LOCUS       NM_005880               3008 bp    mRNA    linear   PRI 07-FEB-2025
DEFINITION  Homo sapiens DnaJ heat shock protein family (Hsp40) member A2
            (DNAJA2), mRNA.
ACCESSION   NM_005880 NM_004222
VERSION     NM_005880.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3008)
  AUTHORS   Lam,A.Y.W., Tsuboyama,K., Tadakuma,H. and Tomari,Y.
  TITLE     DNAJA2 and Hero11 mediate similar conformational extension and
            aggregation suppression of TDP-43
  JOURNAL   RNA 30 (11), 1422-1436 (2024)
   PUBMED   39117455
  REMARK    GeneRIF: DNAJA2 and Hero11 mediate similar conformational extension
            and aggregation suppression of TDP-43.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3008)
  AUTHORS   Velasco-Carneros,L., Bernardo-Seisdedos,G., Marechal,J.D.,
            Millet,O., Moro,F. and Muga,A.
  TITLE     Pseudophosphorylation of single residues of the J-domain of DNAJA2
            regulates the holding/folding balance of the Hsc70 system
  JOURNAL   Protein Sci 33 (8), e5105 (2024)
   PUBMED   39012012
  REMARK    GeneRIF: Pseudophosphorylation of single residues of the J-domain
            of DNAJA2 regulates the holding/folding balance of the Hsc70
            system.
REFERENCE   3  (bases 1 to 3008)
  AUTHORS   Velasco-Carneros,L., Cuellar,J., Dublang,L., Santiago,C.,
            Marechal,J.D., Martin-Benito,J., Maestro,M.,
            Fernandez-Higuero,J.A., Orozco,N., Moro,F., Valpuesta,J.M. and
            Muga,A.
  TITLE     The self-association equilibrium of DNAJA2 regulates its
            interaction with unfolded substrate proteins and with Hsc70
  JOURNAL   Nat Commun 14 (1), 5436 (2023)
   PUBMED   37670029
  REMARK    GeneRIF: The self-association equilibrium of DNAJA2 regulates its
            interaction with unfolded substrate proteins and with Hsc70.
            Erratum:[Nat Commun. 2024 Jan 2;15(1):99. doi:
            10.1038/s41467-023-44499-y.. PMID: 38167402]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3008)
  AUTHORS   Huang,Y., Lu,C., Wang,H., Gu,L., Fu,Y.X. and Li,G.M.
  TITLE     DNAJA2 deficiency activates cGAS-STING pathway via the induction of
            aberrant mitosis and chromosome instability
  JOURNAL   Nat Commun 14 (1), 5246 (2023)
   PUBMED   37640708
  REMARK    GeneRIF: DNAJA2 deficiency activates cGAS-STING pathway via the
            induction of aberrant mitosis and chromosome instability.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3008)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 3008)
  AUTHORS   Terada,K. and Mori,M.
  TITLE     Human DnaJ homologs dj2 and dj3, and bag-1 are positive
            cochaperones of hsc70
  JOURNAL   J Biol Chem 275 (32), 24728-24734 (2000)
   PUBMED   10816573
REFERENCE   7  (bases 1 to 3008)
  AUTHORS   Diefenbach,J. and Kindl,H.
  TITLE     The membrane-bound DnaJ protein located at the cytosolic site of
            glyoxysomes specifically binds the cytosolic isoform 1 of Hsp70 but
            not other Hsp70 species
  JOURNAL   Eur J Biochem 267 (3), 746-754 (2000)
   PUBMED   10651811
REFERENCE   8  (bases 1 to 3008)
  AUTHORS   Scanlan,M.J., Gordan,J.D., Williamson,B., Stockert,E., Bander,N.H.,
            Jongeneel,V., Gure,A.O., Jager,D., Jager,E., Knuth,A., Chen,Y.T.
            and Old,L.J.
  TITLE     Antigens recognized by autologous antibody in patients with
            renal-cell carcinoma
  JOURNAL   Int J Cancer 83 (4), 456-464 (1999)
   PUBMED   10508479
REFERENCE   9  (bases 1 to 3008)
  AUTHORS   Lorain,S., Quivy,J.P., Monier-Gavelle,F., Scamps,C., Lecluse,Y.,
            Almouzni,G. and Lipinski,M.
  TITLE     Core histones and HIRIP3, a novel histone-binding protein, directly
            interact with WD repeat protein HIRA
  JOURNAL   Mol Cell Biol 18 (9), 5546-5556 (1998)
   PUBMED   9710638
REFERENCE   10 (bases 1 to 3008)
  AUTHORS   Edwards,M.C., Liegeois,N., Horecka,J., DePinho,R.A., Sprague,G.F.
            Jr., Tyers,M. and Elledge,S.J.
  TITLE     Human CPR (cell cycle progression restoration) genes impart a Far-
            phenotype on yeast cells
  JOURNAL   Genetics 147 (3), 1063-1076 (1997)
   PUBMED   9383053
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB097731.1, BC015809.2,
            AC018845.7 and BU677823.1.
            
            On Nov 23, 2018 this sequence version replaced NM_005880.3.
            
            Summary: The protein encoded by this gene belongs to the
            evolutionarily conserved DNAJ/HSP40 family of proteins, which
            regulate molecular chaperone activity by stimulating ATPase
            activity. DNAJ proteins may have up to 3 distinct domains: a
            conserved 70-amino acid J domain, usually at the N terminus; a
            glycine/phenylalanine (G/F)-rich region; and a cysteine-rich domain
            containing 4 motifs resembling a zinc finger domain. The product of
            this gene works as a cochaperone of Hsp70s in protein folding and
            mitochondrial protein import in vitro. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.150616.1,
                                           SRR1660807.139541.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03267769 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000317089.10/ ENSP00000314030.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 DB097731.1         115-121
            8-1931              BC015809.2         1-1924
            1932-2983           AC018845.7         95439-96490         c
            2984-3008           BU677823.1         19-43               c
FEATURES             Location/Qualifiers
     source          1..3008
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q11.2"
     gene            1..3008
                     /gene="DNAJA2"
                     /gene_synonym="CPR3; DJ3; DJA2; DNAJ; DNJ3; HIRIP4;
                     PRO3015; RDJ2"
                     /note="DnaJ heat shock protein family (Hsp40) member A2"
                     /db_xref="GeneID:10294"
                     /db_xref="HGNC:HGNC:14884"
                     /db_xref="MIM:611322"
     exon            1..180
                     /gene="DNAJA2"
                     /gene_synonym="CPR3; DJ3; DJA2; DNAJ; DNJ3; HIRIP4;
                     PRO3015; RDJ2"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..1341
                     /gene="DNAJA2"
                     /gene_synonym="CPR3; DJ3; DJA2; DNAJ; DNJ3; HIRIP4;
                     PRO3015; RDJ2"
                     /note="cell cycle progression 3 protein; HIRA interacting
                     protein 4; renal carcinoma antigen NY-REN-14; cell cycle
                     progression restoration gene 3 protein; DnaJ (Hsp40)
                     homolog, subfamily A, member 2"
                     /codon_start=1
                     /product="dnaJ homolog subfamily A member 2"
                     /protein_id="NP_005871.1"
                     /db_xref="CCDS:CCDS10726.1"
                     /db_xref="GeneID:10294"
                     /db_xref="HGNC:HGNC:14884"
                     /db_xref="MIM:611322"
                     /translation="MANVADTKLYDILGVPPGASENELKKAYRKLAKEYHPDKNPNAG
                     DKFKEISFAYEVLSNPEKRELYDRYGEQGLREGSGGGGGMDDIFSHIFGGGLFGFMGN
                     QSRSRNGRRRGEDMMHPLKVSLEDLYNGKTTKLQLSKNVLCSACSGQGGKSGAVQKCS
                     ACRGRGVRIMIRQLAPGMVQQMQSVCSDCNGEGEVINEKDRCKKCEGKKVIKEVKILE
                     VHVDKGMKHGQRITFTGEADQAPGVEPGDIVLLLQEKEHEVFQRDGNDLHMTYKIGLV
                     EALCGFQFTFKHLDGRQIVVKYPPGKVIEPGCVRVVRGEGMPQYRNPFEKGDLYIKFD
                     VQFPENNWINPDKLSELEDLLPSRPEVPNIIGETEEVELQEFDSTRGSGGGQRREAYN
                     DSSDEESSSHHGPGVQCAHQ"
     exon            181..240
                     /gene="DNAJA2"
                     /gene_synonym="CPR3; DJ3; DJA2; DNAJ; DNJ3; HIRIP4;
                     PRO3015; RDJ2"
                     /inference="alignment:Splign:2.1.0"
     exon            241..464
                     /gene="DNAJA2"
                     /gene_synonym="CPR3; DJ3; DJA2; DNAJ; DNJ3; HIRIP4;
                     PRO3015; RDJ2"
                     /inference="alignment:Splign:2.1.0"
     exon            465..545
                     /gene="DNAJA2"
                     /gene_synonym="CPR3; DJ3; DJA2; DNAJ; DNJ3; HIRIP4;
                     PRO3015; RDJ2"
                     /inference="alignment:Splign:2.1.0"
     exon            546..679
                     /gene="DNAJA2"
                     /gene_synonym="CPR3; DJ3; DJA2; DNAJ; DNJ3; HIRIP4;
                     PRO3015; RDJ2"
                     /inference="alignment:Splign:2.1.0"
     exon            680..876
                     /gene="DNAJA2"
                     /gene_synonym="CPR3; DJ3; DJA2; DNAJ; DNJ3; HIRIP4;
                     PRO3015; RDJ2"
                     /inference="alignment:Splign:2.1.0"
     exon            877..1021
                     /gene="DNAJA2"
                     /gene_synonym="CPR3; DJ3; DJA2; DNAJ; DNJ3; HIRIP4;
                     PRO3015; RDJ2"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1149
                     /gene="DNAJA2"
                     /gene_synonym="CPR3; DJ3; DJA2; DNAJ; DNJ3; HIRIP4;
                     PRO3015; RDJ2"
                     /inference="alignment:Splign:2.1.0"
     exon            1150..3008
                     /gene="DNAJA2"
                     /gene_synonym="CPR3; DJ3; DJA2; DNAJ; DNJ3; HIRIP4;
                     PRO3015; RDJ2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1757..1762
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DNAJA2"
                     /gene_synonym="CPR3; DJ3; DJA2; DNAJ; DNJ3; HIRIP4;
                     PRO3015; RDJ2"
                     /note="hexamer: AATAAA"
     polyA_site      1779
                     /gene="DNAJA2"
                     /gene_synonym="CPR3; DJ3; DJA2; DNAJ; DNJ3; HIRIP4;
                     PRO3015; RDJ2"
                     /note="major polyA site"
     regulatory      1964..1969
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DNAJA2"
                     /gene_synonym="CPR3; DJ3; DJA2; DNAJ; DNJ3; HIRIP4;
                     PRO3015; RDJ2"
                     /note="hexamer: AATAAA"
     polyA_site      1988
                     /gene="DNAJA2"
                     /gene_synonym="CPR3; DJ3; DJA2; DNAJ; DNJ3; HIRIP4;
                     PRO3015; RDJ2"
                     /note="major polyA site"
     regulatory      2987..2992
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DNAJA2"
                     /gene_synonym="CPR3; DJ3; DJA2; DNAJ; DNJ3; HIRIP4;
                     PRO3015; RDJ2"
                     /note="hexamer: AATAAA"
     polyA_site      3008
                     /gene="DNAJA2"
                     /gene_synonym="CPR3; DJ3; DJA2; DNAJ; DNJ3; HIRIP4;
                     PRO3015; RDJ2"
                     /note="major polyA site"
ORIGIN      
        1 gctgtctccc tcggcctgtg ccgccgccga cgccgcttgt gggcccgact ccgctctgtc
       61 tgcttcgcca ccttctcccc gagcactgcc cggccggccg ccatggctaa cgtggctgac
      121 acgaagctgt acgacatcct gggcgtcccg cccggcgcca gcgagaacga gctgaagaag
      181 gcatacagaa agttagccaa ggaatatcat cctgataaga atccaaatgc aggagacaaa
      241 tttaaagaaa taagttttgc atatgaagta ctatcaaatc ctgagaagcg tgagttatat
      301 gacagatacg gagagcaagg tcttcgggaa ggcagcggcg gaggtggtgg catggatgat
      361 attttctctc acatttttgg tgggggattg ttcggcttca tgggcaatca gagtagaagt
      421 cgaaatggca gaagaagagg agaggacatg atgcatccac tcaaagtatc tttagaagat
      481 ctgtataatg gcaagacaac caaactacaa cttagcaaga atgtgctctg tagtgcatgc
      541 agtggccaag gcggaaagtc tggagctgtc caaaagtgta gtgcttgtcg aggtcgaggt
      601 gtgcgcatca tgatcagaca gctggctcca gggatggtac aacagatgca gtctgtgtgc
      661 tctgattgta atggagaagg agaggtaatt aatgaaaaag accgctgtaa aaaatgtgaa
      721 gggaagaagg tgattaaaga agtcaagatt cttgaagtcc acgtagacaa aggcatgaaa
      781 catggacaga gaattacatt cactggggaa gcagaccagg ccccaggagt ggaacccgga
      841 gacattgttc ttttgctaca ggagaaagaa catgaggtat ttcagagaga tgggaatgat
      901 ttgcacatga catataaaat aggacttgtt gaagctctat gtggatttca gttcacattt
      961 aagcaccttg atggacgtca gattgtggtg aaataccccc ctggcaaagt aattgaacca
     1021 gggtgtgttc gtgtagttcg aggtgaaggg atgccgcagt atcgtaatcc ctttgaaaaa
     1081 ggtgatcttt acataaagtt tgatgtgcag tttcctgaaa acaactggat caacccagac
     1141 aagctttctg aactagaaga tcttctgcca tctagaccgg aagttcctaa cataattgga
     1201 gaaacagagg aggtagagct tcaggaattt gatagcactc gaggctcagg aggtggtcag
     1261 aggcgtgaag cctataatga tagctctgat gaagaaagca gcagccatca tggacctgga
     1321 gtgcagtgtg cccatcagta aactctgcaa acaaattgca caggtggatt ttctttccac
     1381 atttgcctga tttgttctca gcaatccagc tggagtgtct tatcaatcca gatgaactga
     1441 gggacatctg ttggtctatg tataactttt aaaattggta tagtatctac agagtgtata
     1501 atttaaacta accacaaagc tttacatctt cattttgact gttccatagc agaataaagc
     1561 acttgaaagg aaacaagact ccctttcaca catggattat tataagtttc aatcctggta
     1621 tctgtgcttg atttttatca gttttgtgta gatttttatg tttcatattt taaatttaaa
     1681 tcccacattg taaagtttgt acaatttgtc ctgaagcttt gtgtttggct gcacctgcat
     1741 aagctgctac aaatagaata aagaatttca tagcctgtat ctatcattta gatgcatgga
     1801 aaaaaatggg ctttgcacac aatgggtttg gagctgactg ggaacaatgg aaaaaattac
     1861 attagctgtg gttgtaaagt ttttttgttt ttggttttgt tttttttttc ttttttcttt
     1921 tttttttttt ttaccatctt gtgaaaggtt tctgaaactc gataataaaa agcggttggt
     1981 gtaaattatt cttttgtgtc acatttttag aaggaaaaac ataaaagaat gtatccttag
     2041 tactggttct taaacagccc ataaaaaccc attggcctga agcttatatc tcaggcctat
     2101 gcccatctta tagtcttgga agacaaaagg ctggtagaga cagtcttcag tggcttcagt
     2161 gatgctctgt agaggccagg gtgtcttgag tgctgtaact cccaagcact gggctagcct
     2221 gacttctgta tctccctacc accaccccct taaaaaaata aggtaacagc aaatctatag
     2281 taaaaccatg tctgcataga acgtgttcaa atcctctgtt ttcattaaat gtaaaagatg
     2341 ctgtctccat taagttgaat atttggaatt ggagaagcca ttgattatta ttttgagttt
     2401 ctgtaatgtt ttatagaaaa gtaagatgct tattcagaat ttaagaatga aggcaactga
     2461 aatatgcatt gttgtagtta tttatatttc aaactaaaaa taagcaaaaa aaaaaggctg
     2521 gtttgagaaa aatcaggtaa aattgatgaa acggatgttg tgtttctctt tccatcatct
     2581 ggtttttacc atttcactca gtaggtattt ttagaacaca cttatttgag gaaagagaca
     2641 tcagatgcac aattttacat ttataaagga acaaatgggg aaaactgaaa actaaaaatt
     2701 ttaaatgtat taaatgccat ccctgagcct aaatctagta tttgtagttt atttctaggt
     2761 ctgctagaac ctgaaaacct gaatgaaaaa aggtgtgctg acactaatca agtcctgtga
     2821 ggtttaaatt attgacctat ccactctacc tccattgtac aaaaaatatt ttacaacaag
     2881 cctgggtaag attcaacagc atagtagttt tgtatccaag gttacttccc cacaaccact
     2941 ttaaacataa gaaatgtggt ggcaatataa agtttgtagc ctttccaata aaggtttata
     3001 aaacagtt
//
