LOCUS       NM_145174               2565 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens DnaJ heat shock protein family (Hsp40) member B7
            (DNAJB7), mRNA.
ACCESSION   NM_145174
VERSION     NM_145174.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2565)
  AUTHORS   Scurr,M.J., Greenshields-Watson,A., Campbell,E., Somerville,M.S.,
            Chen,Y., Hulin-Curtis,S.L., Burnell,S.E.A., Davies,J.A.,
            Davies,M.M., Hargest,R., Phillips,S., Christian,A.D.,
            Ashelford,K.E., Andrews,R., Parker,A.L., Stanton,R.J., Gallimore,A.
            and Godkin,A.
  TITLE     Cancer Antigen Discovery Is Enabled by RNA Sequencing of Highly
            Purified Malignant and Nonmalignant Cells
  JOURNAL   Clin Cancer Res 26 (13), 3360-3370 (2020)
   PUBMED   32122920
REFERENCE   2  (bases 1 to 2565)
  AUTHORS   Hageman,J., van Waarde,M.A., Zylicz,A., Walerych,D. and
            Kampinga,H.H.
  TITLE     The diverse members of the mammalian HSP70 machine show distinct
            chaperone-like activities
  JOURNAL   Biochem J 435 (1), 127-142 (2011)
   PUBMED   21231916
REFERENCE   3  (bases 1 to 2565)
  AUTHORS   Collins,J.E., Wright,C.L., Edwards,C.A., Davis,M.P., Grinham,J.A.,
            Cole,C.G., Goward,M.E., Aguado,B., Mallya,M., Mokrab,Y.,
            Huckle,E.J., Beare,D.M. and Dunham,I.
  TITLE     A genome annotation-driven approach to cloning the human ORFeome
  JOURNAL   Genome Biol 5 (10), R84 (2004)
   PUBMED   15461802
REFERENCE   4  (bases 1 to 2565)
  AUTHORS   Ohtsuka,K. and Hata,M.
  TITLE     Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a
            proposal for their classification and nomenclature
  JOURNAL   Cell Stress Chaperones 5 (2), 98-112 (2000)
   PUBMED   11147971
REFERENCE   5  (bases 1 to 2565)
  AUTHORS   Dunham,I., Shimizu,N., Roe,B.A., Chissoe,S., Hunt,A.R.,
            Collins,J.E., Bruskiewich,R., Beare,D.M., Clamp,M., Smink,L.J.,
            Ainscough,R., Almeida,J.P., Babbage,A., Bagguley,C., Bailey,J.,
            Barlow,K., Bates,K.N., Beasley,O., Bird,C.P., Blakey,S.,
            Bridgeman,A.M., Buck,D., Burgess,J., Burrill,W.D., O'Brien,K.P. et
            al.
  TITLE     The DNA sequence of human chromosome 22
  JOURNAL   Nature 402 (6761), 489-495 (1999)
   PUBMED   10591208
  REMARK    Erratum:[Nature 2000 Apr 20;404(6780):904]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF085232.1.
            
            On May 17, 2019 this sequence version replaced NM_145174.1.
            
            Summary: The protein encoded by this intronless gene belongs to the
            evolutionarily conserved DNAJ/HSP40 family of proteins, which
            regulate molecular chaperone activity by stimulating ATPase
            activity. DNAJ proteins may have up to 3 distinct domains: a
            conserved 70-amino acid J domain, usually at the N terminus; a
            glycine/phenylalanine (G/F)-rich region; and a cysteine-rich domain
            containing 4 motifs resembling a zinc finger domain.[provided by
            RefSeq, Mar 2011].
            
            ##Evidence-Data-START##
            Transcript is intronless :: AF085232.1, SRR1660807.25153.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000307221.5/ ENSP00000307197.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2565              AF085232.1         14-2578
FEATURES             Location/Qualifiers
     source          1..2565
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.2"
     gene            1..2565
                     /gene="DNAJB7"
                     /gene_synonym="DJ5; HSC3"
                     /note="DnaJ heat shock protein family (Hsp40) member B7"
                     /db_xref="GeneID:150353"
                     /db_xref="HGNC:HGNC:24986"
                     /db_xref="MIM:611336"
     exon            1..2565
                     /gene="DNAJB7"
                     /gene_synonym="DJ5; HSC3"
                     /inference="alignment:Splign:2.1.0"
     CDS             120..1049
                     /gene="DNAJB7"
                     /gene_synonym="DJ5; HSC3"
                     /note="novel DnaJ domain protein; DnaJ (Hsp40) homolog,
                     subfamily B, member 7"
                     /codon_start=1
                     /product="dnaJ homolog subfamily B member 7"
                     /protein_id="NP_660157.1"
                     /db_xref="CCDS:CCDS14008.1"
                     /db_xref="GeneID:150353"
                     /db_xref="HGNC:HGNC:24986"
                     /db_xref="MIM:611336"
                     /translation="MVDYYEVLGLQRYASPEDIKKAYHKVALKWHPDKNPENKEEAER
                     KFKEVAEAYEVLSNDEKRDIYDKYGTEGLNGGGSHFDDECEYGFTFHKPDDVFKEIFH
                     ERDPFSFHFFEDSLEDLLNRPGSSYGNRNRDAGYFFSTASEYPIFEKFSSYDTGYTSQ
                     GSLGHEGLTSFSSLAFDNSGMDNYISVTTSDKIVNGRNINTKKIIESDQEREAEDNGE
                     LTFFLVNSVANEEGFAKECSWRTQSFNNYSPNSHSSKHVSQYTFVDNDEGGISWVTSN
                     RDPPIFSAGVKEGGKRKKKKRKEVQKKSTKRNC"
     regulatory      1062..1067
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DNAJB7"
                     /gene_synonym="DJ5; HSC3"
                     /note="hexamer: AATATA"
     polyA_site      1083
                     /gene="DNAJB7"
                     /gene_synonym="DJ5; HSC3"
                     /note="major polyA site"
ORIGIN      
        1 aacataaaag tgtacctatt tgcagtcact acctctatca ccaccaccag cagagcctga
       61 gctgaggaaa ccacggttct caatacccag cacacccact tccaactatc tgttaaaaca
      121 tggtggatta ctatgaagtt ctaggactgc aaagatatgc ttcacctgag gacattaaaa
      181 aagcttatca taaagtggca cttaaatggc accctgataa aaatccagaa aataaagaag
      241 aagcagagag aaaattcaaa gaagtagctg aggcatacga ggtattatca aatgatgaga
      301 aacgggacat ttatgataaa tatggcacag aaggattaaa cggaggtgga agtcattttg
      361 atgatgaatg tgagtacggc ttcacattcc ataagccaga tgatgttttt aaagaaattt
      421 ttcatgaaag ggatccattt tcttttcact tctttgaaga ctcgcttgag gacctgttaa
      481 atcgtccagg aagctcctat ggaaacagaa acagagatgc aggatacttt ttctccactg
      541 ccagtgaata tccaattttt gagaaatttt cttcatatga tacaggatat acatcacagg
      601 gttcattggg gcatgaaggc cttacttctt tctcttccct ggcttttgat aatagtggga
      661 tggacaacta catatctgtt acaacttcag acaaaatcgt taatggcaga aatattaata
      721 caaagaaaat tattgaaagt gatcaagaaa gagaagctga agataatgga gagttgacat
      781 tttttcttgt aaatagtgtg gccaatgaag agggctttgc aaaagaatgc agctggagaa
      841 cacagtcatt caacaactat tcaccaaatt ctcacagctc caaacatgta tctcaatata
      901 ctttcgtgga caatgatgag ggaggtatat cttgggttac cagcaacaga gatcccccta
      961 ttttctcagc aggagtcaaa gagggtggta agaggaaaaa aaagaagcgt aaagaggtgc
     1021 aaaagaagtc taccaaaagg aattgttaaa ttgactcttc aaatatataa catttgaaca
     1081 caattgtgtg tgttttggtt aatcacaaat tttgtagata acacttaata ctatactaag
     1141 agcttttcaa cacttttagc aggattgtgg acatttggtt agtagttttt ttgaatgggt
     1201 atgtcagaaa aggatgagtt tgtggtgaca gttggtgcta ataagaattt gcctgggcag
     1261 tatagtgaga tcttttctct acaaaaaatt taaaaattag ccaagtgtgg tggtgtgcac
     1321 ctgtagtccc agctactcgg gaagctggta gaaagactgc ttgagcctgg aagacatagg
     1381 ttgcagtgta atgggatcac gccactgcac tccagcttgg gtgacaaagt aagaccctgt
     1441 cttaaaaaaa aaaaaaagga atttggaaaa ctgcaatgag ttttttactt ttgaattttt
     1501 ctttagtaga gtttatagcc tatttttctt ttttctaatt aaaaccacta tacaaactta
     1561 cgaaacatgc atagcattag aagacaagaa tgtatcaaga cacacaggtt cagactacac
     1621 aattattcat gaaatggctg ttttccaatg gaggaacagc atttgatgca ttataactta
     1681 aaggtactac aaattaaaaa ttaaagtata aagtatttta agttagaaat agacttagct
     1741 gggtgcagtg gctcacacct gtaatcctag catcttggga ggcccaggca ggagggttga
     1801 agtcagaatt tcacgacagt ccgggtaaca taatgagacc tgtcctctat gaaaaaactt
     1861 ttttaaaaat ttagctgggt gtggtggtac gtgcctgtag gcctagctac ttaggaggct
     1921 gaggtgggag gattgcttga gcccaggagt ttgaggttgt agggagctat gatcttgcca
     1981 ttgcactcca gctgagagtg tgaccctgtc tctaaagaaa aactatagaa aatttaaaaa
     2041 attaaaaaac gggtaacatg gtaaatttta tgtagtatat tttaccacat tttttttaaa
     2101 ggccagtctt atcctgaatt cctcagagca gtctgtatgg taggccatca gtgaatcact
     2161 ccagacagga aattttctat ttttgtttag agtttgtaca caaaatctac aaatacatta
     2221 ctctaaaata gcacctatag ccattttaat ttagtcatgt tgggagaaaa atagatgggt
     2281 tacaaataca tcagatatcg agcaaatggt ttgagttaca tctagcagca ctaaaactta
     2341 ttcaactttg gccaaataca aatgcgaaat tagaaaaaaa ttataatatc tgctattttt
     2401 aaaagacagc tatagtcaag agcttgtgtt ttgtatcggt atttgatttt tagtgggcag
     2461 atgggagaag gaaaggttat ttattctata gaagagactg cggacaatta gtattcaaag
     2521 tttattttca gaaaataaaa taataaaagc ccagggtatt ttaaa
//
