LOCUS       NM_145172               2990 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens dynein axonemal intermediate chain 3 (DNAI3),
            transcript variant 1, mRNA.
ACCESSION   NM_145172
VERSION     NM_145172.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2990)
  AUTHORS   Braschi,B., Omran,H., Witman,G.B., Pazour,G.J., Pfister,K.K.,
            Bruford,E.A. and King,S.M.
  TITLE     Consensus nomenclature for dyneins and associated assembly factors
  JOURNAL   J Cell Biol 221 (2) (2022)
   PUBMED   35006274
REFERENCE   2  (bases 1 to 2990)
  AUTHORS   Zhao,K., Wang,D., Zhao,X., Wang,C., Gao,Y., Liu,K., Wang,F., Wu,X.,
            Wang,X., Sun,L., Zang,J. and Mei,Y.
  TITLE     WDR63 inhibits Arp2/3-dependent actin polymerization and mediates
            the function of p53 in suppressing metastasis
  JOURNAL   EMBO Rep 21 (4), e49269 (2020)
   PUBMED   32128961
REFERENCE   3  (bases 1 to 2990)
  AUTHORS   Hofmeister,W., Pettersson,M., Kurtoglu,D., Armenio,M., Eisfeldt,J.,
            Papadogiannakis,N., Gustavsson,P. and Lindstrand,A.
  TITLE     Targeted copy number screening highlights an intragenic deletion of
            WDR63 as the likely cause of human occipital encephalocele and
            abnormal CNS development in zebrafish
  JOURNAL   Hum Mutat 39 (4), 495-505 (2018)
   PUBMED   29285825
  REMARK    GeneRIF: A rare deletion in WDR63 in a case of encephalocele has
            been characterized. Functional study on zebrafish supports role of
            WDR63 deletion in abnormal neural development.
REFERENCE   4  (bases 1 to 2990)
  AUTHORS   Diao,S., Yang,D.M., Dong,R., Wang,L.P., Wang,J.S., Du,J., Wang,S.L.
            and Fan,Z.
  TITLE     Enriched trimethylation of lysine 4 of histone H3 of WDR63 enhanced
            osteogenic differentiation potentials of stem cells from apical
            papilla
  JOURNAL   J Endod 41 (2), 205-211 (2015)
   PUBMED   25498833
  REMARK    GeneRIF: These results indicate that WDR63 is a positive enhancer
            for stem cells from apical papilla osteogenic differentiation and
            suggest that activation of WDR63 signaling might improve tissue
            regeneration mediated by MSCs of dental origin.
REFERENCE   5  (bases 1 to 2990)
  AUTHORS   Greliche,N., Germain,M., Lambert,J.C., Cohen,W., Bertrand,M.,
            Dupuis,A.M., Letenneur,L., Lathrop,M., Amouyel,P., Morange,P.E. and
            Tregouet,D.A.
  TITLE     A genome-wide search for common SNP x SNP interactions on the risk
            of venous thrombosis
  JOURNAL   BMC Med Genet 14, 36 (2013)
   PUBMED   23509962
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2990)
  AUTHORS   Hom,E.F., Witman,G.B., Harris,E.H., Dutcher,S.K., Kamiya,R.,
            Mitchell,D.R., Pazour,G.J., Porter,M.E., Sale,W.S., Wirschell,M.,
            Yagi,T. and King,S.M.
  TITLE     A unified taxonomy for ciliary dyneins
  JOURNAL   Cytoskeleton (Hoboken) 68 (10), 555-565 (2011)
   PUBMED   21953912
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB075669.1 and BC040265.1.
            
            On Nov 22, 2018 this sequence version replaced NM_145172.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK292603.1, AY049724.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000294664.11/ ENSP00000294664.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                DB075669.1         7-23
            18-2990             BC040265.1         1-2973
FEATURES             Location/Qualifiers
     source          1..2990
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p22.3"
     gene            1..2990
                     /gene="DNAI3"
                     /gene_synonym="DIC3; NYD-SP29; WDR63"
                     /note="dynein axonemal intermediate chain 3"
                     /db_xref="GeneID:126820"
                     /db_xref="HGNC:HGNC:30711"
                     /db_xref="MIM:617968"
     exon            1..160
                     /gene="DNAI3"
                     /gene_synonym="DIC3; NYD-SP29; WDR63"
                     /inference="alignment:Splign:2.1.0"
     exon            161..238
                     /gene="DNAI3"
                     /gene_synonym="DIC3; NYD-SP29; WDR63"
                     /inference="alignment:Splign:2.1.0"
     CDS             175..2850
                     /gene="DNAI3"
                     /gene_synonym="DIC3; NYD-SP29; WDR63"
                     /note="isoform 1 is encoded by transcript variant 1; WD
                     repeat-containing protein 63; WD repeat domain 63; dynein
                     intermediate chain 3, axonemal; testis development protein
                     NYD-SP29 (NYD-SP29); testicular tissue protein Li 225"
                     /codon_start=1
                     /product="dynein axonemal intermediate chain 3 isoform 1"
                     /protein_id="NP_660155.2"
                     /db_xref="CCDS:CCDS702.1"
                     /db_xref="GeneID:126820"
                     /db_xref="HGNC:HGNC:30711"
                     /db_xref="MIM:617968"
                     /translation="MAPKQKKKTSRGKKRLKPVLAASEDMEPVNMESMGHPEIYPLVL
                     TTKTQEIFNCRIDEDVTDEQPYKLINKEDIFEDLRNRAAVSDFHPVKKIVQEYPGNEL
                     LLVYDKDFKYGLNFYLIATEEGKENYLNPPEVPEEQEEYKEHIPEDVYIYKPPVSKPW
                     VSLGSEKEIEEESVTESTKQITYMISRKRSEFGAPIKFSDQNASSVKDAYIECTAYPD
                     KNFTLKQLEKDVGMQVIPQIKDISTQTKWTYPKNATTQYYPREFSEEEKETLKQSKPL
                     VDFLNNASISVEIALQQNEIMNTFIDDWKYLAEEEGTFGDKTDTHLKEYQSFTDLHSP
                     TEKMITCVSWHPTIYGLIAVSVAVRLSFEDRVHFSGKLLLQPSLILFWSFSDPIHPQL
                     MLESPDDIFCFKFCPSDPNIIAGGCINGQIVMWDITAHADRIENIKAGGSRSKRATLK
                     PMFLLEPESNKEAMYIRHCAVSSIENGHKKVITDIHWLSDTFEINRMGSVFENRSGIC
                     CQLVTCSADCTICFWDIRPQKPLTPQTTEKKKEESIEIPFDVPSTFLHLDLSWKPLTK
                     VRLSKGETSLDHCPTKISLNEDHLLCKTQDKMLAQSKTEKAEEMNPYHNLESGMANLL
                     KPIDDFCTKFFVGTEEGEVIYTDWKMEKDPETGRLMSKKPVSHHTIHDGTVHTIQRSP
                     FYNDIILTVGGWNVAIWKEGVMTGPLLQSCCAPKRYTSGHWSLTRPGVFYIGREDGYI
                     DIWDLLEKTHEPAQSQNICITMITYIKPWIFSSKQQFIATADYYGTLHILEIPWTLSR
                     PSTNEMASVNHYFEREVKHLEYVEQRKKIREQEKKEMELEMAKKKVKTYQKSKEQMQA
                     ELKMDYESYLELEKTVLINLGLIKVTEKGSYMEVM"
     exon            239..277
                     /gene="DNAI3"
                     /gene_synonym="DIC3; NYD-SP29; WDR63"
                     /inference="alignment:Splign:2.1.0"
     exon            278..459
                     /gene="DNAI3"
                     /gene_synonym="DIC3; NYD-SP29; WDR63"
                     /inference="alignment:Splign:2.1.0"
     exon            460..564
                     /gene="DNAI3"
                     /gene_synonym="DIC3; NYD-SP29; WDR63"
                     /inference="alignment:Splign:2.1.0"
     exon            565..714
                     /gene="DNAI3"
                     /gene_synonym="DIC3; NYD-SP29; WDR63"
                     /inference="alignment:Splign:2.1.0"
     exon            715..914
                     /gene="DNAI3"
                     /gene_synonym="DIC3; NYD-SP29; WDR63"
                     /inference="alignment:Splign:2.1.0"
     exon            915..1031
                     /gene="DNAI3"
                     /gene_synonym="DIC3; NYD-SP29; WDR63"
                     /inference="alignment:Splign:2.1.0"
     exon            1032..1222
                     /gene="DNAI3"
                     /gene_synonym="DIC3; NYD-SP29; WDR63"
                     /inference="alignment:Splign:2.1.0"
     exon            1223..1347
                     /gene="DNAI3"
                     /gene_synonym="DIC3; NYD-SP29; WDR63"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1437
                     /gene="DNAI3"
                     /gene_synonym="DIC3; NYD-SP29; WDR63"
                     /inference="alignment:Splign:2.1.0"
     exon            1438..1524
                     /gene="DNAI3"
                     /gene_synonym="DIC3; NYD-SP29; WDR63"
                     /inference="alignment:Splign:2.1.0"
     exon            1525..1653
                     /gene="DNAI3"
                     /gene_synonym="DIC3; NYD-SP29; WDR63"
                     /inference="alignment:Splign:2.1.0"
     exon            1654..1727
                     /gene="DNAI3"
                     /gene_synonym="DIC3; NYD-SP29; WDR63"
                     /inference="alignment:Splign:2.1.0"
     exon            1728..1872
                     /gene="DNAI3"
                     /gene_synonym="DIC3; NYD-SP29; WDR63"
                     /inference="alignment:Splign:2.1.0"
     exon            1873..1960
                     /gene="DNAI3"
                     /gene_synonym="DIC3; NYD-SP29; WDR63"
                     /inference="alignment:Splign:2.1.0"
     exon            1961..2091
                     /gene="DNAI3"
                     /gene_synonym="DIC3; NYD-SP29; WDR63"
                     /inference="alignment:Splign:2.1.0"
     exon            2092..2155
                     /gene="DNAI3"
                     /gene_synonym="DIC3; NYD-SP29; WDR63"
                     /inference="alignment:Splign:2.1.0"
     exon            2156..2286
                     /gene="DNAI3"
                     /gene_synonym="DIC3; NYD-SP29; WDR63"
                     /inference="alignment:Splign:2.1.0"
     exon            2287..2491
                     /gene="DNAI3"
                     /gene_synonym="DIC3; NYD-SP29; WDR63"
                     /inference="alignment:Splign:2.1.0"
     exon            2492..2583
                     /gene="DNAI3"
                     /gene_synonym="DIC3; NYD-SP29; WDR63"
                     /inference="alignment:Splign:2.1.0"
     exon            2584..2706
                     /gene="DNAI3"
                     /gene_synonym="DIC3; NYD-SP29; WDR63"
                     /inference="alignment:Splign:2.1.0"
     exon            2707..2990
                     /gene="DNAI3"
                     /gene_synonym="DIC3; NYD-SP29; WDR63"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2971..2976
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DNAI3"
                     /gene_synonym="DIC3; NYD-SP29; WDR63"
                     /note="hexamer: ATTAAA"
     polyA_site      2990
                     /gene="DNAI3"
                     /gene_synonym="DIC3; NYD-SP29; WDR63"
                     /note="major polyA site"
ORIGIN      
        1 agatgcgtcc tggcaacagt cggcagagtt gctgcggttt gtgcccttgc gatttctttt
       61 tctgagagag gagagtcaaa ctcccacctc cagctctcga aggagctttt cctgagggca
      121 ctgcaaagag gctccttttc tttcagatca gcagtatcag cccaagtcag aaccatggct
      181 ccaaaacaaa agaaaaagac atcacgtggc aaaaaaagac taaaaccagt attagctgct
      241 agtgaagaca tggaaccagt aaatatggag agcatgggtc atccagaaat ttatccttta
      301 gtattaacca ccaagaccca agaaatattt aactgccgaa tagatgaaga tgtcacagat
      361 gaacaacctt ataagcttat caataaagaa gacatttttg aggacctgcg caacagagct
      421 gcagtatctg atttccaccc agtcaaaaaa attgtccagg aatatcctgg aaatgagctt
      481 ctgcttgttt atgacaaaga cttcaaatat ggacttaact tttatcttat tgcaactgaa
      541 gagggcaaag aaaactattt aaatccccca gaagtaccag aagaacaaga agaatataaa
      601 gaacatattc ctgaagatgt gtatatttat aaaccacctg tctctaaacc atgggtttct
      661 ttgggcagtg aaaaagaaat tgaggaagaa tcagttacgg aatctacaaa gcagattaca
      721 tatatgattt ctcgaaaacg aagtgaattt ggtgcaccaa ttaagttcag tgaccagaat
      781 gcttccagtg taaaagatgc ctatattgaa tgtacagcct acccagataa aaattttacc
      841 cttaaacaac ttgaaaaaga tgttggcatg caagtaatcc cccaaataaa ggacataagc
      901 actcagacaa aatggacata tcctaaaaat gctactacgc aatattatcc aagagaattc
      961 tcagaagagg aaaaagagac actcaaacaa tcaaagcctt tggttgattt tcttaacaat
     1021 gcatccataa gtgttgaaat agccctgcag caaaatgaaa tcatgaacac atttattgat
     1081 gactggaaat acctcgcaga agaagaaggc acctttgggg acaagaccga tacccacctg
     1141 aaagagtacc agtcctttac cgaccttcat agcccaacgg agaaaatgat tacctgtgtc
     1201 tcatggcatc caactatcta tgggctaata gctgtgtcgg tagccgtgcg actttctttt
     1261 gaagacagag ttcacttttc tggtaaatta ttgctgcagc catcactgat tcttttctgg
     1321 agcttctctg atcctataca tcctcagtta atgctggaga gcccagatga catcttctgc
     1381 ttcaagttct gtccgagtga tcctaatatc attgctggag gctgtatcaa tgggcagatt
     1441 gtcatgtggg atatcaccgc acatgcagat cgcatagaaa acattaaggc aggtggtagt
     1501 agaagtaaaa gagccacact gaagcctatg tttctccttg aaccggagag taataaagaa
     1561 gcaatgtata tcagacactg tgcagtctct tcaatagaaa atggacataa gaaagtaatt
     1621 acagatatac actggttgtc tgacacattt gagattaaca gaatgggctc cgtctttgag
     1681 aatcgaagtg gaatatgctg tcaacttgtc acatgttcag cagattgcac aatatgtttt
     1741 tgggatatta gaccacagaa acctttaacc ccccaaacaa cagagaaaaa gaaggaggaa
     1801 agtattgaaa ttccttttga tgtaccatct acttttttgc atctggatct ctcctggaaa
     1861 cctctcacta aggtaaggct gtccaagggt gaaacaagtt tagaccactg tccaaccaag
     1921 ataagcctga atgaagacca tcttctttgc aaaacacaag acaaaatgtt agcacagagc
     1981 aaaacagaga aggcagaaga aatgaacccg tatcataatc tggaaagtgg gatggccaat
     2041 cttctcaagc caatagatga cttctgcaca aagttctttg tgggaacaga ggaaggcgaa
     2101 gtgatataca cagattggaa aatggaaaaa gaccctgaaa ctggccgact tatgtcaaag
     2161 aagccagtga gccaccacac cattcacgac ggaactgtcc acactattca gagatcacct
     2221 ttctacaacg acattattct cacggttgga ggttggaacg tggccatatg gaaagaaggt
     2281 gttatgactg gaccgctcct tcagtcatgc tgtgcaccaa aaaggtacac ctcaggccac
     2341 tggtccctga ctcggcccgg agttttctac atcggccgag aagatggata cattgatatc
     2401 tgggaccttc tggagaaaac ccatgaacca gcccagtctc aaaacatttg cataactatg
     2461 atcacctaca tcaaaccctg gatcttttct tctaaacagc aatttatagc cacagctgat
     2521 tattatggaa cactgcatat attagaaatt ccttggacat taagtcgccc ttccaccaat
     2581 gagatggcaa gtgtcaacca ctattttgaa agagaagtca agcatctgga atacgtagaa
     2641 cagcgcaaaa aaattcgtga gcaagaaaag aaagaaatgg aactagaaat ggcaaagaaa
     2701 aaagttaaaa catatcagaa gtcaaaagaa caaatgcagg ctgaattaaa aatggactat
     2761 gagagttatc tggaactgga aaagactgtt cttatcaacc ttggcctaat caaagtcaca
     2821 gagaaggggt catacatgga ggtgatgtaa aaaagcttcc tgaaggggtg ttttggggac
     2881 ttcttccctc tatttatttt tatgtcaggt gaactggcat gctgaacata tatatatata
     2941 ggctcattta tagactttta tttccctgct attaaaactt ttgaatttta
//
