LOCUS       NM_024763               3817 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens dynein axonemal intermediate chain 4 (DNAI4),
            transcript variant 1, mRNA.
ACCESSION   NM_024763
VERSION     NM_024763.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3817)
  AUTHORS   Hom,E.F., Witman,G.B., Harris,E.H., Dutcher,S.K., Kamiya,R.,
            Mitchell,D.R., Pazour,G.J., Porter,M.E., Sale,W.S., Wirschell,M.,
            Yagi,T. and King,S.M.
  TITLE     A unified taxonomy for ciliary dyneins
  JOURNAL   Cytoskeleton (Hoboken) 68 (10), 555-565 (2011)
   PUBMED   21953912
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA916550.1, BC126381.1 and AL133617.1.
            
            On Nov 23, 2018 this sequence version replaced NM_024763.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX648840.1, SRR1803615.106310.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371026.8/ ENSP00000360065.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-124               DA916550.1         351-474
            125-3242            BC126381.1         131-3248
            3243-3817           AL133617.1         1670-2244
FEATURES             Location/Qualifiers
     source          1..3817
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p31.3"
     gene            1..3817
                     /gene="DNAI4"
                     /gene_synonym="DIC4; WDR78"
                     /note="dynein axonemal intermediate chain 4"
                     /db_xref="GeneID:79819"
                     /db_xref="HGNC:HGNC:26252"
                     /db_xref="MIM:619156"
     exon            1..195
                     /gene="DNAI4"
                     /gene_synonym="DIC4; WDR78"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..2572
                     /gene="DNAI4"
                     /gene_synonym="DIC4; WDR78"
                     /note="isoform 1 is encoded by transcript variant 1; WD
                     repeat-containing protein 78; WD repeat domain 78; dynein
                     intermediate chain 4, axonemal"
                     /codon_start=1
                     /product="dynein axonemal intermediate chain 4 isoform 1"
                     /protein_id="NP_079039.4"
                     /db_xref="CCDS:CCDS635.1"
                     /db_xref="GeneID:79819"
                     /db_xref="HGNC:HGNC:26252"
                     /db_xref="MIM:619156"
                     /translation="MTPGKHSGASARAANGGAWGYRDFRGGQKKGWCTTPQLVATMPV
                     SPAGSHKQQNFGLNNATQPKKSISFFATMKATSVKGYTGANQSRMAVSKTVLIPPELK
                     TVEKPNPNIKTTQVFDINGTDVTPRPLYHPDPLTGTAKPSKLLTSQEGSLGSEFISSY
                     SLYQNTINPSTLGQFTRSVLGSSTVSKSSVSASESIAEDLEEPSYKRERLTSFTDLQV
                     IRAAPEKIVTKEDLEKNIEIILTETETLRFFDLPTVMVSVESEEAEKVTQRNKNYEVL
                     CRNRLGNDLYVERMMQTFNGAPKNKDVQCDKIIMEDKGIMSTAWDLYDSYNAMELVSL
                     SVKQSVVESSSKANVLPKDQDQRLPGSTTEKNSETSSLMDIENVILAKIHEDEEDHSD
                     AILKSDKFHQDLFFMERVLMENIFQPKLAAYRQLPVLKEPEPEEPEDVLESAKHEEVE
                     EESKKEEEEEIHAEESTIPANLERLWSFSCDLTKGLNVSSLAWNKTNPDLLAVGYGHF
                     GFKEQKRGLACCWSIKNPMWPERIYQSPYGVTAVDFSIGAPNLLAVGYHNGTIAIYNV
                     RSNSNVPVLDSSESPQKHLGPVWQLQWIEQDRGTTGDGKREILVSISADGRISKWVIR
                     KGLDCYDLMRLKRTTAASNKKGGEKEKKDEALISRQAPGMCFAFHPKDTNIYLAGTEE
                     GHIHKCSCSYNEQYLDTYRGHKGPVYKVTWNPFCHDVFLSCSADWGVIIWQQENVKPS
                     LSFYPATSVVYDVAWSPKSSYIFAAANENRVEIWDLHISTLDPLIVNTANPGIKFTTI
                     LFAKQTDCLLVGDSDGQVSVYELRNMPTVLETGRGDIMDTLLGSKSNQSA"
     exon            196..370
                     /gene="DNAI4"
                     /gene_synonym="DIC4; WDR78"
                     /inference="alignment:Splign:2.1.0"
     exon            371..555
                     /gene="DNAI4"
                     /gene_synonym="DIC4; WDR78"
                     /inference="alignment:Splign:2.1.0"
     exon            556..668
                     /gene="DNAI4"
                     /gene_synonym="DIC4; WDR78"
                     /inference="alignment:Splign:2.1.0"
     exon            669..825
                     /gene="DNAI4"
                     /gene_synonym="DIC4; WDR78"
                     /inference="alignment:Splign:2.1.0"
     exon            826..965
                     /gene="DNAI4"
                     /gene_synonym="DIC4; WDR78"
                     /inference="alignment:Splign:2.1.0"
     exon            966..1121
                     /gene="DNAI4"
                     /gene_synonym="DIC4; WDR78"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..1316
                     /gene="DNAI4"
                     /gene_synonym="DIC4; WDR78"
                     /inference="alignment:Splign:2.1.0"
     exon            1317..1519
                     /gene="DNAI4"
                     /gene_synonym="DIC4; WDR78"
                     /inference="alignment:Splign:2.1.0"
     exon            1520..1606
                     /gene="DNAI4"
                     /gene_synonym="DIC4; WDR78"
                     /inference="alignment:Splign:2.1.0"
     exon            1607..1758
                     /gene="DNAI4"
                     /gene_synonym="DIC4; WDR78"
                     /inference="alignment:Splign:2.1.0"
     exon            1759..1916
                     /gene="DNAI4"
                     /gene_synonym="DIC4; WDR78"
                     /inference="alignment:Splign:2.1.0"
     exon            1917..2038
                     /gene="DNAI4"
                     /gene_synonym="DIC4; WDR78"
                     /inference="alignment:Splign:2.1.0"
     exon            2039..2137
                     /gene="DNAI4"
                     /gene_synonym="DIC4; WDR78"
                     /inference="alignment:Splign:2.1.0"
     exon            2138..2364
                     /gene="DNAI4"
                     /gene_synonym="DIC4; WDR78"
                     /inference="alignment:Splign:2.1.0"
     exon            2365..2521
                     /gene="DNAI4"
                     /gene_synonym="DIC4; WDR78"
                     /inference="alignment:Splign:2.1.0"
     exon            2522..3817
                     /gene="DNAI4"
                     /gene_synonym="DIC4; WDR78"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3790..3795
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DNAI4"
                     /gene_synonym="DIC4; WDR78"
                     /note="hexamer: AATAAA"
     polyA_site      3817
                     /gene="DNAI4"
                     /gene_synonym="DIC4; WDR78"
                     /note="major polyA site"
ORIGIN      
        1 gttgagccag ggctccaccg tcgccatgac gcccggcaaa cattccggag cctcggcccg
       61 agccgctaac ggaggagctt gggggtacag ggacttcaga ggcggccaaa aaaaggggtg
      121 gtgcaccact ccccagctgg tcgccaccat gccagtctct ccggcaggca gtcacaagca
      181 gcagaacttc gggttgaaca atgccacaca accaaagaag tctattagct tttttgctac
      241 aatgaaagca acttcagtga aaggatatac tggtgcaaat caaagcagaa tggctgtgtc
      301 caaaaccgtg cttattccac ctgaactgaa aactgtagaa aaaccaaatc ccaatataaa
      361 gacaacacag gtatttgaca taaatggaac tgatgttact ccccgacctc tttaccatcc
      421 agatccactt actggtacag caaaaccaag taaactcttg acatcacaag aaggatcact
      481 tggatcagaa tttatatctt cctatagcct ttatcagaat acaataaatc ctagtacgtt
      541 agggcagttt acaaggtcag ttttaggaag cagtacagtt tctaagtcaa gtgtatcagc
      601 aagtgaatca atagcagaag acctggaaga accatcctat aaacgggaaa gattgactag
      661 tttcacagat ttgcaagtta taagggcagc acctgaaaaa attgtaacaa aagaagacct
      721 ggagaagaat atagagataa tactcacaga gacagaaaca ctgagatttt ttgacttgcc
      781 cacagtcatg gtctctgtag aatctgaaga agctgagaaa gtaactcaga gaaacaagaa
      841 ttatgaagtc ctttgtagaa acagattagg caatgaccta tatgttgaaa ggatgatgca
      901 gactttcaat ggagcaccaa agaataaaga tgttcaatgt gataaaatca taatggaaga
      961 taaaggcata atgtccactg cctgggattt gtatgattct tacaatgcta tggaacttgt
     1021 atctttatca gtaaaacaat ctgtggttga gtcaagtagt aaagcaaatg tacttcctaa
     1081 agatcaggac caaagattgc cagggagcac tacagaaaaa aatagtgaaa ctagttctct
     1141 aatggacata gaaaatgtaa ttctggcaaa aatccatgaa gatgaggaag accactcaga
     1201 tgcaatatta aaatctgaca aatttcatca ggacttattt tttatggaac gggttctgat
     1261 ggaaaatata tttcagccca aacttgcagc ttatcgtcag cttcctgttt taaaagaacc
     1321 tgaacctgaa gagcctgaag atgttttaga aagtgcaaaa catgaagagg tagaggaaga
     1381 atctaagaag gaggaggaag aagaaataca tgcagaagaa tcaacaatac ccgccaactt
     1441 ggaacgactt tggtcttttt cctgtgactt aaccaaaggc ctcaatgtga gcagccttgc
     1501 ctggaataaa acaaatccag atcttttggc tgttggctat gggcactttg gatttaaaga
     1561 gcaaaaaaga ggactggctt gctgctggtc aataaagaat cccatgtggc cagaacgtat
     1621 ttatcagagt ccatatggag ttactgctgt ggatttttca attggagcac ctaacctttt
     1681 agccgttggc tatcacaatg gcacaattgc aatttacaat gtacggagca acagtaatgt
     1741 tccagttctg gatagtagtg aatcacctca aaaacatttg ggacctgtat ggcaactaca
     1801 gtggatagaa caagatcgag gaacaacagg agatggcaaa agagaaatac tagtttctat
     1861 atcagcagat ggaagaatct ccaaatgggt tatacgaaaa ggactagact gttatgattt
     1921 gatgcgatta aagagaacta cagctgccag taacaaaaaa ggaggggaaa aggaaaagaa
     1981 agatgaagct ttgatatctc gacaggctcc tggaatgtgt tttgcttttc atcccaagga
     2041 cacaaatatc tatttggctg gcactgaaga aggtcatatt cacaaatgtt cttgttcata
     2101 taatgaacaa tacttagata cctacagagg acataagggt ccagtgtata aagtgacatg
     2161 gaatccattt tgtcatgatg tatttttaag ctgttctgca gattggggtg ttattatatg
     2221 gcaacaggag aatgtcaagc catctttgag tttttatcca gctacttctg ttgtttacga
     2281 cgttgcctgg tctccaaaat catcctatat atttgcagct gcaaatgaga acagggtgga
     2341 gatttgggac cttcatatca gcactttgga ccctctgatt gtgaatactg ctaaccctgg
     2401 aatcaagttc acaaccattc tctttgccaa acaaacagat tgccttctgg taggagacag
     2461 tgatggacag gtttctgtgt atgaactgag aaatatgcct actgttttgg aaactggccg
     2521 gggagatata atggatactt tgcttggatc caagtcaaac caatcagcat aattcatcat
     2581 tcctaatatt tttcttgtag ttgttttaaa aaaggaatta acatccaata ttctgtatta
     2641 catactgtac accagatttt gatttcagaa aacaatattt gatgtataac ttccacttaa
     2701 tttaaattta ataaactttt atttcagaga tatttgatta gtttacaatc taagagttat
     2761 tcttaagagt ttcagtggaa ttttcttaat ttttctaaag atattcctac tctcttgatc
     2821 atattctaag tacatatgag tacatgtaca ttcttataca atgtctaaat gggttagaaa
     2881 attattatac ctatagaagc gaaacttgga aattaataga atcacttaaa ccaaaatctt
     2941 tataagacac aattctattg attttaaagc ttctgctttc caggctctgt tttccagagt
     3001 ttataattac gtagttttta gtagatgaaa ataatggatt cttgtaccta acattttatc
     3061 ctcttagatc taagagccga agctatagaa ctttgttaga ctatttggca agcaaaatat
     3121 atgacagtaa atatcagaat tttatggttt gaccagcgct tatcacattc ccaattcagt
     3181 gagaaaaatt catctgggac acaacagggt actcttctct gtttgcccag aatcagctct
     3241 ggattttaag cccagacttc agtggaccca gatagaaaat ataaagtctc tgatctatag
     3301 gccacatcag gatgttattt tatgaagagt tctagagcaa ggttgcggaa atcggggtgg
     3361 agatggggag cagtgactcc tccaaatatt cattgctaac aggccattct atgcagtttg
     3421 ttttaacaaa tcctgggtta aactgaggcc acaggacatg atgggctgtt ctataaagca
     3481 ttctaagtgg agaggagacg atagggcata tgaaattcac taaactctct ggaaaaaaaa
     3541 tatgtatata ttaaaaacca agactggaat cagtgcaaca gtgggaacta ccttttacaa
     3601 gtatccattg cttcataaac tccatttgtt tggaccaatc ccttaaacaa aagcaaggca
     3661 aattttacat ggatttagag cctaggtcag gttattagga ttataaattt tccactggta
     3721 tgtcattgtg attatctttg tttttgtctt tctgaaagat tggattttct ataacacctt
     3781 gtgtaagaaa ataaaaaact tgatctaact gaaaaaa
//
