LOCUS       XM_006717680            4647 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens DNA replication helicase/nuclease 2 (DNA2),
            transcript variant X1, mRNA.
ACCESSION   XM_006717680
VERSION     XM_006717680.3
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000010.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Jun 6, 2016 this sequence version replaced XM_006717680.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4647
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
     gene            1..4647
                     /gene="DNA2"
                     /gene_synonym="DNA2L; hDNA2; RTS4"
                     /note="DNA replication helicase/nuclease 2; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 9 mRNAs, 23 ESTs, 423 long SRA reads, 6 Proteins, and
                     100% coverage of the annotated genomic feature by RNAseq
                     alignments, including 18 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:1763"
                     /db_xref="HGNC:HGNC:2939"
                     /db_xref="MIM:601810"
     CDS             400..3672
                     /gene="DNA2"
                     /gene_synonym="DNA2L; hDNA2; RTS4"
                     /codon_start=1
                     /product="DNA replication ATP-dependent helicase/nuclease
                     DNA2 isoform X1"
                     /protein_id="XP_006717743.1"
                     /db_xref="GeneID:1763"
                     /db_xref="HGNC:HGNC:2939"
                     /db_xref="MIM:601810"
                     /translation="MKTPCIPSPKQGSKGRGQSPAAQFAIPASRMEQLNELELLMEKS
                     FWEEAELPAELFQKKVVASFPRTVLSTGMDNRYLVLAVNTVQNKEGNCEKRLVITASQ
                     SLENKELCILRNDWCSVPVEPGDIIHLEGDCTSDTWIIDKDFGYLILYPDMLISGTSI
                     ASSIRCMRRAVLSETFRSSDPATRQMLIGTVLHEVFQKAINNSFAPEKLQELAFQTIQ
                     EIRHLKEMYRLNLSQDEIKQEVEDYLPSFCKWAGDFMHKNTSTDFPQMQLSLPSDNSK
                     DNSTCNIEVVKPMDIEESIWSPRFGLKGKIDVTVGVKIHRGYKTKYKIMPLELKTGKE
                     SNSIEHRSQVVLYTLLSQERRADPEAGLLLYLKTGQMYPVPANHLDKRELLKLRNQMA
                     FSLFHRISKSATRQKTQLASLPQIIEEEKTCKYCSQIGNCALYSRAVEQQMDCSSVPI
                     VMLPKIEEETQHLKQTHLEYFSLWCLMLTLESQSKDNKKNHQNIWLMPASEMEKSGSC
                     IGNLIRMEHVKIVCDGQYLHNFQCKHGAIPVTNLMAGDRVIVSGEERSLFALSRGYVK
                     EINMTTVTCLLDRNLSVLPESTLFRLDQEEKNCDIDTPLGNLSKLMENTFVSKKLRDL
                     IIDFREPQFISYLSSVLPHDAKDTVACILKGLNKPQRQAMKKVLLSKDYTLIVGMPGT
                     GKTTTICTLVRILYACGFSVLLTSYTHSAVDNILLKLAKFKIGFLRLGQIQKVHPAIQ
                     QFTEQEICRSKSIKSLALLEELYNSQLIVATTCMGINHPIFSRKIFDFCIVDEASQIS
                     QPICLGPLFFSRRFVLVGDHQQLPPLVLNREARALGMSESLFKRLEQNKSAVVQLTVQ
                     YRMNSKIMSLSNKLTYEGKLECGSDKVANAVINLRHFKDVKLELEFYADYSDNPWLMG
                     VFEPNNPVCFLNTDKVPAPEQVEKGGVSNVTEAKLIVFLTSIFVKAGCSPSDIGIIAP
                     YRQQLKIINDLLARSIGMVEVNTVDKYQGRDKSIVLVSFVRSNKDGTVGELLKDWRRL
                     NVAITRAKHKLILLGCVPSLNCYPPLEKLLNHLNSEKLIIDLPSREHESLCHILGDFQ
                     RE"
ORIGIN      
        1 acctcgtgat cctcccgcct cagccttccg aagtgctggg attacaggcg tgagcctcca
       61 tgcctggcca gaagttttgt agatttagcc gtggcatgat caaggagttc ctatccgaca
      121 gtttctattt tctcaataag ttttctgaaa aaaaggggag aggctgtttc ccagggagtg
      181 cacaattctg aaggctaacc aggggcgcct ggttttgggc aactacaaat gtggttgtgt
      241 tcaaactaag cgtgtaaagg ttgtgttcaa actaagctgg gcgcctgtag tcccagctac
      301 ttgggaggct gaagcaggag aatggtgtga acccgggagg tttcggacac gggttggagt
      361 gtcaagagag aaggcaggag cgtttagtct gcttcagata tgaagactcc ctgtattccc
      421 agtcctaagc aagggagcaa aggcagggga cagagccctg ctgctcagtt tgcgatcccc
      481 gcgtccagga tggagcagct gaacgaactg gagctgctga tggagaagag tttttgggag
      541 gaggcggagc tgccggcgga gctatttcag aagaaagtgg tagcttcctt tccaagaaca
      601 gttctgagca caggaatgga taaccggtac ctggtgttgg cagtcaatac tgtacagaac
      661 aaagagggaa actgtgaaaa gcgcctggtc atcactgctt cacagtcact agaaaataaa
      721 gaactatgca tccttaggaa tgactggtgt tctgttccag tagagccagg agatatcatt
      781 catttggagg gagactgcac atctgacact tggataatag ataaagattt tggatatttg
      841 attctgtatc cagacatgct gatttctggc accagcatag ccagtagtat tcgatgtatg
      901 agaagagctg tcctgagtga aacttttagg agctctgatc cagccacacg ccaaatgcta
      961 attggtacgg ttctccatga ggtgtttcaa aaagccataa ataatagctt tgccccagaa
     1021 aagctacaag aacttgcttt tcaaacaatt caagaaataa gacatttgaa ggaaatgtac
     1081 cgcttaaatc taagtcaaga tgaaataaaa caagaagtag aggactatct tccttcgttt
     1141 tgtaaatggg caggagattt catgcataaa aacacttcga ctgacttccc tcagatgcag
     1201 ctctctctgc caagtgataa tagtaaggat aattcaacat gtaacattga agtcgtgaaa
     1261 ccaatggata ttgaagaaag catttggtcc cctaggtttg gattgaaagg caaaatagat
     1321 gttacagttg gtgtgaaaat acatcgaggg tataaaacaa aatacaagat aatgccgctg
     1381 gaacttaaaa ctggcaaaga atcaaattct attgaacacc gtagtcaggt tgttctgtac
     1441 actctactaa gccaagagag aagagctgat ccagaggctg gcttgcttct ctacctcaag
     1501 actggtcaga tgtaccctgt gcctgccaac catctagata aaagagaatt attaaagcta
     1561 agaaaccaga tggcattctc attgtttcac cgtattagca aatctgctac tagacagaag
     1621 acacagcttg cttctttgcc acaaataatt gaggaagaga aaacttgtaa atattgttca
     1681 caaattggca attgtgctct ttatagcaga gcagttgaac aacagatgga ttgtagttca
     1741 gtcccaattg tgatgctgcc caaaatagaa gaagaaaccc agcatctgaa gcaaacacac
     1801 ttagaatatt tcagcctttg gtgtctaatg ttaaccctgg agtcacaatc gaaggataat
     1861 aaaaagaatc accaaaatat ctggctaatg cctgcttcgg aaatggagaa gagtggcagt
     1921 tgcattggaa acctgattag aatggaacat gtaaagatag tttgtgatgg gcaatattta
     1981 cataatttcc aatgtaaaca tggtgccata cctgtcacaa atctaatggc aggtgacaga
     2041 gttattgtaa gtggagaaga aaggtcactg tttgctttgt ctagaggata tgtgaaggag
     2101 attaacatga caacagtaac ttgtttatta gacagaaact tgtcggtcct tccagaatca
     2161 actttgttca gattagacca agaagaaaaa aattgtgata tagatacccc attaggaaat
     2221 ctttccaaat tgatggaaaa cacgtttgtc agcaaaaaac ttcgagattt aattattgac
     2281 tttcgtgaac ctcagtttat atcctacctt agttctgttc ttccacatga tgcaaaggat
     2341 acagttgcct gcattctaaa gggtttgaat aagcctcaga ggcaagcgat gaaaaaggta
     2401 cttctttcaa aagactacac actcatcgtg ggtatgcctg ggacaggaaa aacaactacg
     2461 atatgtactc tcgtaagaat tctctacgcc tgtggtttta gcgttttgtt gaccagctat
     2521 acacactctg ctgttgacaa tattcttttg aagttagcca agtttaaaat aggatttttg
     2581 cgtttgggtc agattcagaa ggttcatcca gctatccagc aatttacaga gcaagaaatt
     2641 tgcagatcaa agtccattaa atccttagct cttctagaag aactctacaa tagtcaactt
     2701 atagttgcaa caacatgtat gggaataaac catccaatat tttcccgtaa aatttttgat
     2761 ttttgtattg tggatgaagc ctctcaaatt agccaaccaa tttgtctggg cccccttttt
     2821 ttttcacgga gatttgtgtt agtgggggac catcagcagc ttcctcccct ggtgctaaac
     2881 cgtgaagcaa gagctcttgg catgagtgaa agcttattca agaggctgga gcagaataag
     2941 agtgctgttg tacagttaac cgtgcagtac agaatgaaca gtaaaattat gtccttaagt
     3001 aataagctga cctatgaggg caagctggag tgtggatcag acaaagtggc caatgcagtg
     3061 ataaacctac gtcactttaa agatgtgaag ctggaactgg aattttatgc tgactattct
     3121 gataatcctt ggttgatggg agtatttgaa cccaacaatc ctgtttgttt ccttaataca
     3181 gacaaggttc cagcgccaga acaagttgaa aaaggtggtg tgagcaatgt aacagaagcc
     3241 aaactcatag ttttcctaac ctccattttt gttaaggctg gatgcagtcc ctctgatatt
     3301 ggtattattg caccgtacag gcagcaatta aagatcatca atgatttatt ggcacgttct
     3361 attgggatgg tcgaagttaa tacagtagac aaataccaag gaagggacaa aagtattgtc
     3421 ctagtatctt ttgttagaag taataaggat ggaactgttg gtgaactctt gaaagattgg
     3481 cgacgtctta atgttgctat aaccagagcc aaacataaac tgattcttct ggggtgtgtg
     3541 ccctcactaa attgctatcc tcctttggag aagctgctta atcatttaaa ctcagaaaaa
     3601 ttaatcattg atcttccatc aagagaacat gaaagtcttt gccacatatt gggtgacttt
     3661 caaagagaat aaaacactat ttcccttgcc ttttcatact agggcagtat ctcctctagc
     3721 tagtgcccat acagaaaatt ctatcaccat acaaaattta atgcagtatt tatgttttaa
     3781 agcacaggtg taccgaaaac tgtgaaaagt ctgaatttat gggttctatg catgcatttt
     3841 tgcctaacct agagaaagag tttgataaat ttttaccagc tttgaagatg gattaacttt
     3901 tgactttgag ctttaaactt ttaagtcaga catttcagga ctaatttgat tttgtagata
     3961 tcattgtaag aactttattt gaaagactga ataaagggat ttgatttgtt ttcatcattt
     4021 aagcacagtc ttgtgatgat gagaacataa gtgtgattct tttctgtatt ttgaggtccc
     4081 taatccaaag cccattttgc taggattttt tctgctatca gatgtgtttt cactctaaac
     4141 ctagtctttt atgacatgaa ttgattactt cctgttaatt ttctatcctc ccttactatc
     4201 ctcctttttt gttttcagta ttcagtattt cagtattcta gagtagattt tgatataaaa
     4261 gaaaataatt cttacatcat cttttgcaac aaattttgtt ttctgaattg ataataaatt
     4321 taaaaagttg attcctattt tcacatatgt tcatatgccc ctatgtttgg gggtatcact
     4381 cagttttccc ttttttgtgt aaagatgttt tgtaaaacaa aattgtctca aagtgattat
     4441 attatatata taaaaagtaa cagattttaa caaaggttaa aagattcttg gggtaacaga
     4501 ttcttctggg gcttggaaat cttccatttc tcttgagggt tttttttaat gagtgttaaa
     4561 tatgttaaaa tttttatttc tacctcatgt gtttttttaa attattactt gaagtttttt
     4621 atttaataaa ttttttctac taatgga
//
