LOCUS       NM_001142327            3702 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens cyclin D binding myb like transcription factor 1
            (DMTF1), transcript variant 2, mRNA.
ACCESSION   NM_001142327
VERSION     NM_001142327.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3702)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   2  (bases 1 to 3702)
  AUTHORS   Li,J., Shi,K., Xu,T., Hu,J., Li,T., Li,G., Chen,K., Li,D., Inoue,K.
            and Sui,G.
  TITLE     Mechanisms regulating DMTF1beta/gamma expression and their
            functional interplay with DMTF1alpha
  JOURNAL   Int J Oncol 58 (1), 20-32 (2021)
   PUBMED   33367929
  REMARK    GeneRIF: Mechanisms regulating DMTF1beta/gamma expression and their
            functional interplay with DMTF1alpha.
REFERENCE   3  (bases 1 to 3702)
  AUTHORS   Fry,E.A., Niehans,G.E., Kratzke,R.A., Kai,F. and Inoue,K.
  TITLE     Survival of Lung Cancer Patients Dependent on the LOH Status for
            DMP1, ARF, and p53
  JOURNAL   Int J Mol Sci 21 (21), 7971 (2020)
   PUBMED   33120969
  REMARK    GeneRIF: Survival of Lung Cancer Patients Dependent on the LOH
            Status for DMP1, ARF, and p53.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3702)
  AUTHORS   Yang,X., Lou,Y., Wang,M., Liu,C., Liu,Y. and Huang,W.
  TITLE     miR-675 promotes colorectal cancer cell growth dependent on tumor
            suppressor DMTF1
  JOURNAL   Mol Med Rep 19 (3), 1481-1490 (2019)
   PUBMED   30592263
  REMARK    GeneRIF: the results of the study demonstrated that miR6753p
            directly regulated the expression of DMTF1, which contributed to
            the further regulation of Colorectal cancer cell proliferation.
REFERENCE   5  (bases 1 to 3702)
  AUTHORS   Fry,E.A. and Inoue,K.
  TITLE     c-MYB and DMTF1 in Cancer
  JOURNAL   Cancer Invest 37 (1), 46-65 (2019)
   PUBMED   30599775
  REMARK    GeneRIF: DMTF1 is hemizygously deleted in 35-42% of human cancers
            and is associated with longer survival. [review]
            Review article
REFERENCE   6  (bases 1 to 3702)
  AUTHORS   Mallakin,A., Sugiyama,T., Taneja,P., Matise,L.A., Frazier,D.P.,
            Choudhary,M., Hawkins,G.A., D'Agostino,R.B. Jr., Willingham,M.C.
            and Inoue,K.
  TITLE     Mutually exclusive inactivation of DMP1 and ARF/p53 in lung cancer
  JOURNAL   Cancer Cell 12 (4), 381-394 (2007)
   PUBMED   17936562
  REMARK    GeneRIF: Loss of heterozygosity (LOH) of the hDMP1 gene was
            detectable in approximately 35% of human lung carcinomas, which was
            found in mutually exclusive fashion with LOH of INK4a/ARF or that
            of P53. DMP1 is a pivotal tumor suppressor for human lung cancers.
REFERENCE   7  (bases 1 to 3702)
  AUTHORS   Inoue,K., Mallakin,A. and Frazier,D.P.
  TITLE     Dmp1 and tumor suppression
  JOURNAL   Oncogene 26 (30), 4329-4335 (2007)
   PUBMED   17237816
  REMARK    Review article
REFERENCE   8  (bases 1 to 3702)
  AUTHORS   Forsti,A., Angelini,S., Festa,F., Sanyal,S., Zhang,Z.,
            Grzybowska,E., Pamula,J., Pekala,W., Zientek,H., Hemminki,K. and
            Kumar,R.
  TITLE     Single nucleotide polymorphisms in breast cancer
  JOURNAL   Oncol Rep 11 (4), 917-922 (2004)
   PUBMED   15010895
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 3702)
  AUTHORS   Tschan,M.P., Fischer,K.M., Fung,V.S., Pirnia,F., Borner,M.M.,
            Fey,M.F., Tobler,A. and Torbett,B.E.
  TITLE     Alternative splicing of the human cyclin D-binding Myb-like protein
            (hDMP1) yields a truncated protein isoform that alters macrophage
            differentiation patterns
  JOURNAL   J Biol Chem 278 (44), 42750-42760 (2003)
   PUBMED   12917399
  REMARK    GeneRIF: hDMP1beta antagonizes hDMP1alpha activity and cellular
            functions of hDMP1 may be regulated by cellular hDMP1 isoform
            levels
REFERENCE   10 (bases 1 to 3702)
  AUTHORS   Bodner,S.M., Naeve,C.W., Rakestraw,K.M., Jones,B.G.,
            Valentine,V.A., Valentine,M.B., Luthardt,F.W., Willman,C.L.,
            Raimondi,S.C., Downing,J.R., Roussel,M.F., Sherr,C.J. and Look,A.T.
  TITLE     Cloning and chromosomal localization of the gene encoding human
            cyclin D-binding Myb-like protein (hDMP1)
  JOURNAL   Gene 229 (1-2), 223-228 (1999)
   PUBMED   10095122
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF084530.1 and BC007418.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Feb 27, 2020 this sequence version replaced NM_001142327.1.
            
            Summary: This gene encodes a transcription factor that contains a
            cyclin D-binding domain, three central Myb-like repeats, and two
            flanking acidic transactivation domains at the N- and C-termini.
            The encoded protein is induced by the oncogenic Ras signaling
            pathway and functions as a tumor suppressor by activating the
            transcription of ARF and thus the ARF-p53 pathway to arrest cell
            growth or induce apoptosis. It also activates the transcription of
            aminopeptidase N and may play a role in hematopoietic cell
            differentiation. The transcriptional activity of this protein is
            regulated by binding of D-cyclins. This gene is hemizygously
            deleted in approximately 40% of human non-small-cell lung cancer
            and is a potential prognostic and gene-therapy target for
            non-small-cell lung cancer. Multiple transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Dec 2008].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 encode the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF084530.1, SRR11853567.27444.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000331242.12/ ENSP00000332171.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2594              AF084530.1         42-2635
            2595-3702           BC007418.2         1636-2743
FEATURES             Location/Qualifiers
     source          1..3702
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q21.12"
     gene            1..3702
                     /gene="DMTF1"
                     /gene_synonym="DMP1; DMTF; hDMP1; MRUL"
                     /note="cyclin D binding myb like transcription factor 1"
                     /db_xref="GeneID:9988"
                     /db_xref="HGNC:HGNC:14603"
                     /db_xref="MIM:608491"
     exon            1..103
                     /gene="DMTF1"
                     /gene_synonym="DMP1; DMTF; hDMP1; MRUL"
                     /inference="alignment:Splign:2.1.0"
     exon            104..226
                     /gene="DMTF1"
                     /gene_synonym="DMP1; DMTF; hDMP1; MRUL"
                     /inference="alignment:Splign:2.1.0"
     exon            227..343
                     /gene="DMTF1"
                     /gene_synonym="DMP1; DMTF; hDMP1; MRUL"
                     /inference="alignment:Splign:2.1.0"
     CDS             235..2517
                     /gene="DMTF1"
                     /gene_synonym="DMP1; DMTF; hDMP1; MRUL"
                     /note="isoform a is encoded by transcript variant 2;
                     hDMTF1; cyclin-D-interacting Myb-like protein 1; cyclin
                     D-binding Myb-like protein"
                     /codon_start=1
                     /product="cyclin-D-binding Myb-like transcription factor 1
                     isoform a"
                     /protein_id="NP_001135799.1"
                     /db_xref="CCDS:CCDS5601.1"
                     /db_xref="GeneID:9988"
                     /db_xref="HGNC:HGNC:14603"
                     /db_xref="MIM:608491"
                     /translation="MSTVEEDSDTVTVETVNSVTLTQDTEGNLILHCPQNEADEIDSE
                     DSIEPPHKRLCLSSEDDQSIDDSTPCISVVALPLSENDQSFEVTMTATTEVADDEVTE
                     GTVTQIQILQNEQLDEISPLGNEEVSAVSQAWFTTKEDKDSLTNKGHKWKQGMWSKEE
                     IDILMNNIERYLKARGIKDATEIIFEMSKDERKDFYRTIAWGLNRPLFAVYRRVLRMY
                     DDRNHVGKYTPEEIEKLKELRIKHGNDWATIGAALGRSASSVKDRCRLMKDTCNTGKW
                     TEEEEKRLAEVVHELTSTEPGDIVTQGVSWAAVAERVGTRSEKQCRSKWLNYLNWKQS
                     GGTEWTKEDEINLILRIAELDVADENDINWDLLAEGWSSVRSPQWLRSKWWTIKRQIA
                     NHKDVSFPVLIKGLKQLHENQKNNPTLLENKSGSGVPNSNTNSSVQHVQIRVARLEDN
                     TAISSSPMAALQIPVQITHVSSADSPATVDSETITLNSGTLQTFEILPSFHLQPTGTP
                     GTYLLQTSSSQGLPLTLTASPTVTLTAAAPASPEQIIVHALSPEHLLNTSDNVTVQCH
                     TPRVIIQTVATEDITSSISQAELTVDSDIQSSDFPEPPDALEADTFPDEIHHPKMTVE
                     PSFNDAHVSKFSDQNSTELMNSVMVRTEEEISDTDLKQEESPSDLASAYVTEGLESPT
                     IEEQVDQTIDDETILIVPSPHGFIQASDVIDTESVLPLTTLTDPILQHHQEESNIIGS
                     SLGSPVSEDSKDVEDLVNCH"
     exon            344..466
                     /gene="DMTF1"
                     /gene_synonym="DMP1; DMTF; hDMP1; MRUL"
                     /inference="alignment:Splign:2.1.0"
     exon            467..561
                     /gene="DMTF1"
                     /gene_synonym="DMP1; DMTF; hDMP1; MRUL"
                     /inference="alignment:Splign:2.1.0"
     exon            562..676
                     /gene="DMTF1"
                     /gene_synonym="DMP1; DMTF; hDMP1; MRUL"
                     /inference="alignment:Splign:2.1.0"
     exon            677..753
                     /gene="DMTF1"
                     /gene_synonym="DMP1; DMTF; hDMP1; MRUL"
                     /inference="alignment:Splign:2.1.0"
     exon            754..911
                     /gene="DMTF1"
                     /gene_synonym="DMP1; DMTF; hDMP1; MRUL"
                     /inference="alignment:Splign:2.1.0"
     exon            912..944
                     /gene="DMTF1"
                     /gene_synonym="DMP1; DMTF; hDMP1; MRUL"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1054
                     /gene="DMTF1"
                     /gene_synonym="DMP1; DMTF; hDMP1; MRUL"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1283
                     /gene="DMTF1"
                     /gene_synonym="DMP1; DMTF; hDMP1; MRUL"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..1435
                     /gene="DMTF1"
                     /gene_synonym="DMP1; DMTF; hDMP1; MRUL"
                     /inference="alignment:Splign:2.1.0"
     exon            1436..1645
                     /gene="DMTF1"
                     /gene_synonym="DMP1; DMTF; hDMP1; MRUL"
                     /inference="alignment:Splign:2.1.0"
     exon            1646..1728
                     /gene="DMTF1"
                     /gene_synonym="DMP1; DMTF; hDMP1; MRUL"
                     /inference="alignment:Splign:2.1.0"
     exon            1729..1884
                     /gene="DMTF1"
                     /gene_synonym="DMP1; DMTF; hDMP1; MRUL"
                     /inference="alignment:Splign:2.1.0"
     exon            1885..2262
                     /gene="DMTF1"
                     /gene_synonym="DMP1; DMTF; hDMP1; MRUL"
                     /inference="alignment:Splign:2.1.0"
     exon            2263..2407
                     /gene="DMTF1"
                     /gene_synonym="DMP1; DMTF; hDMP1; MRUL"
                     /inference="alignment:Splign:2.1.0"
     exon            2408..3702
                     /gene="DMTF1"
                     /gene_synonym="DMP1; DMTF; hDMP1; MRUL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3681..3686
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DMTF1"
                     /gene_synonym="DMP1; DMTF; hDMP1; MRUL"
                     /note="hexamer: AATAAA"
     polyA_site      3702
                     /gene="DMTF1"
                     /gene_synonym="DMP1; DMTF; hDMP1; MRUL"
                     /note="major polyA site"
ORIGIN      
        1 actccagctg cagccactct cgcccgtggc tgcttcctcc atcctggtat tttttggagc
       61 ttccatcctg gttcttccaa agtgcccgga cccaaaacag gaaagtgttg cggagatagg
      121 aacatgggag agaaacaatc tgggtaacat gaaagtgatg ctggttgcta agggaaggca
      181 acttgattct gtgggaaggg ctgtagctga tccatccgtt gtctagattt gagtatgagc
      241 acagtggaag aggattctga cacagtaaca gtagaaactg tgaactctgt gactttgact
      301 caggacacag aagggaatct cattcttcac tgccctcaga atgaagcgga tgaaatagac
      361 tcagaagata gtattgaacc tccacataaa aggctttgtt tgtcctctga ggatgatcag
      421 agtattgatg attctactcc ttgcatatca gttgttgcac ttccactttc agaaaatgat
      481 cagagctttg aagtgaccat gactgcaacc acagaagtag cagatgatga ggttactgag
      541 gggactgtga cacagataca gattttgcag aatgagcaac tagatgaaat atctcccttg
      601 ggtaacgagg aagtttcagc agttagccaa gcatggttta caactaaaga agataaggat
      661 tctctgacta ataaaggaca taaatggaag caggggatgt ggtccaagga agaaattgat
      721 attttgatga acaatattga acgctatctt aaggcacgcg gaataaaaga tgctacagaa
      781 atcatctttg agatgtcaaa agacgaaaga aaagatttct acaggactat agcatggggt
      841 ctgaaccggc ctttgtttgc agtttataga agagtgcttc gcatgtatga tgacagaaac
      901 catgtgggaa aatatacacc tgaagaaatt gagaagctca aggagctccg gataaagcat
      961 ggcaatgact gggcaacaat aggggcggcg ctaggaagaa gtgcatcttc tgtcaaagat
     1021 cggtgccgac tgatgaagga tacttgcaac acagggaagt ggacagaaga agaagaaaag
     1081 agacttgcag aagtggttca tgagttgaca agcactgagc caggtgacat agtcacacag
     1141 ggtgtgtctt gggcagctgt ggctgaacga gtcggtaccc gctcagaaaa gcaatgtcgt
     1201 tctaaatggc tcaactacct gaattggaaa cagagtgggg gtactgaatg gaccaaggaa
     1261 gatgaaatca atctcatcct caggatagca gaacttgatg tagctgatga aaatgacatt
     1321 aactgggatc tgttagctga gggatggagt agtgtccgtt caccacaatg gctacgaagt
     1381 aaatggtgga ccatcaaaag gcaaattgca aaccataagg atgtttcgtt ccctgtctta
     1441 ataaaaggtc ttaaacagtt acatgagaac caaaaaaaca acccaacgct tttggagaat
     1501 aaatcaggat ctggagttcc aaacagtaat accaattcca gtgtgcagca tgttcagata
     1561 agagttgccc gcttggaaga taatacagcc atctcttcta gccccatggc agcattgcag
     1621 attccagtcc agatcaccca tgtttcttca gcagactctc ctgctaccgt tgactcagaa
     1681 acaataacac taaacagtgg aacactacag acatttgaga ttcttccctc tttccatcta
     1741 cagcccactg gcactccagg cacctaccta cttcaaacaa gctcaagcca aggccttccc
     1801 ctaactctga ctgctagtcc cacagtaacc ctgacagctg ctgctcctgc ttctcctgaa
     1861 cagattattg ttcatgcttt atccccagaa catttgttga acacaagtga taatgttaca
     1921 gtgcagtgtc acacaccaag agtcatcatt cagactgttg ccacagagga catcacttct
     1981 tccatatccc aagcagaact gacagtcgat agtgatattc agtcatctga ttttcctgag
     2041 cctccagacg ccctagaagc agacactttc ccagatgaaa ttcatcaccc taagatgact
     2101 gtggagccat catttaatga tgctcatgta tccaaattca gtgaccaaaa tagcacagaa
     2161 ctgatgaata gtgttatggt cagaacagaa gaagaaatct ctgacaccga ccttaaacaa
     2221 gaggaatcac cctctgattt agccagtgct tatgttactg agggtttaga gtctcccact
     2281 atagaagaac aagttgatca aacaattgat gatgaaacaa tacttatcgt tccttcacca
     2341 catggcttta tccaggcatc tgatgttata gatactgaat ctgtcttgcc tttgacaaca
     2401 ctaacagatc ccatactcca acatcatcag gaagaatcaa atatcattgg atcatccttg
     2461 ggcagtcctg tttcagaaga ttcaaaggat gtcgaagatt tggtaaactg tcattagaat
     2521 aattcttaga aataggcagt tcaagcaaag aaggcacact gttaattaca acctcttcaa
     2581 agaaatagga gcaaccccca agaggcttaa tttaccaatt taaatagcca cagtccttaa
     2641 gccacacaca ttgttgctgc tatgactttt tacctccttt aaacacatca tctgaggttg
     2701 agttttatga cagtatgtag ttgagtggag gctgggagtt ttaagcataa atccctgttt
     2761 agtgttacat gggaataagg aatttcattc acttcagcca ctaagaaaag tttagaatca
     2821 cgaaagctta actgctgtgg tttaaagtac agtttctcta aagatcagac atggcactgt
     2881 ctcctctcaa gcctggttgt agttcagatg agtcttttca acatggtctt caacatggtc
     2941 tagagcttac cagtgatctt ctgatcttca agaagactaa gtttgagact tgaccagcat
     3001 acaagtatag agacctagga ggtggtcttg tggtggtaca tttggttaac ccattgctgg
     3061 cagtgggagc tgatttaggc agggtaaaca ggaaagcatt aaaagttaaa attcactaca
     3121 ggttttttgt tacttttaaa gggaatatgg ataagcatag taacaaaacc caccagaatc
     3181 taagcagttt tcaccccctc agaaaccact gtcattagtt tacaaagtta gcactttgaa
     3241 gtaaaactaa atgaggaagg aagtaatgtt acctatcctt gataccatga ccatttatta
     3301 gatgttttgc tatataaatt accgagagaa tagtttgtca tccacttagt gtgttagctg
     3361 gtggggtaca atataacctc tcatctcagg ctattttaaa aaaacaatat ttgcttctat
     3421 aacaaaagga aacaaatcta agaatcattc ctgtactaca gaagggttaa ggcaaaggta
     3481 gccttttggg ctttttaatg aatatgaccc ctatagaaaa gtcaagaaaa aaaaaccctt
     3541 gtataaatta ttttatttat tattgtaatt agatcttcac aaagttgtct tttcactgtg
     3601 ttttgtcaac gtgaaattaa attgtagtta taagcaaaag ttggttgcct agggaacaat
     3661 tgtatattca gtttaacaga aataaaagaa tatttgtctt aa
//
