LOCUS       NM_001386972            1460 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens DMRT like family C1B (DMRTC1B), transcript variant 3,
            mRNA.
ACCESSION   NM_001386972 XM_006724684
VERSION     NM_001386972.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1460)
  AUTHORS   Ross,M.T., Grafham,D.V., Coffey,A.J., Scherer,S., McLay,K.,
            Muzny,D., Platzer,M., Howell,G.R., Burrows,C., Bird,C.P.,
            Frankish,A., Lovell,F.L., Howe,K.L., Ashurst,J.L., Fulton,R.S.,
            Sudbrak,R., Wen,G., Jones,M.C., Hurles,M.E., Andrews,T.D.,
            Scott,C.E., Searle,S., Ramser,J., Whittaker,A., Deadman,R.,
            Carter,N.P., Hunt,S.E., Chen,R., Cree,A., Gunaratne,P., Havlak,P.,
            Hodgson,A., Metzker,M.L., Richards,S., Scott,G., Steffen,D.,
            Sodergren,E., Wheeler,D.A., Worley,K.C., Ainscough,R.,
            Ambrose,K.D., Ansari-Lari,M.A., Aradhya,S., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Ballabio,A., Banerjee,R., Barker,G.E.,
            Barlow,K.F., Barrett,I.P., Bates,K.N., Beare,D.M., Beasley,H.,
            Beasley,O., Beck,A., Bethel,G., Blechschmidt,K., Brady,N.,
            Bray-Allen,S., Bridgeman,A.M., Brown,A.J., Brown,M.J., Bonnin,D.,
            Bruford,E.A., Buhay,C., Burch,P., Burford,D., Burgess,J.,
            Burrill,W., Burton,J., Bye,J.M., Carder,C., Carrel,L., Chako,J.,
            Chapman,J.C., Chavez,D., Chen,E., Chen,G., Chen,Y., Chen,Z.,
            Chinault,C., Ciccodicola,A., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S., Clerc-Blankenburg,K., Clifford,K., Cobley,V., Cole,C.G.,
            Conquer,J.S., Corby,N., Connor,R.E., David,R., Davies,J., Davis,C.,
            Davis,J., Delgado,O., Deshazo,D., Dhami,P., Ding,Y., Dinh,H.,
            Dodsworth,S., Draper,H., Dugan-Rocha,S., Dunham,A., Dunn,M.,
            Durbin,K.J., Dutta,I., Eades,T., Ellwood,M., Emery-Cohen,A.,
            Errington,H., Evans,K.L., Faulkner,L., Francis,F., Frankland,J.,
            Fraser,A.E., Galgoczy,P., Gilbert,J., Gill,R., Glockner,G.,
            Gregory,S.G., Gribble,S., Griffiths,C., Grocock,R., Gu,Y.,
            Gwilliam,R., Hamilton,C., Hart,E.A., Hawes,A., Heath,P.D.,
            Heitmann,K., Hennig,S., Hernandez,J., Hinzmann,B., Ho,S., Hoffs,M.,
            Howden,P.J., Huckle,E.J., Hume,J., Hunt,P.J., Hunt,A.R.,
            Isherwood,J., Jacob,L., Johnson,D., Jones,S., de Jong,P.J.,
            Joseph,S.S., Keenan,S., Kelly,S., Kershaw,J.K., Khan,Z.,
            Kioschis,P., Klages,S., Knights,A.J., Kosiura,A., Kovar-Smith,C.,
            Laird,G.K., Langford,C., Lawlor,S., Leversha,M., Lewis,L., Liu,W.,
            Lloyd,C., Lloyd,D.M., Loulseged,H., Loveland,J.E., Lovell,J.D.,
            Lozado,R., Lu,J., Lyne,R., Ma,J., Maheshwari,M., Matthews,L.H.,
            McDowall,J., McLaren,S., McMurray,A., Meidl,P., Meitinger,T.,
            Milne,S., Miner,G., Mistry,S.L., Morgan,M., Morris,S., Muller,I.,
            Mullikin,J.C., Nguyen,N., Nordsiek,G., Nyakatura,G., O'Dell,C.N.,
            Okwuonu,G., Palmer,S., Pandian,R., Parker,D., Parrish,J.,
            Pasternak,S., Patel,D., Pearce,A.V., Pearson,D.M., Pelan,S.E.,
            Perez,L., Porter,K.M., Ramsey,Y., Reichwald,K., Rhodes,S.,
            Ridler,K.A., Schlessinger,D., Schueler,M.G., Sehra,H.K.,
            Shaw-Smith,C., Shen,H., Sheridan,E.M., Shownkeen,R., Skuce,C.D.,
            Smith,M.L., Sotheran,E.C., Steingruber,H.E., Steward,C.A.,
            Storey,R., Swann,R.M., Swarbreck,D., Tabor,P.E., Taudien,S.,
            Taylor,T., Teague,B., Thomas,K., Thorpe,A., Timms,K., Tracey,A.,
            Trevanion,S., Tromans,A.C., d'Urso,M., Verduzco,D., Villasana,D.,
            Waldron,L., Wall,M., Wang,Q., Warren,J., Warry,G.L., Wei,X.,
            West,A., Whitehead,S.L., Whiteley,M.N., Wilkinson,J.E.,
            Willey,D.L., Williams,G., Williams,L., Williamson,A.,
            Williamson,H., Wilming,L., Woodmansey,R.L., Wray,P.W., Yen,J.,
            Zhang,J., Zhou,J., Zoghbi,H., Zorilla,S., Buck,D., Reinhardt,R.,
            Poustka,A., Rosenthal,A., Lehrach,H., Meindl,A., Minx,P.J.,
            Hillier,L.W., Willard,H.F., Wilson,R.K., Waterston,R.H., Rice,C.M.,
            Vaudin,M., Coulson,A., Nelson,D.L., Weinstock,G., Sulston,J.E.,
            Durbin,R., Hubbard,T., Gibbs,R.A., Beck,S., Rogers,J. and
            Bentley,D.R.
  TITLE     The DNA sequence of the human X chromosome
  JOURNAL   Nature 434 (7031), 325-337 (2005)
   PUBMED   15772651
REFERENCE   2  (bases 1 to 1460)
  AUTHORS   Ottolenghi,C., Fellous,M., Barbieri,M. and McElreavey,K.
  TITLE     Novel paralogy relations among human chromosomes support a link
            between the phylogeny of doublesex-related genes and the evolution
            of sex determination
  JOURNAL   Genomics 79 (3), 333-343 (2002)
   PUBMED   11863363
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC240504.3.
            
            On Sep 17, 2020 this sequence version replaced XM_006724684.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.62132.1,
                                           SRR5189664.104130.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968832, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000334036.10/ ENSP00000334501.5
            RefSeq Select criteria :: based on manual assertion, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-359               AC240504.3         94359-94717         c
            360-517             AC240504.3         26408-26565         c
            518-576             AC240504.3         26050-26108         c
            577-710             AC240504.3         25602-25735         c
            711-771             AC240504.3         24662-24722         c
            772-919             AC240504.3         24330-24477         c
            920-1460            AC240504.3         22804-23344         c
FEATURES             Location/Qualifiers
     source          1..1460
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq13.1"
     gene            1..1460
                     /gene="DMRTC1B"
                     /note="DMRT like family C1B"
                     /db_xref="GeneID:728656"
                     /db_xref="HGNC:HGNC:31686"
     exon            1..359
                     /gene="DMRTC1B"
                     /inference="alignment:Splign:2.1.0"
     exon            360..517
                     /gene="DMRTC1B"
                     /inference="alignment:Splign:2.1.0"
     CDS             454..1032
                     /gene="DMRTC1B"
                     /note="isoform 1 is encoded by transcript variant 3;
                     doublesex- and mab-3-related transcription factor C1;
                     DMRT-like family C1"
                     /codon_start=1
                     /product="doublesex- and mab-3-related transcription
                     factor C1 isoform 1"
                     /protein_id="NP_001373901.1"
                     /db_xref="CCDS:CCDS43971.1"
                     /db_xref="GeneID:728656"
                     /db_xref="HGNC:HGNC:31686"
                     /translation="MAAPPKAPIRVRNLTIRAGALTGKENNMLQPETHIFTAPEEGSS
                     QGALLLGQAPEPLSLPCTPVTLEQQLVSPSGDPHRAPALPSICSTLILQPCATLDPLL
                     LQPQVPKVSDQALVSAHSEWQRKLEAAEALLTLRNSAQAPPDSISLHQPCNPPAPAGD
                     KGFQPPSPSLRPRPASSISLPIGHLGCISLLS"
     exon            518..576
                     /gene="DMRTC1B"
                     /inference="alignment:Splign:2.1.0"
     exon            577..710
                     /gene="DMRTC1B"
                     /inference="alignment:Splign:2.1.0"
     exon            711..771
                     /gene="DMRTC1B"
                     /inference="alignment:Splign:2.1.0"
     exon            772..919
                     /gene="DMRTC1B"
                     /inference="alignment:Splign:2.1.0"
     exon            920..1460
                     /gene="DMRTC1B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1435..1440
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DMRTC1B"
                     /note="hexamer: AATAAA"
     polyA_site      1460
                     /gene="DMRTC1B"
                     /note="major polyA site"
ORIGIN      
        1 attcccacag ctccgggaag acccgggcgg cggaggctta gccccctccc ctcccgcttc
       61 ttcctcctcc tcctcctcct cctcctcctc ctcctcctcc tcctcctcct cctgctcctc
      121 ctcctcctgc tcctcctcct cctcctcctc ctcctcctcc ttctcctcct cctcccggtc
      181 tgagggcggc ggtctccgac tcaagaccct ggggctccgg gtcttcttag cagccgccgc
      241 agcagccgcg gcgacgtcac tgtcctctcg gcctggcaca cagcgctccg gccgccgaat
      301 gcccgtggac gcgcatctct tcccagagtt cctgcttcct gggccagcca aagccgcaga
      361 gaacgcctca gggtcttgcc tgctgtgagt gccttgaaga gggagcagcg ggcacgatca
      421 aagagacacc tggctcaagg accaataagg agtatggctg cccctcccaa agctcccatc
      481 cgtgtcagga atttgaccat cagagcagga gccctcactg ggaaggagaa caacatgctg
      541 cagcccgaga cccacatctt cacagccccc gaggagggga gctcccaagg ggctctgctg
      601 cttggccagg ccccagaacc tttgtctctg ccctgtactc cagtgacctt ggagcagcaa
      661 ctggtttctc cttctgggga tccccacagg gcccctgccc tgcccagcat atgctcaact
      721 ctgatcctcc agccctgtgc cacccttgac cctcttctac tgcagccaca ggtccccaaa
      781 gtctctgacc aggctttggt ttctgcccac tcagagtggc agcggaagct ggaggccgct
      841 gaggctctgc tgactctgag aaactctgcc caggcccctc ctgactccat ctccctgcac
      901 cagccttgca acccaccagc tcctgctgga gataaaggat tccagcctcc cagcccctct
      961 ctccgcccca ggccagccag ctccatctcg ctgcctattg gacatctggg atgcatctcc
     1021 ctcttgagct aggaacccag aggaggaggc ctcaatagag cactgcctat ttggtatcca
     1081 gtttctgaat gtgcaaaatg gttaacgtcc aaaacgctta acgtcttttt ttaaagcctt
     1141 caggtgtttt ataagctttt tattatatgg ggcaactcct tggctgaggg tggatattct
     1201 tgtacctctg tcccttactc ttttggatgc tggggccttt ttctgtctca taaagacagg
     1261 attgtgcaat ctaagttgat cagtctctca gtggggttct gtgtgagttc atatgccaga
     1321 gtttttattc gtcttgtgat tgctgacata cctgtgcact catgtgtata cccctgcatg
     1381 tggaaacatg aagatgtttt cactttgtgt ctaggtttat gtacgtgaac aaataataaa
     1441 ccgttgttgt tataaggcac
//
