LOCUS       NM_022365               2100 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens DnaJ heat shock protein family (Hsp40) member C1
            (DNAJC1), mRNA.
ACCESSION   NM_022365
VERSION     NM_022365.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2100)
  AUTHORS   Zhang,H., Zheng,W., Chen,X., Sa,L., Huo,Y., Zhang,L., Shan,L. and
            Wang,T.
  TITLE     DNAJC1 facilitates glioblastoma progression by promoting
            extracellular matrix reorganization and macrophage infiltration
  JOURNAL   J Cancer Res Clin Oncol 150 (6), 315 (2024)
   PUBMED   38909166
  REMARK    GeneRIF: DNAJC1 facilitates glioblastoma progression by promoting
            extracellular matrix reorganization and macrophage infiltration.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2100)
  AUTHORS   Chevalier,B., Baatallah,N., Najm,M., Castanier,S., Jung,V.,
            Pranke,I., Golec,A., Stoven,V., Marullo,S., Antigny,F.,
            Guerrera,I.C., Sermet-Gaudelus,I., Edelman,A. and Hinzpeter,A.
  TITLE     Differential CFTR-Interactome Proximity Labeling Procedures
            Identify Enrichment in Multiple SLC Transporters
  JOURNAL   Int J Mol Sci 23 (16), 8937 (2022)
   PUBMED   36012204
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2100)
  AUTHORS   Lim,S.H., Snider,J., Birimberg-Schwartz,L., Ip,W., Serralha,J.C.,
            Botelho,H.M., Lopes-Pacheco,M., Pinto,M.C., Moutaoufik,M.T.,
            Zilocchi,M., Laselva,O., Esmaeili,M., Kotlyar,M., Lyakisheva,A.,
            Tang,P., Lopez Vazquez,L., Akula,I., Aboualizadeh,F., Wong,V.,
            Grozavu,I., Opacak-Bernardi,T., Yao,Z., Mendoza,M., Babu,M.,
            Jurisica,I., Gonska,T., Bear,C.E., Amaral,M.D. and Stagljar,I.
  TITLE     CFTR interactome mapping using the mammalian membrane two-hybrid
            high-throughput screening system
  JOURNAL   Mol Syst Biol 18 (2), e10629 (2022)
   PUBMED   35156780
REFERENCE   4  (bases 1 to 2100)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 2100)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 2100)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   7  (bases 1 to 2100)
  AUTHORS   Sung,Y.J., Perusse,L., Sarzynski,M.A., Fornage,M., Sidney,S.,
            Sternfeld,B., Rice,T., Terry,J.G., Jacobs,D.R. Jr., Katzmarzyk,P.,
            Curran,J.E., Jeffrey Carr,J., Blangero,J., Ghosh,S., Despres,J.P.,
            Rankinen,T., Rao,D.C. and Bouchard,C.
  TITLE     Genome-wide association studies suggest sex-specific loci
            associated with abdominal and visceral fat
  JOURNAL   Int J Obes (Lond) 40 (4), 662-674 (2016)
   PUBMED   26480920
  REMARK    GeneRIF: Our results provide evidence for new loci influencing
            abdominal visceral (BBS9, ADCY8, KCNK9) and subcutaneous
            (MLLT10/DNAJC1/EBLN1) fat, and confirmed a locus (THNSL2)
            previously reported to be associated with abdominal fat in women.
REFERENCE   8  (bases 1 to 2100)
  AUTHORS   Kroczynska,B., King-Simmons,L., Alloza,L., Alava,M.A.,
            Elguindi,E.C. and Blond,S.Y.
  TITLE     BIP co-chaperone MTJ1/ERDJ1 interacts with inter-alpha-trypsin
            inhibitor heavy chain 4
  JOURNAL   Biochem Biophys Res Commun 338 (3), 1467-1477 (2005)
   PUBMED   16271702
  REMARK    GeneRIF: ITIH4 and MTJ1 co-immunoprecipitate from total liver
            protein extracts and SANT domain of HTJ1 protects the
            ITIH4(588-930) recombinant fragment
REFERENCE   9  (bases 1 to 2100)
  AUTHORS   Kroczynska,B., Evangelista,C.M., Samant,S.S., Elguindi,E.C. and
            Blond,S.Y.
  TITLE     The SANT2 domain of the murine tumor cell DnaJ-like protein 1 human
            homologue interacts with alpha1-antichymotrypsin and kinetically
            interferes with its serpin inhibitory activity
  JOURNAL   J Biol Chem 279 (12), 11432-11443 (2004)
   PUBMED   14668352
REFERENCE   10 (bases 1 to 2100)
  AUTHORS   Chevalier,M., Rhee,H., Elguindi,E.C. and Blond,S.Y.
  TITLE     Interaction of murine BiP/GRP78 with the DnaJ homologue MTJ1
  JOURNAL   J Biol Chem 275 (26), 19620-19627 (2000)
   PUBMED   10777498
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL445431.16 and BC110894.1.
            
            On Nov 23, 2018 this sequence version replaced NM_022365.3.
            
            Summary: The membrane protein encoded by this gene is a DNAJ-like
            heat shock protein that binds the molecular chaperone BiP. In
            addition, the encoded protein contains two SANT domains that have
            been shown to bind serpin alpha1-antichymotrypsin and inter-alpha
            trypsin inhibitor heavy chain 4. [provided by RefSeq, Jul 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC110894.1, SRR1163655.240719.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000376980.8/ ENSP00000366179.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 AL445431.16        97216-97224         c
            10-2100             BC110894.1         1-2091
FEATURES             Location/Qualifiers
     source          1..2100
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10p12.31"
     gene            1..2100
                     /gene="DNAJC1"
                     /gene_synonym="DNAJL1; ERdj1; HTJ1; MTJ1"
                     /note="DnaJ heat shock protein family (Hsp40) member C1"
                     /db_xref="GeneID:64215"
                     /db_xref="HGNC:HGNC:20090"
                     /db_xref="MIM:611207"
     exon            1..518
                     /gene="DNAJC1"
                     /gene_synonym="DNAJL1; ERdj1; HTJ1; MTJ1"
                     /inference="alignment:Splign:2.1.0"
     CDS             297..1961
                     /gene="DNAJC1"
                     /gene_synonym="DNAJL1; ERdj1; HTJ1; MTJ1"
                     /note="dnaJ homolog subfamily C member 1; DnaJ-like
                     protein; dnaJ protein homolog MTJ1; DnaJ (Hsp40) homolog,
                     subfamily C, member 1"
                     /codon_start=1
                     /product="dnaJ homolog subfamily C member 1 precursor"
                     /protein_id="NP_071760.2"
                     /db_xref="CCDS:CCDS7136.1"
                     /db_xref="GeneID:64215"
                     /db_xref="HGNC:HGNC:20090"
                     /db_xref="MIM:611207"
                     /translation="MTAPCSQPAQLPGRRQLGLVPFPPPPPRTPLLWLLLLLLAAVAP
                     ARGWESGDLELFDLVEEVQLNFYQFLGVQQDASSADIRKAYRKLSLTLHPDKNKDENA
                     ETQFRQLVAIYEVLKDDERRQRYDDILINGLPDWRQPVFYYRRVRKMSNAELALLLFI
                     ILTVGHYAVVWSIYLEKQLDELLSRKKREKKKKTGSKSVDVSKLGASEKNERLLMKPQ
                     WHDLLPCKLGIWFCLTLKALPHLIQDAGQFYAKYKETRLKEKEDALTRTELETLQKQK
                     KVKKPKPEFPVYTPLETTYIQSYDHGTSIEEIEEQMDDWLENRNRTQKKQAPEWTEED
                     LSQLTRSMVKFPGGTPGRWEKIAHELGRSVTDVTTKAKQLKDSVTCSPGMVRLSELKS
                     TVQNSRPIKTATTLPDDMITQREDAEGVAAEEEQEGDSGEQETGATDARPRRRKPARL
                     LEATAKPEPEEKSRAKRQKDFDIAEQNESSDEESLRKERARSAEEPWTQNQQKLLELA
                     LQQYPRGSSDRWDKIARCVPSKSKEDCIARYKLLVELVQKKKQAKS"
     exon            519..620
                     /gene="DNAJC1"
                     /gene_synonym="DNAJL1; ERdj1; HTJ1; MTJ1"
                     /inference="alignment:Splign:2.1.0"
     exon            621..667
                     /gene="DNAJC1"
                     /gene_synonym="DNAJL1; ERdj1; HTJ1; MTJ1"
                     /inference="alignment:Splign:2.1.0"
     exon            668..833
                     /gene="DNAJC1"
                     /gene_synonym="DNAJL1; ERdj1; HTJ1; MTJ1"
                     /inference="alignment:Splign:2.1.0"
     exon            834..931
                     /gene="DNAJC1"
                     /gene_synonym="DNAJL1; ERdj1; HTJ1; MTJ1"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1025
                     /gene="DNAJC1"
                     /gene_synonym="DNAJL1; ERdj1; HTJ1; MTJ1"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1116
                     /gene="DNAJC1"
                     /gene_synonym="DNAJL1; ERdj1; HTJ1; MTJ1"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..1274
                     /gene="DNAJC1"
                     /gene_synonym="DNAJL1; ERdj1; HTJ1; MTJ1"
                     /inference="alignment:Splign:2.1.0"
     exon            1275..1394
                     /gene="DNAJC1"
                     /gene_synonym="DNAJL1; ERdj1; HTJ1; MTJ1"
                     /inference="alignment:Splign:2.1.0"
     exon            1395..1443
                     /gene="DNAJC1"
                     /gene_synonym="DNAJL1; ERdj1; HTJ1; MTJ1"
                     /inference="alignment:Splign:2.1.0"
     exon            1444..1892
                     /gene="DNAJC1"
                     /gene_synonym="DNAJL1; ERdj1; HTJ1; MTJ1"
                     /inference="alignment:Splign:2.1.0"
     exon            1893..2100
                     /gene="DNAJC1"
                     /gene_synonym="DNAJL1; ERdj1; HTJ1; MTJ1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2089..2094
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DNAJC1"
                     /gene_synonym="DNAJL1; ERdj1; HTJ1; MTJ1"
                     /note="hexamer: AATAAA"
     polyA_site      2100
                     /gene="DNAJC1"
                     /gene_synonym="DNAJL1; ERdj1; HTJ1; MTJ1"
                     /note="major polyA site"
ORIGIN      
        1 actgtgcagc ccaggcgccg ggcgctgcct ctacagctgt gtgtaggcct gggggcgagg
       61 gtcttcggaa cgtagcgctg gctgcggccc cgcccgccta cccacccgcc cgtccggcag
      121 ccggctcccg ccgcctccgc gctctgtctg gggccagcca cctggcgggc cgctccggtg
      181 cgcctgcccg cgcttttcac tgacaggcgc tgttccccac agccagcgcc gcccgccacg
      241 tcccagctct cggccaacgg agctgcgcgg cgggtgacct ttccgagccc agcgcgatga
      301 cggctccttg ctcccagccg gcgcagcttc ctggacgccg ccagctcggg ctggtgccgt
      361 tcccgccgcc gccgccgcgg acgccgctgc tgtggctgct gctgctgctg ctggccgccg
      421 tggcgccggc gcgcggctgg gagagcggag acctggagtt gtttgactta gtggaggagg
      481 tgcagctcaa cttctaccag ttcctcgggg tgcagcagga tgcatcatct gcagacatca
      541 gaaaagcata tcgtaagctt tcactaactt tacatccaga caagaataaa gatgaaaatg
      601 cagaaactca gtttagacaa ttggtggcca tttatgaagt tttaaaggat gatgaacgaa
      661 ggcagaggta tgatgatatt ctgatcaatg gacttccaga ttggcgacag cctgtattct
      721 actacaggcg ggtgagaaaa atgagcaatg ctgagctggc attactcttg ttcattattc
      781 tcacagtggg tcattatgct gtggtttggt caatctacct ggaaaaacaa ctggatgaac
      841 tactaagtag aaaaaagaga gaaaagaaaa aaaagactgg cagcaagagt gtggatgtat
      901 caaaactcgg tgcttcagaa aaaaatgaaa gattgctgat gaaaccacag tggcatgatt
      961 tgcttccatg caaactgggg atttggtttt gccttacact aaaagcatta cctcacctca
     1021 tccaggatgc tgggcagttt tatgctaaat ataaagaaac aagattgaag gaaaaggaag
     1081 atgcactgac tagaactgaa cttgaaacac ttcaaaaaca gaagaaagtt aaaaaaccaa
     1141 aacctgaatt tcctgtatac acacctttag aaactacata tattcagtct tatgatcatg
     1201 gaacttccat agaagaaatt gaggaacaaa tggatgattg gttggaaaac aggaaccgaa
     1261 cacagaaaaa acaggcacct gaatggacag aagaggacct cagccaactg acaagaagta
     1321 tggttaagtt cccaggaggg actccaggtc gatgggaaaa gattgcccac gaattgggtc
     1381 gatctgtgac agatgtgaca accaaagcca agcaactgaa ggattcagtg acctgctccc
     1441 caggaatggt tagactctcc gaactcaaat cgacagttca gaattccagg cccatcaaaa
     1501 cggccaccac cttgcccgat gacatgatca cccagcgaga ggacgcagag ggggtggcag
     1561 cggaggagga gcaggaggga gactccggtg agcaggagac cggggccact gatgcccggc
     1621 ctcggaggcg gaagccagcc aggctgctgg aggctacagc gaagccggag ccagaggaga
     1681 agtccagagc caagcggcag aaggactttg acatagcaga acaaaacgag tccagcgacg
     1741 aggagagcct gagaaaagag agagctcggt ctgcagagga gccgtggact caaaatcaac
     1801 agaaacttct ggaactggcg ttgcagcagt acccaagggg atcctctgac cgctgggaca
     1861 aaatagccag atgtgtcccg tccaagagca aggaagactg tatcgctagg tacaagttgc
     1921 tggttgaact ggtccaaaag aaaaaacaag ctaaaagctg aatattctgg gagatgatgt
     1981 tcaccttcat tttccaaaat gaatatctta aaaatcttat gcagaaattt gcattttgta
     2041 cctcaatatt tctacgtcat gtgccttagt aaaaaaaaat aataaataaa taaaagatga
//
