LOCUS       NM_001288563            2873 bp    mRNA    linear   PRI 11-JUN-2024
DEFINITION  Homo sapiens dynein axonemal intermediate chain 3 (DNAI3),
            transcript variant 2, mRNA.
ACCESSION   NM_001288563 XM_005270437
VERSION     NM_001288563.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2873)
  AUTHORS   Braschi,B., Omran,H., Witman,G.B., Pazour,G.J., Pfister,K.K.,
            Bruford,E.A. and King,S.M.
  TITLE     Consensus nomenclature for dyneins and associated assembly factors
  JOURNAL   J Cell Biol 221 (2) (2022)
   PUBMED   35006274
REFERENCE   2  (bases 1 to 2873)
  AUTHORS   Zhao,K., Wang,D., Zhao,X., Wang,C., Gao,Y., Liu,K., Wang,F., Wu,X.,
            Wang,X., Sun,L., Zang,J. and Mei,Y.
  TITLE     WDR63 inhibits Arp2/3-dependent actin polymerization and mediates
            the function of p53 in suppressing metastasis
  JOURNAL   EMBO Rep 21 (4), e49269 (2020)
   PUBMED   32128961
REFERENCE   3  (bases 1 to 2873)
  AUTHORS   Hofmeister,W., Pettersson,M., Kurtoglu,D., Armenio,M., Eisfeldt,J.,
            Papadogiannakis,N., Gustavsson,P. and Lindstrand,A.
  TITLE     Targeted copy number screening highlights an intragenic deletion of
            WDR63 as the likely cause of human occipital encephalocele and
            abnormal CNS development in zebrafish
  JOURNAL   Hum Mutat 39 (4), 495-505 (2018)
   PUBMED   29285825
  REMARK    GeneRIF: A rare deletion in WDR63 in a case of encephalocele has
            been characterized. Functional study on zebrafish supports role of
            WDR63 deletion in abnormal neural development.
REFERENCE   4  (bases 1 to 2873)
  AUTHORS   Diao,S., Yang,D.M., Dong,R., Wang,L.P., Wang,J.S., Du,J., Wang,S.L.
            and Fan,Z.
  TITLE     Enriched trimethylation of lysine 4 of histone H3 of WDR63 enhanced
            osteogenic differentiation potentials of stem cells from apical
            papilla
  JOURNAL   J Endod 41 (2), 205-211 (2015)
   PUBMED   25498833
  REMARK    GeneRIF: These results indicate that WDR63 is a positive enhancer
            for stem cells from apical papilla osteogenic differentiation and
            suggest that activation of WDR63 signaling might improve tissue
            regeneration mediated by MSCs of dental origin.
REFERENCE   5  (bases 1 to 2873)
  AUTHORS   Greliche,N., Germain,M., Lambert,J.C., Cohen,W., Bertrand,M.,
            Dupuis,A.M., Letenneur,L., Lathrop,M., Amouyel,P., Morange,P.E. and
            Tregouet,D.A.
  TITLE     A genome-wide search for common SNP x SNP interactions on the risk
            of venous thrombosis
  JOURNAL   BMC Med Genet 14, 36 (2013)
   PUBMED   23509962
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2873)
  AUTHORS   Hom,E.F., Witman,G.B., Harris,E.H., Dutcher,S.K., Kamiya,R.,
            Mitchell,D.R., Pazour,G.J., Porter,M.E., Sale,W.S., Wirschell,M.,
            Yagi,T. and King,S.M.
  TITLE     A unified taxonomy for ciliary dyneins
  JOURNAL   Cytoskeleton (Hoboken) 68 (10), 555-565 (2011)
   PUBMED   21953912
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB075669.1, AK054629.1 and BX648851.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001288563.1.
            
            Transcript Variant: This variant (2) lacks an in-frame exon in the
            central coding region, compared to variant 1. The encoded isoform
            (2) is shorter, compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK054629.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2151119 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                DB075669.1         7-23
            18-2872             AK054629.1         1-2855
            2873-2873           BX648851.1         3025-3025
FEATURES             Location/Qualifiers
     source          1..2873
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p22.3"
     gene            1..2873
                     /gene="DNAI3"
                     /gene_synonym="DIC3; NYD-SP29; WDR63"
                     /note="dynein axonemal intermediate chain 3"
                     /db_xref="GeneID:126820"
                     /db_xref="HGNC:HGNC:30711"
                     /db_xref="MIM:617968"
     exon            1..160
                     /gene="DNAI3"
                     /gene_synonym="DIC3; NYD-SP29; WDR63"
                     /inference="alignment:Splign:2.1.0"
     exon            161..238
                     /gene="DNAI3"
                     /gene_synonym="DIC3; NYD-SP29; WDR63"
                     /inference="alignment:Splign:2.1.0"
     CDS             175..2733
                     /gene="DNAI3"
                     /gene_synonym="DIC3; NYD-SP29; WDR63"
                     /note="isoform 2 is encoded by transcript variant 2; WD
                     repeat-containing protein 63; WD repeat domain 63; dynein
                     intermediate chain 3, axonemal; testis development protein
                     NYD-SP29 (NYD-SP29); testicular tissue protein Li 225"
                     /codon_start=1
                     /product="dynein axonemal intermediate chain 3 isoform 2"
                     /protein_id="NP_001275492.1"
                     /db_xref="CCDS:CCDS72818.1"
                     /db_xref="GeneID:126820"
                     /db_xref="HGNC:HGNC:30711"
                     /db_xref="MIM:617968"
                     /translation="MAPKQKKKTSRGKKRLKPVLAASEDMEPVNMESMGHPEIYPLVL
                     TTKTQEIFNCRIDEDVTDEQPYKLINKEDIFEDLRNRAAVSDFHPVKKIVQEYPGNEL
                     LLVYDKDFKYGLNFYLIATEEGKENYLNPPEVPEEQEEYKEHIPEDVYIYKPPVSKPW
                     VSLGSEKEIEEESVTESTKQITYMISRKRSEFGAPIKFSDQNASSVKDAYIECTAYPD
                     KNFTLKQLEKDVGMQVIPQIKDISTQTKCVEIALQQNEIMNTFIDDWKYLAEEEGTFG
                     DKTDTHLKEYQSFTDLHSPTEKMITCVSWHPTIYGLIAVSVAVRLSFEDRVHFSGKLL
                     LQPSLILFWSFSDPIHPQLMLESPDDIFCFKFCPSDPNIIAGGCINGQIVMWDITAHA
                     DRIENIKAGGSRSKRATLKPMFLLEPESNKEAMYIRHCAVSSIENGHKKVITDIHWLS
                     DTFEINRMGSVFENRSGICCQLVTCSADCTICFWDIRPQKPLTPQTTEKKKEESIEIP
                     FDVPSTFLHLDLSWKPLTKVRLSKGETSLDHCPTKISLNEDHLLCKTQDKMLAQSKTE
                     KAEEMNPYHNLESGMANLLKPIDDFCTKFFVGTEEGEVIYTDWKMEKDPETGRLMSKK
                     PVSHHTIHDGTVHTIQRSPFYNDIILTVGGWNVAIWKEGVMTGPLLQSCCAPKRYTSG
                     HWSLTRPGVFYIGREDGYIDIWDLLEKTHEPAQSQNICITMITYIKPWIFSSKQQFIA
                     TADYYGTLHILEIPWTLSRPSTNEMASVNHYFEREVKHLEYVEQRKKIREQEKKEMEL
                     EMAKKKVKTYQKSKEQMQAELKMDYESYLELEKTVLINLGLIKVTEKGSYMEVM"
     exon            239..277
                     /gene="DNAI3"
                     /gene_synonym="DIC3; NYD-SP29; WDR63"
                     /inference="alignment:Splign:2.1.0"
     exon            278..459
                     /gene="DNAI3"
                     /gene_synonym="DIC3; NYD-SP29; WDR63"
                     /inference="alignment:Splign:2.1.0"
     exon            460..564
                     /gene="DNAI3"
                     /gene_synonym="DIC3; NYD-SP29; WDR63"
                     /inference="alignment:Splign:2.1.0"
     exon            565..714
                     /gene="DNAI3"
                     /gene_synonym="DIC3; NYD-SP29; WDR63"
                     /inference="alignment:Splign:2.1.0"
     exon            715..914
                     /gene="DNAI3"
                     /gene_synonym="DIC3; NYD-SP29; WDR63"
                     /inference="alignment:Splign:2.1.0"
     exon            915..1105
                     /gene="DNAI3"
                     /gene_synonym="DIC3; NYD-SP29; WDR63"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1230
                     /gene="DNAI3"
                     /gene_synonym="DIC3; NYD-SP29; WDR63"
                     /inference="alignment:Splign:2.1.0"
     exon            1231..1320
                     /gene="DNAI3"
                     /gene_synonym="DIC3; NYD-SP29; WDR63"
                     /inference="alignment:Splign:2.1.0"
     exon            1321..1407
                     /gene="DNAI3"
                     /gene_synonym="DIC3; NYD-SP29; WDR63"
                     /inference="alignment:Splign:2.1.0"
     exon            1408..1536
                     /gene="DNAI3"
                     /gene_synonym="DIC3; NYD-SP29; WDR63"
                     /inference="alignment:Splign:2.1.0"
     exon            1537..1610
                     /gene="DNAI3"
                     /gene_synonym="DIC3; NYD-SP29; WDR63"
                     /inference="alignment:Splign:2.1.0"
     exon            1611..1755
                     /gene="DNAI3"
                     /gene_synonym="DIC3; NYD-SP29; WDR63"
                     /inference="alignment:Splign:2.1.0"
     exon            1756..1843
                     /gene="DNAI3"
                     /gene_synonym="DIC3; NYD-SP29; WDR63"
                     /inference="alignment:Splign:2.1.0"
     exon            1844..1974
                     /gene="DNAI3"
                     /gene_synonym="DIC3; NYD-SP29; WDR63"
                     /inference="alignment:Splign:2.1.0"
     exon            1975..2038
                     /gene="DNAI3"
                     /gene_synonym="DIC3; NYD-SP29; WDR63"
                     /inference="alignment:Splign:2.1.0"
     exon            2039..2169
                     /gene="DNAI3"
                     /gene_synonym="DIC3; NYD-SP29; WDR63"
                     /inference="alignment:Splign:2.1.0"
     exon            2170..2374
                     /gene="DNAI3"
                     /gene_synonym="DIC3; NYD-SP29; WDR63"
                     /inference="alignment:Splign:2.1.0"
     exon            2375..2466
                     /gene="DNAI3"
                     /gene_synonym="DIC3; NYD-SP29; WDR63"
                     /inference="alignment:Splign:2.1.0"
     exon            2467..2589
                     /gene="DNAI3"
                     /gene_synonym="DIC3; NYD-SP29; WDR63"
                     /inference="alignment:Splign:2.1.0"
     exon            2590..2873
                     /gene="DNAI3"
                     /gene_synonym="DIC3; NYD-SP29; WDR63"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2854..2859
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DNAI3"
                     /gene_synonym="DIC3; NYD-SP29; WDR63"
                     /note="hexamer: ATTAAA"
     polyA_site      2873
                     /gene="DNAI3"
                     /gene_synonym="DIC3; NYD-SP29; WDR63"
                     /note="major polyA site"
ORIGIN      
        1 agatgcgtcc tggcaacagt cggcagagtt gctgcggttt gtgcccttgc gatttctttt
       61 tctgagagag gagagtcaaa ctcccacctc cagctctcga aggagctttt cctgagggca
      121 ctgcaaagag gctccttttc tttcagatca gcagtatcag cccaagtcag aaccatggct
      181 ccaaaacaaa agaaaaagac atcacgtggc aaaaaaagac taaaaccagt attagctgct
      241 agtgaagaca tggaaccagt aaatatggag agcatgggtc atccagaaat ttatccttta
      301 gtattaacca ccaagaccca agaaatattt aactgccgaa tagatgaaga tgtcacagat
      361 gaacaacctt ataagcttat caataaagaa gacatttttg aggacctgcg caacagagct
      421 gcagtatctg atttccaccc agtcaaaaaa attgtccagg aatatcctgg aaatgagctt
      481 ctgcttgttt atgacaaaga cttcaaatat ggacttaact tttatcttat tgcaactgaa
      541 gagggcaaag aaaactattt aaatccccca gaagtaccag aagaacaaga agaatataaa
      601 gaacatattc ctgaagatgt gtatatttat aaaccacctg tctctaaacc atgggtttct
      661 ttgggcagtg aaaaagaaat tgaggaagaa tcagttacgg aatctacaaa gcagattaca
      721 tatatgattt ctcgaaaacg aagtgaattt ggtgcaccaa ttaagttcag tgaccagaat
      781 gcttccagtg taaaagatgc ctatattgaa tgtacagcct acccagataa aaattttacc
      841 cttaaacaac ttgaaaaaga tgttggcatg caagtaatcc cccaaataaa ggacataagc
      901 actcagacaa aatgtgttga aatagccctg cagcaaaatg aaatcatgaa cacatttatt
      961 gatgactgga aatacctcgc agaagaagaa ggcacctttg gggacaagac cgatacccac
     1021 ctgaaagagt accagtcctt taccgacctt catagcccaa cggagaaaat gattacctgt
     1081 gtctcatggc atccaactat ctatgggcta atagctgtgt cggtagccgt gcgactttct
     1141 tttgaagaca gagttcactt ttctggtaaa ttattgctgc agccatcact gattcttttc
     1201 tggagcttct ctgatcctat acatcctcag ttaatgctgg agagcccaga tgacatcttc
     1261 tgcttcaagt tctgtccgag tgatcctaat atcattgctg gaggctgtat caatgggcag
     1321 attgtcatgt gggatatcac cgcacatgca gatcgcatag aaaacattaa ggcaggtggt
     1381 agtagaagta aaagagccac actgaagcct atgtttctcc ttgaaccgga gagtaataaa
     1441 gaagcaatgt atatcagaca ctgtgcagtc tcttcaatag aaaatggaca taagaaagta
     1501 attacagata tacactggtt gtctgacaca tttgagatta acagaatggg ctccgtcttt
     1561 gagaatcgaa gtggaatatg ctgtcaactt gtcacatgtt cagcagattg cacaatatgt
     1621 ttttgggata ttagaccaca gaaaccttta accccccaaa caacagagaa aaagaaggag
     1681 gaaagtattg aaattccttt tgatgtacca tctacttttt tgcatctgga tctctcctgg
     1741 aaacctctca ctaaggtaag gctgtccaag ggtgaaacaa gtttagacca ctgtccaacc
     1801 aagataagcc tgaatgaaga ccatcttctt tgcaaaacac aagacaaaat gttagcacag
     1861 agcaaaacag agaaggcaga agaaatgaac ccgtatcata atctggaaag tgggatggcc
     1921 aatcttctca agccaataga tgacttctgc acaaagttct ttgtgggaac agaggaaggc
     1981 gaagtgatat acacagattg gaaaatggaa aaagaccctg aaactggccg acttatgtca
     2041 aagaagccag tgagccacca caccattcac gacggaactg tccacactat tcagagatca
     2101 cctttctaca acgacattat tctcacggtt ggaggttgga acgtggccat atggaaagaa
     2161 ggtgttatga ctggaccgct ccttcagtca tgctgtgcac caaaaaggta cacctcaggc
     2221 cactggtccc tgactcggcc cggagttttc tacatcggcc gagaagatgg atacattgat
     2281 atctgggacc ttctggagaa aacccatgaa ccagcccagt ctcaaaacat ttgcataact
     2341 atgatcacct acatcaaacc ctggatcttt tcttctaaac agcaatttat agccacagct
     2401 gattattatg gaacactgca tatattagaa attccttgga cattaagtcg cccttccacc
     2461 aatgagatgg caagtgtcaa ccactatttt gaaagagaag tcaagcatct ggaatacgta
     2521 gaacagcgca aaaaaattcg tgagcaagaa aagaaagaaa tggaactaga aatggcaaag
     2581 aaaaaagtta aaacatatca gaagtcaaaa gaacaaatgc aggctgaatt aaaaatggac
     2641 tatgagagtt atctggaact ggaaaagact gttcttatca accttggcct aatcaaagtc
     2701 acagagaagg ggtcatacat ggaggtgatg taaaaaagct tcctgaaggg gtgttttggg
     2761 gacttcttcc ctctatttat ttttatgtca ggtgaactgg catgctgaac atatatatat
     2821 ataggctcat ttatagactt ttatttccct gctattaaaa cttttgaatt tta
//
