LOCUS       NM_012328               2409 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens DnaJ heat shock protein family (Hsp40) member B9
            (DNAJB9), mRNA.
ACCESSION   NM_012328
VERSION     NM_012328.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2409)
  AUTHORS   Minchenko,D.O., Rudnytska,O.V., Khita,O.O., Kulish,Y.V.,
            Viletska,Y.M., Halkin,O.V., Danilovskyi,S.V., Ratushna,O.O. and
            Minchenko,O.H.
  TITLE     Expression of DNAJB9 and some other genes is more sensitive to
            SWCNTs in normal human astrocytes than glioblastoma cells
  JOURNAL   Endocr Regul 57 (1), 162-172 (2023)
   PUBMED   37561833
  REMARK    GeneRIF: Expression of DNAJB9 and some other genes is more
            sensitive to SWCNTs in normal human astrocytes than glioblastoma
            cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2409)
  AUTHORS   Liang,S., Chen,D., Liang,D., Xu,F., Zhang,M., Yang,F., Zhu,X.,
            Li,P. and Zeng,C.
  TITLE     Clinicopathological characteristics and outcome of patients with
            fibrillary glomerulonephritis: DNAJB9 is a valuable histologic
            marker
  JOURNAL   J Nephrol 34 (3), 883-892 (2021)
   PUBMED   32557205
  REMARK    GeneRIF: Clinicopathological characteristics and outcome of
            patients with fibrillary glomerulonephritis: DNAJB9 is a valuable
            histologic marker.
REFERENCE   3  (bases 1 to 2409)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 2409)
  AUTHORS   Kim,H.Y., Kim,Y.M. and Hong,S.
  TITLE     DNAJB9 suppresses the metastasis of triple-negative breast cancer
            by promoting FBXO45-mediated degradation of ZEB1
  JOURNAL   Cell Death Dis 12 (5), 461 (2021)
   PUBMED   33966034
  REMARK    GeneRIF: DNAJB9 suppresses the metastasis of triple-negative breast
            cancer by promoting FBXO45-mediated degradation of ZEB1.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2409)
  AUTHORS   Said,S.M., Leung,N., Alexander,M.P., Cornell,L.D., Fidler,M.E.,
            Grande,J.P., Herrera,L.H., Sethi,S., Zhang,P. and Nasr,S.H.
  TITLE     DNAJB9-positive monotypic fibrillary glomerulonephritis is not
            associated with monoclonal gammopathy in the vast majority of
            patients
  JOURNAL   Kidney Int 98 (2), 498-504 (2020)
   PUBMED   32622524
  REMARK    GeneRIF: DNAJB9-positive monotypic fibrillary glomerulonephritis is
            not associated with monoclonal gammopathy in the vast majority of
            patients.
REFERENCE   6  (bases 1 to 2409)
  AUTHORS   Chung,K.T., Shen,Y. and Hendershot,L.M.
  TITLE     BAP, a mammalian BiP-associated protein, is a nucleotide exchange
            factor that regulates the ATPase activity of BiP
  JOURNAL   J Biol Chem 277 (49), 47557-47563 (2002)
   PUBMED   12356756
REFERENCE   7  (bases 1 to 2409)
  AUTHORS   Shen,Y., Meunier,L. and Hendershot,L.M.
  TITLE     Identification and characterization of a novel endoplasmic
            reticulum (ER) DnaJ homologue, which stimulates ATPase activity of
            BiP in vitro and is induced by ER stress
  JOURNAL   J Biol Chem 277 (18), 15947-15956 (2002)
   PUBMED   11836248
REFERENCE   8  (bases 1 to 2409)
  AUTHORS   Prols,F., Mayer,M.P., Renner,O., Czarnecki,P.G., Ast,M.,
            Gassler,C., Wilting,J., Kurz,H. and Christ,B.
  TITLE     Upregulation of the cochaperone Mdg1 in endothelial cells is
            induced by stress and during in vitro angiogenesis
  JOURNAL   Exp Cell Res 269 (1), 42-53 (2001)
   PUBMED   11525638
REFERENCE   9  (bases 1 to 2409)
  AUTHORS   Ohtsuka,K. and Hata,M.
  TITLE     Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a
            proposal for their classification and nomenclature
  JOURNAL   Cell Stress Chaperones 5 (2), 98-112 (2000)
   PUBMED   11147971
REFERENCE   10 (bases 1 to 2409)
  AUTHORS   Prols,F., Liehr,T., Rinke,R. and Rautenstrauss,B.
  TITLE     Assignment of the microvascular endothelial differentiation gene 1
            (MDG1) to human chromosome band 14q24.2-->q24.3 by fluorescence in
            situ hybridization
  JOURNAL   Cytogenet Cell Genet 79 (1-2), 149-150 (1997)
   PUBMED   9533036
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA202575.1 and AB026908.1.
            
            On Nov 23, 2018 this sequence version replaced NM_012328.2.
            
            Summary: This gene is a member of the J protein family. J proteins
            function in many cellular processes by regulating the ATPase
            activity of 70 kDa heat shock proteins. This gene is a member of
            the type 2 subgroup of DnaJ proteins. The encoded protein is
            localized to the endoplasmic reticulum. This protein is induced by
            endoplasmic reticulum stress and plays a role in protecting
            stressed cells from apoptosis. [provided by RefSeq, Dec 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.178169.1,
                                           SRR3476690.1086571.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000249356.4/ ENSP00000249356.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-38                DA202575.1         130-167
            39-2409             AB026908.1         1-2371
FEATURES             Location/Qualifiers
     source          1..2409
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q31.1"
     gene            1..2409
                     /gene="DNAJB9"
                     /gene_synonym="ERdj4; MDG-1; MDG1; MST049; MSTP049"
                     /note="DnaJ heat shock protein family (Hsp40) member B9"
                     /db_xref="GeneID:4189"
                     /db_xref="HGNC:HGNC:6968"
                     /db_xref="MIM:602634"
     exon            1..230
                     /gene="DNAJB9"
                     /gene_synonym="ERdj4; MDG-1; MDG1; MST049; MSTP049"
                     /inference="alignment:Splign:2.1.0"
     exon            231..457
                     /gene="DNAJB9"
                     /gene_synonym="ERdj4; MDG-1; MDG1; MST049; MSTP049"
                     /inference="alignment:Splign:2.1.0"
     CDS             241..912
                     /gene="DNAJB9"
                     /gene_synonym="ERdj4; MDG-1; MDG1; MST049; MSTP049"
                     /note="endoplasmic reticulum DnaJ homolog 4; dnaJ homolog
                     subfamily B member 9; microvascular endothelial
                     differentiation gene 1 protein; ER-resident protein ERdj4;
                     endoplasmic reticulum DNA J domain-containing protein 4;
                     DnaJ (Hsp40) homolog, subfamily B, member 9"
                     /codon_start=1
                     /product="dnaJ homolog subfamily B member 9 precursor"
                     /protein_id="NP_036460.1"
                     /db_xref="CCDS:CCDS5752.1"
                     /db_xref="GeneID:4189"
                     /db_xref="HGNC:HGNC:6968"
                     /db_xref="MIM:602634"
                     /translation="MATPQSIFIFAICILMITELILASKSYYDILGVPKSASERQIKK
                     AFHKLAMKYHPDKNKSPDAEAKFREIAEAYETLSDANRRKEYDTLGHSAFTSGKGQRG
                     SGSSFEQSFNFNFDDLFKDFGFFGQNQNTGSKKRFENHFQTRQDGGSSRQRHHFQEFS
                     FGGGLFDDMFEDMEKMFSFSGFDSTNQHTVQTENRFHGSSKHCRTVTQRRGNMVTTYT
                     DCSGQ"
     exon            458..2409
                     /gene="DNAJB9"
                     /gene_synonym="ERdj4; MDG-1; MDG1; MST049; MSTP049"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1942..1947
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DNAJB9"
                     /gene_synonym="ERdj4; MDG-1; MDG1; MST049; MSTP049"
                     /note="hexamer: TATAAA"
     polyA_site      1961
                     /gene="DNAJB9"
                     /gene_synonym="ERdj4; MDG-1; MDG1; MST049; MSTP049"
                     /note="major polyA site"
     regulatory      2387..2392
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DNAJB9"
                     /gene_synonym="ERdj4; MDG-1; MDG1; MST049; MSTP049"
                     /note="hexamer: AATAAA"
     polyA_site      2409
                     /gene="DNAJB9"
                     /gene_synonym="ERdj4; MDG-1; MDG1; MST049; MSTP049"
ORIGIN      
        1 gaggtggtgg cgccagcggc tacctcctgc ctgtgaggag ctggctgaga ggggactggg
       61 cgccggcggg gaaggaggag cgctaggtcg gtgtacgacc gagattaggg tgcgtgccag
      121 ctccgggagg ccgcggtgag gggccgggcc caagctgccg acccgagccg atcgtcaggg
      181 tcgccagcgc ctcagctctg tggaggagca gcagtagtcg gagggtgcag gatattagaa
      241 atggctactc cccagtcaat tttcatcttt gcaatctgca ttttaatgat aacagaatta
      301 attctggcct caaaaagcta ctatgatatc ttaggtgtgc caaaatcggc atcagagcgc
      361 caaatcaaga aggcctttca caagttggcc atgaagtacc accctgacaa aaataagagc
      421 ccggatgctg aagcaaaatt cagagagatt gcagaagcat atgaaacact ctcagatgct
      481 aatagacgaa aagagtatga tacacttgga cacagtgctt ttactagtgg taaaggacaa
      541 agaggtagtg gaagttcttt tgagcagtca tttaacttca attttgatga cttatttaaa
      601 gactttggct tttttggtca aaaccaaaac actggatcca agaagcgttt tgaaaatcat
      661 ttccagacac gccaggatgg tggttccagt agacaaaggc atcatttcca agaattttct
      721 tttggaggtg gattatttga tgacatgttt gaagatatgg agaaaatgtt ttcttttagt
      781 ggttttgact ctaccaatca gcatacagta cagactgaaa atagatttca tggatctagc
      841 aagcactgca ggactgtcac tcaacgaaga ggaaatatgg ttactacata cactgactgt
      901 tcaggacagt agttcttatt ctattctcac taaatccaac tggttgactc ttcctcatta
      961 tctttgatgc taaacaattt tctgtgaact attttgacaa gtgcatgatt tcactttaaa
     1021 caatttgata tagctattaa atatatttaa gggttttttt tttttgacaa attcaacatt
     1081 caacgagtag acaaaatgct aattatttcc ctgattagga aagtttcttt aaaaaacacg
     1141 taattttgcc tagtgctttt tctctacctg cccttgggct cactaatatc accagtatta
     1201 ttaccaagaa aatattgagt ttacctgatt aaactttaaa agttaattgt agatttaaat
     1261 tgtgtgaacc taatgatttt tgcagtgaaa cctttactaa ttcaaagttg catgttctat
     1321 gacatctgtg acttgcgttg cagagtgtac atgaaactgt ataattgagt cattcagtaa
     1381 aggagaacag tatcttggtt aattgctact gaaaggttga gaaaggaatg gtttgatatt
     1441 taccacagcg ctgtgccttt ctacagtaga actggggtaa aggaaatggt tttattgccc
     1501 atagtcattt aggctggaaa aaagttgaaa acttaacgaa atattgccaa gagattgtta
     1561 tgtgtttggt tccagcctaa aaatgatttt gtagtgttga aatcatagct acttacatag
     1621 ctttttcata tttctttctt agttgttggc actcttaggt cttagtatgg atttatgtgt
     1681 ttgtgtgtgt gtagtttatc ctctctctca tctttatcta gagattgact gatacctcat
     1741 tctgtttgta aaaccagcca gtaatttctg tgcaacctta ctatgtgcaa tatttttaaa
     1801 tcctgagaaa tgtgtgcttt tgttttcgga tagacttatt tctttagttc tgcacttttc
     1861 cacattatac tccatatgag tattaatcct atggatacat attaaaacaa gtgtctcata
     1921 caacattgta tgtgagagaa atataaatat ttacaacctg atattcgttg ttgttttatt
     1981 gttaaaagtt tattatgcaa ctctggaggt atagagggca tataagctat gggacatatg
     2041 ctgatcacag gctatattca tgaagttact tttgaccaac ctgaaaactg ataggatttt
     2101 gtttgtcatt tggtaatttc tactgcattc ttaccatcct tctctcacaa attttgatag
     2161 cttgaagatc tttttaatta taattttgtt gtatttgttt cctaggagca agtgttcctg
     2221 ctgccagttc tttcctcttt aggcgtggtt gagaaaaagc agaaacttta cataaagctg
     2281 tatttcttaa tcatctttaa tttgaaactt aagaaaatga atttattctg ttatatttat
     2341 gtaacttatt tcctggaagt tatatctact agttttgttt gataataata aaattagcta
     2401 taccttgaa
//
