LOCUS       NM_001130182            3127 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens DnaJ heat shock protein family (Hsp40) member A4
            (DNAJA4), transcript variant 2, mRNA.
ACCESSION   NM_001130182
VERSION     NM_001130182.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3127)
  AUTHORS   Zhang,Q., Feng,P., Zhu,X.H., Zhou,S.Q., Ye,M.L., Yang,X.J.,
            Gong,S., Huang,S.Y., Tan,X.R., He,S.W. and Li,Y.Q.
  TITLE     DNAJA4 suppresses epithelial-mesenchymal transition and metastasis
            in nasopharyngeal carcinoma via PSMD2-mediated MYH9 degradation
  JOURNAL   Cell Death Dis 14 (10), 697 (2023)
   PUBMED   37875476
  REMARK    GeneRIF: DNAJA4 suppresses epithelial-mesenchymal transition and
            metastasis in nasopharyngeal carcinoma via PSMD2-mediated MYH9
            degradation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3127)
  AUTHORS   Liu,Z., Xie,D., He,X., Zhou,T. and Li,W.
  TITLE     DNAJA4 Promotes the Replication of the Chinese Giant Salamander
            Iridovirus
  JOURNAL   Genes (Basel) 14 (1), 58 (2022)
   PUBMED   36672799
  REMARK    GeneRIF: DNAJA4 Promotes the Replication of the Chinese Giant
            Salamander Iridovirus.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3127)
  AUTHORS   Zhang,H., Xue,F., Zhao,H., Chen,L., Wang,T. and Wu,X.
  TITLE     DNA methylation status of DNAJA4 is essential for human
            erythropoiesis
  JOURNAL   Epigenomics 14 (20), 1249-1267 (2022)
   PUBMED   36420716
  REMARK    GeneRIF: DNA methylation status of DNAJA4 is essential for human
            erythropoiesis.
REFERENCE   4  (bases 1 to 3127)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 3127)
  AUTHORS   Liu,R.J., Niu,X.L., Yuan,J.P., Chen,H.D., Gao,X.H. and Qi,R.Q.
  TITLE     DnaJA4 is involved in responses to hyperthermia by regulating the
            expression of F-actin in HaCaT cells
  JOURNAL   Chin Med J (Engl) 134 (4), 456-462 (2020)
   PUBMED   32925288
  REMARK    GeneRIF: DnaJA4 is involved in responses to hyperthermia by
            regulating the expression of F-actin in HaCaT cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3127)
  AUTHORS   Sun,Y.Z., Ren,Y., Zhang,Y.J., Han,Y., Yang,Y., Gao,Y.L., Zhu,L.L.,
            Qi,R.Q., Chen,H.D. and Gao,X.H.
  TITLE     DNAJA4 deficiency enhances NF-kappa B-related growth arrest induced
            by hyperthermia in human keratinocytes
  JOURNAL   J Dermatol Sci 91 (3), 256-267 (2018)
   PUBMED   29807809
  REMARK    GeneRIF: Hyperthermia reduced HaCaT cell proliferation and promoted
            cytokine expressions responsible for anti-viral activity, mainly
            through a NF-kB dependent pathway. DNAJA4-deficiency enhanced the
            activation of NF-kB by hyperthermia in HaCaT cells.
REFERENCE   7  (bases 1 to 3127)
  AUTHORS   Taipale,M., Tucker,G., Peng,J., Krykbaeva,I., Lin,Z.Y., Larsen,B.,
            Choi,H., Berger,B., Gingras,A.C. and Lindquist,S.
  TITLE     A quantitative chaperone interaction network reveals the
            architecture of cellular protein homeostasis pathways
  JOURNAL   Cell 158 (2), 434-448 (2014)
   PUBMED   25036637
REFERENCE   8  (bases 1 to 3127)
  AUTHORS   Pencheva,N., Tran,H., Buss,C., Huh,D., Drobnjak,M., Busam,K. and
            Tavazoie,S.F.
  TITLE     Convergent multi-miRNA targeting of ApoE drives LRP1/LRP8-dependent
            melanoma metastasis and angiogenesis
  JOURNAL   Cell 151 (5), 1068-1082 (2012)
   PUBMED   23142051
REFERENCE   9  (bases 1 to 3127)
  AUTHORS   Hageman,J., van Waarde,M.A., Zylicz,A., Walerych,D. and
            Kampinga,H.H.
  TITLE     The diverse members of the mammalian HSP70 machine show distinct
            chaperone-like activities
  JOURNAL   Biochem J 435 (1), 127-142 (2011)
   PUBMED   21231916
REFERENCE   10 (bases 1 to 3127)
  AUTHORS   Ohtsuka,K. and Hata,M.
  TITLE     Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a
            proposal for their classification and nomenclature
  JOURNAL   Cell Stress Chaperones 5 (2), 98-112 (2000)
   PUBMED   11147971
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC090607.6.
            
            On Oct 2, 2020 this sequence version replaced NM_001130182.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK096616.1, SRR11853567.10597.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000394852.8/ ENSP00000378321.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-334               AC090607.6         80950-81283
            335-515             AC090607.6         86885-87065
            516-620             AC090607.6         89483-89587
            621-848             AC090607.6         90585-90812
            849-1079            AC090607.6         91886-92116
            1080-1180           AC090607.6         96433-96533
            1181-3127           AC090607.6         96633-98579
FEATURES             Location/Qualifiers
     source          1..3127
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q25.1"
     gene            1..3127
                     /gene="DNAJA4"
                     /gene_synonym="MST104; MSTP104; PRO1472"
                     /note="DnaJ heat shock protein family (Hsp40) member A4"
                     /db_xref="GeneID:55466"
                     /db_xref="HGNC:HGNC:14885"
     exon            1..334
                     /gene="DNAJA4"
                     /gene_synonym="MST104; MSTP104; PRO1472"
                     /inference="alignment:Splign:2.1.0"
     CDS             203..1396
                     /gene="DNAJA4"
                     /gene_synonym="MST104; MSTP104; PRO1472"
                     /note="isoform 2 is encoded by transcript variant 2; dnaJ
                     homolog subfamily A member 4; DnaJ (Hsp40) homolog,
                     subfamily A, member 4"
                     /codon_start=1
                     /product="dnaJ homolog subfamily A member 4 isoform 2"
                     /protein_id="NP_001123654.1"
                     /db_xref="CCDS:CCDS45316.1"
                     /db_xref="GeneID:55466"
                     /db_xref="HGNC:HGNC:14885"
                     /translation="MVKETQYYDILGVKPSASPEEIKKAYRKLALKYHPDKNPDEGEK
                     FKLISQAYEVLSDPKKRDVYDQGGEQAIKEGGSGSPSFSSPMDIFDMFFGGGGRMARE
                     RRGKNVVHQLSVTLEDLYNGVTKKLALQKNVICEKCEGVGGKKGSVEKCPLCKGRGMQ
                     IHIQQIGPGMVQQIQTVCIECKGQGERINPKDRCESCSGAKVIREKKIIEVHVEKGMK
                     DGQKILFHGEGDQEPELEPGDVIIVLDQKDHSVFQRRGHDLIMKMKIQLSEALCGFKK
                     TIKTLDNRILVITSKAGEVIKHGDLRCVRDEGMPIYKAPLEKGILIIQFLVIFPEKHW
                     LSLEKLPQLEALLPPRQKVRITDDMDQVELKEFCPNEQNWRQHREAYEEDEDGPQAGV
                     QCQTA"
     exon            335..515
                     /gene="DNAJA4"
                     /gene_synonym="MST104; MSTP104; PRO1472"
                     /inference="alignment:Splign:2.1.0"
     exon            516..620
                     /gene="DNAJA4"
                     /gene_synonym="MST104; MSTP104; PRO1472"
                     /inference="alignment:Splign:2.1.0"
     exon            621..848
                     /gene="DNAJA4"
                     /gene_synonym="MST104; MSTP104; PRO1472"
                     /inference="alignment:Splign:2.1.0"
     exon            849..1079
                     /gene="DNAJA4"
                     /gene_synonym="MST104; MSTP104; PRO1472"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1180
                     /gene="DNAJA4"
                     /gene_synonym="MST104; MSTP104; PRO1472"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..3127
                     /gene="DNAJA4"
                     /gene_synonym="MST104; MSTP104; PRO1472"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3105..3110
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DNAJA4"
                     /gene_synonym="MST104; MSTP104; PRO1472"
                     /note="hexamer: ATTAAA"
     polyA_site      3127
                     /gene="DNAJA4"
                     /gene_synonym="MST104; MSTP104; PRO1472"
                     /note="major polyA site"
ORIGIN      
        1 agtgcggtgg agccaggcgt ggaagtcggt ccggcgcggg gcggggggcg ggcgggagct
       61 acaagcggcg gcggcggcgg cgaccgtgac cgtgacgcgc gagcgggcgg cgggggcgcg
      121 ggccaggggc gcgggccagg gtgccggcag gggcgtccgg ggcgctctga ccggcctcgc
      181 ccgccccccc cgcagacaca agatggtgaa ggagacccag tactatgaca tcctgggcgt
      241 gaagcccagc gcgtccccgg aggagatcaa gaaggcctat cggaagctgg cgctcaagta
      301 ccacccggac aagaacccgg atgagggcga gaagtttaaa ctcatatccc aggcatatga
      361 agtgctttca gatccaaaga aaagggatgt ttatgaccaa ggcggagagc aggcaattaa
      421 agaaggaggc tcaggcagcc ccagcttctc ttcacccatg gacatctttg acatgttctt
      481 tggtggtggt ggacggatgg ctagagagag aagaggcaag aatgttgtac accagttatc
      541 tgtaactctt gaagatctat ataatggagt cacgaagaaa ttggccctcc agaaaaatgt
      601 aatttgtgag aaatgtgaag gtgttggtgg gaagaaggga tcggtggaga agtgcccgct
      661 gtgcaagggg cgggggatgc agatccacat ccagcagatc gggccgggca tggtacagca
      721 gatccagacc gtgtgcatcg agtgcaaggg ccagggtgag cgcatcaacc ccaaggaccg
      781 ctgcgagagc tgcagcgggg ccaaggtgat ccgtgagaag aagattatcg aggtacatgt
      841 tgaaaaaggt atgaaagatg ggcaaaagat actatttcat ggagaaggag atcaggagcc
      901 tgagctggag cctggtgatg tcataattgt gcttgatcag aaggatcata gtgtctttca
      961 gagacgaggc catgacttga tcatgaaaat gaaaattcag ctttctgaag ctctttgtgg
     1021 cttcaagaag acgataaaaa cattggacaa tcgaattctt gttattacat ccaaagcagg
     1081 tgaggtgata aagcacgggg acctgagatg cgtgcgcgat gaaggaatgc ccatctacaa
     1141 agcacccctg gaaaaaggga ttctgatcat acagttttta gtaatctttc ctgaaaaaca
     1201 ctggctttct ctggaaaagc ttcctcagct ggaagcttta ctccctcctc gacagaaagt
     1261 gaggattaca gatgacatgg atcaggtgga gctgaaggag ttttgtccca atgagcagaa
     1321 ctggcgtcag cacagggagg cctacgagga ggacgaagac gggccccagg ctggagtgca
     1381 gtgccagacg gcatgacgtg gtgcggggca gcgtggcccc accggactag cacatgatga
     1441 atgtaaagtt ggcacaatga aaatgacatc gctttaatgg ccttgtgttt gggatgtcct
     1501 gtgtatgtgt tcagcattct taattgctga gtgtcttttt ggcttttctt ttggttgtaa
     1561 cttaagttat agcttaattt atatttaaat gttttaagta taaatcacct ctagtctgca
     1621 tatggaatct gttcatttct attttcagga tatacttttg agatgtcagt gattgcacca
     1681 atactttgtg cttctagtgg ctttgccata attcagtgtc accaataagg cacagcccag
     1741 ttagcagctt agccccccta gcaaacccca aggcacaaag tgggcatcct gactcatctc
     1801 taggtctgtg gtttctcccc tcttcccttg gcagagttat tgagggcatg atctcagggc
     1861 tgctaagata acatttctga ggattctaga tgatcctctt aaagaataaa agcacatccg
     1921 tggatcggac atggctgcat gtgcctgctt aacagggcca acttagttcc tactgttctg
     1981 tgcccttcag tggatggaac gtgagtgtct gatcatctct cttggaagtt ttctgaacct
     2041 tccaagctct gtggtgagga caaaccagtg tttgaatcat atgctgataa ctgtttgcct
     2101 gtgaccctca caccttgttc ttcagggttt taatgatttt ctgttgacaa cttttgcaat
     2161 gctttcccac caaagtgctt acttgtaaag aaaactaaat ccttctgtgt ccccggcagc
     2221 ctcagtgcag caacagaagc caagggagaa tgctgctggt ttggcccatg gcacagccag
     2281 cttctctgac cagtaatccg gggtgacttg agggtctgca aaggcataga actccccagt
     2341 gttttccacc tcattctccc agattgagct cccttccaaa ggatcgttcc tctcattgca
     2401 cagccatatt acaaagggtt tcctgctcaa gtgatgtttt ggtaagaact tcgctgagtt
     2461 ccactgtgga ttacagtttg tatggactac tactgtaaat tatagcttgt ttggagggat
     2521 attagtcatt attttattca tgacaggtag actacaattc gaacttaggg ttacctcagt
     2581 ctttagccat tactgcttat ttcttttccc caagtcacaa aaaacttgta agctgctggg
     2641 ttaaagcaga ggccacctgt cagatctacc ctacccttat ttggttacat ggcacctgag
     2701 agtttcactc agaccaggga tcttccttag gagggtcaaa gtgcagatca gaccatgcag
     2761 gtaaggtgaa ccagctgcac ggaccaggtt cccgcaaaac attgccagct agtgaggcat
     2821 aatttgctca aagtatagaa acagcccacc tgtgcccact ttgaccattg gtgaggatag
     2881 atataaaatc acttcttcca acgaagccta ggtgaaaatc tatttataaa tggaccacaa
     2941 ctctggggtg tcgtttttgt gctgtgactt cctaattatt gctaaagaac tactgtttag
     3001 ttggtaatgg tgtaaaatta cattcagctc cttcttgtca tataaaagga atttggaggg
     3061 tgtcgcttaa aattttattc cacctgtaca tttgtcactt taaaattaaa attgagctgg
     3121 tatgaga
//
