LOCUS       NM_001040283            1805 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens DMRT like family C2 (DMRTC2), mRNA.
ACCESSION   NM_001040283
VERSION     NM_001040283.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1805)
  AUTHORS   Yin,Y., Morgunova,E., Jolma,A., Kaasinen,E., Sahu,B.,
            Khund-Sayeed,S., Das,P.K., Kivioja,T., Dave,K., Zhong,F.,
            Nitta,K.R., Taipale,M., Popov,A., Ginno,P.A., Domcke,S., Yan,J.,
            Schubeler,D., Vinson,C. and Taipale,J.
  TITLE     Impact of cytosine methylation on DNA binding specificities of
            human transcription factors
  JOURNAL   Science 356 (6337) (2017)
   PUBMED   28473536
REFERENCE   2  (bases 1 to 1805)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   3  (bases 1 to 1805)
  AUTHORS   Ottolenghi,C., Fellous,M., Barbieri,M. and McElreavey,K.
  TITLE     Novel paralogy relations among human chromosomes support a link
            between the phylogeny of doublesex-related genes and the evolution
            of sex determination
  JOURNAL   Genomics 79 (3), 333-343 (2002)
   PUBMED   11863363
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB026313.1, AJ291669.1, AC243967.3 and AC010616.5.
            
            On Nov 22, 2018 this sequence version replaced NM_001040283.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC029202.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000269945.8/ ENSP00000269945.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-548               DB026313.1         23-570
            549-915             AJ291669.1         384-750
            916-916             AC243967.3         61344-61344         c
            917-1182            AJ291669.1         752-1017
            1183-1802           AC010616.5         12917-13536
            1803-1805           AC243967.3         59572-59574         c
FEATURES             Location/Qualifiers
     source          1..1805
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.2"
     gene            1..1805
                     /gene="DMRTC2"
                     /note="DMRT like family C2"
                     /db_xref="GeneID:63946"
                     /db_xref="HGNC:HGNC:13911"
                     /db_xref="MIM:614806"
     exon            1..60
                     /gene="DMRTC2"
                     /inference="alignment:Splign:2.1.0"
     exon            61..288
                     /gene="DMRTC2"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..1168
                     /gene="DMRTC2"
                     /codon_start=1
                     /product="doublesex- and mab-3-related transcription
                     factor C2"
                     /protein_id="NP_001035373.1"
                     /db_xref="CCDS:CCDS33034.1"
                     /db_xref="GeneID:63946"
                     /db_xref="HGNC:HGNC:13911"
                     /db_xref="MIM:614806"
                     /translation="MEPSDMPAGYHCPLDSAPWDETRDPQSTELIPRRAISRSPTCAR
                     CRNHGVTAHLKGHKRLCLFQACECHKCVLILERRRVMAAQVALRRQQEAQLKKHLMRR
                     GEASPKAPNHFRKGTTQPQVPSGKENIAPQPQTPHGAVLLAPTPPGKNSCGPLLLSHP
                     PEASPLSWTPVPPGPWVPGHWLPPGFSMPPPVVCRLLYQEPAVSLPPFPGFDPGTSLQ
                     LPTHGPFTTCPGSHPVLTAPLSGEPQGPPSQPRTHSTLILQPCGTPDPLQLQPQASGA
                     SCLARTSGPSEWQLQQEAAEALVGLKDSSQAPRVTPSVPPNPAWISLLHPCGPPAPAG
                     GRGFQPVGPCLRPSPAPSVALHIGRLGSISLLS"
     exon            289..434
                     /gene="DMRTC2"
                     /inference="alignment:Splign:2.1.0"
     exon            435..511
                     /gene="DMRTC2"
                     /inference="alignment:Splign:2.1.0"
     exon            512..692
                     /gene="DMRTC2"
                     /inference="alignment:Splign:2.1.0"
     exon            693..819
                     /gene="DMRTC2"
                     /inference="alignment:Splign:2.1.0"
     exon            820..880
                     /gene="DMRTC2"
                     /inference="alignment:Splign:2.1.0"
     exon            881..1055
                     /gene="DMRTC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1805
                     /gene="DMRTC2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1607..1612
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DMRTC2"
                     /note="hexamer: AATAAA"
     polyA_site      1631
                     /gene="DMRTC2"
                     /note="major polyA site"
     regulatory      1778..1783
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DMRTC2"
                     /note="hexamer: AATAAA"
     polyA_site      1805
                     /gene="DMRTC2"
ORIGIN      
        1 actttctcac agtgtctttg ggcgtcttct tgactgaatc tgactccatt ggaggctgtg
       61 atccatggaa cccagtgaca tgcctgctgg ctaccactgc cccttagact ctgccccctg
      121 ggatgagacc agagaccccc agagcacaga gctgatcccc aggagagcca tcagccgctc
      181 tccaacctgc gcccgctgcc gcaaccatgg tgtcaccgcc catctcaagg gccacaagcg
      241 cctctgcctc ttccaggctt gcgagtgtca caaatgtgtc ctcatcctgg agcgccgcag
      301 ggtcatggct gcccaggtgg ccttgcgtag gcagcaggag gcgcagctaa agaagcacct
      361 gatgaggaga ggggaagcct ctcccaaagc tcccaaccac ttcagaaagg gaaccactca
      421 gccacaggtc ccctctggaa aggagaacat agcaccccag cctcagaccc cccatggggc
      481 agtcctgctg gcaccgacac cccccgggaa gaactcctgt gggcctctgc tgctcagcca
      541 tcccccggaa gcctcgccct tgtcctggac tccggtgcct cctggccctt gggtccctgg
      601 acactggctg cctccaggct tctccatgcc accaccagtg gtgtgccgcc tgctgtacca
      661 agaacctgct gtctctctgc ctcccttccc tggctttgac cctggcacct ccctccagct
      721 gcccactcat gggcccttca ccacctgccc aggatctcac ccagtactga cagctcctct
      781 ttctggagag ccccaagggc cccctagcca gccccgcaca cactcaactc tgatactcca
      841 gccctgtggc accccagacc ctcttcagct acagccacag gcctctggag cctcgtgcct
      901 ggcccggaca tctggcccct cagagtggca gctgcagcaa gaggcagctg aagccctcgt
      961 ggggctgaaa gattcatccc aggctcctcg tgtgacccct tctgtgcccc ccaaccctgc
     1021 ctggatctcc ctgcttcacc cctgtggccc accagctcct gctggaggaa gaggattcca
     1081 gcctgttggc ccctgtcttc gacccagccc agccccctct gttgctctgc atattggccg
     1141 tctggggtcc atctccctcc tgagctagaa acccagagat ggaggctgtc ttgctatggc
     1201 agggaggtga cagcctgctg gcactgtata tttagtgtct tacttaagga tttatgcatg
     1261 gaatttaatg tagtacaagc ttcgggcttt tttgtttgtt tgtttgtttg tttgtttaag
     1321 ctttcaggtg cttcattagc tttcagttcc tttggtagtg tgggcatttc cttggctgac
     1381 agtggatatt cttgtaccct tcttgggtcc tgggatctct tgaaatcccc aataaagaga
     1441 gagttgtgct atttaagctg accagtatct ataaacgtgt ttgcatgagt ttacatccca
     1501 ggattccatg attctgtaaa tgcctatgca ttcatgtctg tctccatgca tgtgaaaaca
     1561 ggagagtgtt ttcattttgt gtctaggttt gtgtgagtaa gcaagaaata aacctttgtt
     1621 gttgtaagcc actgagattt ggagagtgtt accacagcct aacctagtct atcctgactg
     1681 acagaaagga cttgttcatt tcgcttctca aagtgaaaaa tctgttatcc aatagctacc
     1741 atagatgaaa acaaacttgg atttttttct ttgtccaaat aaaaaaaaat gatgtaaaga
     1801 aataa
//
