttgaa cccgggaggc agaggttaca gtgagctgag gtcacgtcac tgtactccag
    16441 cctgggcaac aagagtgaaa ctctatctca aaaaaaaaaa aaaaaattac aatagtaata
    16501 attatgcctt ctaacactaa aatcaaataa ccttacttat cagttacatt gcctactaag
    16561 ctgacttatt ttctgacttt tcctttgctt tattctctta tttcttccaa gtaaccatat
    16621 tctcttttac cctcctgttc aactgtctat gctccttctc tctttgttca ctattttgat
    16681 atttaaatgt tatgacttat tttcaagtaa atattttttt aatttcttca tttgggataa
    16741 aatattcact acataaattt agtggataaa tacccccaca gagatcgacc ctgcatgaaa
    16801 tgtgttccct cagaagtagg gcaattcatt cattatgaga tcaagccata aaatttaaat
    16861 ccaagcagta attctccaat taaagtaact ctagagctta gttttcagtc ctcctgaatc
    16921 ataactagtt ggcaacaaaa actagtatgc cttggtgtga ataaacctta acatagaaac
    16981 tcacccagcc tcaaaagtta aaaattaaga gagatatgta ttcaggtggc catttataca
    17041 caatattttt gaatactatt ctggccaaat tagtataaaa tgggttactc taaaatgaaa
    17101 ttttaaaagt atataaacat cttaaacttt aaaacttcag cccagctaga agtcaacgtg
    17161 tgtttctgaa actatgctgg ggaaagtagc tctgtccata atgattatat agttgttagc
    17221 aaaatattgg tcaaaacttt ttcagtttaa tgagtttcaa gatattcttc aaactggcct
    17281 ctgtgaactc tttcttgaca agtgaaacct ggctccaaca atgactactt tattctacct
    17341 ctcatttatt ttctgtttaa taaatccagt atttgggcat acaaactgta tacaacattt
    17401 tataacactc taatgtggat aagacacctc aaaaacagga gtttagtcat ttcagtcaca
    17461 tgtttctaat acatgataag atttgcagtt atcgtttaat taattgcaat atggaaatag
    17521 atactaaaaa atctaaattg catcttacat ttcaacaatg gatgtttaaa gcgtttaaaa
    17581 gttatgtttt gcattttaca acatattgaa gatacacatt ttaaatttaa ctctaaacaa
    17641 tgcaataatc tagagaatca gagaattgga tcctgaaaca ccttataagt tcagtcctgt
    17701 tgattagtat gtttccctgt cctagagtgc atgaactttc aaagccagga cacaatcttg
    17761 ttcacttttc atgccatcat cttgacactc aatacatgtt caaagagtaa attaaagaaa
    17821 aaagagatgc tcaagtcaat ttataagtaa tcctcacaaa tgcttgcata ccatcagtga
    17881 acaattattt ttttatctcc atgctataat cttgcacaag tttcattaga attaaatgca
    17941 ctatctgaag tctatgttta ttaaatgagg attacagtag ttggttatct ttgtgagggg
    18001 ttttgagggt tgtggaacag gataacattt tgaggtacaa aaaataatga agaggatata
    18061 ttccaatttc tttccttccc caaggctttt cattacagct gttataaacc ctggtagaat
    18121 tgattggttt ccttttcagc ttcctgtttt gtccctcaat gttcacaaaa gtcccatctg
    18181 ataaatgtat tgtttaacct ctcattgttt gaaagaacac ctctttgctc cccacagatt
    18241 acagacctat tggcttaagc agtccatcta aatgcatgcc agtttctttc ttgataaatt
    18301 agaggcctat aacctcaaac cagtttatct gcaagagaag tgtgtgaagt tagactcaat
    18361 tcttccgcta atggaacatc gtaatcctcc ttgtcatctt tcctttggcc ttcctgaata
    18421 gaaatcattt atgaggaagt tacatgagct caacatgagc cccatgtcac tcagcaaaca
    18481 tttatttgag tacttacaat gtgctaggct ttgttctatg catttaagat agtgtattaa
    18541 atgtattgac ctcatgaaga ttctattctc gcagtgggga gatagacaat aaacaattaa
    18601 tataagcaaa tgttaagtat gttagaagta tgttagaaga tgtgctgtga aataaagaaa
    18661 aaggtagacc agggtatgag ggattaggag tgtgggggca gcagcaggag agtttcggta
    18721 ttaaataggg tggacagggc aggtctcttg gagaagatgc cattgaagga ggtggaaaaa
    18781 atgtagccac taaatgggct gagggtagag catatgaaca gagagaaagg ccagaggaca
    18841 ggctccaagg catgcttggc aggttcaagg aacagcaggg aggctcatgt ggctggaatg
    18901 gagtgagcta gcaggagaga agatgaagtt agagggagag agaaagtggg gagccagatc
    18961 atagagggct ttgcaggtca cttgtaagga ctttagcttt ctaacttttg taaggacttc
    19021 aacttctact cacagtgaaa ttgtgaaatt ccagaaccaa aaagaagatc ctggtaaaag
    19081 agaaactttc agcaaaatat atttaacatt ttatttgagt gaagaacaat tcatccatca
    19141 ggcagcactg agaaccagaa gacattcaga gagctctgct ttgcgaggta tgcagtgaac
    19201 attcatagac agaaaacaaa aattaagtac agaaatagct tgattggtta cagataggca
    19261 tttgccttat ttggacatgg tctgctccaa ataaggcaag ttggcagcat gcaattggct
    19321 gtgacctatc tgttacaaaa atatatctat ataatcctaa attaggtttc agtttattta
    19381 agtactaaat taggttgcaa tttattacat gggaactcaa agtctggaga cagcctcagg
    19441 ccaaggtcct cttgcttatt taatttagca atcctaaaat tttccagaga ggaaacacat
    19501 cacacacaca cacacacaca cacacacaca cacacacaca cacactacct acaaaaaaat
    19561 aacaattaga aagtaattgg agcttgaagt attctagaag actttggagc aaagccttcc
    19621 aaattctgag aggaaaatat ttttaaccta ggattctatt catacctacc cagactaaca
    19681 agtagcaggc agatgataaa tatattttta ggtggttagg tgatgaaaca cctcctccaa
    19741 atgaaggcat aaacaacaat gcatggggat ccaagaaaca gtgactccaa cccaagagag
    19801 cagtgaacaa atccacagga cagcagctaa gtaggaggcc taaacatcac ctggggcaga
    19861 tggggcgaga gagcagagag cttgggaaag aagtctctga ggagaaagaa tgaggcaata
    19921 agtcagatgc gtatttgcgg acctcagaaa aatttgagta cataggaaac aatagatgaa
    19981 ggatagaaat aatccattca gattctctcc tttgcatgat gaccacatta aacttacaga
    20041 gtaagaaatg tcattctaga tttgattcta ctgtttgtct ttgcagtgag ctatgttttt
    20101 ttataacatg tagaagtgaa ataaacttgt cacaaaaatg caaa
//
