LOCUS       NM_016306               1640 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens DnaJ heat shock protein family (Hsp40) member B11
            (DNAJB11), transcript variant 1, mRNA.
ACCESSION   NM_016306
VERSION     NM_016306.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1640)
  AUTHORS   Aiello,V., Ciurli,F., Conti,A., Cristalli,C.P., Lerario,S.,
            Montanari,F., Sciascia,N., Vischini,G., Fabbrizio,B., Di
            Costanzo,R., Olivucci,G., Pietra,A., Lopez,A., Zambianchi,L., La
            Manna,G. and Capelli,I.
  TITLE     DNAJB11 Mutation in ADPKD Patients: Clinical Characteristics in a
            Monocentric Cohort
  JOURNAL   Genes (Basel) 15 (1), 3 (2023)
   PUBMED   38275584
  REMARK    GeneRIF: DNAJB11 Mutation in ADPKD Patients: Clinical
            Characteristics in a Monocentric Cohort.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1640)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1640)
  AUTHORS   Huynh,V.T., Audrezet,M.P., Sayer,J.A., Ong,A.C., Lefevre,S., Le
            Brun,V., Despres,A., Senum,S.R., Chebib,F.T., Barroso-Gil,M.,
            Patel,C., Mallett,A.J., Goel,H., Mallawaarachchi,A.C., Van
            Eerde,A.M., Ponlot,E., Kribs,M., Le Meur,Y., Harris,P.C. and
            Cornec-Le Gall,E.
  CONSRTM   Genkyst Study Group, Genomics England Research Consortium
  TITLE     Clinical spectrum, prognosis and estimated prevalence of
            DNAJB11-kidney disease
  JOURNAL   Kidney Int 98 (2), 476-487 (2020)
   PUBMED   32631624
  REMARK    GeneRIF: Clinical spectrum, prognosis and estimated prevalence of
            DNAJB11-kidney disease.
REFERENCE   4  (bases 1 to 1640)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1640)
  AUTHORS   Nakanishi,K., Kamiguchi,K., Torigoe,T., Nabeta,C., Hirohashi,Y.,
            Asanuma,H., Tobioka,H., Koge,N., Harada,O., Tamura,Y., Nagano,H.,
            Yano,S., Chiba,S., Matsumoto,H. and Sato,N.
  TITLE     Localization and function in endoplasmic reticulum stress tolerance
            of ERdj3, a new member of Hsp40 family protein
  JOURNAL   Cell Stress Chaperones 9 (3), 253-264 (2004)
   PUBMED   15544163
  REMARK    GeneRIF: These data suggest that ERdj3 might have diverse roles in
            the ER, including that of the molecular cochaperone of BiP and an
            as yet unknown protective action against vero toxin.(ERDJ3)
REFERENCE   6  (bases 1 to 1640)
  AUTHORS   Meunier,L., Usherwood,Y.K., Chung,K.T. and Hendershot,L.M.
  TITLE     A subset of chaperones and folding enzymes form multiprotein
            complexes in endoplasmic reticulum to bind nascent proteins
  JOURNAL   Mol Biol Cell 13 (12), 4456-4469 (2002)
   PUBMED   12475965
REFERENCE   7  (bases 1 to 1640)
  AUTHORS   Lau,P.P., Villanueva,H., Kobayashi,K., Nakamuta,M., Chang,B.H. and
            Chan,L.
  TITLE     A DnaJ protein, apobec-1-binding protein-2, modulates
            apolipoprotein B mRNA editing
  JOURNAL   J Biol Chem 276 (49), 46445-46452 (2001)
   PUBMED   11584023
REFERENCE   8  (bases 1 to 1640)
  AUTHORS   Yu,M., Haslam,R.H. and Haslam,D.B.
  TITLE     HEDJ, an Hsp40 co-chaperone localized to the endoplasmic reticulum
            of human cells
  JOURNAL   J Biol Chem 275 (32), 24984-24992 (2000)
   PUBMED   10827079
REFERENCE   9  (bases 1 to 1640)
  AUTHORS   Ohtsuka,K. and Hata,M.
  TITLE     Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a
            proposal for their classification and nomenclature
  JOURNAL   Cell Stress Chaperones 5 (2), 98-112 (2000)
   PUBMED   11147971
REFERENCE   10 (bases 1 to 1640)
  AUTHORS   Harris,P.C. and Torres,V.E.
  TITLE     Polycystic Kidney Disease, Autosomal Dominant
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301424
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC068631.16.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Feb 13, 2020 this sequence version replaced NM_016306.5.
            
            Summary: This gene encodes a soluble glycoprotein of the
            endoplasmic reticulum (ER) lumen that functions as a co-chaperone
            of binding immunoglobulin protein, a 70 kilodalton heat shock
            protein chaperone required for the proper folding and assembly of
            proteins in the ER. The encoded protein contains a highly conserved
            J domain of about 70 amino acids with a characteristic His-Pro-Asp
            (HPD) motif and may regulate the activity of binding immunoglobulin
            protein by stimulating ATPase activity. [provided by RefSeq, Mar
            2014].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF277317.1, AY359043.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000265028.8/ ENSP00000265028.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-246               AC068631.16        90607-90852         c
            247-403             AC068631.16        89321-89477         c
            404-501             AC068631.16        85635-85732         c
            502-634             AC068631.16        83772-83904         c
            635-777             AC068631.16        80059-80201         c
            778-860             AC068631.16        79495-79577         c
            861-918             AC068631.16        78799-78856         c
            919-1030            AC068631.16        77596-77707         c
            1031-1190           AC068631.16        76983-77142         c
            1191-1640           AC068631.16        75779-76228         c
FEATURES             Location/Qualifiers
     source          1..1640
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q27.3"
     gene            1..1640
                     /gene="DNAJB11"
                     /gene_synonym="ABBP-2; ABBP2; Dj-9; DJ9; EDJ; ERdj3; ERj3;
                     ERj3p; PKD6; PRO1080; UNQ537"
                     /note="DnaJ heat shock protein family (Hsp40) member B11"
                     /db_xref="GeneID:51726"
                     /db_xref="HGNC:HGNC:14889"
                     /db_xref="MIM:611341"
     exon            1..246
                     /gene="DNAJB11"
                     /gene_synonym="ABBP-2; ABBP2; Dj-9; DJ9; EDJ; ERdj3; ERj3;
                     ERj3p; PKD6; PRO1080; UNQ537"
                     /inference="alignment:Splign:2.1.0"
     CDS             179..1255
                     /gene="DNAJB11"
                     /gene_synonym="ABBP-2; ABBP2; Dj-9; DJ9; EDJ; ERdj3; ERj3;
                     ERj3p; PKD6; PRO1080; UNQ537"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; ER-associated Hsp40 co-chaperone;
                     PWP1-interacting protein 4; ER-associated DNAJ protein 3;
                     DnaJ protein 9; ER-resident protein ERdj3; endoplasmic
                     reticulum DNA J domain-containing protein 3; dnaJ homolog
                     subfamily B member 11; APOBEC1-binding protein 2; DnaJ
                     (Hsp40) homolog, subfamily B, member 11"
                     /codon_start=1
                     /product="dnaJ homolog subfamily B member 11 isoform 1
                     precursor"
                     /protein_id="NP_057390.1"
                     /db_xref="CCDS:CCDS3277.1"
                     /db_xref="GeneID:51726"
                     /db_xref="HGNC:HGNC:14889"
                     /db_xref="MIM:611341"
                     /translation="MAPQNLSTFCLLLLYLIGAVIAGRDFYKILGVPRSASIKDIKKA
                     YRKLALQLHPDRNPDDPQAQEKFQDLGAAYEVLSDSEKRKQYDTYGEEGLKDGHQSSH
                     GDIFSHFFGDFGFMFGGTPRQQDRNIPRGSDIIVDLEVTLEEVYAGNFVEVVRNKPVA
                     RQAPGKRKCNCRQEMRTTQLGPGRFQMTQEVVCDECPNVKLVNEERTLEVEIEPGVRD
                     GMEYPFIGEGEPHVDGEPGDLRFRIKVVKHPIFERRGDDLYTNVTISLVESLVGFEMD
                     ITHLDGHKVHISRDKITRPGAKLWKKGEGLPNFDNNNIKGSLIITFDVDFPKEQLTEE
                     AREGIKQLLKQGSVQKVYNGLQGY"
     exon            247..403
                     /gene="DNAJB11"
                     /gene_synonym="ABBP-2; ABBP2; Dj-9; DJ9; EDJ; ERdj3; ERj3;
                     ERj3p; PKD6; PRO1080; UNQ537"
                     /inference="alignment:Splign:2.1.0"
     exon            404..501
                     /gene="DNAJB11"
                     /gene_synonym="ABBP-2; ABBP2; Dj-9; DJ9; EDJ; ERdj3; ERj3;
                     ERj3p; PKD6; PRO1080; UNQ537"
                     /inference="alignment:Splign:2.1.0"
     exon            502..634
                     /gene="DNAJB11"
                     /gene_synonym="ABBP-2; ABBP2; Dj-9; DJ9; EDJ; ERdj3; ERj3;
                     ERj3p; PKD6; PRO1080; UNQ537"
                     /inference="alignment:Splign:2.1.0"
     exon            635..777
                     /gene="DNAJB11"
                     /gene_synonym="ABBP-2; ABBP2; Dj-9; DJ9; EDJ; ERdj3; ERj3;
                     ERj3p; PKD6; PRO1080; UNQ537"
                     /inference="alignment:Splign:2.1.0"
     exon            778..860
                     /gene="DNAJB11"
                     /gene_synonym="ABBP-2; ABBP2; Dj-9; DJ9; EDJ; ERdj3; ERj3;
                     ERj3p; PKD6; PRO1080; UNQ537"
                     /inference="alignment:Splign:2.1.0"
     exon            861..918
                     /gene="DNAJB11"
                     /gene_synonym="ABBP-2; ABBP2; Dj-9; DJ9; EDJ; ERdj3; ERj3;
                     ERj3p; PKD6; PRO1080; UNQ537"
                     /inference="alignment:Splign:2.1.0"
     exon            919..1030
                     /gene="DNAJB11"
                     /gene_synonym="ABBP-2; ABBP2; Dj-9; DJ9; EDJ; ERdj3; ERj3;
                     ERj3p; PKD6; PRO1080; UNQ537"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1190
                     /gene="DNAJB11"
                     /gene_synonym="ABBP-2; ABBP2; Dj-9; DJ9; EDJ; ERdj3; ERj3;
                     ERj3p; PKD6; PRO1080; UNQ537"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1640
                     /gene="DNAJB11"
                     /gene_synonym="ABBP-2; ABBP2; Dj-9; DJ9; EDJ; ERdj3; ERj3;
                     ERj3p; PKD6; PRO1080; UNQ537"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1261..1266
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DNAJB11"
                     /gene_synonym="ABBP-2; ABBP2; Dj-9; DJ9; EDJ; ERdj3; ERj3;
                     ERj3p; PKD6; PRO1080; UNQ537"
                     /note="hexamer: AATAAA"
     polyA_site      1284
                     /gene="DNAJB11"
                     /gene_synonym="ABBP-2; ABBP2; Dj-9; DJ9; EDJ; ERdj3; ERj3;
                     ERj3p; PKD6; PRO1080; UNQ537"
                     /note="major polyA site"
     regulatory      1619..1624
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DNAJB11"
                     /gene_synonym="ABBP-2; ABBP2; Dj-9; DJ9; EDJ; ERdj3; ERj3;
                     ERj3p; PKD6; PRO1080; UNQ537"
                     /note="hexamer: AATACA"
     polyA_site      1640
                     /gene="DNAJB11"
                     /gene_synonym="ABBP-2; ABBP2; Dj-9; DJ9; EDJ; ERdj3; ERj3;
                     ERj3p; PKD6; PRO1080; UNQ537"
ORIGIN      
        1 actcccggga agtggaccgg cagaagaggg ggctagctag ctgtctctgc ggaccaagga
       61 gacccccgcg cccccccggt gtgaggcggc ctcacagggc cgggtgggct ggcgagccga
      121 cgcggcggcg gaggaggctg tgaggagtgt gtggaacagg acccgggaca gaggaaccat
      181 ggctccgcag aacctgagca ccttttgcct gttgctgcta tacctcatcg gggcggtgat
      241 tgccggacga gatttctata agatcttggg ggtgcctcga agtgcctcta taaaggatat
      301 taaaaaggcc tataggaaac tagccctgca gcttcatccc gaccggaacc ctgatgatcc
      361 acaagcccag gagaaattcc aggatctggg tgctgcttat gaggttctgt cagatagtga
      421 gaaacggaaa cagtacgata cttatggtga agaaggatta aaagatggtc atcagagctc
      481 ccatggagac attttttcac acttctttgg ggattttggt ttcatgtttg gaggaacccc
      541 tcgtcagcaa gacagaaata ttccaagagg aagtgatatt attgtagatc tagaagtcac
      601 tttggaagaa gtatatgcag gaaattttgt ggaagtagtt agaaacaaac ctgtggcaag
      661 gcaggctcct ggcaaacgga agtgcaattg tcggcaagag atgcggacca cccagctggg
      721 ccctgggcgc ttccaaatga cccaggaggt ggtctgcgac gaatgcccta atgtcaaact
      781 agtgaatgaa gaacgaacgc tggaagtaga aatagagcct ggggtgagag acggcatgga
      841 gtaccccttt attggagaag gtgagcctca cgtggatggg gagcctggag atttacggtt
      901 ccgaatcaaa gttgtcaagc acccaatatt tgaaaggaga ggagatgatt tgtacacaaa
      961 tgtgacaatc tcattagttg agtcactggt tggctttgag atggatatta ctcacttgga
     1021 tggtcacaag gtacatattt cccgggataa gatcaccagg ccaggagcga agctatggaa
     1081 gaaaggggaa gggctcccca actttgacaa caacaatatc aagggctctt tgataatcac
     1141 ttttgatgtg gattttccaa aagaacagtt aacagaggaa gcgagagaag gtatcaaaca
     1201 gctactgaaa caagggtcag tgcagaaggt atacaatgga ctgcaaggat attgagagtg
     1261 aataaaattg gactttgttt aaaataagtg aataagcgat atttattatc tgcaaggttt
     1321 ttttgtgtgt gtttttgttt ttattttcaa tatgcaagtt aggcttaatt tttttatcta
     1381 atgatcatca tgaaatgaat aagagggctt aagaatttgt ccatttgcat tcggaaaaga
     1441 atgaccagca aaaggtttac taatacctct ccctttgggg atttaatgtc tggtgctgcc
     1501 gcctgagttt caagaattaa agctgcaaga ggactccagg agcaaaagaa acacaatata
     1561 gagggttgga gttgttagca atttcattca aaatgccaac tggagaagtc tgtttttaaa
     1621 tacattttgt tgttattttt
//
