LOCUS       NM_005147               2700 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens DnaJ heat shock protein family (Hsp40) member A3
            (DNAJA3), transcript variant 1, mRNA; nuclear gene for
            mitochondrial product.
ACCESSION   NM_005147
VERSION     NM_005147.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2700)
  AUTHORS   Jang,J., Lee,S.H., Kang,D.H., Sim,D.W., Ryu,K.S., Jo,K.S., Lee,J.,
            Ryu,H., Kim,E.H., Won,H.S. and Kim,J.H.
  TITLE     Structural resemblance of the DNAJA-family protein, Tid1, to the
            DNAJB-family Hsp40
  JOURNAL   BMB Rep 55 (10), 488-493 (2022)
   PUBMED   35651334
  REMARK    GeneRIF: Structural resemblance of the DNAJA-family protein, Tid1,
            to the DNAJB-family Hsp40.
REFERENCE   2  (bases 1 to 2700)
  AUTHORS   Salokas,K., Liu,X., Ohman,T., Chowdhury,I., Gawriyski,L.,
            Keskitalo,S. and Varjosalo,M.
  TITLE     Physical and functional interactome atlas of human receptor
            tyrosine kinases
  JOURNAL   EMBO Rep 23 (6), e54041 (2022)
   PUBMED   35384245
REFERENCE   3  (bases 1 to 2700)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   4  (bases 1 to 2700)
  AUTHORS   Ahn,B.Y., Trinh,D.L., Zajchowski,L.D., Lee,B., Elwi,A.N. and
            Kim,S.W.
  TITLE     Tid1 is a new regulator of p53 mitochondrial translocation and
            apoptosis in cancer
  JOURNAL   Oncogene 29 (8), 1155-1166 (2010)
   PUBMED   19935715
REFERENCE   5  (bases 1 to 2700)
  AUTHORS   Kim,S.W., Chao,T.H., Xiang,R., Lo,J.F., Campbell,M.J., Fearns,C.
            and Lee,J.D.
  TITLE     Tid1, the human homologue of a Drosophila tumor suppressor, reduces
            the malignant activity of ErbB-2 in carcinoma cells
  JOURNAL   Cancer Res 64 (21), 7732-7739 (2004)
   PUBMED   15520177
REFERENCE   6  (bases 1 to 2700)
  AUTHORS   Trentin,G.A., Yin,X., Tahir,S., Lhotak,S., Farhang-Fallah,J., Li,Y.
            and Rozakis-Adcock,M.
  TITLE     A mouse homologue of the Drosophila tumor suppressor l(2)tid gene
            defines a novel Ras GTPase-activating protein (RasGAP)-binding
            protein
  JOURNAL   J Biol Chem 276 (16), 13087-13095 (2001)
   PUBMED   11116152
REFERENCE   7  (bases 1 to 2700)
  AUTHORS   Shinohara,M., Gasior,S.L., Bishop,D.K. and Shinohara,A.
  TITLE     Tid1/Rdh54 promotes colocalization of rad51 and dmc1 during meiotic
            recombination
  JOURNAL   Proc Natl Acad Sci U S A 97 (20), 10814-10819 (2000)
   PUBMED   11005857
REFERENCE   8  (bases 1 to 2700)
  AUTHORS   Ohtsuka,K. and Hata,M.
  TITLE     Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a
            proposal for their classification and nomenclature
  JOURNAL   Cell Stress Chaperones 5 (2), 98-112 (2000)
   PUBMED   11147971
REFERENCE   9  (bases 1 to 2700)
  AUTHORS   Syken,J., De-Medina,T. and Munger,K.
  TITLE     TID1, a human homolog of the Drosophila tumor suppressor l(2)tid,
            encodes two mitochondrial modulators of apoptosis with opposing
            functions
  JOURNAL   Proc Natl Acad Sci U S A 96 (15), 8499-8504 (1999)
   PUBMED   10411904
REFERENCE   10 (bases 1 to 2700)
  AUTHORS   Schilling,B., De-Medina,T., Syken,J., Vidal,M. and Munger,K.
  TITLE     A novel human DnaJ protein, hTid-1, a homolog of the Drosophila
            tumor suppressor protein Tid56, can interact with the human
            papillomavirus type 16 E7 oncoprotein
  JOURNAL   Virology 247 (1), 74-85 (1998)
   PUBMED   9683573
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK223105.1, BC011855.2 and
            AB209923.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_005147.5.
            
            Summary: This gene encodes a member of the DNAJ/Hsp40 protein
            family. DNAJ/Hsp40 proteins stimulate the ATPase activity of Hsp70
            chaperones and play critical roles in protein folding, degradation,
            and multimeric complex assembly. The encoded protein is localized
            to mitochondria and mediates several cellular processes including
            proliferation, survival and apoptotic signal transduction. The
            encoded protein also plays a critical role in tumor suppression
            through interactions with oncogenic proteins including ErbB2 and
            the p53 tumor suppressor protein. Alternatively spliced transcript
            variants encoding multiple isoforms have been observed for this
            gene. [provided by RefSeq, Aug 2011].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1, also known as
            TID1L).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.495647.1,
                                           SRR3476690.1054958.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000262375.11/
                                                  ENSP00000262375.4
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1806              AK223105.1         4-1809
            1807-2155           BC011855.2         1794-2142
            2156-2697           AB209923.1         2138-2679
            2698-2700           BC011855.2         2685-2687
FEATURES             Location/Qualifiers
     source          1..2700
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
     gene            1..2700
                     /gene="DNAJA3"
                     /gene_synonym="HCA57; hTID-1; TID1; Tid1-L; Tid1-S"
                     /note="DnaJ heat shock protein family (Hsp40) member A3"
                     /db_xref="GeneID:9093"
                     /db_xref="HGNC:HGNC:11808"
                     /db_xref="MIM:608382"
     exon            1..225
                     /gene="DNAJA3"
                     /gene_synonym="HCA57; hTID-1; TID1; Tid1-L; Tid1-S"
                     /inference="alignment:Splign:2.1.0"
     CDS             15..1457
                     /gene="DNAJA3"
                     /gene_synonym="HCA57; hTID-1; TID1; Tid1-L; Tid1-S"
                     /note="isoform 1 is encoded by transcript variant 1; dnaJ
                     homolog subfamily A member 3, mitochondrial; dnaJ protein
                     Tid-1; tumorous imaginal discs protein Tid56 homolog;
                     hepatocellular carcinoma-associated antigen 57; DnaJ
                     (Hsp40) homolog, subfamily A, member 3"
                     /codon_start=1
                     /product="dnaJ homolog subfamily A member 3, mitochondrial
                     isoform 1"
                     /protein_id="NP_005138.3"
                     /db_xref="CCDS:CCDS10515.1"
                     /db_xref="GeneID:9093"
                     /db_xref="HGNC:HGNC:11808"
                     /db_xref="MIM:608382"
                     /translation="MAARCSTRWLLVVVGTPRLPAISGRGARPPREGVVGAWLSRKLS
                     VPAFASSLTSCGPRALLTLRPGVSLTGTKHNPFICTASFHTSAPLAKEDYYQILGVPR
                     NASQKEIKKAYYQLAKKYHPDTNKDDPKAKEKFSQLAEAYEVLSDEVKRKQYDAYGSA
                     GFDPGASGSQHSYWKGGPTVDPEELFRKIFGEFSSSSFGDFQTVFDQPQEYFMELTFN
                     QAAKGVNKEFTVNIMDTCERCNGKGNEPGTKVQHCHYCGGSGMETINTGPFVMRSTCR
                     RCGGRGSIIISPCVVCRGAGQAKQKKRVMIPVPAGVEDGQTVRMPVGKREIFITFRVQ
                     KSPVFRRDGADIHSDLFISIAQALLGGTARAQGLYETINVTIPPGTQTDQKIRMGGKG
                     IPRINSYGYGDHYIHIKIRVPKRLTSRQQSLILSYAEDETDVEGTVNGVTLTSSGGST
                     MDSSAGSKARREAGEDEEGFLSKLKKMFTS"
     exon            226..359
                     /gene="DNAJA3"
                     /gene_synonym="HCA57; hTID-1; TID1; Tid1-L; Tid1-S"
                     /inference="alignment:Splign:2.1.0"
     exon            360..443
                     /gene="DNAJA3"
                     /gene_synonym="HCA57; hTID-1; TID1; Tid1-L; Tid1-S"
                     /inference="alignment:Splign:2.1.0"
     exon            444..644
                     /gene="DNAJA3"
                     /gene_synonym="HCA57; hTID-1; TID1; Tid1-L; Tid1-S"
                     /inference="alignment:Splign:2.1.0"
     exon            645..797
                     /gene="DNAJA3"
                     /gene_synonym="HCA57; hTID-1; TID1; Tid1-L; Tid1-S"
                     /inference="alignment:Splign:2.1.0"
     exon            798..945
                     /gene="DNAJA3"
                     /gene_synonym="HCA57; hTID-1; TID1; Tid1-L; Tid1-S"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1010
                     /gene="DNAJA3"
                     /gene_synonym="HCA57; hTID-1; TID1; Tid1-L; Tid1-S"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1139
                     /gene="DNAJA3"
                     /gene_synonym="HCA57; hTID-1; TID1; Tid1-L; Tid1-S"
                     /inference="alignment:Splign:2.1.0"
     exon            1140..1255
                     /gene="DNAJA3"
                     /gene_synonym="HCA57; hTID-1; TID1; Tid1-L; Tid1-S"
                     /inference="alignment:Splign:2.1.0"
     exon            1256..1353
                     /gene="DNAJA3"
                     /gene_synonym="HCA57; hTID-1; TID1; Tid1-L; Tid1-S"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..1470
                     /gene="DNAJA3"
                     /gene_synonym="HCA57; hTID-1; TID1; Tid1-L; Tid1-S"
                     /inference="alignment:Splign:2.1.0"
     exon            1471..2700
                     /gene="DNAJA3"
                     /gene_synonym="HCA57; hTID-1; TID1; Tid1-L; Tid1-S"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2604..2609
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DNAJA3"
                     /gene_synonym="HCA57; hTID-1; TID1; Tid1-L; Tid1-S"
                     /note="hexamer: AATAAA"
     polyA_site      2627
                     /gene="DNAJA3"
                     /gene_synonym="HCA57; hTID-1; TID1; Tid1-L; Tid1-S"
                     /note="major polyA site"
     regulatory      2661..2666
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DNAJA3"
                     /gene_synonym="HCA57; hTID-1; TID1; Tid1-L; Tid1-S"
                     /note="hexamer: AATAAG"
     polyA_site      2700
                     /gene="DNAJA3"
                     /gene_synonym="HCA57; hTID-1; TID1; Tid1-L; Tid1-S"
                     /note="major polyA site"
ORIGIN      
        1 gtccccgggc caagatggct gcgcggtgct ccacacgctg gttgctggtg gttgtgggga
       61 ccccgcggct gccggctata tcgggtagag gggcccggcc gcccagggag ggcgtggtgg
      121 gggcatggct gagccgcaag ctgagcgtcc ccgcctttgc gtcttccctg acctcttgcg
      181 gcccccgagc gctgctgaca ttgagacctg gtgtcagcct tacaggaaca aaacataacc
      241 ctttcatttg tactgcctcc ttccacacga gtgccccttt ggccaaagaa gattattatc
      301 agatattagg agtgcctcga aatgccagcc agaaagagat caagaaagcc tattatcagc
      361 ttgccaagaa gtatcaccct gacacaaata aggatgatcc caaagccaag gagaagttct
      421 cccagctggc agaagcctat gaggttttga gtgatgaggt gaagaggaag cagtacgatg
      481 cctacggctc tgcaggcttc gatcctgggg ccagcggctc ccagcatagc tactggaagg
      541 gaggccccac tgtggacccc gaggagctgt tcaggaagat ctttggcgag ttctcatcct
      601 cttcatttgg agatttccag accgtgtttg atcagcctca ggaatacttc atggagttga
      661 cattcaatca agctgcaaag ggggtcaaca aggagttcac cgtgaacatc atggacacgt
      721 gtgagcgctg caacggcaag gggaacgagc ccggcaccaa ggtgcagcat tgccactact
      781 gtggcggctc cggcatggaa accatcaaca caggcccttt tgtgatgcgt tccacgtgta
      841 ggagatgtgg tggccgcggc tccatcatca tatcgccctg tgtggtctgc aggggagcag
      901 gacaagccaa gcagaaaaag cgagtgatga tccctgtgcc tgcaggagtc gaggatggcc
      961 agaccgtgag gatgcctgtg ggaaaaaggg aaattttcat tacgttcagg gtgcagaaaa
     1021 gccctgtgtt ccggagggac ggcgcagaca tccactccga cctctttatt tctatagctc
     1081 aggctcttct tgggggtaca gccagagccc agggcctgta cgagacgatc aacgtgacga
     1141 tcccccctgg gactcagaca gaccagaaga ttcggatggg tgggaaaggc atcccccgga
     1201 ttaacagcta cggctacgga gaccactaca tccacatcaa gatacgagtt ccaaagaggc
     1261 taacgagccg gcagcagagc ctgatcctga gctacgccga ggacgagaca gatgtggagg
     1321 ggacggtgaa cggcgtcacc ctcaccagct ctggtggcag caccatggat agctccgcag
     1381 gaagcaaggc taggcgtgag gctggggagg acgaggaggg attcctttcc aaacttaaga
     1441 aaatgtttac ctcatgatat cccagccgag gaaaaagatc cactggaaac taggccggga
     1501 agcagcagcc cctccaaggg ccagggcacc tgggagacgg gaggattcca gaacagcagc
     1561 actgagctcc cacccgcaga gcctctggac ggccttggca acagcaaaat catgggacaa
     1621 cacctctctc cacggaaagg tcacagtgga cagcccgggc agtaggatgc agccccagag
     1681 gctggtggca gtttcctgtc cattggtagg tgacggcccc tggctcaggc agagggagat
     1741 ggttagactc ttgcagggct aaaactctaa tttggaattg aatattgtgg atatcttagt
     1801 taaaggccat gcttacagct tagaaatgaa gccttaagct gcatcaagtt acgaagtgat
     1861 taatttcctt ctcagcaaac ctccgggagg ttccagaatg agttcttcct gacaggttgt
     1921 cttcactggg agcgtggggc ccccaggccc caccagcacc gtcctcccct aatgaggggc
     1981 cctgccgagg catcagctgc tctgctcagt tagtttttat tcccggggta ccaagcagct
     2041 gcacagtcgg tgcctgggag gcacgtagag gcccagagag tccctggggg ttctgctctg
     2101 accgtgtggg tggtgatcct tgtcaggatg tacagtcctt gctcccaccc catccgggat
     2161 ggccgcctgt ccctgactat tgagtcctgt tgttgtaagc caggcatgga gggctcctgc
     2221 ccttctgctg agccacagcc cattgcagca ctgtgctggc cagacttcag ctgccttggg
     2281 aactgaagcc ctgccactgt tgctagtcag gggcttggtt ctcccactta cactgttgac
     2341 atctattttc tgaagtgtgt ttaaattatt cagtgctaat cattgttttt tcctttgtaa
     2401 atgttgattc agaaaaggaa agcacaggct aagcagttga aggttcccca ccattcagtg
     2461 agagcagaac ccccattccc cagcctctgc tggtagcatg tcgcagtttc catgtgtttc
     2521 aggatcttcg ggctgtcgtt agacaggtta atgaagaaca cttctcaaca gtttcctttt
     2581 tgttttcctt tataattcac taaaataaag catctattag tgtctgattt aggaatgtaa
     2641 aatgattctg tattaatgta aataagatta tctattgcaa aaagatattt caaacctaaa
//
