LOCUS       NM_001290321           11538 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens Dmx like 1 (DMXL1), transcript variant 1, mRNA.
ACCESSION   NM_001290321 XM_005271911
VERSION     NM_001290321.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 11538)
  AUTHORS   Davis,L.K., Meyer,K.J., Schindler,E.I., Beck,J.S., Rudd,D.S.,
            Grundstad,A.J., Scheetz,T.E., Braun,T.A., Fingert,J.H.,
            Alward,W.L., Kwon,Y.H., Folk,J.C., Russell,S.R., Wassink,T.H.,
            Sheffield,V.C. and Stone,E.M.
  TITLE     Copy number variations and primary open-angle glaucoma
  JOURNAL   Invest Ophthalmol Vis Sci 52 (10), 7122-7133 (2011)
   PUBMED   21310917
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 11538)
  AUTHORS   Oshikawa,M., Tsutsui,C., Ikegami,T., Fuchida,Y., Matsubara,M.,
            Toyama,S., Usami,R., Ohtoko,K. and Kato,S.
  TITLE     Full-length transcriptome analysis of human retina-derived cell
            lines ARPE-19 and Y79 using the vector-capping method
  JOURNAL   Invest Ophthalmol Vis Sci 52 (9), 6662-6670 (2011)
   PUBMED   21697133
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 11538)
  AUTHORS   Koldehoff,M., Zakrzewski,J.L., Klein-Hitpass,L., Beelen,D.W. and
            Elmaagacli,A.H.
  TITLE     Gene profiling of growth factor independence 1B gene (Gfi-1B) in
            leukemic cells
  JOURNAL   Int J Hematol 87 (1), 39-47 (2008)
   PUBMED   18224412
REFERENCE   4  (bases 1 to 11538)
  AUTHORS   van den Boom,J., Wolter,M., Blaschke,B., Knobbe,C.B. and
            Reifenberger,G.
  TITLE     Identification of novel genes associated with astrocytoma
            progression using suppression subtractive hybridization and
            real-time reverse transcription-polymerase chain reaction
  JOURNAL   Int J Cancer 119 (10), 2330-2338 (2006)
   PUBMED   16865689
REFERENCE   5  (bases 1 to 11538)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   6  (bases 1 to 11538)
  AUTHORS   Kraemer,C., Enklaar,T., Zabel,B. and Schmidt,E.R.
  TITLE     Mapping and structure of DMXL1, a human homologue of the DmX gene
            from Drosophila melanogaster coding for a WD repeat protein
  JOURNAL   Genomics 64 (1), 97-101 (2000)
   PUBMED   10708522
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AB593142.1, BM828759.1,
            BC144537.1 and AJ005821.1.
            
            On May 8, 2020 this sequence version replaced NM_001290321.2.
            
            Summary: The protein encoded by this gene is a member of the WD
            repeat superfamily of proteins, which have regulatory functions.
            This gene is expressed in many tissue types including several types
            of eye tissue, and it has been associated with ocular phenotypes.
            In addition, it is upregulated in cultured cells that overexpress
            growth factor independence 1B, a transcription factor that is
            essential for hematopoietic cell development. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Nov
            2014].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC144537.1, SRR14038193.786151.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000539542.6/ ENSP00000439479.1
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-302               AB593142.1         1-302
            303-457             BM828759.1         1-155
            458-5206            BC144537.1         1-4749
            5207-7000           AJ005821.1         4804-6597
            7001-9776           BC144537.1         6544-9319
            9777-11538          AB593142.1         11025-12786
FEATURES             Location/Qualifiers
     source          1..11538
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q23.1"
     gene            1..11538
                     /gene="DMXL1"
                     /note="Dmx like 1"
                     /db_xref="GeneID:1657"
                     /db_xref="HGNC:HGNC:2937"
                     /db_xref="MIM:605671"
     exon            1..570
                     /gene="DMXL1"
                     /inference="alignment:Splign:2.1.0"
     CDS             484..9630
                     /gene="DMXL1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     dmX-like protein 1"
                     /codon_start=1
                     /product="dmX-like protein 1 isoform 1"
                     /protein_id="NP_001277250.1"
                     /db_xref="CCDS:CCDS75289.1"
                     /db_xref="GeneID:1657"
                     /db_xref="HGNC:HGNC:2937"
                     /db_xref="MIM:605671"
                     /translation="MNLHQVLTGAVNPGDHCFSVGSIGDQRFTAYASGCDIVILGSDF
                     ERLQIIPGAKHGNIQVGCVDCSMQQGKIAASYGNVISIFEPVNLPKQKKNLELYSQWQ
                     KSGQFFLESIAHNITWDPTGSRLLTGSSYLQLWSNTNLEKPTEDENLNKTDLNFGDWK
                     CIWHCKTASQVHLMKFSPDGEFFATAGKDDCLLKVWYNVENWRTAVTSPDGSSEKQSQ
                     GEIDFSFVYLAHPRAVNGFSWRKTSKYMPRASVCNVLLTCCKDNVCRLWVETFLPNDC
                     LLYGGDCSHWTESINLTNNFKRNASSKERVQNALEVNLRHFRRGRRRSLALVAHTGYL
                     PHQQDPHHVHRNTPLHANALCHFHIAASINPATDIPLLPSITSLSLNENEEKTGPFVV
                     HWLNNKELHFTLSMEVFLQQLRKSFEQPSSEASVEDSNQADVKSDEETDDGVDDLKIN
                     PEKKELGCDKMVPNSSFTSLSSAAIDHQIEVLLSEWSKNADMLFSIHPMDGSLLVWHV
                     DWLDEYQPGMFRQVQVSFVSRIPVAFPTGDANSLCKSIMMYACTKNVDLAIQQGKQKP
                     SGLTRSTSMLISSGHNKSSNSLKLSIFTPNVMMISKHADGSLNQWLVSFAEESAFSTV
                     LSISHKSRYCGHRFHLNDLACHSVLPLLLTTSHHNALRTPDVDNPEQPFDALNIEECS
                     LTQQNKSTVDVAFQDPSAVYSELILWRVDPVGPLSFSGGVSELARINSLHVSAFSNVA
                     WLPTLIPSYCLGAYCNSPSACFVASDGQYLRLYEAVIDAKKLLSELSNPEISKYVGEV
                     FNIVSQQSTARPGCIIALDPITKLHGRKTQLLHVFEEDFILNNLEKKSLGKDSILSNA
                     GSSPNGFSEKFYLIVIECTQDNRSLLHMWNLHLKSIPVSLDEKVDTKLSEAVWQPEEH
                     YSSSPEKILSPFSQKYQACRANLQSTSRLTLFSEMVYSQELHLPEGVEIISIKPSAGH
                     LSSSSIYPACSAPYLLATSCSDEKVRFWRCRVTDGESATSKNGKIDLAYIWEEWPLLI
                     EDGLQSNSSITVPGRPVEVSCAHTNRLAVAYKQPASNSRSSQDFVMHVSIFECESTGG
                     SCWVLEQTIHLDELSTVLDSGISVDSNLVAYNKQDMYLSSKENITSNTKHLVHLDWMS
                     REDGSHILTVGIGSKLFMYGPLAGKVQDQTGKETLAFPLWESTKVVPLSKFVLLRSVD
                     LVSSVDGSPPFPVSLSWVRDGILVVGMDCEMHVYCQWQPSSKQEPVITDSYSGSTPSI
                     TSLIKQSNSSSGLHPPKKTLTRSMTSLAQKICGKKTAFDPSVDMEDSGLFEAAHVLSP
                     TLPQYHPLQLLELMDLGKVRRAKAILSHLVKCIAGEVVALNEAESNHERRLRSLTISA
                     SGSTTRDPQAFNKAENTDYTEIDSVPPLPLYALLAADDDSCYSSLEKSSNESTLSKSN
                     QLSKESYDELFQTQLLMTDTHMLETDEENTKPRVIDLSQYSPTYFGPEHAQVLSGHLL
                     HSSLPGLSRMEQMSLMALADTIATTSTDIGESRDRSQGGETLDECGLKFLLAVRLHTF
                     LTTSLPAYRAQLLHQGLSTSHFAWAFHSVAEEELLNMLPAMQKDDPTWSELRAMGVGW
                     WVRNTRILRKCIEKVAKAAFYRKNDPLDAAIFYLAMKKKAVIWGLYRAEKNTRMTQFF
                     GHNFEDERWRKAALKNAFSLLGKQRFEHSAAFFLLAGCLRDAIEVCLEKLNDIQLALV
                     IARLYESEFDTSAAYKSILRKKVLGIDSPVSELCSLNINMHHDPFLRSMAYWILEDYS
                     GALETLIKQPIRENDDQVLSASNPTVFNFYNYLRTHPLLLRRHFGSSDTFSTHMSLTG
                     KSGLAGTINLSERRLFFTTASAHLKAGCPMLALEVLSKMPKVIKKTRPFYRASSFLDT
                     SKDCSPSSPLKLDAREDKSSAVDWSQSLINGFGSSSEGSSEKQSNSTLSFDWSQPSVV
                     FQDDSLELKWDSDNDEENEDVPISMKELKPLQRKTDKKLDDISSNYTESFSTLDENDL
                     LNPSEDIIAVQLKFRACLKILTVELRTLSTGYEIDGGKLRYQLYHWLEKEVIALQRTC
                     DFCSDAEELQSAFGRNEDEFGLNEDAEDLPHQTKVKQLRENFQEKRQWLLKYQSLLRM
                     FLSYCILHGSHGGGLASVRMELILLLQESQQETSEPLFSSPLSEQTSVPLLFACTANA
                     KTVVANPLLHLSNLTHDILHAIINFDSPPHPDIQSNKVYVMHTLAASLSACIYQCLCG
                     SHNYSSFQTNQFTGMVYQTVLLPHRPSLKTGSLDEALTPNTSPAQWPGITCLIRLLNS
                     SGEEAQSGLTVLLCEILTAVYLSLFIHGLATHSSNELFRIVAHPLNEKMWSAVFGGGA
                     HVPSKEQTHSKTLPVSSLVEEGEKQNKRFRPSKMSCRESAPLTPSSAPVSQESLAVKE
                     KFIPPELSIWDYFIAKPFLPSSQSRAEYDSEESLGSDDDDNDDDDDVLASDFHLQEHS
                     NSNSYSWSLMRLAMVQLVLNNLKTFYPFAGHDLAELPVSSPLCHAVLKTLQCWEQVLL
                     RRLEIHGGPPQNYIASHTAEESLSAGPAILRHKALLEPTNTPFKSKHHLALSVKRLWQ
                     YLVKQEEIQETFIKNIFTKKRCLNESLEDNSETIKNSMMEEPNINKIEADLGYPGGKA
                     RIIHKESDIITAFAVNKANRNCIAIASSHDVQELDVSGILATQVYTWVDDDIEVETKG
                     SEDFLVIHARDDLTAVQGTTPYTHSNPGTPINMPWLGSTQTGRGASVMIKKAINNVRR
                     MTSHPTLPYYLTGAQDGSVRMFEWGHSQQITCFRSGGNSRVTRMRFNYQGNKFGIVDA
                     DGYLSLYQTNWKCCPVTGSMPKPYLTWQCHNKTANDFVFVSSSSLIATAGLSTDNRNV
                     CLWDTLVAPANSLVHAFTCHDSGATVLAYAPKHQLLISGGRKGFTYVFDLCQRQQRQL
                     FQSHDSPVKAVAVDPTEEYFVTGSAEGNIKIWSLSTFGLLHTFVSEHARQSIFRNIGT
                     GVMQIETGPANHIFSCGADGTMKMRILPDQFSPLNEVLKNDVKFML"
     exon            571..696
                     /gene="DMXL1"
                     /inference="alignment:Splign:2.1.0"
     exon            697..768
                     /gene="DMXL1"
                     /inference="alignment:Splign:2.1.0"
     exon            769..847
                     /gene="DMXL1"
                     /inference="alignment:Splign:2.1.0"
     exon            848..980
                     /gene="DMXL1"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1047
                     /gene="DMXL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1226
                     /gene="DMXL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1416
                     /gene="DMXL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1417..1585
                     /gene="DMXL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1586..1798
                     /gene="DMXL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1799..2052
                     /gene="DMXL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2053..2737
                     /gene="DMXL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2738..2859
                     /gene="DMXL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2860..2949
                     /gene="DMXL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2950..3052
                     /gene="DMXL1"
                     /inference="alignment:Splign:2.1.0"
     exon            3053..3172
                     /gene="DMXL1"
                     /inference="alignment:Splign:2.1.0"
     exon            3173..3394
                     /gene="DMXL1"
                     /inference="alignment:Splign:2.1.0"
     exon            3395..5077
                     /gene="DMXL1"
                     /inference="alignment:Splign:2.1.0"
     exon            5078..5185
                     /gene="DMXL1"
                     /inference="alignment:Splign:2.1.0"
     exon            5186..5355
                     /gene="DMXL1"
                     /inference="alignment:Splign:2.1.0"
     exon            5356..5453
                     /gene="DMXL1"
                     /inference="alignment:Splign:2.1.0"
     exon            5454..5619
                     /gene="DMXL1"
                     /inference="alignment:Splign:2.1.0"
     exon            5620..5881
                     /gene="DMXL1"
                     /inference="alignment:Splign:2.1.0"
     exon            5882..6972
                     /gene="DMXL1"
                     /inference="alignment:Splign:2.1.0"
     exon            6973..7164
                     /gene="DMXL1"
                     /inference="alignment:Splign:2.1.0"
     exon            7165..7241
                     /gene="DMXL1"
                     /inference="alignment:Splign:2.1.0"
     exon            7242..7369
                     /gene="DMXL1"
                     /inference="alignment:Splign:2.1.0"
     exon            7370..7618
                     /gene="DMXL1"
                     /inference="alignment:Splign:2.1.0"
     exon            7619..7797
                     /gene="DMXL1"
                     /inference="alignment:Splign:2.1.0"
     exon            7798..7940
                     /gene="DMXL1"
                     /inference="alignment:Splign:2.1.0"
     exon            7941..8026
                     /gene="DMXL1"
                     /inference="alignment:Splign:2.1.0"
     exon            8027..8228
                     /gene="DMXL1"
                     /inference="alignment:Splign:2.1.0"
     exon            8229..8346
                     /gene="DMXL1"
                     /inference="alignment:Splign:2.1.0"
     exon            8347..8409
                     /gene="DMXL1"
                     /inference="alignment:Splign:2.1.0"
     exon            8410..8496
                     /gene="DMXL1"
                     /inference="alignment:Splign:2.1.0"
     exon            8497..8618
                     /gene="DMXL1"
                     /inference="alignment:Splign:2.1.0"
     exon            8619..8760
                     /gene="DMXL1"
                     /inference="alignment:Splign:2.1.0"
     exon            8761..8821
                     /gene="DMXL1"
                     /inference="alignment:Splign:2.1.0"
     exon            8822..8949
                     /gene="DMXL1"
                     /inference="alignment:Splign:2.1.0"
     exon            8950..9042
                     /gene="DMXL1"
                     /inference="alignment:Splign:2.1.0"
     exon            9043..9134
                     /gene="DMXL1"
                     /inference="alignment:Splign:2.1.0"
     exon            9135..9187
                     /gene="DMXL1"
                     /inference="alignment:Splign:2.1.0"
     exon            9188..9405
                     /gene="DMXL1"
                     /inference="alignment:Splign:2.1.0"
     exon            9406..11538
                     /gene="DMXL1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      11515..11520
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DMXL1"
                     /note="hexamer: AATAAA"
     polyA_site      11530
                     /gene="DMXL1"
                     /note="major polyA site"
     polyA_site      11538
                     /gene="DMXL1"
                     /note="major polyA site"
ORIGIN      
        1 agaggcgcgt agtgagtggc ggaggactgt gggggtggcg ggcaccggag ccgggaaggg
       61 acaggtcagg cggggagtgc gagcgcgtac tgcttgcgcc actcgggctg ggtcaggagc
      121 ggctgcccga ggtccagagg aagtgtgtgg acagcgcggc cttcctggcc ggtgagtcgg
      181 ccccgggtcg tggccggtga ggggaccctg agcttcacct gggctagcgc ggggagtgac
      241 aggtgcgcga aggagcgcgg cgctccgccc tctcgccgac ccgccccctc cgggcctcgc
      301 cctccggggc tcgggatgag tcgcgggccc cagctgagcg gctccggctc caggcgcctg
      361 tcgctgcttc tgccgtcgcc accgaagagc ggccgccgcc cctgagggaa ggagggaggg
      421 aagcagccgc tgacccgtgg catgagctgg atgcggtgtc cgttgcagga ctagggcgcc
      481 gacatgaacc tgcaccaggt gctgaccggg gctgtgaacc ctggcgacca ctgcttctcc
      541 gtgggcagca ttggcgacca gcgcttcacg gcttatgcat ctggatgtga cattgtaata
      601 ctgggaagcg attttgaaag attacagata atcccaggag ctaaacatgg aaatattcaa
      661 gtgggatgtg tagactgttc aatgcaacaa ggcaagattg cagcgtctta tggaaatgtt
      721 atctccattt ttgaaccagt taacctacca aaacaaaaga aaaatttgga attatatagt
      781 cagtggcaga aaagtggcca attttttctg gaatcaatag cacacaatat aacctgggat
      841 cccacaggca gtcgtctttt aactggttcc agctatttgc aactctggtc caatactaac
      901 ttggagaagc caactgaaga tgaaaattta aataaaacag atcttaactt tggagattgg
      961 aaatgcattt ggcattgcaa aactgcttcc caagttcatt taatgaaatt ttcaccagat
     1021 ggagaatttt ttgccactgc tgggaaggat gactgtcttt tgaaggtttg gtataatgta
     1081 gaaaactggc ggacagctgt tacttctcca gatggaagtt cagaaaaaca atcccaagga
     1141 gaaattgact tttcttttgt gtatctggcc catcctcgag cagtaaatgg attttcctgg
     1201 cgtaaaacaa gcaaatatat gcctagggct tctgtatgta atgtactgtt gacttgctgc
     1261 aaagataatg tgtgtcgtct ttgggtagag acatttttac caaatgattg tttgctatac
     1321 ggaggtgact gcagccattg gactgaatca attaatttaa caaataactt caagagaaat
     1381 gcttccagta aagaacgagt tcaaaatgct ttagaagtaa atctgagaca ttttcgtaga
     1441 ggtcggagga gatcacttgc tcttgtagca catacgggat atctaccaca tcagcaggat
     1501 cctcatcatg ttcacaggaa cactccactg catgccaatg cactttgcca ctttcatatt
     1561 gcagccagca tcaacccagc cacagacatt ccacttcttc catctattac atctctgagt
     1621 ctaaatgaaa atgaagagaa gaccggacct tttgttgtac actggctaaa caataaagaa
     1681 ctgcatttta ctttgtccat ggaagttttt ttacagcaac ttagaaaaag ttttgaacaa
     1741 ccatcttctg aggccagtgt agaagattct aatcaggcag atgtaaaatc tgatgaagaa
     1801 actgatgatg gtgttgatga tctgaaaata aatcccgaaa agaaggaatt aggctgtgat
     1861 aaaatggtac caaactcaag ttttacatca ttatcgtcag ctgccattga tcatcagatt
     1921 gaagtacttc tgtctgaatg gagtaaaaat gcagatatgc tatttagtat tcatcccatg
     1981 gatggttctt tgctagtttg gcatgtggat tggctggatg aataccagcc tggtatgttt
     2041 cgtcaagtac aggtgtcctt tgtttccaga attccagtag ctttccccac aggtgatgca
     2101 aactctctct gtaaaagcat aatgatgtat gcctgtacca agaatgttga cttggctatt
     2161 cagcagggga aacaaaaacc ttctggcctc acccgttcca catcaatgct tatttcttct
     2221 ggtcacaata aatcatctaa tagtttaaaa ttaagtattt ttacgcctaa tgttatgatg
     2281 atatcaaaac atgctgatgg ttctctgaat cagtggctgg tcagttttgc cgaggaatct
     2341 gctttttcta ctgttctcag tatttcccac aaatccagat attgtggtca tcgttttcat
     2401 cttaatgatt tagcttgcca ctcagtatta ccattattgc tgacaacatc acaccataat
     2461 gcattaagga caccagatgt tgataaccca gagcaacctt ttgatgctct aaatattgaa
     2521 gaatgctctt tgacacaaca aaataaaagc actgttgacg tggcatttca ggatcccagt
     2581 gcagtttaca gtgagcttat tctgtggagg gttgacccag ttgggccatt gtctttttct
     2641 ggaggagttt ctgagcttgc ccggattaat tctcttcatg tttctgcctt ttccaatgtg
     2701 gcatggctgc ccactcttat acccagttat tgtctgggtg catactgcaa ctctcctagt
     2761 gcatgctttg tagccagtga tggacaatat ctgagattat atgaagcagt tattgatgct
     2821 aagaaacttt tatctgagct ttctaaccct gaaatttcta aatatgttgg tgaagtcttt
     2881 aacatcgtca gtcaacaatc aacagccagg ccaggatgca ttattgcatt agatcccatt
     2941 accaaacttc atggcagaaa aacccaactg cttcatgttt ttgaagaaga cttcattttg
     3001 aataaccttg agaagaaaag ccttggcaaa gacagcattt tatctaatgc aggcagctca
     3061 cctaatggat tttctgagaa gttctaccta attgtaatag aatgcactca agacaaccgt
     3121 tcactgttac acatgtggaa tttacatcta aagtcaattc ctgtctcatt agatgaaaaa
     3181 gtagatacaa aattatccga agcggtttgg cagccagaag aacattattc ttcttctcca
     3241 gagaagatcc tatctccttt ttcacaaaag tatcaggctt gcagagcaaa tctccagagt
     3301 accagcaggt tgactctgtt ttcagaaatg gtttatagcc aagaattgca tttaccagaa
     3361 ggagttgaga taataagtat taagccatca gcaggacatc tgagttcatc ttctatatat
     3421 cctgcatgca gtgctcctta tttattggca acttcatgtt cagatgagaa agtaagattc
     3481 tggagatgca gagtaacaga tggagaatct gccacgtcaa agaatggaaa aattgatctt
     3541 gcatacattt gggaagaatg gccattactt attgaagatg gacttcagag caatagtagt
     3601 ataactgtac ctggtaggcc tgtagaagtt agctgtgcac atacaaatcg tttagcagta
     3661 gcttataagc agcctgcatc taatagtaga tcttcccagg actttgtgat gcatgtaagt
     3721 atttttgaat gtgagtcaac aggaggttca tgttgggtcc ttgagcagac aattcattta
     3781 gatgagttaa gcacagtatt ggattctggc attagtgttg atagcaattt agtggcctat
     3841 aataaacaag acatgtattt atctagtaaa gagaatatca catcaaacac aaagcattta
     3901 gttcacttag attggatgtc tagagaagac ggttctcata tcctgactgt aggaattgga
     3961 tcaaaacttt ttatgtatgg acccctggct ggcaaggtac aagaccaaac tggtaaggaa
     4021 accctggcat ttcctctctg ggagagtacc aaagttgtgc ccctttctaa atttgtacta
     4081 ttacgaagtg tggacctagt ttcttctgta gatggctccc caccttttcc tgtttcttta
     4141 tcgtgggtcc gggatggcat ccttgtggta ggaatggact gtgaaatgca tgtgtattgc
     4201 caatggcaac catcttctaa acaagaacct gttataacag attcgtacag tgggagcact
     4261 ccatctataa caagtttaat aaaacagagt aactccagtt ctgggttaca tcctccaaag
     4321 aaaactctga ctcgatccat gaccagtctt gcacagaaaa tctgtggaaa gaaaactgca
     4381 ttcgatcctt cagtggatat ggaagattca ggtctttttg aagcagctca tgtactttcc
     4441 ccgactctac ctcagtatca tcccttgcag cttttggaac tcatggatct tggtaaagtt
     4501 cggagagcca aggccatctt gtcccatctt gttaagtgca ttgctgggga agttgtggct
     4561 ctgaatgaag ctgaatctaa tcatgaacgc cgccttaggt ctctcacaat cagtgctagt
     4621 ggaagcacta ccagagaccc ccaggcattc aacaaggctg aaaatacaga ttacacagaa
     4681 atagattctg ttcctccact tcctttatat gccttacttg cagcagatga tgatagctgt
     4741 tactcatctt tggagaaatc tagtaatgag agtacgttaa gtaaatcaaa ccaattatct
     4801 aaagaaagtt atgatgagct ttttcagact caacttctaa tgactgatac tcatatgtta
     4861 gagacagatg aagaaaatac aaagcctaga gttattgacc tttcacagta cagtccgact
     4921 tactttggac ctgagcatgc tcaggttctt tctggccact tacttcattc tagtttacca
     4981 ggactcagcc ggatggagca gatgtctttg atggccttag cagatacaat tgcaactaca
     5041 agcactgata ttggagaaag ccgagacaga agccaaggtg gagaaactct tgatgaatgt
     5101 gggttaaaat ttcttttggc tgttcgactc catacctttc ttacaacttc ccttccagcc
     5161 tatcgagctc aactccttca ccaaggcctg tctacaagtc attttgcttg ggcatttcac
     5221 tcagtagcag aagaagaact gctgaacatg ttgccagcca tgcagaaaga tgatcccact
     5281 tggtctgaac taagagctat gggtgtgggg tggtgggtcc ggaatacccg catcttacgc
     5341 aaatgcatag aaaaagtagc taaagcagcc ttttatagaa agaatgatcc tttagatgct
     5401 gccatttttt accttgcaat gaaaaagaaa gctgtgattt ggggattata tagagctgaa
     5461 aaaaacacca ggatgacaca gttttttgga cacaattttg aggatgagag gtggcgtaaa
     5521 gcagctttaa agaatgcttt ttctttgcta ggcaaacaaa gatttgaaca ttctgcagca
     5581 ttttttcttt tagctggttg cctcagagat gcaattgagg tatgtcttga gaaattgaat
     5641 gacattcagt tggctcttgt aatagcaaga ctctatgagt ctgaatttga tacatctgca
     5701 gcatataaat ctattttacg taaaaaagtt ttgggaatcg attctcctgt cagtgaactg
     5761 tgttcattga acataaatat gcatcatgat ccttttcttc ggagcatggc atattggatt
     5821 ttggaagatt atagtggtgc tctggaaaca ttaataaagc aacctatcag agagaatgat
     5881 gatcaagttt tatcagccag taatcctaca gtttttaatt tctacaatta tctaagaaca
     5941 catcctcttt tgctgagacg tcattttgga tcatctgata cattttccac acatatgagc
     6001 ctaacaggaa aaagtggact ggcaggaaca attaatttaa gtgaaagacg tttatttttt
     6061 accactgcca gtgctcattt aaaagctggc tgcccaatgt tggctttgga agtattatca
     6121 aagatgccta aagtcatcaa gaaaacaaga cctttttata gggcttctag ttttctggat
     6181 actagtaaag actgttctcc ttcttctcca ttaaagttgg atgcaaggga agataagtct
     6241 tctgctgttg attggtcaca gtcactgata aatggttttg gatcttcttc agagggttcc
     6301 tcagagaagc aatcaaactc cactctttct tttgactgga gccaaccaag tgttgtgttt
     6361 caggatgact ctttagagtt aaaatgggac agtgataatg atgaagaaaa tgaggatgtc
     6421 cctatttcaa tgaaagaact aaaaccttta cagagaaaaa cagataaaaa gttggatgac
     6481 ataagttcta actacacaga atctttcagc acactagatg aaaatgacct tttaaatcca
     6541 tcagaagata taattgcagt tcagttaaaa tttagagcat gtttaaagat tctcacagta
     6601 gaacttcgta ctttatctac tggctatgaa atagatggtg gaaaattgcg ttaccaacta
     6661 taccactggc ttgaaaaaga ggtgatagct cttcagagga cttgtgactt ttgctcagat
     6721 gctgaagaac tacagtctgc atttggcaga aatgaagatg aatttggatt aaatgaggat
     6781 gctgaagatt tgcctcacca aacaaaagtg aaacaactga gagaaaattt tcaggaaaaa
     6841 agacagtggc tcttgaagta tcagtcactt ttgagaatgt ttcttagtta ctgcatactt
     6901 catggatccc atggtggggg tcttgcatct gtaagaatgg aattgatttt gcttttgcaa
     6961 gaatctcagc aggaaacatc agaaccacta ttttctagcc ctctgtcaga gcaaacctca
     7021 gtgcctctcc tctttgcttg tacagccaat gccaaaacag tagttgccaa tccattattg
     7081 caccttagta atctgacaca tgatattctc catgccataa taaactttga ttcaccaccc
     7141 caccctgata tccaaagcaa taaagtgtat gtaatgcata ctttagcagc ttcactttct
     7201 gcttgtattt atcagtgcct ttgtggtagt cataactaca gttcatttca gacgaatcag
     7261 tttactggaa tggtatatca gacagtactg cttcctcatc gaccttcttt gaaaacagga
     7321 agcttagatg aagcattaac tcccaatacg tcaccagctc aatggccagg aataacttgt
     7381 ctaattcgac ttttgaattc ttctggcgag gaagcccagt cagggcttac agtcttgctc
     7441 tgtgagattc tcacagcagt gtatcttagt ctcttcatcc atggcctggc cacacattca
     7501 agtaatgagc tatttcggat tgtggcccat cctctaaatg agaaaatgtg gtctgctgtg
     7561 tttggtggag gtgcacatgt tcctagcaaa gaacagacac attcaaaaac tttacctgtt
     7621 tcttcactag ttgaagaagg agaaaaacag aacaaacgtt ttaggccgtc aaaaatgtct
     7681 tgcagagaat ctgccccact gaccccttcc tcggcaccag taagccagga gtcactggcg
     7741 gttaaagaaa agttcatccc acctgagctc agtatctggg actatttcat agctaagcct
     7801 tttctaccct cttctcaaag tagagccgaa tatgattcag aggagagtct gggaagtgat
     7861 gatgatgaca atgatgatga tgatgatgtt ttagcatcag atttccatct ccaggaacat
     7921 tctaattcaa attcatatag ttggtccttg atgcggttgg cgatggtgca attggtgctc
     7981 aacaatttga agacttttta tcccttcgca ggtcatgatc ttgcagagct tccagttagt
     8041 tcacctcttt gtcatgcggt tctaaaaact cttcaatgtt gggaacaagt tcttctccga
     8101 cgacttgaaa tccatggtgg gccacctcaa aattatatcg caagtcatac cgccgaagag
     8161 agtttgtctg caggtcctgc aattcttcgc cacaaagctt tactggaacc tacaaacact
     8221 cctttcaaat ccaaacacca tctggcactg tctgtgaaga ggctttggca gtatttggtg
     8281 aagcaggaag aaattcagga aacctttatc aaaaatatat tcacaaagaa acggtgtcta
     8341 aatgagtcat tagaggacaa cagtgaaacc atcaaaaatt ctatgatgga ggagccaaac
     8401 atcaataaga tagaagcaga tttgggatat cctggaggta aagcaagaat tattcataag
     8461 gaatctgata tcattactgc gtttgctgtt aataaggcaa atagaaactg catagcaatc
     8521 gcttccagtc atgatgttca agaactggat gtttctggaa ttctggccac acaggtctac
     8581 acttgggtag atgatgatat agaagtggaa accaaaggat cagaagattt cttggttata
     8641 catgctcgtg atgatttaac agctgttcaa ggtacaactc catatacaca tagcaatcct
     8701 ggcactccaa tcaacatgcc atggcttggt agtacacaga ctggcagagg agcatctgtg
     8761 atgattaaga aagccattaa taatgttaga agaatgactt ctcatccaac tcttccttac
     8821 tatctgacag gagctcaaga tggaagtgtc agaatgtttg aatggggcca ttctcaacaa
     8881 ataacctgtt ttcgatctgg tggcaattca agagttacaa gaatgagatt taactatcag
     8941 ggaaataagt ttggaatagt tgatgctgat ggatatttaa gtttgtatca aacaaactgg
     9001 aaatgttgtc cagttactgg aagcatgcct aagccatacc tgacttggca gtgtcataac
     9061 aaaacagcca atgattttgt cttcgttagt tcctcctctc tgatagctac agctggtctt
     9121 tcaactgaca atagaaacgt atgtttgtgg gatactcttg tagcacctgc caatagttta
     9181 gtccatgcat ttacctgcca tgacagtgga gccacagttt tagcatatgc tccaaaacat
     9241 cagctactaa tatcaggtgg cagaaaaggt tttacatatg tatttgacct ttgtcaacga
     9301 caacagaggc agcttttcca gagccatgat tctcctgtta aagccgttgc tgttgatcca
     9361 actgaagagt actttgttac aggatctgcc gaaggcaata taaagatttg gagtctctct
     9421 acctttggtc ttctccatac ttttgtcagt gaacatgctc ggcagtccat ttttagaaat
     9481 attggaactg gagtgatgca aattgagaca gggcctgcaa atcacatttt ctcctgtgga
     9541 gctgatggaa caatgaaaat gagaatactg ccagatcagt ttagcccttt aaatgaagtg
     9601 ttgaaaaatg atgtgaaatt tatgctataa catttttaca ataagatgta caatttatta
     9661 cctatatgga agtggccaac agatataata tacagtgatc attctctatg ccacaaatta
     9721 gctaatgctt tcttgttttt atatttattt tatggagctt tgcccttgat gcactgatgc
     9781 cttaaaaatt aacaaggtca ttcagaagta gattacattg cctaaagtag aatgtgtaag
     9841 taatgctgta ataatacata tcatagtata ttataatcag tatgtcatag tgttaaaggt
     9901 gttttgtttt cttattgata cttttccaca ggcatctctg catgaatttc ttccacagta
     9961 aaaatacgtt ttttgtaaag gcaattgtac ataatactca tcacttaatt caccacactc
    10021 tcacttcctt tattagcctt atacatctca aactcttctc ttaattaatg ataggtattt
    10081 gagtaagaat gaaaaaaata atgaacatct tcattaaaat tgtcattgag acgtcagtga
    10141 taaatgagct agatggctca atatgtaagg ttttcagtag tttaccctcc ggaacccaag
    10201 ttgtatgtat gtatacgtgt gtgtgtgtgt gtgtgtgtgt atcttacaca tcttatttga
    10261 acttagttgt atatattagc gaaaactggt ttttcatgtg tttttgtgcc ataacaacta
    10321 ttgccaccag aataactttt tttttgcaac tgtgcttttc atttttaaaa aatttttgaa
    10381 ttcccatcct aattttcaaa taagtttcaa ggagactatc aggattatta ttttaaagat
    10441 tagatttagt caaataagtc ttagcaggca ataaagtttc tgtggtggca tatatcatgt
    10501 aagacactta aagtaagttt gtgaatttgt caactttcga gcatcaaaca aatattttac
    10561 ttaaatttta ttttatctta tttttaggtg cttttaatct caaaattctg aaaagcgaat
    10621 agcagtgttt tcagaaacaa atgtgaaagc agtcaaatta agtagatact atttagaaat
    10681 gtaaaatact ctccagatct accattaata gaaaataaac taaaccttat attttatttt
    10741 tgccaaaata ttttattata aaatatgacc aaaatattta aaatgcacaa tgcttttaac
    10801 ttaaatgtgc taaccctgtt tctgtctgtt ttgtgctgta ccttttctga ttcagaatta
    10861 tagaaaactt gataaatact tgattttaac caatgagact acaggcagat gggactaagt
    10921 gtttatggga caattatgta ctatttaact taaatatatt ttgtttaata ggaaatatat
    10981 aataatagca ttttatgtaa taaaatatgg gcaacgatta tcttggaaat taaagagtca
    11041 aagcaaagaa atgaagggct ggtaaaatga attttgtaat atcctcagga tacttttatc
    11101 ttaaaagtat gttgttaaag attttgtaaa ttgtatttca acaattttaa atgtgttgag
    11161 caagttgcag tgcaaacact gtcattatgt agagagttta tatgcacata ataacctgta
    11221 cctataaatc gtgcaataac catatgcgac tattttgcca tggagaaatc tgacagcatt
    11281 gcaaacaata gtattgtttg atgtagttaa ccttaagtta tttttcagta atttcttcac
    11341 aaatcaagat tcaaacagct ttaaacactt ccaatgagat aaaatattta ctattatgct
    11401 tattagaaca aaaggtgttt aaggatgaac taaatatttt aattgagcat ttatatggat
    11461 aatcatacat tatgtaagcc catatgtatt tacatccaga gtcataatat tttaaataaa
    11521 caatcatgca gaaacttt
//
