LOCUS       NM_007034               2903 bp    mRNA    linear   PRI 18-JUL-2024
DEFINITION  Homo sapiens DnaJ heat shock protein family (Hsp40) member B4
            (DNAJB4), transcript variant 1, mRNA.
ACCESSION   NM_007034
VERSION     NM_007034.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2903)
  AUTHORS   Park,E.G., Lee,D.H., Kim,W.R., Lee,Y.J., Bae,W.H., Kim,J.M.,
            Shin,H.J., Ha,H., Yi,J.M., Cho,S.G., Choi,Y.H., Leem,S.H.,
            Cha,H.J., Kim,S.W. and Kim,H.S.
  TITLE     Human Endogenous Retrovirus-H-Derived miR-4454 Inhibits the
            Expression of DNAJB4 and SASH1 in Non-Muscle-Invasive Bladder
            Cancer
  JOURNAL   Genes (Basel) 14 (7), 1410 (2023)
   PUBMED   37510314
  REMARK    GeneRIF: Human Endogenous Retrovirus-H-Derived miR-4454 Inhibits
            the Expression of DNAJB4 and SASH1 in Non-Muscle-Invasive Bladder
            Cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2903)
  AUTHORS   Dicanio,M., Giaccherini,M., Clay-Gilmour,A., Macauda,A., Sainz,J.,
            Machiela,M.J., Rybicka-Ramos,M., Norman,A.D., Tyczynska,A.,
            Chanock,S.J., Barington,T., Kumar,S.K., Bhatti,P., Cozen,W.,
            Brown,E.E., Suska,A., Haastrup,E.K., Orlowski,R.Z., Dudzinski,M.,
            Garcia-Sanz,R., Kruszewski,M., Martinez-Lopez,J., Beider,K.,
            Iskierka-Jazdzewska,E., Pelosini,M., Berndt,S.I., Razny,M.,
            Jamroziak,K., Rajkumar,S.V., Jurczyszyn,A., Vangsted,A.J.,
            Collado,P.G., Vogel,U., Hofmann,J.N., Petrini,M., Butrym,A.,
            Slager,S.L., Ziv,E., Subocz,E., Giles,G.G., Andersen,N.F.,
            Mazur,G., Watek,M., Lesueur,F., Hildebrandt,M.A.T., Zawirska,D.,
            Ebbesen,L.H., Marques,H., Gemignani,F., Dumontet,C., Varkonyi,J.,
            Buda,G., Nagler,A., Druzd-Sitek,A., Wu,X., Kadar,K., Camp,N.J.,
            Grzasko,N., Waller,R.G., Vachon,C., Canzian,F. and Campa,D.
  TITLE     A pleiotropic variant in DNAJB4 is associated with multiple myeloma
            risk
  JOURNAL   Int J Cancer 152 (2), 239-248 (2023)
   PUBMED   36082445
  REMARK    GeneRIF: A pleiotropic variant in DNAJB4 is associated with
            multiple myeloma risk.
REFERENCE   3  (bases 1 to 2903)
  AUTHORS   Weihl,C.C., Topf,A., Bengoechea,R., Duff,J., Charlton,R.,
            Garcia,S.K., Dominguez-Gonzalez,C., Alsaman,A., Hernandez-Lain,A.,
            Franco,L.V., Sanchez,M.E.P., Beecroft,S.J., Goullee,H., Daw,J.,
            Bhadra,A., True,H., Inoue,M., Findlay,A.R., Laing,N., Olive,M.,
            Ravenscroft,G. and Straub,V.
  TITLE     Loss of function variants in DNAJB4 cause a myopathy with early
            respiratory failure
  JOURNAL   Acta Neuropathol 145 (1), 127-143 (2023)
   PUBMED   36264506
REFERENCE   4  (bases 1 to 2903)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 2903)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 2903)
  AUTHORS   Wang,C.C., Tsai,M.F., Hong,T.M., Chang,G.C., Chen,C.Y., Yang,W.M.,
            Chen,J.J. and Yang,P.C.
  TITLE     The transcriptional factor YY1 upregulates the novel invasion
            suppressor HLJ1 expression and inhibits cancer cell invasion
  JOURNAL   Oncogene 24 (25), 4081-4093 (2005)
   PUBMED   15782117
  REMARK    GeneRIF: The increase in HLJ1 and E-cadherin expression, as well as
            the suppression of invasion ability, can be reversed specifically
            by HLJ1 siRNA.
REFERENCE   7  (bases 1 to 2903)
  AUTHORS   Borges,J.C., Fischer,H., Craievich,A.F. and Ramos,C.H.
  TITLE     Low resolution structural study of two human HSP40 chaperones in
            solution. DJA1 from subfamily A and DJB4 from subfamily B have
            different quaternary structures
  JOURNAL   J Biol Chem 280 (14), 13671-13681 (2005)
   PUBMED   15661747
  REMARK    GeneRIF: Results indicate that DjA1 and DjB4 of subfamilies A and B
            of human Hsp40 have different quaternary structures and chaperone
            functions.
REFERENCE   8  (bases 1 to 2903)
  AUTHORS   Rush,J., Moritz,A., Lee,K.A., Guo,A., Goss,V.L., Spek,E.J.,
            Zhang,H., Zha,X.M., Polakiewicz,R.D. and Comb,M.J.
  TITLE     Immunoaffinity profiling of tyrosine phosphorylation in cancer
            cells
  JOURNAL   Nat Biotechnol 23 (1), 94-101 (2005)
   PUBMED   15592455
REFERENCE   9  (bases 1 to 2903)
  AUTHORS   Ohtsuka,K. and Hata,M.
  TITLE     Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a
            proposal for their classification and nomenclature
  JOURNAL   Cell Stress Chaperones 5 (2), 98-112 (2000)
   PUBMED   11147971
REFERENCE   10 (bases 1 to 2903)
  AUTHORS   Hoe,K.L., Won,M., Chung,K.S., Jang,Y.J., Lee,S.B., Kim,D.U.,
            Lee,J.W., Yun,J.H. and Yoo,H.S.
  TITLE     Isolation of a new member of DnaJ-like heat shock protein 40
            (Hsp40) from human liver
  JOURNAL   Biochim Biophys Acta 1383 (1), 4-8 (1998)
   PUBMED   9546042
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA354925.1, BC034721.1,
            AC103591.3 and BM972589.1.
            
            On Nov 23, 2018 this sequence version replaced NM_007034.4.
            
            Summary: The protein encoded by this gene is a molecular chaperone,
            tumor suppressor, and member of the heat shock protein-40 family.
            The encoded protein binds the cell adhesion protein E-cadherin and
            targets it to the plasma membrane. This protein also binds
            incorrectly folded E-cadherin and targets it for endoplasmic
            reticulum-associated degradation. This gene is a strong tumor
            suppressor for colorectal carcinoma, and downregulation of it may
            serve as a good biomarker for predicting patient outcomes. Several
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, Nov 2015].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a). Variants 1 and 2 both encode the same isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189655.215750.1,
                                           SRR1660803.114052.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000370763.6/ ENSP00000359799.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                DA354925.1         112-124
            14-2253             BC034721.1         1-2240
            2254-2720           AC103591.3         74496-74962         c
            2721-2903           BM972589.1         17-199              c
FEATURES             Location/Qualifiers
     source          1..2903
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p31.1"
     gene            1..2903
                     /gene="DNAJB4"
                     /gene_synonym="CMYO21; CMYP21; DjB4; DNAJW; HLJ1"
                     /note="DnaJ heat shock protein family (Hsp40) member B4"
                     /db_xref="GeneID:11080"
                     /db_xref="HGNC:HGNC:14886"
                     /db_xref="MIM:611327"
     exon            1..383
                     /gene="DNAJB4"
                     /gene_synonym="CMYO21; CMYP21; DjB4; DNAJW; HLJ1"
                     /inference="alignment:Splign:2.1.0"
     CDS             173..1186
                     /gene="DNAJB4"
                     /gene_synonym="CMYO21; CMYP21; DjB4; DNAJW; HLJ1"
                     /note="isoform a is encoded by transcript variant 1;
                     DnaJ-like heat shock protein 40; dnaJ homolog subfamily B
                     member 4; HSP40 homolog; heat shock protein 40 homolog;
                     human liver DnaJ-like protein; heat shock 40 kDa protein 1
                     homolog; DnaJ (Hsp40) homolog, subfamily B, member 4"
                     /codon_start=1
                     /product="dnaJ homolog subfamily B member 4 isoform a"
                     /protein_id="NP_008965.2"
                     /db_xref="CCDS:CCDS684.1"
                     /db_xref="GeneID:11080"
                     /db_xref="HGNC:HGNC:14886"
                     /db_xref="MIM:611327"
                     /translation="MGKDYYCILGIEKGASDEDIKKAYRKQALKFHPDKNKSPQAEEK
                     FKEVAEAYEVLSDPKKREIYDQFGEEGLKGGAGGTDGQGGTFRYTFHGDPHATFAAFF
                     GGSNPFEIFFGRRMGGGRDSEEMEIDGDPFSAFGFSMNGYPRDRNSVGPSRLKQDPPV
                     IHELRVSLEEIYSGCTKRMKISRKRLNADGRSYRSEDKILTIEIKKGWKEGTKITFPR
                     EGDETPNSIPADIVFIIKDKDHPKFKRDGSNIIYTAKISLREALCGCSINVPTLDGRN
                     IPMSVNDIVKPGMRRRIIGYGLPFPKNPDQRGDLLIEFEVSFPDTISSSSKEVLRKHL
                     PAS"
     exon            384..952
                     /gene="DNAJB4"
                     /gene_synonym="CMYO21; CMYP21; DjB4; DNAJW; HLJ1"
                     /inference="alignment:Splign:2.1.0"
     exon            953..2903
                     /gene="DNAJB4"
                     /gene_synonym="CMYO21; CMYP21; DjB4; DNAJW; HLJ1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2122..2127
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DNAJB4"
                     /gene_synonym="CMYO21; CMYP21; DjB4; DNAJW; HLJ1"
                     /note="hexamer: AATAAA"
     polyA_site      2147
                     /gene="DNAJB4"
                     /gene_synonym="CMYO21; CMYP21; DjB4; DNAJW; HLJ1"
                     /note="major polyA site"
     regulatory      2233..2238
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DNAJB4"
                     /gene_synonym="CMYO21; CMYP21; DjB4; DNAJW; HLJ1"
                     /note="hexamer: AATATA"
     polyA_site      2257
                     /gene="DNAJB4"
                     /gene_synonym="CMYO21; CMYP21; DjB4; DNAJW; HLJ1"
                     /note="major polyA site"
     regulatory      2685..2690
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DNAJB4"
                     /gene_synonym="CMYO21; CMYP21; DjB4; DNAJW; HLJ1"
                     /note="hexamer: AATAGA"
     polyA_site      2701
                     /gene="DNAJB4"
                     /gene_synonym="CMYO21; CMYP21; DjB4; DNAJW; HLJ1"
     regulatory      2887..2892
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DNAJB4"
                     /gene_synonym="CMYO21; CMYP21; DjB4; DNAJW; HLJ1"
                     /note="hexamer: AATAAT"
     polyA_site      2903
                     /gene="DNAJB4"
                     /gene_synonym="CMYO21; CMYP21; DjB4; DNAJW; HLJ1"
                     /note="major polyA site"
ORIGIN      
        1 aggattgaat acagagacgc tgtctgcttg ctgccttaag acagctagct gaattgctga
       61 ttaactttta aaatacccag cttggtttat ttttcttaga atctgttgct aagactgggg
      121 acgctgtttt cttttacaaa gggaaatcta agttaatttc aaggcattcg aaatggggaa
      181 agactattat tgcattttgg gaattgagaa aggagcttca gatgaagata ttaaaaaggc
      241 ttaccgaaaa caagccctca aatttcatcc ggacaagaac aaatctcctc aggcagagga
      301 aaaatttaaa gaggtcgcag aagcttatga agtattgagt gatcctaaaa agagagaaat
      361 atatgatcag tttggggagg aagggttgaa aggaggagca ggaggtactg atggacaagg
      421 aggtaccttc cggtacacct ttcatggcga tcctcatgct acatttgctg catttttcgg
      481 agggtccaac ccctttgaaa ttttctttgg aagacgaatg ggtggtggta gagattctga
      541 agaaatggaa atagatggtg atccttttag tgcctttggt ttcagcatga atggatatcc
      601 aagagacagg aattctgtgg ggccatcccg cctcaaacaa gatcctccag ttattcatga
      661 acttagagta tcacttgaag agatatatag tggttgtacc aaacggatga agatttctcg
      721 aaaaaggcta aacgctgatg gaaggagtta cagatctgag gacaaaattc ttaccattga
      781 gattaaaaaa gggtggaaag aaggcaccaa aattactttt ccaagagaag gagatgaaac
      841 accaaatagt attccagcag acattgtttt tatcattaaa gacaaagatc atccaaaatt
      901 taaaagggat ggatcaaata taatttatac tgctaaaatt agtttacgag aggcattgtg
      961 tggctgctca attaatgtac caacactgga tggaagaaac atacctatgt cagtaaatga
     1021 tattgtgaaa cccggaatga ggagaagaat tattggatat gggctgccat ttccaaaaaa
     1081 tcctgaccaa cgtggtgacc ttctaataga atttgaggtg tccttcccag atactatatc
     1141 ttcttcatcc aaagaagtac ttaggaaaca tcttcctgcc tcatagaatg aagaactttg
     1201 ttacacatat tttgataagg cactgaaaat ataaaaggac tggtagttta ctgatgtaga
     1261 tgtgaattct gtataaagat gtgtaaattc ttttgagggt tcattaaatt gcatgaatag
     1321 agacgggtca aataaatagg caaaagggat ttttacagtt agagataaaa gagaaaacca
     1381 ttcactgtat tttatttcat ttctcctgat tcagatattt ttagtaattt gcttatatgt
     1441 aaaagttgtt tttgtggagt cagtggatat atttctaatg aagtgctaga ctatccaatt
     1501 acttaatttc ttataccttt agataatcag tatgaaaagt tcccatttat aatggaaatg
     1561 aaaattctta actaaactat acatgtaata tgtatttcta gaagagaata aaaacccaag
     1621 tcagttatta gatttaaatc accttctgaa atgctgctat agggctggta tctgtaaaag
     1681 aatatcctga tgcatctgtt tcaccatttt gatttttaaa gtatgctgta gcatttctta
     1741 ataacatcgt tgtgatgttc ttaaggcaga tctttcttca taaaaaggaa agtaatggca
     1801 atttctctcc tgtggaaatc ccaattgctt gaattactga tattttagaa tagacttttt
     1861 aaaatgccat atgtaatttt atgcaagttg actatatatc ttgtacttaa taaattatag
     1921 gctcattttg ttctctgcta gtttaaagta attcgtttaa taatagatgt gtttttagag
     1981 gaaatgctgt tacttggaat taattttcca gttatacagt cttctataac ttactaataa
     2041 tattctatat gtactttatg taatttccct aaaaagaatg aactaccact acactatggt
     2101 gttaaaccaa aatataggga aaataaacac taactgctgc ttatggataa tgttgcaact
     2161 acttgttatg catataaata ttttactttt tcacatgtat agattgcatt tcttaggtgt
     2221 tttaattttt taaatatatt tatgttttaa aaatttagtt ttgttttctg ttttataact
     2281 atagtgagaa tgatgttttg aagcaaaatt tttggttata aaatagtttt caggattata
     2341 tatatatata ctggatccta tcgcctttta gtagaatatg aaatattctt ttagaaatcc
     2401 aatataaata ggttataata gccatattct ttattacttt attgagatat aatttacatg
     2461 ccataaagtt tacccttaaa atatataatt cagtggtttt tagtgatatt tacaaagtgg
     2521 tacaatcatc atcactttct aattccagaa tattttcatc accccaaaaa gaaatcctaa
     2581 atccattagc agttacttcc cattcttccc ttcctccagc ccctgaaaac actaccatct
     2641 acttttcatc tgtatggatt tgtctgttct ggacatttca cataaataga ctcaaacaat
     2701 atatggcttt tttttttttt ggtctggcct ctttcattta gcttaatgtt ttcaaggttc
     2761 atctatgttg tatcacgtat cagtacttta ttttttgtgt ggcacgtcat atggatatac
     2821 cacaatttgt ttatcttttc attaattatg ggcatttggc ttatttctac ttttttggct
     2881 attataaata atgctgctgt gaa
//
