LOCUS       NM_138458               2591 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens dynein axonemal assembly factor 10 (DNAAF10),
            transcript variant 1, mRNA.
ACCESSION   NM_138458
VERSION     NM_138458.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2591)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2591)
  AUTHORS   Cloutier,P., Poitras,C., Faubert,D., Bouchard,A., Blanchette,M.,
            Gauthier,M.S. and Coulombe,B.
  TITLE     Upstream ORF-Encoded ASDURF Is a Novel Prefoldin-like Subunit of
            the PAQosome
  JOURNAL   J Proteome Res 19 (1), 18-27 (2020)
   PUBMED   31738558
REFERENCE   3  (bases 1 to 2591)
  AUTHORS   Yadav,L., Tamene,F., Goos,H., van Drogen,A., Katainen,R.,
            Aebersold,R., Gstaiger,M. and Varjosalo,M.
  TITLE     Systematic Analysis of Human Protein Phosphatase Interactions and
            Dynamics
  JOURNAL   Cell Syst 4 (4), 430-444 (2017)
   PUBMED   28330616
REFERENCE   4  (bases 1 to 2591)
  AUTHORS   Boldt,K., van Reeuwijk,J., Lu,Q., Koutroumpas,K., Nguyen,T.M.,
            Texier,Y., van Beersum,S.E., Horn,N., Willer,J.R., Mans,D.A.,
            Dougherty,G., Lamers,I.J., Coene,K.L., Arts,H.H., Betts,M.J.,
            Beyer,T., Bolat,E., Gloeckner,C.J., Haidari,K., Hetterschijt,L.,
            Iaconis,D., Jenkins,D., Klose,F., Knapp,B., Latour,B.,
            Letteboer,S.J., Marcelis,C.L., Mitic,D., Morleo,M., Oud,M.M.,
            Riemersma,M., Rix,S., Terhal,P.A., Toedt,G., van Dam,T.J., de
            Vrieze,E., Wissinger,Y., Wu,K.M., Apic,G., Beales,P.L.,
            Blacque,O.E., Gibson,T.J., Huynen,M.A., Katsanis,N., Kremer,H.,
            Omran,H., van Wijk,E., Wolfrum,U., Kepes,F., Davis,E.E., Franco,B.,
            Giles,R.H., Ueffing,M., Russell,R.B. and Roepman,R.
  CONSRTM   UK10K Rare Diseases Group
  TITLE     An organelle-specific protein landscape identifies novel diseases
            and molecular mechanisms
  JOURNAL   Nat Commun 7, 11491 (2016)
   PUBMED   27173435
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2591)
  AUTHORS   Hein,M.Y., Hubner,N.C., Poser,I., Cox,J., Nagaraj,N., Toyoda,Y.,
            Gak,I.A., Weisswange,I., Mansfeld,J., Buchholz,F., Hyman,A.A. and
            Mann,M.
  TITLE     A human interactome in three quantitative dimensions organized by
            stoichiometries and abundances
  JOURNAL   Cell 163 (3), 712-723 (2015)
   PUBMED   26496610
REFERENCE   6  (bases 1 to 2591)
  AUTHORS   Inoue,M., Saeki,M., Egusa,H., Niwa,H. and Kamisaki,Y.
  TITLE     PIH1D1, a subunit of R2TP complex, inhibits doxorubicin-induced
            apoptosis
  JOURNAL   Biochem Biophys Res Commun 403 (3-4), 340-344 (2010)
   PUBMED   21078300
REFERENCE   7  (bases 1 to 2591)
  AUTHORS   Cloutier,P., Al-Khoury,R., Lavallee-Adam,M., Faubert,D., Jiang,H.,
            Poitras,C., Bouchard,A., Forget,D., Blanchette,M. and Coulombe,B.
  TITLE     High-resolution mapping of the protein interaction network for the
            human transcription machinery and affinity purification of RNA
            polymerase II-associated complexes
  JOURNAL   Methods 48 (4), 381-386 (2009)
   PUBMED   19450687
  REMARK    GeneRIF: Is part of an RNA polymerase II-associated complex with
            possible chaperone activity.
REFERENCE   8  (bases 1 to 2591)
  AUTHORS   Itsuki,Y., Saeki,M., Nakahara,H., Egusa,H., Irie,Y., Terao,Y.,
            Kawabata,S., Yatani,H. and Kamisaki,Y.
  TITLE     Molecular cloning of novel Monad binding protein containing
            tetratricopeptide repeat domains
  JOURNAL   FEBS Lett 582 (16), 2365-2370 (2008)
   PUBMED   18538670
REFERENCE   9  (bases 1 to 2591)
  AUTHORS   Han,Z., Guo,L., Wang,H., Shen,Y., Deng,X.W. and Chai,J.
  TITLE     Structural basis for the specific recognition of methylated histone
            H3 lysine 4 by the WD-40 protein WDR5
  JOURNAL   Mol Cell 22 (1), 137-144 (2006)
   PUBMED   16600877
REFERENCE   10 (bases 1 to 2591)
  AUTHORS   Saeki,M., Irie,Y., Ni,L., Yoshida,M., Itsuki,Y. and Kamisaki,Y.
  TITLE     Monad, a WD40 repeat protein, promotes apoptosis induced by
            TNF-alpha
  JOURNAL   Biochem Biophys Res Commun 342 (2), 568-572 (2006)
   PUBMED   16487927
  REMARK    GeneRIF: Monad may function as a novel modulator of apoptosis
            pathway.
            GeneRIF: Monad could be involved in apoptosis induced by TNF-alpha
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BP271204.1, AK056303.1 and AC017083.7.
            
            On Nov 22, 2018 this sequence version replaced NM_138458.3.
            
            Summary: This gene encodes a protein with two WD40 repeat domains
            thought to be involved in an apoptosis via activation of caspase-3.
            Multiple transcript variants encoding different isoforms have been
            found for this gene. [provided by RefSeq, Feb 2012].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer protein (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.411496.1,
                                           SRR1660805.245545.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142853, SAMEA2152798
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000295121.11/ ENSP00000295121.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 BP271204.1         34-36
            4-1481              AK056303.1         1-1478
            1482-2247           AK056303.1         1482-2247
            2248-2591           AC017083.7         49316-49659         c
FEATURES             Location/Qualifiers
     source          1..2591
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p14"
     gene            1..2591
                     /gene="DNAAF10"
                     /gene_synonym="WDR92"
                     /note="dynein axonemal assembly factor 10"
                     /db_xref="GeneID:116143"
                     /db_xref="HGNC:HGNC:25176"
                     /db_xref="MIM:610729"
     exon            1..267
                     /gene="DNAAF10"
                     /gene_synonym="WDR92"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..1158
                     /gene="DNAAF10"
                     /gene_synonym="WDR92"
                     /note="isoform 1 is encoded by transcript variant 1;
                     monad; WD repeat-containing protein 92; testicular
                     secretory protein Li 67; WD repeat-containing protein
                     Monad; WD repeat domain 92"
                     /codon_start=1
                     /product="dynein axonemal assembly factor 10 isoform 1"
                     /protein_id="NP_612467.1"
                     /db_xref="CCDS:CCDS1884.1"
                     /db_xref="GeneID:116143"
                     /db_xref="HGNC:HGNC:25176"
                     /db_xref="MIM:610729"
                     /translation="MSAFEKPQIIAHIQKGFNYTVFDCKWVPCSAKFVTMGNFARGTG
                     VIQLYEIQHGDLKLLREIEKAKPIKCGTFGATSLQQRYLATGDFGGNLHIWNLEAPEM
                     PVYSVKGHKEIINAIDGIGGLGIGEGAPEIVTGSRDGTVKVWDPRQKDDPVANMEPVQ
                     GENKRDCWTVAFGNAYNQEERVVCAGYDNGDIKLFDLRNMALRWETNIKNGVCSLEFD
                     RKDISMNKLVATSLEGKFHVFDMRTQHPTKGFASVSEKAHKSTVWQVRHLPQNRELFL
                     TAGGAGGLHLWKYEYPIQRSKKDSEGIEMGVAGSVSLLQNVTLSTQPISSLDWSPDKR
                     GLCVCSSFDQTVRVLIVTKLNKI"
     exon            268..368
                     /gene="DNAAF10"
                     /gene_synonym="WDR92"
                     /inference="alignment:Splign:2.1.0"
     exon            369..499
                     /gene="DNAAF10"
                     /gene_synonym="WDR92"
                     /inference="alignment:Splign:2.1.0"
     exon            500..601
                     /gene="DNAAF10"
                     /gene_synonym="WDR92"
                     /inference="alignment:Splign:2.1.0"
     exon            602..717
                     /gene="DNAAF10"
                     /gene_synonym="WDR92"
                     /inference="alignment:Splign:2.1.0"
     exon            718..852
                     /gene="DNAAF10"
                     /gene_synonym="WDR92"
                     /inference="alignment:Splign:2.1.0"
     exon            853..950
                     /gene="DNAAF10"
                     /gene_synonym="WDR92"
                     /inference="alignment:Splign:2.1.0"
     exon            951..2591
                     /gene="DNAAF10"
                     /gene_synonym="WDR92"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1742..1747
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DNAAF10"
                     /gene_synonym="WDR92"
                     /note="hexamer: ATTAAA"
     polyA_site      1761
                     /gene="DNAAF10"
                     /gene_synonym="WDR92"
                     /note="major polyA site"
     regulatory      1894..1899
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DNAAF10"
                     /gene_synonym="WDR92"
                     /note="hexamer: AATACA"
     polyA_site      1909
                     /gene="DNAAF10"
                     /gene_synonym="WDR92"
                     /note="major polyA site"
     regulatory      2510..2515
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DNAAF10"
                     /gene_synonym="WDR92"
                     /note="hexamer: AATAAA"
     polyA_site      2534
                     /gene="DNAAF10"
                     /gene_synonym="WDR92"
                     /note="major polyA site"
     regulatory      2568..2573
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DNAAF10"
                     /gene_synonym="WDR92"
                     /note="hexamer: AATAAA"
     polyA_site      2591
                     /gene="DNAAF10"
                     /gene_synonym="WDR92"
                     /note="major polyA site"
ORIGIN      
        1 gccaatgttt ggagtctggt ttccaggttg ccgtttttgg gggctctggg tgtggcggtt
       61 gccgtagctg aaattggctg caccatgtcg gccttcgaga agcctcagat catcgcccat
      121 atccagaagg gcttcaacta cacggtgttt gactgtaagt gggtgccctg cagcgccaaa
      181 tttgtgacca tgggcaactt cgcacggggc accggcgtca ttcagctgta cgagatccag
      241 cacggggacc tgaagctgct tcgggagatt gaaaaggcca aacctattaa atgtggaaca
      301 tttggtgcaa catctttaca gcagagatat ttagctactg gagattttgg tggaaacctt
      361 catatatgga atttagaagc tccagagatg ccagtatatt ctgtaaaggg ccataaagaa
      421 attataaatg ccatagatgg cataggtgga ctaggaattg gagaaggagc acctgaaatt
      481 gtgactggca gccgagatgg aactgtgaag gtgtgggacc caaggcaaaa agatgatcct
      541 gttgctaata tggaacctgt acaaggagaa aacaagagag actgttggac tgtggcattt
      601 ggcaatgctt ataatcaaga agaacgtgtt gtttgtgctg gctatgacaa tggggatatc
      661 aaactatttg atctcagaaa tatggcatta cggtgggaga caaacatcaa aaatggggtg
      721 tgtagcttgg agtttgacag aaaagacata agtatgaata agttagtagc cacatctctg
      781 gaaggaaagt tccatgtttt tgacatgaga acacagcatc caaccaaagg ttttgcctct
      841 gtttcagaaa aggctcataa atctactgtg tggcaggtcc gacacctgcc gcagaacagg
      901 gagctctttc tgacagctgg aggcgccggc ggccttcacc tctggaagta tgaataccct
      961 attcagcggt caaagaaaga ttctgaggga atagaaatgg gagtcgcagg ttctgtaagc
     1021 cttctgcaga atgttacgtt gtccacccag cccatttcaa gtttggattg gagtccagat
     1081 aaaaggggtc tctgcgtctg tagttcattt gaccaaacgg tgagagtact gatcgttaca
     1141 aagctcaata aaatttgact tcaagacttt ggacttgagg ctgggcacgg tggctcactc
     1201 ctgtaatccc agcactttgg gaggccgagg cgggtggatc agaaggtcag gagatcgaga
     1261 ccatcctggc taacatggtg aaaccccgtc tctactaaaa atataaaaaa aaatttgctg
     1321 ggtgtcatgg cgggcatctg tagtcctagc tacttgggag gctgaggcag gagaatggcg
     1381 tgaacccggg aggcggaggt tgcagtgagc cgagattgtg ccactgcact ccagcctggg
     1441 caactgagca agactgtctc aaaaaaaaaa aaaaaaaaaa agactttgga cttgaaacct
     1501 tccagaggaa cactcacaca atttaagata ggttctggag tcctctgacc ctcattgaac
     1561 aaagctggat ttggctgatg ataaaagacc ccagccacaa gcctctgggc cagcctccag
     1621 cctctctcgg ggcttgtttg ctgacttgct gctgcacgtg ggtatcagaa gcaccaagta
     1681 aactatctcc agggccagtt cttttctctc ccttccattt ctaagtcaat agttgtctat
     1741 aattaaacat atttcagatt tgttctgtgt ccctgaagtt ccatatttta tctttatgct
     1801 tgtgttatgt tttagtgtct ataatgttgt ggtgggaatc atttcatttg gtttaaaaga
     1861 gtttgccttg gaaaaactga attaaccttc ataaatacat tttgagagat ttcagtgtga
     1921 gtaattttct ggacataata ttattgtata aaatatcaaa atggtgggcc aggcgtggta
     1981 gctcacgcct gtaattccag cactttggga ggctgaggcg ggtgaatcac gaggtcagga
     2041 attcgagacc agcctggcca acatggtcaa aacccgtctc tactaaaaat acaaaaaatt
     2101 agctgggctt agtggcgggc gcctgtaatc acagctactt gggaggctga ggcaggagaa
     2161 tcacttgaac ccaggaggtg gagattgcag tgagctgaga ttgcgccact gcactccagc
     2221 cctggcgaca gagtgagact ccgtctcaaa aaaaaaaaaa acaaatatat atatatatat
     2281 ctctctctct caaaacggca cggttggtct agatttgggt agctattttc tgcaatttaa
     2341 ttcataaaac aaaatgcttt gattttaaag agctcttttt tacttaaaat acaggaactg
     2401 aattggtgag acttttggtt tttgactgtg gtaagtgatg gtgaaatgta caagattgta
     2461 ggggttttgt agtcttattt ttggtcatac tttaaaaatg cattttatga ataaacttct
     2521 gtttttgaga tctacagaag ctttgattct gttaccttaa cagtagtaat aaagttaaca
     2581 ttgtcacatc a
//
